GB2459983B - Methods of treating dyspnea associated with acute heart failure - Google Patents

Methods of treating dyspnea associated with acute heart failure

Info

Publication number
GB2459983B
GB2459983B GB0908432A GB0908432A GB2459983B GB 2459983 B GB2459983 B GB 2459983B GB 0908432 A GB0908432 A GB 0908432A GB 0908432 A GB0908432 A GB 0908432A GB 2459983 B GB2459983 B GB 2459983B
Authority
GB
United Kingdom
Prior art keywords
methods
heart failure
acute heart
dyspnea associated
treating dyspnea
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB0908432A
Other languages
English (en)
Other versions
GB2459983A (en
GB0908432D0 (en
Inventor
Elaine Unemori
Sam L Teichman
Gad Cotter
Dennis R Stewart
Martha Jo Whitehouse
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Corthera Inc
Original Assignee
Corthera Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corthera Inc filed Critical Corthera Inc
Priority to GB0918132A priority Critical patent/GB2462221B/en
Publication of GB0908432D0 publication Critical patent/GB0908432D0/en
Publication of GB2459983A publication Critical patent/GB2459983A/en
Application granted granted Critical
Publication of GB2459983B publication Critical patent/GB2459983B/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2221—Relaxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/64—Relaxins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB0908432A 2008-05-16 2009-05-15 Methods of treating dyspnea associated with acute heart failure Expired - Fee Related GB2459983B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB0918132A GB2462221B (en) 2008-05-16 2009-05-15 Administration of relaxin to reduce diuretic use in humans with acute decompensated heart failure

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US12788908P 2008-05-16 2008-05-16
US19054508P 2008-08-28 2008-08-28
US20124008P 2008-12-08 2008-12-08
US16433309P 2009-03-27 2009-03-27

Publications (3)

Publication Number Publication Date
GB0908432D0 GB0908432D0 (en) 2009-06-24
GB2459983A GB2459983A (en) 2009-11-18
GB2459983B true GB2459983B (en) 2010-04-28

Family

ID=40834101

Family Applications (2)

Application Number Title Priority Date Filing Date
GB0918132A Expired - Fee Related GB2462221B (en) 2008-05-16 2009-05-15 Administration of relaxin to reduce diuretic use in humans with acute decompensated heart failure
GB0908432A Expired - Fee Related GB2459983B (en) 2008-05-16 2009-05-15 Methods of treating dyspnea associated with acute heart failure

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB0918132A Expired - Fee Related GB2462221B (en) 2008-05-16 2009-05-15 Administration of relaxin to reduce diuretic use in humans with acute decompensated heart failure

Country Status (30)

Country Link
US (7) US8053411B2 (OSRAM)
EP (2) EP2829280A1 (OSRAM)
JP (4) JP5651586B2 (OSRAM)
CN (3) CN102036679A (OSRAM)
AR (1) AR071810A1 (OSRAM)
AU (1) AU2009246114B2 (OSRAM)
BR (1) BRPI0913011A2 (OSRAM)
CA (1) CA2724540C (OSRAM)
CR (1) CR11749A (OSRAM)
CY (1) CY1116925T1 (OSRAM)
DK (1) DK2288373T3 (OSRAM)
EA (2) EA022948B1 (OSRAM)
ES (1) ES2546287T3 (OSRAM)
GB (2) GB2462221B (OSRAM)
HK (1) HK1202054A1 (OSRAM)
HR (1) HRP20150845T1 (OSRAM)
HU (1) HUE025483T2 (OSRAM)
IL (3) IL208992A (OSRAM)
MA (1) MA32389B1 (OSRAM)
MX (1) MX2010012450A (OSRAM)
MY (2) MY159803A (OSRAM)
NZ (3) NZ589009A (OSRAM)
PL (1) PL2288373T3 (OSRAM)
PT (1) PT2288373E (OSRAM)
SG (2) SG10201609580YA (OSRAM)
SI (1) SI2288373T1 (OSRAM)
TW (1) TWI386202B (OSRAM)
UA (1) UA99953C2 (OSRAM)
WO (1) WO2009140659A2 (OSRAM)
ZA (1) ZA201007449B (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013059879A1 (en) * 2011-10-26 2013-05-02 Howard Florey Institute Of Experimental Physiology And Medicine Compositions and methods for the treatment of fibrosis and fibrotic diseases

