CA2745114A1 - Centrifugation apparatus and methods for concentrating biological material - Google Patents

Centrifugation apparatus and methods for concentrating biological material Download PDF

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Publication number
CA2745114A1
CA2745114A1 CA2745114A CA2745114A CA2745114A1 CA 2745114 A1 CA2745114 A1 CA 2745114A1 CA 2745114 A CA2745114 A CA 2745114A CA 2745114 A CA2745114 A CA 2745114A CA 2745114 A1 CA2745114 A1 CA 2745114A1
Authority
CA
Canada
Prior art keywords
chamber
sedimentation
suspension
cells
chambers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2745114A
Other languages
English (en)
French (fr)
Inventor
Kyungyoon Min
Thomas E. Dudar
James C. Laird
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxalta GmbH
Baxalta Inc
Original Assignee
Baxter Healthcare SA
Baxter International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Healthcare SA, Baxter International Inc filed Critical Baxter Healthcare SA
Publication of CA2745114A1 publication Critical patent/CA2745114A1/en
Abandoned legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
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    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5021—Test tubes specially adapted for centrifugation purposes
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    • B01L3/56—Labware specially adapted for transferring fluids
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    • B01L3/5635—Joints or fittings ; Separable fluid transfer means to transfer fluids between at least two containers, e.g. connectors connecting two containers face to face, e.g. comprising a filter
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/02—Separating microorganisms from the culture medium; Concentration of biomass
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/02—Access sites
    • A61M39/04—Access sites having pierceable self-sealing members
    • A61M39/045—Access sites having pierceable self-sealing members pre-slit to be pierced by blunt instrument
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
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    • B01D21/26—Separation of sediment aided by centrifugal force or centripetal force
    • B01D21/262—Separation of sediment aided by centrifugal force or centripetal force by using a centrifuge
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Sustainable Development (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • External Artificial Organs (AREA)
CA2745114A 2008-12-01 2009-11-13 Centrifugation apparatus and methods for concentrating biological material Abandoned CA2745114A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12/326,061 2008-12-01
US12/326,061 US8309343B2 (en) 2008-12-01 2008-12-01 Apparatus and method for processing biological material
PCT/US2009/064297 WO2010065261A1 (en) 2008-12-01 2009-11-13 Apparatus and methods for processing biological material

Publications (1)

Publication Number Publication Date
CA2745114A1 true CA2745114A1 (en) 2010-06-10

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA2745114A Abandoned CA2745114A1 (en) 2008-12-01 2009-11-13 Centrifugation apparatus and methods for concentrating biological material

Country Status (7)

Country Link
US (5) US8309343B2 (enExample)
EP (5) EP3112451A1 (enExample)
JP (1) JP5401555B2 (enExample)
CA (1) CA2745114A1 (enExample)
DK (1) DK2361301T3 (enExample)
ES (1) ES2613966T3 (enExample)
WO (1) WO2010065261A1 (enExample)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9782526B2 (en) 2011-04-14 2017-10-10 Maternal Life, Llc. Device and method for collecting and dispensing colostrum
US8979819B2 (en) 2011-04-14 2015-03-17 Maternal Life, Llc Device and method for collecting and dispensing colostrum
US8998879B2 (en) 2011-04-14 2015-04-07 Maternal Life, Llc Device and method for collecting and dispensing colostrum
US9513291B2 (en) * 2012-11-30 2016-12-06 Rarecyte, Inc. Apparatus, system, and method for collecting a target material
US10054524B2 (en) * 2012-11-30 2018-08-21 Rarecyte, Inc. Apparatus, system and method for collecting a target material
US9539570B2 (en) * 2012-11-30 2017-01-10 Rarecyte, Inc. Apparatus, system, and method for collecting a target material
US9956555B2 (en) * 2012-11-30 2018-05-01 Rarecyte, Inc. Apparatus, system, and method for collecting a target material
