CA2728574C - Cancer diagnosis based on levels of antibodies against globo h and its fragments - Google Patents

Cancer diagnosis based on levels of antibodies against globo h and its fragments Download PDF

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Publication number
CA2728574C
CA2728574C CA2728574A CA2728574A CA2728574C CA 2728574 C CA2728574 C CA 2728574C CA 2728574 A CA2728574 A CA 2728574A CA 2728574 A CA2728574 A CA 2728574A CA 2728574 C CA2728574 C CA 2728574C
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cancer
globo
sample
antibodies
mixing
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CA2728574A
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English (en)
French (fr)
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CA2728574A1 (en
Inventor
Chi-Huey Wong
Chung-Yi Wu
Cheng-Chi Wang
Alice L. Yu
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Academia Sinica
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Academia Sinica
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/57585—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds identifiable in body fluids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57515—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the breast

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA2728574A 2008-06-16 2009-06-16 Cancer diagnosis based on levels of antibodies against globo h and its fragments Active CA2728574C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6197408P 2008-06-16 2008-06-16
US61/061,974 2008-06-16
PCT/US2009/047532 WO2010008736A2 (en) 2008-06-16 2009-06-16 Cancer diagnosis based on levels of antibodies against globo h and its fragments

Publications (2)

Publication Number Publication Date
CA2728574A1 CA2728574A1 (en) 2010-01-21
CA2728574C true CA2728574C (en) 2020-10-20

Family

ID=41431641

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2728574A Active CA2728574C (en) 2008-06-16 2009-06-16 Cancer diagnosis based on levels of antibodies against globo h and its fragments

Country Status (11)

Country Link
US (1) US8158367B2 (enExample)
EP (1) EP2307887B1 (enExample)
JP (1) JP5216139B2 (enExample)
KR (1) KR101324109B1 (enExample)
CN (1) CN102066940B (enExample)
AU (1) AU2009271411B2 (enExample)
CA (1) CA2728574C (enExample)
ES (1) ES2477549T3 (enExample)
MX (1) MX2010013931A (enExample)
NZ (1) NZ590064A (enExample)
WO (1) WO2010008736A2 (enExample)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7960139B2 (en) 2007-03-23 2011-06-14 Academia Sinica Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells
DK2318832T3 (da) 2008-07-15 2014-01-20 Academia Sinica Glycan-arrays på PTFE-lignende aluminiumcoatede objektglas og relaterede fremgangsmåder
US11377485B2 (en) 2009-12-02 2022-07-05 Academia Sinica Methods for modifying human antibodies by glycan engineering
US10087236B2 (en) 2009-12-02 2018-10-02 Academia Sinica Methods for modifying human antibodies by glycan engineering
CN102781442B (zh) 2009-12-15 2016-02-17 儿童医院 使用奈福泮化合物治疗瘢痕和β-联蛋白介导的疾病的方法
WO2011130332A1 (en) 2010-04-12 2011-10-20 Academia Sinica Glycan arrays for high throughput screening of viruses
WO2013010003A1 (en) 2011-07-12 2013-01-17 University Of Medicine And Dentistry Of New Jersey Diagnostic biomarker profiles for the detection and diagnosis of alzheimer's disease
US10130714B2 (en) 2012-04-14 2018-11-20 Academia Sinica Enhanced anti-influenza agents conjugated with anti-inflammatory activity
US20150198600A1 (en) * 2012-07-27 2015-07-16 Rowan University Autoantibody Profiles in the Early Detection and Diagnosis of Cancer
US9914956B2 (en) 2012-08-18 2018-03-13 Academia Sinica Cell-permeable probes for identification and imaging of sialidases
WO2014210397A1 (en) * 2013-06-26 2014-12-31 Academia Sinica Rm2 antigens and use thereof
EP3013347B1 (en) 2013-06-27 2019-12-11 Academia Sinica Glycan conjugates and use thereof
EP3041484B1 (en) 2013-09-06 2021-03-03 Academia Sinica Human inkt cell activation using glycolipids with altered glycosyl groups
CN104698183A (zh) * 2013-12-04 2015-06-10 苏州中赢医疗科技有限公司 一种肝癌肿瘤标志物、其抗体及应用
US10150818B2 (en) 2014-01-16 2018-12-11 Academia Sinica Compositions and methods for treatment and detection of cancers
KR20160104727A (ko) 2014-01-16 2016-09-05 아카데미아 시니카 암의 치료 및 검출을 위한 조성물 및 방법
TW201622743A (zh) 2014-03-19 2016-07-01 財團法人臺灣基督長老教會馬偕紀念社會事業基金會馬偕紀念醫院 免疫原醣肽、包含該醣肽之組合物及其用途
TWI797430B (zh) 2014-03-27 2023-04-01 中央研究院 反應性標記化合物及其用途
ES2772817T3 (es) 2014-04-10 2020-07-08 Obi Pharma Inc Anticuerpos de unión a antígenos de carbohidrato asociados a tumor, composiciones farmacéuticas y sus usos
KR20170010003A (ko) 2014-05-27 2017-01-25 아카데미아 시니카 박테로이드 기원의 푸코시다제 및 이의 사용 방법
US10118969B2 (en) 2014-05-27 2018-11-06 Academia Sinica Compositions and methods relating to universal glycoforms for enhanced antibody efficacy
EP4116329A1 (en) 2014-05-27 2023-01-11 Academia Sinica Anti-her2 glycoantibodies and uses thereof
JP2017518989A (ja) 2014-05-27 2017-07-13 アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ 抗ｃｄ２０糖操作抗体群およびその使用
JP7063538B2 (ja) 2014-05-28 2022-05-09 アカデミア シニカ 抗ＴＮＦα糖操作抗体群およびその使用
EP3191500A4 (en) 2014-09-08 2018-04-11 Academia Sinica HUMAN iNKT CELL ACTIVATION USING GLYCOLIPIDS
US10495645B2 (en) 2015-01-16 2019-12-03 Academia Sinica Cancer markers and methods of use thereof
US9975965B2 (en) 2015-01-16 2018-05-22 Academia Sinica Compositions and methods for treatment and detection of cancers
TWI710571B (zh) 2015-01-24 2020-11-21 中央研究院 腫瘤標記及其使用方法
AU2015378564A1 (en) 2015-01-24 2017-07-13 Academia Sinica Novel glycan conjugates and methods of use thereof
CN114702581B (zh) 2015-01-30 2025-08-01 台湾地区“中央研究院” 增进抗体功效的通用糖型组合物及方法
JP6822957B2 (ja) * 2015-07-30 2021-01-27 京セラ株式会社 測定方法、および測定装置
EP3344806A4 (en) * 2015-09-04 2019-03-20 OBI Pharma, Inc. GLYCANARRAYS AND METHOD OF USE
CN109195996A (zh) 2016-03-08 2019-01-11 中央研究院 N-聚醣及其阵列的模组化合成方法
KR102528998B1 (ko) * 2016-07-29 2023-05-03 오비아이 파머 인코퍼레이티드 인간 항체, 제약 조성물 및 방법
CA3034057A1 (en) 2016-08-22 2018-03-01 CHO Pharma Inc. Antibodies, binding fragments, and methods of use

