JP5651586B2 - 急性心不全に伴う呼吸困難のリラキシンによる治療 - Google Patents

急性心不全に伴う呼吸困難のリラキシンによる治療 Download PDF

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Publication number
JP5651586B2
JP5651586B2 JP2011509783A JP2011509783A JP5651586B2 JP 5651586 B2 JP5651586 B2 JP 5651586B2 JP 2011509783 A JP2011509783 A JP 2011509783A JP 2011509783 A JP2011509783 A JP 2011509783A JP 5651586 B2 JP5651586 B2 JP 5651586B2
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Prior art keywords
relaxin
day
heart failure
subject
acute
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Japanese (ja)
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JP2011520918A (ja
JP2011520918A5 (OSRAM
Inventor
ウネモリ,エライネ
タイクマン,サム,エル.
コッター,ガッド
スチュアート,デニス,アール.
ホワイトハウス,マーサ,ジョー
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コーセラ,インコーポレーテッド
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/2221Relaxins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10Antioedematous agents; Diuretics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/64Relaxins

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2011509783A 2008-05-16 2009-05-15 急性心不全に伴う呼吸困難のリラキシンによる治療 Expired - Fee Related JP5651586B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US12788908P 2008-05-16 2008-05-16
US61/127,889 2008-05-16
US19054508P 2008-08-28 2008-08-28
US61/190,545 2008-08-28
US20124008P 2008-12-08 2008-12-08
US61/201,240 2008-12-08
US16433309P 2009-03-27 2009-03-27
US61/164,333 2009-03-27
PCT/US2009/044249 WO2009140659A2 (en) 2008-05-16 2009-05-15 Method of treating dyspnea associated with acute heart failure

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012200728A Division JP5638044B2 (ja) 2008-05-16 2012-09-12 急性心不全に伴う呼吸困難のリラキシンによる治療

Publications (3)

Publication Number Publication Date
JP2011520918A JP2011520918A (ja) 2011-07-21
JP2011520918A5 JP2011520918A5 (OSRAM) 2012-11-01
JP5651586B2 true JP5651586B2 (ja) 2015-01-14

Family

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Family Applications (4)

Application Number Title Priority Date Filing Date
JP2011509783A Expired - Fee Related JP5651586B2 (ja) 2008-05-16 2009-05-15 急性心不全に伴う呼吸困難のリラキシンによる治療
JP2012200728A Expired - Fee Related JP5638044B2 (ja) 2008-05-16 2012-09-12 急性心不全に伴う呼吸困難のリラキシンによる治療
JP2014165276A Expired - Fee Related JP5875646B2 (ja) 2008-05-16 2014-08-14 急性心不全に伴う呼吸困難のリラキシンによる治療
JP2015201153A Pending JP2016053040A (ja) 2008-05-16 2015-10-09 急性心不全に伴う呼吸困難のリラキシンによる治療

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2012200728A Expired - Fee Related JP5638044B2 (ja) 2008-05-16 2012-09-12 急性心不全に伴う呼吸困難のリラキシンによる治療
JP2014165276A Expired - Fee Related JP5875646B2 (ja) 2008-05-16 2014-08-14 急性心不全に伴う呼吸困難のリラキシンによる治療
JP2015201153A Pending JP2016053040A (ja) 2008-05-16 2015-10-09 急性心不全に伴う呼吸困難のリラキシンによる治療

Country Status (30)

Country Link
US (7) US8053411B2 (OSRAM)
EP (2) EP2829280A1 (OSRAM)
JP (4) JP5651586B2 (OSRAM)
CN (3) CN102036679A (OSRAM)
AR (1) AR071810A1 (OSRAM)
AU (1) AU2009246114B2 (OSRAM)
BR (1) BRPI0913011A2 (OSRAM)
CA (1) CA2724540C (OSRAM)
CR (1) CR11749A (OSRAM)
CY (1) CY1116925T1 (OSRAM)
DK (1) DK2288373T3 (OSRAM)
EA (2) EA022948B1 (OSRAM)
ES (1) ES2546287T3 (OSRAM)
GB (2) GB2462221B (OSRAM)
HK (1) HK1202054A1 (OSRAM)
HR (1) HRP20150845T1 (OSRAM)
HU (1) HUE025483T2 (OSRAM)
IL (3) IL208992A (OSRAM)
MA (1) MA32389B1 (OSRAM)
MX (1) MX2010012450A (OSRAM)
MY (2) MY159803A (OSRAM)
NZ (3) NZ589009A (OSRAM)
PL (1) PL2288373T3 (OSRAM)
PT (1) PT2288373E (OSRAM)
SG (2) SG10201609580YA (OSRAM)
SI (1) SI2288373T1 (OSRAM)
TW (1) TWI386202B (OSRAM)
UA (1) UA99953C2 (OSRAM)
WO (1) WO2009140659A2 (OSRAM)
ZA (1) ZA201007449B (OSRAM)