US9533303B2 (en) * 2012-11-30 2017-01-03 Rarecyte, Inc. Apparatus, system, and method for collecting a target material
CN105408472A (zh) * 2013-03-15 2016-03-16 马卡斯凯尔·托莱夫·拉尔森 用于脐带血收集及细胞分离的细胞、方法和装置
US9218826B1 (en) 2013-08-16 2015-12-22 Seagate Technology Llc Tuned horizontally symmetric magnetic stack
US10086120B2 (en) 2013-09-05 2018-10-02 Lansinoh Laboratories, Inc. Connector for collection and dispensing of breast milk or colostrum
US10426705B2 (en) 2013-09-05 2019-10-01 Lansinoh Laboratories, Inc. Colostrum collection system
US10080825B2 (en) 2013-09-05 2018-09-25 Lansinoh Laboratories, Inc. Connector for collection and dispensing of breast milk or colostrum
US10388047B2 (en) * 2015-02-20 2019-08-20 Adobe Inc. Providing visualizations of characteristics of an image
GB201514216D0 (en) 2015-08-12 2015-09-23 Ihod Ltd An apparatus for generating hydrogen
USD853580S1 (en) * 2015-09-29 2019-07-09 Actim Oy Tube assembly with funnel
CA3044657C (en) 2015-11-24 2022-10-18 Royal Biologics Methods and apparatus for separating fluid components
GB2556127B (en) * 2016-11-17 2022-03-09 Ihod Ltd An apparatus for generating hydrogen
KR101953846B1 (ko) * 2016-09-30 2019-03-06 대한민국 농축액 플라스크
US11542473B2 (en) 2016-10-21 2023-01-03 Amniotics Ab Methods and compositions for generating hematopoietic cells
CN106475164B (zh) * 2016-10-24 2019-01-11 深圳市孔雀生物科技有限公司 一种组合式离心装置
NL2020385B1 (en) * 2018-02-06 2019-08-14 Labonovum B V Device for extraction of blood serum constituents
CN108918359B (zh) * 2018-07-27 2020-09-15 国家电网有限公司 泥沙颗粒沉积模拟试验装置和方法
US10857271B2 (en) 2018-09-06 2020-12-08 Lansinoh Laboratories, Inc. Closed loop electric breast pump
US11426499B2 (en) 2018-09-06 2022-08-30 Lansinoh Laboratories, Inc. Breast pumps
US10617806B2 (en) 2018-09-06 2020-04-14 Lansinoh Laboratories, Inc. Vibratory waveform for breast pump
JP7226738B2 (ja) * 2019-03-28 2023-02-21 国立大学法人滋賀医科大学 細胞濃縮用容器
EP3986358A4 (en) 2019-06-20 2023-06-21 Amniotics AB DEVICE FOR FILTERING FRUIT WATER
US20220372444A1 (en) 2019-10-18 2022-11-24 Amniotics Ab Processes and apparatuses for obtaining amniotic mesenchymal stem cells from amniotic fluid and cells derived thereof
US12435308B2 (en) 2020-11-06 2025-10-07 Amniotics Ab Immunomodulation by amniotic fluid mesenchymal stem cells
WO2023028137A1 (en) * 2021-08-26 2023-03-02 Entegris, Inc. Apparatus and methods for clean transfer of centrifuged materials
CN217554498U (zh) * 2022-07-14 2022-10-11 苏州壹达生物科技有限公司 一种液瓶

Family Cites Families (208)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE222724C (enExample) *
NL60433C (enExample) * 1942-04-08 1948-01-15
US2928591A (en) * 1956-12-27 1960-03-15 Deaver George Lee Method and apparatus for separating particles in a fluid dispersion
GB1189775A (en) 1967-03-14 1970-04-29 Sklarny Kavalier Filtering Attachment.
US3750645A (en) * 1970-10-20 1973-08-07 Becton Dickinson Co Method of collecting blood and separating cellular components thereof
US3713778A (en) * 1971-09-23 1973-01-30 N Karamian Separatory funnel
US3911918A (en) 1972-04-13 1975-10-14 Ralph D Turner Blood collection, storage and administering bag
US3897902A (en) * 1974-02-01 1975-08-05 Sindco Corp Phase separating tube
US3914985A (en) 1974-03-29 1975-10-28 American Hospital Supply Corp Centrifuging device and method
US4035294A (en) * 1975-05-23 1977-07-12 Denver Chemical Manufacturing Company Pressure differential filtering device and method
US4040959A (en) * 1976-06-22 1977-08-09 Berman Irwin R Multi-purpose blood bag
US4066414A (en) * 1977-02-15 1978-01-03 Donald Selby One piece tube and microscope slide manipulative laboratory device
US4344560A (en) 1979-11-02 1982-08-17 Asahi Kasei Kogyo Kabushiki Kaisha Container, apparatus and method for separating platelets
US4268393A (en) * 1980-05-05 1981-05-19 The Institutes Of Medical Sciences Apparatus for centrifugal separation of platelet-rich plasma
US4416778A (en) 1981-10-20 1983-11-22 Neocyte, Inc. Means for preparing neocyte enriched blood
SE8206767D0 (sv) 1982-11-26 1982-11-26 Seroteknik Hb Sett och anordning for satsvis centrifugalseparering av blod
US4582606A (en) * 1984-01-30 1986-04-15 Neotech, Inc. Apparatus for separating or collecting different density liquid components
US4975186A (en) 1984-03-02 1990-12-04 Miles Laboratories, Inc. Container for fine separation of blood and blood components
DE3587885T2 (de) 1984-03-21 1994-11-03 Mclaughlin William F Filtration einer flüssigen Suspension.
