CA2724540C - Treating dyspnea associated with acute heart failure with relaxin - Google Patents
Treating dyspnea associated with acute heart failure with relaxin Download PDFInfo
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- CA2724540C CA2724540C CA2724540A CA2724540A CA2724540C CA 2724540 C CA2724540 C CA 2724540C CA 2724540 A CA2724540 A CA 2724540A CA 2724540 A CA2724540 A CA 2724540A CA 2724540 C CA2724540 C CA 2724540C
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- A—HUMAN NECESSITIES
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Landscapes
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Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12788908P | 2008-05-16 | 2008-05-16 | |
| US61/127,889 | 2008-05-16 | ||
| US19054508P | 2008-08-28 | 2008-08-28 | |
| US61/190,545 | 2008-08-28 | ||
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| AR071810A1 (es) | 2008-05-16 | 2010-07-14 | Corthera Inc | Metodo de tratamiento de la disnea asociada con la insuficiencia cardiaca aguda. relaxina h2. uso. |
| WO2009140657A2 (en) * | 2008-05-16 | 2009-11-19 | Corthera, Inc. | Method of treating chronic heart failure |
| RU2564900C2 (ru) * | 2010-03-10 | 2015-10-10 | Дзе Юниверсити Оф Флорида Рисерч Фаундейшн, Инк. | Модулирование аквапоринов релаксином |
| US8501418B2 (en) | 2010-08-06 | 2013-08-06 | Pronata N.V. | Method of treating renal dysfunction based on perlecan as a biomarker |
| EP3572091B1 (en) | 2010-08-17 | 2023-12-13 | Ambrx, Inc. | Modified relaxin polypeptides and their uses |
| US9567386B2 (en) | 2010-08-17 | 2017-02-14 | Ambrx, Inc. | Therapeutic uses of modified relaxin polypeptides |
| CN103930440A (zh) * | 2011-07-01 | 2014-07-16 | 拜耳知识产权有限责任公司 | 松弛素融合多肽及其用途 |
| WO2013059879A1 (en) * | 2011-10-26 | 2013-05-02 | Howard Florey Institute Of Experimental Physiology And Medicine | Compositions and methods for the treatment of fibrosis and fibrotic diseases |
| KR102107482B1 (ko) * | 2012-02-14 | 2020-05-08 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 심혈관 질환 및 다른 증상에 대한 파라크린 유전자의 전신 전달 및 조절 발현 |
| EP2844345B1 (en) | 2012-05-04 | 2022-08-03 | The United States of America, as Represented by The Secretary, Department of Health and Human Services | Modulators of the relaxin receptor 1 |
| EP2925128B1 (en) | 2012-10-26 | 2018-04-11 | Chiesi Farmaceutici S.p.A. | Methods for controlling blood pressure and reducing dyspnea in heart failure |
| EP2981258B8 (en) * | 2013-04-05 | 2020-11-11 | scPharmaceuticals Inc. | Pharmaceutical formulations for subcutaneous administration of furosemide |
| US9707154B2 (en) | 2013-04-24 | 2017-07-18 | Corning Incorporated | Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients |
| EA201691562A2 (ru) * | 2014-02-03 | 2017-01-30 | Новартис Аг | Фильтры для инфузионных наборов |
| EP2946788A1 (en) * | 2014-05-23 | 2015-11-25 | Immundiagnostik AG | Method and composition for treating heart failure with preserved ejection fraction |
| AU2015273097A1 (en) * | 2014-06-13 | 2016-11-17 | Novartis Ag | Use of serelaxin to reduce GDF-15 |
| EP4011919A3 (en) | 2015-12-09 | 2022-10-12 | The Scripps Research Institute | Relaxin immunoglobulin fusion proteins and methods of use |
| EP3413783B1 (en) | 2016-02-12 | 2025-01-22 | Cardiac Pacemakers, Inc. | Systems and methods for patient monitoring |
| WO2018148419A1 (en) | 2017-02-08 | 2018-08-16 | Bristol-Myers Squibb Company | Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof |
| US11832970B2 (en) | 2017-07-26 | 2023-12-05 | Cardiac Pacemakers, Inc. | Worsening heart failure stratification |
| CN107335051A (zh) * | 2017-08-18 | 2017-11-10 | 温州医科大学附属第医院 | 一种保护慢性心衰肾功能的药物组合物 |
| WO2020120482A1 (en) | 2018-12-10 | 2020-06-18 | Sq Innovation Ag | Pharmaceutical compositions of furosemide and uses thereof |
| US12397005B2 (en) | 2019-01-04 | 2025-08-26 | Sq Innovation Ag | Pharmaceutical compositions of torsemide and uses thereof |
| CN113271923B (zh) | 2019-01-04 | 2025-05-13 | Sq创新股份公司 | 呋塞米的药物组合物及其用途 |
| PH12021551811A1 (en) | 2019-01-31 | 2022-03-21 | Scpharmaceuticals Inc | Concentrated liquid pharmaceutical formulations of furosemide and methods of administering the same |
| CN119947743A (zh) | 2022-08-31 | 2025-05-06 | 雷拉科斯拉制药有限责任公司 | 免疫抑制药物及治疗方法 |
| WO2025056188A1 (en) | 2023-09-15 | 2025-03-20 | Relaxera Pharmazeutische Gmbh & Co. Kg | Relaxin medication |
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| US5023321A (en) | 1982-12-13 | 1991-06-11 | Howard Florey Institute Of Experimental Physiology & Medicine | Molecular cloning and characterization of a further gene sequence coding for human relaxin |
| US5166191A (en) * | 1991-08-19 | 1992-11-24 | Genentech, Inc. | Use of relaxin in cardiovascular therapy |
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| EP0707650B1 (en) | 1993-06-21 | 2003-05-21 | Genentech, Inc. | Process for producing human relaxin |
| EP0675732B1 (en) | 1993-07-27 | 2006-06-28 | Mario Bigazzi | Use of relaxin in the manufacture of therapeutic agents |
| US5760069A (en) | 1995-02-08 | 1998-06-02 | Boehringer Mannheim Pharmaceuticals Corporation-Smithkline Beecham Corporation Limited Partnership #1 | Method of treatment for decreasing mortality resulting from congestive heart failure |
| US5811395A (en) * | 1995-06-07 | 1998-09-22 | Medical University Of South Carolina | Relaxin analogs and derivatives methods and uses thereof |
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| DE60128540T2 (de) * | 2000-02-09 | 2008-01-31 | Bas Medical, Inc., San Mateo | Verwendung von relaxin zur behandlung von durch gefässverengung bedingten erkrankungen |
| DE10155843A1 (de) | 2000-11-16 | 2003-01-30 | Immundiagnostik Ag | Verfahren zur Prognose und Diagnose von Herzinsuffizienz |
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| US7878978B2 (en) * | 2004-03-18 | 2011-02-01 | University Of Pittsburgh- Of The Commonwealth System Of Higher Education | Use of relaxin to increase arterial compliance |
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| WO2007008907A2 (en) * | 2005-07-11 | 2007-01-18 | Abbott Laboratories | Methods for determining how to treat congestive heart failure |
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| WO2009140657A2 (en) | 2008-05-16 | 2009-11-19 | Corthera, Inc. | Method of treating chronic heart failure |
| AR071810A1 (es) * | 2008-05-16 | 2010-07-14 | Corthera Inc | Metodo de tratamiento de la disnea asociada con la insuficiencia cardiaca aguda. relaxina h2. uso. |
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