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AU2009246112B2 (en) * 2008-05-16 2013-05-02 Corthera, Inc. Method of treating chronic heart failure
CA2724540C (en) * 2008-05-16 2014-07-08 Corthera, Inc. Treating dyspnea associated with acute heart failure with relaxin
MX2012010382A (es) * 2010-03-10 2013-01-29 Univ Melbourne Modulacion de acuaporinas con relaxina.
US8501418B2 (en) * 2010-08-06 2013-08-06 Pronata N.V. Method of treating renal dysfunction based on perlecan as a biomarker
US9567386B2 (en) 2010-08-17 2017-02-14 Ambrx, Inc. Therapeutic uses of modified relaxin polypeptides
ES2742296T3 (es) * 2010-08-17 2020-02-13 Ambrx Inc Polipéptidos de relaxina modificados y sus usos
AU2012280474A1 (en) * 2011-07-01 2014-01-16 Bayer Intellectual Property Gmbh Relaxin fusion polypeptides and uses thereof
AU2013202269A1 (en) * 2011-10-26 2013-05-16 Howard Florey Institute Of Experimental Physiology And Medicine Compositions and methods for the treatment of fibrosis and fibrotic diseases
KR102107482B1 (ko) * 2012-02-14 2020-05-08 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 심혈관 질환 및 다른 증상에 대한 파라크린 유전자의 전신 전달 및 조절 발현
US9452973B2 (en) 2012-05-04 2016-09-27 The United States Of America, As Represented By The Secretary Department Of Health And Human Services Modulators of the relaxin receptor 1
KR102299073B1 (ko) 2012-10-26 2021-09-09 치에시 파마슈티시 에스.피.아. 심부전에서 혈압을 조절하고 호흡곤란을 감소시키는 방법
US9884039B2 (en) 2013-04-05 2018-02-06 Scpharmaceuticals Inc. Pharmaceutical formulations for subcutaneous administration of furosemide
US9707154B2 (en) 2013-04-24 2017-07-18 Corning Incorporated Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
SG11201605273XA (en) * 2014-02-03 2016-08-30 Novartis Ag Filters for infusion sets
EP2946788A1 (en) 2014-05-23 2015-11-25 Immundiagnostik AG Method and composition for treating heart failure with preserved ejection fraction
BR112016028833A2 (pt) * 2014-06-13 2017-08-22 Novartis Ag uso de serelaxinaa para reduzir gdf-15
DK3387019T3 (da) 2015-12-09 2022-01-10 Scripps Research Inst Relaxin-immunoglobulinfusionsproteiner og anvendelsesfremgangsmåder
WO2017139164A1 (en) 2016-02-12 2017-08-17 Cardiac Pacemakers, Inc. Systems and methods for patient monitoring
KR102670432B1 (ko) 2017-02-08 2024-05-28 브리스톨-마이어스 스큅 컴퍼니 약동학적 인핸서를 포함하는 변형된 렐락신 폴리펩티드 및 그의 용도
US11832970B2 (en) 2017-07-26 2023-12-05 Cardiac Pacemakers, Inc. Worsening heart failure stratification
CN107335051A (zh) * 2017-08-18 2017-11-10 温州医科大学附属第医院 一种保护慢性心衰肾功能的药物组合物
US12403120B2 (en) 2018-12-10 2025-09-02 Sq Innovation Ag Pharmaceutical compositions of furosemide and uses thereof
US12397005B2 (en) 2019-01-04 2025-08-26 Sq Innovation Ag Pharmaceutical compositions of torsemide and uses thereof
WO2020141224A1 (en) 2019-01-04 2020-07-09 Sq Innovation Ag Pharmaceutical compositions of furosemide and uses thereof
AU2020214314B2 (en) 2019-01-31 2025-09-18 Scpharmaceuticals Inc. Concentrated liquid pharmaceutical formulations of furosemide and methods of administering the same
EP4580653A1 (en) 2022-08-31 2025-07-09 Relaxera Pharmazeutische Gesellschaft mbH & Co. KG Immunosuppressive medicament and method of treatment
WO2025056188A1 (en) 2023-09-15 2025-03-20 Relaxera Pharmazeutische Gmbh & Co. Kg Relaxin medication