IL74967A (en) * 1985-04-18 1988-10-31 Assaf Pharmaceutical Ind Separation of materials from a liquid dispersion by sedimentation
JPH0698754B2 (ja) 1985-05-13 1994-12-07 キヤノン株式会社 記録装置
US5628781A (en) * 1985-06-06 1997-05-13 Thomas Jefferson University Implant materials, methods of treating the surface of implants with microvascular endothelial cells, and the treated implants themselves
US4820626A (en) * 1985-06-06 1989-04-11 Thomas Jefferson University Method of treating a synthetic or naturally occuring surface with microvascular endothelial cells, and the treated surface itself
US5372945A (en) 1985-06-06 1994-12-13 Alchas; Paul G. Device and method for collecting and processing fat tissue and procuring microvessel endothelial cells to produce endothelial cell product
US5230693A (en) * 1985-06-06 1993-07-27 Thomas Jefferson University Implantable prosthetic device for implantation into a human patient having a surface treated with microvascular endothelial cells
US5441539A (en) * 1985-06-06 1995-08-15 Thomas Jefferson University Endothelial cell deposition device
US5312380A (en) 1985-06-06 1994-05-17 Thomas Jefferson University Endothelial cell procurement and deposition kit
US5035708A (en) * 1985-06-06 1991-07-30 Thomas Jefferson University Endothelial cell procurement and deposition kit
US4772273A (en) * 1985-12-13 1988-09-20 Becton, Dickinson And Company Variable-volume vented container
ES2004281A6 (es) * 1986-04-04 1988-12-16 Univ Jefferson Una superficie protesica implantable para implantacion en un paciente humano
US6027750A (en) * 1986-09-04 2000-02-22 Gautsch; James Systems and methods for the rapid isolation of nucleic acids
US4683916A (en) * 1986-09-25 1987-08-04 Burron Medical Inc. Normally closed automatic reflux valve
US4811866A (en) * 1987-01-02 1989-03-14 Helena Laboratories Corporation Method and apparatus for dispensing liquids
US5370802A (en) 1987-01-30 1994-12-06 Baxter International Inc. Enhanced yield platelet collection systems and methods
US6780333B1 (en) * 1987-01-30 2004-08-24 Baxter International Inc. Centrifugation pheresis method
US5079160A (en) * 1987-06-08 1992-01-07 Lacy Paul E Method to isolate clusters of cell subtypes from organs
US4889524A (en) 1987-09-04 1989-12-26 Haemonetics Corporation Portable centrifuge apparatus
US4818386A (en) 1987-10-08 1989-04-04 Becton, Dickinson And Company Device for separating the components of a liquid sample having higher and lower specific gravities
US4834703A (en) * 1987-11-23 1989-05-30 Dubrul Will R Liposuction filter and lipoplasty device
EP0354947B1 (en) * 1988-01-25 1994-07-20 BAXTER INTERNATIONAL INC. (a Delaware corporation) Pre-slit injection site and tapered cannula
CA1335167C (en) * 1988-01-25 1995-04-11 Steven C. Jepson Pre-slit injection site and associated cannula
US4981654A (en) * 1988-05-06 1991-01-01 Davstar Industries, Inc. Unitary centrifuge tube and separable dispensing receptacle
US5312386A (en) * 1989-02-15 1994-05-17 Johnson & Johnson Disposable sanitary pad
US5103821A (en) * 1989-03-06 1992-04-14 Angeion Corporation Method of providing a biological pacemaker
US5019512A (en) * 1989-03-17 1991-05-28 Baxter International Inc. Spin filter for removing substantially cell-free culture medium from suspension cell culture system
DE3924862A1 (de) 1989-07-27 1991-01-31 Kuehn Hermann Prof Dr Dr Med Ausstrichtupfer und diesem angepasstes zentrifugenroehrchen
US5030215A (en) * 1990-01-03 1991-07-09 Cryolife, Inc. Preparation of fibrinogen/factor XIII precipitate
JP2884664B2 (ja) 1990-02-13 1999-04-19 日本電気株式会社 変復調装置切替方式
US5641622A (en) * 1990-09-13 1997-06-24 Baxter International Inc. Continuous centrifugation process for the separation of biological components from heterogeneous cell populations
US5115054A (en) * 1990-10-12 1992-05-19 Phillips Petroleum Company Catalysts containing poly(3-ethyl-1-hexene) and uses thereof
