CA2730120A1 - Method of treating blepharitis - Google Patents
Method of treating blepharitis Download PDFInfo
- Publication number
- CA2730120A1 CA2730120A1 CA2730120A CA2730120A CA2730120A1 CA 2730120 A1 CA2730120 A1 CA 2730120A1 CA 2730120 A CA2730120 A CA 2730120A CA 2730120 A CA2730120 A CA 2730120A CA 2730120 A1 CA2730120 A1 CA 2730120A1
- Authority
- CA
- Canada
- Prior art keywords
- subject
- azithromycin
- blepharitis
- weeks
- effective amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 description 1
- 229940072172 tetracycline antibiotic Drugs 0.000 description 1
- DHCDFWKWKRSZHF-UHFFFAOYSA-L thiosulfate(2-) Chemical compound [O-]S([S-])(=O)=O DHCDFWKWKRSZHF-UHFFFAOYSA-L 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000759 toxicological effect Toxicity 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 229960000281 trometamol Drugs 0.000 description 1
- 235000019871 vegetable fat Nutrition 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 239000003871 white petrolatum Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7977208P | 2008-07-10 | 2008-07-10 | |
| US61/079,772 | 2008-07-10 | ||
| PCT/US2009/050311 WO2010006306A1 (en) | 2008-07-10 | 2009-07-10 | Method of treating blepharitis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2730120A1 true CA2730120A1 (en) | 2010-01-14 |
Family
ID=41507457
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2730120A Abandoned CA2730120A1 (en) | 2008-07-10 | 2009-07-10 | Method of treating blepharitis |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8349806B2 (enExample) |
| EP (1) | EP2313103B1 (enExample) |
| JP (2) | JP2011527709A (enExample) |
| AU (1) | AU2009268372B2 (enExample) |
| CA (1) | CA2730120A1 (enExample) |
| MX (1) | MX2011000247A (enExample) |
| WO (1) | WO2010006306A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9925087B2 (en) | 2000-09-15 | 2018-03-27 | Bruder Healthcare Company, Llc | Wound and therapy compress and dressing |
| US10105259B2 (en) | 2000-09-15 | 2018-10-23 | Bruder Healthcare Company, Llc | Wound and therapy compress and dressing |
| ATE460146T1 (de) | 2000-09-15 | 2010-03-15 | Bruder Healthcare Co | Wund- und behandlungskompresse und verband |
| US8349806B2 (en) | 2008-07-10 | 2013-01-08 | Inspire Pharmaceuticals, Inc. | Method of treating blepharitis |
| US20100190734A1 (en) * | 2009-01-23 | 2010-07-29 | Romulus Kimbro Brazzell | Method of treating dry eye disease with azithromycin |
| US20130281390A1 (en) * | 2010-12-29 | 2013-10-24 | Kurt E. Brubaker | Method for treating dry eye |
| WO2012092378A1 (en) * | 2010-12-29 | 2012-07-05 | Inspire Pharmaceuticals, Inc. | Method for treating blepharitis |
| JP2014518275A (ja) * | 2011-06-29 | 2014-07-28 | インサイト・ビジョン・インコーポレイテッド | 再発性マイボーム腺障害の処置方法およびそれによる再発頻度の減少方法 |
| WO2013191167A1 (ja) * | 2012-06-19 | 2013-12-27 | 参天製薬株式会社 | ヘアレス動物の眼瞼状態の変化方法 |
| WO2014143139A1 (en) | 2013-03-15 | 2014-09-18 | Bruder Healthcare Company | Wound and therapy compress and dressing |
| CN104045674B (zh) * | 2014-05-21 | 2017-01-04 | 丽珠医药集团股份有限公司 | 一种阿奇霉素的制备方法 |
| CN105106109A (zh) * | 2015-09-11 | 2015-12-02 | 江苏锦宇环境工程有限公司 | 一种阿奇霉素缓释滴眼剂的制备方法 |
| CN108289908A (zh) * | 2015-12-22 | 2018-07-17 | 日油株式会社 | 泪液油层稳定剂及含有该泪液油层稳定剂的滴眼剂 |
| US12029681B2 (en) | 2016-03-01 | 2024-07-09 | The Hilsinger Company Parent, Llc | Therapeutic eye mask system |
| US12011388B2 (en) | 2016-03-01 | 2024-06-18 | The Hilsinger Company Parent, Llc | Therapeutic thermal compress with phase-change material |
| US12156831B2 (en) | 2016-03-01 | 2024-12-03 | The Hilsinger Company Parent, Llc | Therapeutic eye compress system |
| US9981041B2 (en) * | 2016-08-23 | 2018-05-29 | Ira Jason Salzman | Ophthalmic lubricating spray |
| USD844795S1 (en) | 2016-11-30 | 2019-04-02 | Bruder Healthcare Company, Llc | Therapeutic eye mask |
| USD871598S1 (en) | 2016-11-30 | 2019-12-31 | Bruder Healthcare Company, Llc | Therapeutic eye mask |
| CN109381707B (zh) * | 2017-08-03 | 2022-02-15 | 沈阳药科大学 | 一种阿奇霉素离子对脂质体滴眼液及其制备方法 |
| JP2023133646A (ja) * | 2020-06-26 | 2023-09-27 | 参天製薬株式会社 | 脂質分泌促進剤 |
| CA3199736A1 (en) | 2020-11-23 | 2022-05-27 | Sight Sciences, Inc. | Formulations and methods for treating conditions of the eye |
| US20240050446A1 (en) * | 2021-02-25 | 2024-02-15 | Sun Pharmaceutical Industries Limited | Dexamethasone for treatment of blepharitis |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6861411B1 (en) | 1997-12-02 | 2005-03-01 | Pfizer, Inc. | Method of treating eye infections with azithromycin |