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Also Published As

Publication number Publication date
MA32389B1 (fr) 2011-06-01
NZ589009A (en) 2012-05-25
US20120040902A1 (en) 2012-02-16
MY158327A (en) 2016-09-30
CN102036679A (zh) 2011-04-27
US20130210730A1 (en) 2013-08-15
JP2011520918A (ja) 2011-07-21
HUE025483T2 (en) 2016-02-29
CR11749A (es) 2011-02-11
NZ701038A (en) 2016-01-29
TWI386202B (zh) 2013-02-21
US20170151311A1 (en) 2017-06-01
AU2009246114B2 (en) 2013-01-31
CN106177914A (zh) 2016-12-07
JP2016053040A (ja) 2016-04-14
HK1202054A1 (en) 2015-09-18
UA99953C2 (uk) 2012-10-25
JP5875646B2 (ja) 2016-03-02
US20100048475A1 (en) 2010-02-25
EA201001771A1 (ru) 2011-06-30
NZ598709A (en) 2013-09-27
US20150320834A1 (en) 2015-11-12
AR071810A1 (es) 2010-07-14
GB2459983B (en) 2010-04-28
CA2724540C (en) 2014-07-08
MX2010012450A (es) 2011-03-21
JP2015013870A (ja) 2015-01-22
JP5638044B2 (ja) 2014-12-10
WO2009140659A2 (en) 2009-11-19
WO2009140659A3 (en) 2010-07-22
TW200948353A (en) 2009-12-01
GB0918132D0 (en) 2009-12-02
GB2459983A (en) 2009-11-18
MY159803A (en) 2017-02-15
SG10201609580YA (en) 2016-12-29
DK2288373T3 (en) 2015-09-28
HK1187550A1 (zh) 2014-04-11
BRPI0913011A2 (pt) 2019-09-03
AU2009246114A1 (en) 2009-11-19
EP2288373A2 (en) 2011-03-02
JP2013040174A (ja) 2013-02-28
PL2288373T3 (pl) 2015-11-30
EA022948B1 (ru) 2016-03-31
US8053411B2 (en) 2011-11-08
CN103212063A (zh) 2013-07-24
ZA201007449B (en) 2011-06-29
HK1151229A1 (en) 2012-01-27
US8415301B2 (en) 2013-04-09
US20130116181A1 (en) 2013-05-09
US9579363B2 (en) 2017-02-28
US20120040903A1 (en) 2012-02-16
HK1139051A1 (en) 2010-09-10
CN103212063B (zh) 2015-07-22
US8372809B2 (en) 2013-02-12
EA201500552A1 (ru) 2016-07-29
CY1116925T1 (el) 2017-04-05
IL208992A (en) 2013-09-30
SI2288373T1 (sl) 2015-12-31
SG191587A1 (en) 2013-07-31
US9205132B2 (en) 2015-12-08
EP2829280A1 (en) 2015-01-28
ES2546287T3 (es) 2015-09-22
IL247351A0 (en) 2016-09-29
HRP20150845T1 (hr) 2015-11-06
PT2288373E (pt) 2015-10-19
IL208992A0 (en) 2011-01-31
CA2724540A1 (en) 2009-11-19
GB2462221A (en) 2010-02-03
EP2288373B1 (en) 2015-06-24
IL228244A (en) 2016-10-31
US9066916B2 (en) 2015-06-30
GB0908432D0 (en) 2009-06-24
GB2462221B (en) 2010-09-01
HK1140693A1 (en) 2010-10-22

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