NZ242533A (en) 1991-05-03 1995-05-26 Becton Dickinson Co Device for collecting and processing fat tissue; vessel with rinsing and digesting chamber, drain chamber and isolation chamber
DK167517B1 (da) 1991-11-11 1993-11-15 Squibb & Sons Inc Beholder til optagelse og adskillelse af en vaeske, fortrinsvis blodplasma, i dennes bestanddele
JPH05218376A (ja) 1992-02-04 1993-08-27 Konica Corp 固体撮像装置における電荷転送素子の取付け構造
JPH05287479A (ja) 1992-04-16 1993-11-02 Kawasaki Steel Corp 金属板表面の連続処理槽
US5271852A (en) * 1992-05-01 1993-12-21 E. I. Du Pont De Nemours And Company Centrifugal methods using a phase-separation tube
AU665813B2 (en) * 1992-05-11 1996-01-18 Sulzer Medizinaltechnik Ag Process and apparatus for producing endoprostheses
SE470376B (sv) 1992-06-30 1994-02-07 Pharmacia Biosensor Ab Anordning och system för blodseparation
US5957972A (en) 1992-09-29 1999-09-28 Arizona Board Of Regents On Behalf Of The University Of Arizona Implants possessing a surface of endothelial cells genetically-modified to inhibit intimal thickening
US5316681A (en) * 1992-11-06 1994-05-31 Baxter International Inc. Method of filtering body fluid using a rinse chamber bag
US5364386A (en) 1993-05-05 1994-11-15 Hikari Seiyaku Kabushiki Kaisha Infusion unit
US6832996B2 (en) * 1995-06-07 2004-12-21 Arthrocare Corporation Electrosurgical systems and methods for treating tissue
JP3331398B2 (ja) 1993-05-28 2002-10-07 バクスター、インターナショナル、インコーポレイテッド 不均質な細胞混合物から特定の細胞集団を分離するための方法、装置およびシステム
US5409833A (en) * 1993-07-01 1995-04-25 Baxter International Inc. Microvessel cell isolation apparatus
AU1331595A (en) * 1993-11-30 1995-06-19 Medex, Inc. Anti-reflux valve with environmental barrier
PL173226B1 (pl) 1993-12-28 1998-02-27 "Mpw Medinstruments" Spoldzielnia Pracy Urządzenie do uzyskiwania osadu i nadsączu z ubogokomórkowych biologicznych płynów ustrojowych poprzez oddziaływanie sił odśrodkowych
AU699256B2 (en) 1994-02-16 1998-11-26 Flsmidth A/S Separation of a suspension into its component parts
AU700743B2 (en) 1994-08-31 1999-01-14 Dendreon Corporation Cell separation apparatus and method
US5577513A (en) * 1994-08-31 1996-11-26 Activated Cell Therapy, Inc. Centrifugation syringe, system and method
FR2729398A1 (fr) 1995-01-17 1996-07-19 Hospal R & D Int Dispositif de digestion d'organe et procede pour isoler des cellules ou amas de cellules d'interet biologique a partir d'un organe
US5804366A (en) * 1995-02-09 1998-09-08 Baxter International Inc. Method and apparatus for sodding microvessel cells onto a synthetic vascular graft
JPH08271971A (ja) 1995-04-03 1996-10-18 Asahi Optical Co Ltd プリントサイズ識別カメラ
JPH08278822A (ja) 1995-04-06 1996-10-22 Hitachi Metals Ltd インピーダンス制御方法
JPH08278821A (ja) 1995-04-06 1996-10-22 Kobe Steel Ltd サーボ制御系の制振方法
US5679565A (en) * 1995-04-10 1997-10-21 The Regents Of The University Of California Method of preserving pancreatic islets
US5707331A (en) * 1995-05-05 1998-01-13 John R. Wells Automatic multiple-decanting centrifuge
USRE38730E1 (en) * 1995-05-05 2005-04-26 Harvest Technologies Corporation Automatic multiple-decanting centrifuge and method of treating physiological fluids
US5888409A (en) * 1995-06-07 1999-03-30 Cedars-Sinai Medical Center Methods for cell isolation and collection
US5656154A (en) * 1995-06-07 1997-08-12 Organ, Inc. Method and apparatus for separating a fluid into components and for washing a material
US5643193A (en) 1995-12-13 1997-07-01 Haemonetics Corporation Apparatus for collection washing and reinfusion of shed blood
US5772643A (en) 1996-02-29 1998-06-30 Becton Dickinson And Company Barbed luer adapter
US5707876A (en) * 1996-03-25 1998-01-13 Stephen C. Wardlaw Method and apparatus for harvesting constituent layers from a centrifuged material mixture
DE69605062T2 (de) 1996-04-24 2000-07-13 Claude Fell Zelltrennungsvorrichtung für biologische flüssigkeiten wie blut