| ATE319456T1 (de) | 1998-05-08 | 2006-03-15 | Univ Miami | Verwendung von tetracyclinen zur behandlung von störungen der meibomschen drüsen |
| US7056893B2 (en) | 1999-03-31 | 2006-06-06 | Insite Vision, Inc. | Topical treatment for prevention of ocular infections |
| US6239113B1 (en) | 1999-03-31 | 2001-05-29 | Insite Vision, Incorporated | Topical treatment or prevention of ocular infections |
| US7063857B1 (en) | 1999-04-30 | 2006-06-20 | Sucampo Ag | Use of macrolide compounds for the treatment of dry eye |
| IT1313610B1 (it) * | 1999-08-09 | 2002-09-09 | S I F I Societa Ind Farmaceuti | Processo per la preparazione di formulazioni acquose per uso oftalmico |
| AR031135A1 (es) | 2000-10-10 | 2003-09-10 | Upjohn Co | Composiciones de antibiotico topico para el tratamiento de infecciones oculares |
| HRP20010301A2 (en) * | 2001-04-27 | 2001-12-31 | Pliva D D | New therapeutic indication for azithromycin in the treatment of non-infective inflammatory diseases |
| WO2004091436A2 (en) | 2003-04-15 | 2004-10-28 | The Regents Of The University Of California | Methods and compositions for treating ocular disease |
| US7087237B2 (en) | 2003-09-19 | 2006-08-08 | Advanced Ocular Systems Limited | Ocular solutions |
| US20050137205A1 (en) * | 2003-12-22 | 2005-06-23 | Van Breen Eduard T. | Formulation for treating periocular disease |
| US8425929B2 (en) | 2004-04-30 | 2013-04-23 | Allergan, Inc. | Sustained release intraocular implants and methods for preventing retinal dysfunction |
| WO2005110374A1 (en) | 2004-04-30 | 2005-11-24 | Allergan, Inc. | Intraocular drug delivery systems containing a therapeutic component, a cyclodextrin, and a polymeric component |
| US8372814B2 (en) | 2004-06-07 | 2013-02-12 | Ista Pharmaceuticals, Inc. | Ophthalmic formulations and uses thereof |
| US8349352B2 (en) | 2005-02-04 | 2013-01-08 | Auburn University | Therapeutic contact lenses with anti-fungal delivery |
| US8663639B2 (en) | 2005-02-09 | 2014-03-04 | Santen Pharmaceutical Co., Ltd. | Formulations for treating ocular diseases and conditions |
| US7247623B2 (en) | 2005-08-19 | 2007-07-24 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with non-drying antihistamines |
| US20070105788A1 (en) * | 2005-11-09 | 2007-05-10 | Serena Mraz-Gernhard | Azithromycin for treatment of granulomatous rosacea |
| TWI435729B (zh) | 2005-11-09 | 2014-05-01 | Combinatorx Inc | 治療病症之方法，組合物及套組 |
| CA2635797C (en) | 2006-02-09 | 2015-03-31 | Macusight, Inc. | Stable formulations, and methods of their preparation and use |
| EP2364707B1 (en) * | 2006-08-07 | 2013-04-03 | Bausch & Lomb Incorporated | Compositions and methods for treating, controlling, reducing, or ameliorating infections and sequelae thereof |
| US11078262B2 (en) | 2007-04-30 | 2021-08-03 | Allergan, Inc. | High viscosity macromolecular compositions for treating ocular conditions |
| US20080286338A1 (en) | 2007-05-15 | 2008-11-20 | Boston Foundation For Sight | Drug delivery system with scleral lens |
| US8349806B2 (en) | 2008-07-10 | 2013-01-08 | Inspire Pharmaceuticals, Inc. | Method of treating blepharitis |
| US20100190734A1 (en) | 2009-01-23 | 2010-07-29 | Romulus Kimbro Brazzell | Method of treating dry eye disease with azithromycin |
-
2009
- 2009-07-10 US US12/501,316 patent/US8349806B2/en active Active
- 2009-07-10 MX MX2011000247A patent/MX2011000247A/es active IP Right Grant
- 2009-07-10 AU AU2009268372A patent/AU2009268372B2/en not_active Ceased
- 2009-07-10 WO PCT/US2009/050311 patent/WO2010006306A1/en not_active Ceased
- 2009-07-10 CA CA2730120A patent/CA2730120A1/en not_active Abandoned
- 2009-07-10 JP JP2011517670A patent/JP2011527709A/ja not_active Withdrawn
- 2009-07-10 EP EP09795262.6A patent/EP2313103B1/en not_active Not-in-force
-
2014
- 2014-09-18 JP JP2014190105A patent/JP2014240433A/ja not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| MX2011000247A (es) | 2011-03-30 |
| US8349806B2 (en) | 2013-01-08 |
| EP2313103A1 (en) | 2011-04-27 |
| AU2009268372B2 (en) | 2015-06-04 |
| JP2014240433A (ja) | 2014-12-25 |
| WO2010006306A1 (en) | 2010-01-14 |
| EP2313103A4 (en) | 2012-08-08 |
| EP2313103B1 (en) | 2014-06-18 |
| JP2011527709A (ja) | 2011-11-04 |
| AU2009268372A1 (en) | 2010-01-14 |
| US20100022465A1 (en) | 2010-01-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20150710 |