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2009246112B2 (en) * 2008-05-16 2013-05-02 Corthera, Inc. Method of treating chronic heart failure
CA2724540C (en) * 2008-05-16 2014-07-08 Corthera, Inc. Treating dyspnea associated with acute heart failure with relaxin
MX2012010382A (es) * 2010-03-10 2013-01-29 Univ Melbourne Modulacion de acuaporinas con relaxina.
US8501418B2 (en) * 2010-08-06 2013-08-06 Pronata N.V. Method of treating renal dysfunction based on perlecan as a biomarker
US9567386B2 (en) 2010-08-17 2017-02-14 Ambrx, Inc. Therapeutic uses of modified relaxin polypeptides
ES2742296T3 (es) * 2010-08-17 2020-02-13 Ambrx Inc Polipéptidos de relaxina modificados y sus usos
AU2012280474A1 (en) * 2011-07-01 2014-01-16 Bayer Intellectual Property Gmbh Relaxin fusion polypeptides and uses thereof
KR102107482B1 (ko) * 2012-02-14 2020-05-08 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 심혈관 질환 및 다른 증상에 대한 파라크린 유전자의 전신 전달 및 조절 발현
US9452973B2 (en) 2012-05-04 2016-09-27 The United States Of America, As Represented By The Secretary Department Of Health And Human Services Modulators of the relaxin receptor 1
KR102299073B1 (ko) 2012-10-26 2021-09-09 치에시 파마슈티시 에스.피.아. 심부전에서 혈압을 조절하고 호흡곤란을 감소시키는 방법
US9884039B2 (en) 2013-04-05 2018-02-06 Scpharmaceuticals Inc. Pharmaceutical formulations for subcutaneous administration of furosemide
US9707154B2 (en) 2013-04-24 2017-07-18 Corning Incorporated Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
SG11201605273XA (en) * 2014-02-03 2016-08-30 Novartis Ag Filters for infusion sets
EP2946788A1 (en) 2014-05-23 2015-11-25 Immundiagnostik AG Method and composition for treating heart failure with preserved ejection fraction
BR112016028833A2 (pt) * 2014-06-13 2017-08-22 Novartis Ag uso de serelaxinaa para reduzir gdf-15
DK3387019T3 (da) 2015-12-09 2022-01-10 Scripps Research Inst Relaxin-immunoglobulinfusionsproteiner og anvendelsesfremgangsmåder
WO2017139164A1 (en) 2016-02-12 2017-08-17 Cardiac Pacemakers, Inc. Systems and methods for patient monitoring
KR102670432B1 (ko) 2017-02-08 2024-05-28 브리스톨-마이어스 스큅 컴퍼니 약동학적 인핸서를 포함하는 변형된 렐락신 폴리펩티드 및 그의 용도
US11832970B2 (en) 2017-07-26 2023-12-05 Cardiac Pacemakers, Inc. Worsening heart failure stratification
CN107335051A (zh) * 2017-08-18 2017-11-10 温州医科大学附属第医院 一种保护慢性心衰肾功能的药物组合物
US12403120B2 (en) 2018-12-10 2025-09-02 Sq Innovation Ag Pharmaceutical compositions of furosemide and uses thereof
US12397005B2 (en) 2019-01-04 2025-08-26 Sq Innovation Ag Pharmaceutical compositions of torsemide and uses thereof
WO2020141224A1 (en) 2019-01-04 2020-07-09 Sq Innovation Ag Pharmaceutical compositions of furosemide and uses thereof
AU2020214314B2 (en) 2019-01-31 2025-09-18 Scpharmaceuticals Inc. Concentrated liquid pharmaceutical formulations of furosemide and methods of administering the same
EP4580653A1 (en) 2022-08-31 2025-07-09 Relaxera Pharmazeutische Gesellschaft mbH & Co. KG Immunosuppressive medicament and method of treatment
WO2025056188A1 (en) 2023-09-15 2025-03-20 Relaxera Pharmazeutische Gmbh & Co. Kg Relaxin medication

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5166191A (en) * 1991-08-19 1992-11-24 Genentech, Inc. Use of relaxin in cardiovascular therapy
WO1993003755A2 (en) * 1991-08-19 1993-03-04 Genentech, Inc. Use of relaxin in cardiovascular therapy and in the treatment of neurodegenerative diseases
WO2002040500A2 (en) * 2000-11-16 2002-05-23 Immundiagnostik Ag Method of prognosis and diagnosis of congestive heart failure