WO2000062828A1 (en) * 1996-04-30 2000-10-26 Medtronic, Inc. Autologous fibrin sealant and method for making the same
US5837444A (en) 1996-07-16 1998-11-17 Shah; Kumarpal A. Islet cell transplantation machine for diabetes cure
TW391881B (en) 1996-09-25 2000-06-01 Baxter Int Method and apparatus for filtering suspensions of medical and biological fluids or the like
KR100457361B1 (ko) * 1996-11-18 2004-11-16 나이프로 인크. 스웝 가능한 루어-원추형 밸브
US5824272A (en) * 1996-12-16 1998-10-20 Uchida; Toshiki Compound centrifuge tube
US5957898A (en) * 1997-05-20 1999-09-28 Baxter International Inc. Needleless connector
CA2260781A1 (en) * 1997-05-20 1998-11-26 Baxter International Inc. Needleless connector
US5786207A (en) * 1997-05-28 1998-07-28 University Of Pittsburgh Tissue dissociating system and method
US6979307B2 (en) * 1997-06-24 2005-12-27 Cascade Medical Enterprises Llc Systems and methods for preparing autologous fibrin glue
DE19729028C1 (de) * 1997-07-08 1999-05-06 Fraunhofer Ges Forschung Vorrichtung sowie Verfahren zur Isolierung von Zellmaterial aus einem Gewebeverband und/oder einer Flüssigkeit
DK1007631T4 (da) 1997-07-14 2009-04-27 Osiris Therapeutics Inc Hjertemuskelregeneration ved anvendelse af mesenkymale stamceller
US6001643A (en) 1997-08-04 1999-12-14 C-Med Inc. Controlled hydrodynamic cell culture environment for three dimensional tissue growth
IT1295939B1 (it) 1997-10-31 1999-05-28 Giammaria Sitar Dispositivo e metodo per la separazione di cellule umane od animali aventi densita' diverse da dispersioni cellulari che le contengono
EP0918221B1 (en) 1997-11-19 2006-09-06 Grifols, S.A. Apparatus for performing laboratory tests automatically
US6177009B1 (en) * 1998-04-03 2001-01-23 Macherey, Nagel Gmbh & Co. Apparatus for treating biomolecules
US6090572A (en) 1998-06-26 2000-07-18 Biostar, Incorporated Filtration and extraction device and method of using the same
US6123696A (en) 1998-07-16 2000-09-26 Thermogenesis Corp. Centrifugation bag with yieldable partitions
US6448076B2 (en) 1998-09-15 2002-09-10 The Regents Of The University Of Michigan Method for chemically acellularizing a biological tissue sample
US6497325B1 (en) 1998-12-05 2002-12-24 Becton Dickinson And Company Device for separating components of a fluid sample
US6280400B1 (en) * 1998-12-05 2001-08-28 Becton Dickinson And Company Device and method for separating component of a liquid sample
DE69930192T2 (de) 1998-12-05 2006-11-23 Becton Dickinson And Co. Vorrichtung und Verfahren zur Trennung von Bestandteilen einer flüssigen Probe
US6516953B1 (en) 1998-12-05 2003-02-11 Becton, Dickinson And Company Device for separating components of a fluid sample
US6479298B1 (en) 1998-12-05 2002-11-12 Becton, Dickinson And Company Device and method for separating components of a fluid sample
EP1025904B1 (en) * 1999-02-02 2007-05-09 Nipro Corporation Tube for sperm washing and concentration and method for sperm washing and concentration
US6238922B1 (en) * 1999-02-26 2001-05-29 Stemcells, Inc. Use of collagenase in the preparation of neural stem cell cultures
US20050153442A1 (en) * 1999-03-10 2005-07-14 Adam Katz Adipose-derived stem cells and lattices
US6777231B1 (en) * 1999-03-10 2004-08-17 The Regents Of The University Of California Adipose-derived stem cells and lattices
US20050076396A1 (en) * 1999-03-10 2005-04-07 Katz Adam J. Adipose-derived stem cells and lattices
US20030082152A1 (en) * 1999-03-10 2003-05-01 Hedrick Marc H. Adipose-derived stem cells and lattices
ATE318625T1 (de) 1999-03-15 2006-03-15 Implant Innovations Inc Sammelsystem für thrombozyten
WO2000061256A1 (en) 1999-04-12 2000-10-19 Harvest Technologies Corporation Method and apparatus for producing platelet rich plasma and/or platelet concentrate
US6316247B1 (en) 1999-06-15 2001-11-13 University Of Pittsburgh System and method for refining liposuctioned adipose tissue