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0996455B1 (en) * 1997-04-16 2009-12-16 Sloan-Kettering Institute For Cancer Research Alpha-o-linked glycoconjugates with clustered (2,6)-st epitopes, methods of preparation and uses thereof
CN1235831A (zh) * 1999-03-02 1999-11-24 第一军医大学珠江医院 含红细胞糖苷脂的药物组合物及其应用
US20020006629A1 (en) * 2000-02-29 2002-01-17 Danishefsky Samuel J. Affinity matrix bearing tumor-associated carbohydrate-or glycopeptide-based antigens and uses thereof
WO2006068758A2 (en) * 2004-11-19 2006-06-29 The Scripps Research Institute Detection, prevention and treatment of breast cancer
US20060269979A1 (en) * 2005-04-26 2006-11-30 Dwek Raymond A High throughput glycan analysis for diagnosing and monitoring rheumatoid arthritis and other autoimmune diseases
US20090162405A1 (en) * 2006-12-14 2009-06-25 Yong Qian Proteinase-engineered cancer vaccine induces immune responses to prevent cancer and to systemically kill cancer cells
JP2011524375A (ja) 2008-06-16 2011-09-01 アカデミア シニカ ＧｌｏｂｏＨおよびＳＳＥＡ３に特異的な免疫反応を誘起する組成物および癌治療におけるその使用

Also Published As

Publication number Publication date
MX2010013931A (es) 2011-06-01
US8158367B2 (en) 2012-04-17
AU2009271411A1 (en) 2010-01-21
WO2010008736A2 (en) 2010-01-21
WO2010008736A3 (en) 2010-03-11
KR20110033919A (ko) 2011-04-01
HK1153273A1 (en) 2012-03-23
EP2307887A4 (en) 2011-09-21
JP5216139B2 (ja) 2013-06-19
CN102066940A (zh) 2011-05-18
AU2009271411B2 (en) 2013-02-07
EP2307887B1 (en) 2014-05-07
JP2011524537A (ja) 2011-09-01
CA2728574A1 (en) 2010-01-21
NZ590064A (en) 2012-05-25
US20090317837A1 (en) 2009-12-24
ES2477549T3 (es) 2014-07-17
EP2307887A2 (en) 2011-04-13
CN102066940B (zh) 2015-05-13
KR101324109B1 (ko) 2013-10-31

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