US6716187B1 (en) * 1999-07-08 2004-04-06 Implant Innovations, Inc. Platelet concentration syringe kit
US6803022B2 (en) 1999-12-06 2004-10-12 Becton, Dickinson And Company Device and method for separating components of a fluid sample
US20030050591A1 (en) * 2000-02-08 2003-03-13 Patrick Mchale Anthony Loading system and method for using the same
GB0005898D0 (en) * 2000-03-10 2000-05-03 Templeton Stephen J Method and apparatus for introducing a moving liquid into a larger mass of moving liquid
US6401552B1 (en) * 2000-04-17 2002-06-11 Carlos D. Elkins Centrifuge tube and method for collecting and dispensing mixed concentrated fluid samples
US6988004B2 (en) * 2000-05-16 2006-01-17 Bioheart, Inc. Method for inducing angiogenesis by electrical stimulation of muscles
EP1301228B1 (en) * 2000-07-13 2008-07-23 Abbott Cardiovascular Systems Inc. Deployment system for myocardial cellular material
US7270996B2 (en) * 2000-10-02 2007-09-18 Cannon Thomas F Automated bioculture and bioculture experiments system
US20020146817A1 (en) * 2000-10-02 2002-10-10 Cannon Thomas F. Automated bioculture and bioculture experiments system
US6602718B1 (en) * 2000-11-08 2003-08-05 Becton, Dickinson And Company Method and device for collecting and stabilizing a biological sample
US20020077687A1 (en) * 2000-12-14 2002-06-20 Ahn Samuel S. Catheter assembly for treating ischemic tissue
US7045349B2 (en) * 2001-01-23 2006-05-16 Benedict Daniel J Method of islet isolation using process control
US7341062B2 (en) * 2001-03-12 2008-03-11 Bioheart, Inc. Method of providing a dynamic cellular cardiac support
EP1381410A2 (en) * 2001-04-09 2004-01-21 Medtronic, Inc. Methods of isolating blood components using a centrifuge and uses thereof
US6582350B2 (en) 2001-04-09 2003-06-24 Medtronic, Inc. Centrifuge container having curved linear shape
US6610002B2 (en) * 2001-04-09 2003-08-26 Medtronic, Inc. Method for handling blood sample to ensure blood components are isolated
AUPR540301A0 (en) 2001-06-01 2001-06-28 Walter And Eliza Hall Institute Of Medical Research, The A method of purification of cells
US6623959B2 (en) 2001-06-13 2003-09-23 Ethicon, Inc. Devices and methods for cell harvesting
US7483749B2 (en) * 2001-06-13 2009-01-27 Bioheart, Inc. Method of enhancing myogenesis by electrical stimulation
DE10136375A1 (de) 2001-07-26 2003-02-13 Cellgenix Technologie Transfer Verfahren zur Anreicherung von Zellen
EP1421361B1 (de) * 2001-08-29 2010-08-25 Dahm, Michael W., Dr. Dr. Verfahren und vorrichtung zur vorbereitung einer biologischen urprobe für die bestimmung zumindest einer darin enthaltenen komponente
US6589153B2 (en) * 2001-09-24 2003-07-08 Medtronic, Inc. Blood centrifuge with exterior mounted, self-balancing collection chambers
FR2830785B1 (fr) * 2001-10-12 2004-01-23 Millipore Sas Procede et instrument pour deverrouiller un dispositif comportant deux corps encliquetes axialement
AUPR862001A0 (en) 2001-11-02 2001-11-29 Qed Corporation Limited Apparatus for treatment of contaminated liquids
US6833270B2 (en) 2001-11-27 2004-12-21 Biorep Technologies, Inc. Apparatus and method for isolating cells from organs
JP4215489B2 (ja) 2001-11-27 2009-01-28 株式会社ｉｎｄｕｓｔｒｉａ 遠心分離装置
US20030161816A1 (en) 2001-12-07 2003-08-28 Fraser John K. Systems and methods for treating patients with processed lipoaspirate cells
US7585670B2 (en) 2001-12-07 2009-09-08 Cytori Therapeutics, Inc. Automated methods for isolating and using clinically safe adipose derived regenerative cells
US7651684B2 (en) * 2001-12-07 2010-01-26 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in augmenting autologous fat transfer
US7595043B2 (en) * 2001-12-07 2009-09-29 Cytori Therapeutics, Inc. Method for processing and using adipose-derived stem cells
US7514075B2 (en) * 2001-12-07 2009-04-07 Cytori Therapeutics, Inc. Systems and methods for separating and concentrating adipose derived stem cells from tissue
US7188994B2 (en) * 2002-02-22 2007-03-13 Biorep Technologies, Inc. Orbital shaker for cell extraction
AU2003220424A1 (en) 2002-03-19 2003-10-08 Advanced Research And Technology Transfer Adipose stromal stem cells for tissue and vascular modification
US8202725B2 (en) 2004-12-23 2012-06-19 Tissue Genesis Incorporated Cell sodding method and apparatus
US9144583B2 (en) * 2002-03-29 2015-09-29 Tissue Genesis, Inc. Cell separation apparatus and methods of use
US7179391B2 (en) 2002-05-24 2007-02-20 Biomet Manufacturing Corp. Apparatus and method for separating and concentrating fluids containing multiple components
US6905612B2 (en) * 2003-03-21 2005-06-14 Hanuman Llc Plasma concentrate apparatus and method
US20060278588A1 (en) * 2002-05-24 2006-12-14 Woodell-May Jennifer E Apparatus and method for separating and concentrating fluids containing multiple components
US7118676B2 (en) 2003-09-04 2006-10-10 Arryx, Inc. Multiple laminar flow-based particle and cellular separation with laser steering
DE10243086A1 (de) 2002-09-16 2004-03-25 Amaxa Gmbh Vorrichtung und Verfahren zur Behandlung von biologischem Material
AU2003262095A1 (en) 2002-09-17 2004-04-08 Ken-Ichiro Hata Cell dispersing apparatus, cell dispersion cassette and tissue retention part
HK1079748B (zh) * 2002-09-19 2009-02-06 丰收技术股份有限公司 用於无菌可置换单元的容器
CN1742093A (zh) * 2002-11-18 2006-03-01 新加坡科技研究局 细胞和/或核酸分子分离的方法和系统
US20040248077A1 (en) 2002-11-27 2004-12-09 Horacio L. Rodriguez Rilo Cell separation apparatus
US20040162540A1 (en) 2003-02-13 2004-08-19 Becton, Dickinson And Company Transfer device
US7118522B2 (en) 2003-04-15 2006-10-10 Beckman Coulter, Inc. Centrifuge adapter
AU2004234627A1 (en) * 2003-05-02 2004-11-11 Insception Bioscience, Inc. Apparatus and methods for amplification of blood stem cell numbers
GB0312400D0 (en) 2003-05-29 2003-07-02 Isis Innovation Digestion chamber for cell isolation
US20050026275A1 (en) * 2003-06-23 2005-02-03 Andrej Bahoric Device, system and method for receiving, processing and dispersing cells
KR20060102325A (ko) * 2003-09-22 2006-09-27 바텔리 메모리얼 인스티튜트 조직 분리 장치
CN100417428C (zh) 2003-09-30 2008-09-10 博奥生物有限公司 离心分离的仪器和方法
EP2450433A3 (en) 2003-10-08 2012-08-08 Vet-Stem Inc Methods of preparing and using stem cell compositions and kits comprising the same
US20050125049A1 (en) * 2003-10-21 2005-06-09 The Regents Of The University Of Michigan Tissue engineered vascular construct and method for producing same
US20050124073A1 (en) 2003-12-09 2005-06-09 Entire Interest Fat collection and preparation system and method
JP4482322B2 (ja) * 2003-12-18 2010-06-16 浜松ホトニクス株式会社 微粒子の製造方法、及び製造装置
DE102004011400A1 (de) 2004-03-05 2005-09-22 Cavis Microcaps Gmbh Technischer Prozess sowie Anlage zur Gewinnung und/oder Verkapselung von lebenden Zellen aus Organen
US7108679B2 (en) * 2004-03-11 2006-09-19 Becton, Dickinson And Company Intradermal syringe and needle assembly
EP2298861B1 (en) 2004-03-22 2017-09-13 Mesoblast International Sàrl Mesenchymal stem cells and uses therefor
DE102004036840B4 (de) 2004-07-29 2012-04-19 Orthogen Ag Verfahren und Mittel zur Gewinnung von thrombocytenreichem Plasma
US20060045872A1 (en) * 2004-08-25 2006-03-02 Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco Use of adipose tissue-derived stromal stem cells in treating fistula
US20060134781A1 (en) * 2004-12-07 2006-06-22 Bacterin International, Inc. Three-dimensional cell culture system
TWI266631B (en) * 2004-12-16 2006-11-21 Chih Shin Biomedical Technolog Method and apparatus are provided for rapid cell separation
WO2006069737A1 (de) * 2004-12-27 2006-07-06 Fresenius Medical Care Deutschland Gmbh Reaktor und reaktoreinheit mit hohlfasern
JP4510898B2 (ja) * 2005-02-07 2010-07-28 ハヌマン リミテッド ライアビリティ カンパニー 血漿濃縮装置
EP2666494B1 (en) 2005-02-07 2018-01-17 Hanuman LLC Platelet rich plasma concentrate apparatus and method
EP1893253B1 (en) 2005-03-23 2010-05-19 Biosafe S.A. Integrated system for collecting, processing and transplanting cell subsets, including adult stem cells, for regenerative medicine
KR101617319B1 (ko) 2005-04-12 2016-05-02 메소블라스트, 아이엔씨. 조직 비특이적인 알카리 포스파타제에 의한 다분화성 성체 세포의 분리
KR20060129647A (ko) * 2005-06-13 2006-12-18 노틸러스효성 주식회사 금융자동화기기의 출금장치
JP2008546686A (ja) 2005-06-17 2008-12-25 セレゲン，インコーポレーテッド 虚血組織の治療方法
US7781211B2 (en) 2005-06-17 2010-08-24 Homeotherapy, Co. Ltd Isolation of multi-lineage stem cells
WO2007000966A1 (ja) 2005-06-27 2007-01-04 Sekisui Chemical Co., Ltd. 検体採取容器
CA2614180A1 (en) * 2005-07-06 2007-01-11 The Regents Of The University Of California Apparatuses, systems, and methods for isolating and separating biological materials
US8048297B2 (en) 2005-08-23 2011-11-01 Biomet Biologics, Llc Method and apparatus for collecting biological materials
US7771590B2 (en) * 2005-08-23 2010-08-10 Biomet Manufacturing Corp. Method and apparatus for collecting biological materials
US20070131612A1 (en) 2005-10-27 2007-06-14 Duffy Neil F Jr Cell separation method and apparatus
KR100679642B1 (ko) * 2005-11-16 2007-02-06 주식회사 알앤엘바이오 인간 지방조직 유래 다분화능 줄기세포 및 이를 함유하는세포치료제
US7867765B2 (en) 2005-12-28 2011-01-11 The General Hospital Corporation Blood cell sorting methods and systems
US20070154465A1 (en) * 2005-12-30 2007-07-05 Alexandar Kharazi Stem cell therapy for retinal disease
GB0600595D0 (en) 2006-01-12 2006-02-22 Colonix Ltd Container
US20070243574A1 (en) 2006-01-27 2007-10-18 University Of Arizona Vascular mimic for drug and device evaluation
JP4950277B2 (ja) * 2006-03-20 2012-06-13 ロンシャン リ 細胞ブロック作製システム及びその使用方法
US20070267444A1 (en) * 2006-05-05 2007-11-22 De Buzzaccarini Francesco Concentrated compositions contained in bottom dispensing containers
US20070278154A1 (en) 2006-05-30 2007-12-06 Sysmex Corporation Cell processing method and cell processing apparatus
WO2007139551A1 (en) * 2006-05-30 2007-12-06 Cytori Therapeutics, Inc. Systems and methods for manipulation of regenerative cells from adipose tissue
US7874756B2 (en) 2006-06-07 2011-01-25 Beiersdorf Ag Kit for the application of a fluid preparation
US20100111910A1 (en) 2006-07-12 2010-05-06 Angioblast Systems, Inc. Treatment of excessive neovascularization
US7858363B2 (en) * 2006-07-22 2010-12-28 Zymo Research Corporation Plasmid DNA isolation
CA2661935C (en) * 2006-08-29 2013-07-09 Tissue Genesis, Inc. Catheter for cell delivery
EP2061873B1 (en) * 2006-09-21 2011-11-23 Tissue Genesis Cell delivery matrices
JP5105925B2 (ja) * 2007-03-26 2012-12-26 京セラメディカル株式会社 遠心分離用デバイス
JP5479319B2 (ja) 2007-04-12 2014-04-23 バイオメット・バイオロジックス・リミテッド・ライアビリティ・カンパニー ブイ式懸濁液分画システム
EP2205251B1 (en) 2007-10-01 2017-01-11 University of Miami A method to amplify cardiac stem cells in vitro and in vivo
US7846394B2 (en) 2007-10-02 2010-12-07 Becton, Dickinson And Company Apparatus and method for separating particles within a specimen
WO2009073724A1 (en) * 2007-12-04 2009-06-11 Ingeneron, Inc. Apparatus and methods for cell isolation

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US9423327B2 (en) 2016-08-23
US9176038B2 (en) 2015-11-03
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EP3112451A1 (en) 2017-01-04
EP3112453A1 (en) 2017-01-04
JP5401555B2 (ja) 2014-01-29
EP3121260A1 (en) 2017-01-25
EP2361301B1 (en) 2016-11-02
JP2012510272A (ja) 2012-05-10
WO2010065261A1 (en) 2010-06-10
ES2613966T3 (es) 2017-05-29
US20130005032A1 (en) 2013-01-03
US20130001157A1 (en) 2013-01-03
US8309343B2 (en) 2012-11-13
US20130005023A1 (en) 2013-01-03
DK2361301T3 (en) 2017-02-13
US9097631B2 (en) 2015-08-04
US20130005031A1 (en) 2013-01-03
US20100136679A1 (en) 2010-06-03
EP3112452A1 (en) 2017-01-04
US9182328B2 (en) 2015-11-10

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