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5023321A (en) * 1982-12-13 1991-06-11 Howard Florey Institute Of Experimental Physiology & Medicine Molecular cloning and characterization of a further gene sequence coding for human relaxin
WO1995000645A2 (en) 1993-06-21 1995-01-05 Genentech, Inc. Process for producing relaxin
EP0675732B1 (en) * 1993-07-27 2006-06-28 Mario Bigazzi Use of relaxin in the manufacture of therapeutic agents
US5760069A (en) 1995-02-08 1998-06-02 Boehringer Mannheim Pharmaceuticals Corporation-Smithkline Beecham Corporation Limited Partnership #1 Method of treatment for decreasing mortality resulting from congestive heart failure
US5811395A (en) 1995-06-07 1998-09-22 Medical University Of South Carolina Relaxin analogs and derivatives methods and uses thereof
EP0845992B1 (en) 1995-08-15 2002-11-20 Connetics Corporation Use of relaxin for promoting angiogenesis
CA2397200C (en) * 2000-02-09 2010-11-23 Connetics Corporation Use of relaxin to treat diseases related to vasoconstriction
US20050113286A1 (en) 2002-03-18 2005-05-26 Schreiner George F. Methods for treating congestive heart failure
US7878978B2 (en) 2004-03-18 2011-02-01 University Of Pittsburgh- Of The Commonwealth System Of Higher Education Use of relaxin to increase arterial compliance
US20070202080A1 (en) 2004-03-30 2007-08-30 Industry-University Cooperation Foundation Yonsei Gene Delivery System Containing Relaxin Gene And Pharmaceutical Composition Using Relaxin
US20060264367A1 (en) 2005-05-21 2006-11-23 Howard Florey Institute Prevention of fibrosis following cardiac injury
WO2007008907A2 (en) 2005-07-11 2007-01-18 Abbott Laboratories Methods for determining how to treat congestive heart failure
JP5355561B2 (ja) 2007-07-12 2013-11-27 コンピュゲン エルティーディー． 生物活性ペプチドおよびその使用方法
CA2724540C (en) * 2008-05-16 2014-07-08 Corthera, Inc. Treating dyspnea associated with acute heart failure with relaxin
AU2009246112B2 (en) 2008-05-16 2013-05-02 Corthera, Inc. Method of treating chronic heart failure

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5166191A (en) * 1991-08-19 1992-11-24 Genentech, Inc. Use of relaxin in cardiovascular therapy
WO1993003755A2 (en) * 1991-08-19 1993-03-04 Genentech, Inc. Use of relaxin in cardiovascular therapy and in the treatment of neurodegenerative diseases
WO2002040500A2 (en) * 2000-11-16 2002-05-23 Immundiagnostik Ag Method of prognosis and diagnosis of congestive heart failure

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Ann NY Acad Sci; Vol 1160, pp 387-392 (2009). Dschietzig et al. "First clinical experience with intravenous recombinant human relaxin in compensated heart failure" *
Faseb J; Vol 15, pp 2187-2195 (2001). Dschietzig et al. "The pregnancy hormone relaxin is a player in human heart failure" *
The Lancet; Vol 373, pp 1429-1439 (2009). Teerlink et al. "Relaxing for the treatment of patients with acute heart failure...." *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013059879A1 (en) * 2011-10-26 2013-05-02 Howard Florey Institute Of Experimental Physiology And Medicine Compositions and methods for the treatment of fibrosis and fibrotic diseases

Also Published As

Publication number Publication date
MA32389B1 (fr) 2011-06-01
NZ589009A (en) 2012-05-25
US20120040902A1 (en) 2012-02-16
MY158327A (en) 2016-09-30
CN102036679A (zh) 2011-04-27
US20130210730A1 (en) 2013-08-15
JP5651586B2 (ja) 2015-01-14
JP2011520918A (ja) 2011-07-21
HUE025483T2 (en) 2016-02-29
CR11749A (es) 2011-02-11
NZ701038A (en) 2016-01-29
TWI386202B (zh) 2013-02-21
US20170151311A1 (en) 2017-06-01
AU2009246114B2 (en) 2013-01-31
CN106177914A (zh) 2016-12-07
JP2016053040A (ja) 2016-04-14
HK1202054A1 (en) 2015-09-18
UA99953C2 (uk) 2012-10-25
JP5875646B2 (ja) 2016-03-02
US20100048475A1 (en) 2010-02-25
EA201001771A1 (ru) 2011-06-30
NZ598709A (en) 2013-09-27
US20150320834A1 (en) 2015-11-12
AR071810A1 (es) 2010-07-14
CA2724540C (en) 2014-07-08
MX2010012450A (es) 2011-03-21
JP2015013870A (ja) 2015-01-22
JP5638044B2 (ja) 2014-12-10
WO2009140659A2 (en) 2009-11-19
WO2009140659A3 (en) 2010-07-22
TW200948353A (en) 2009-12-01
GB0918132D0 (en) 2009-12-02
GB2459983A (en) 2009-11-18
MY159803A (en) 2017-02-15
SG10201609580YA (en) 2016-12-29
DK2288373T3 (en) 2015-09-28
HK1187550A1 (zh) 2014-04-11
BRPI0913011A2 (pt) 2019-09-03
AU2009246114A1 (en) 2009-11-19
EP2288373A2 (en) 2011-03-02
JP2013040174A (ja) 2013-02-28
PL2288373T3 (pl) 2015-11-30
EA022948B1 (ru) 2016-03-31
US8053411B2 (en) 2011-11-08
CN103212063A (zh) 2013-07-24
ZA201007449B (en) 2011-06-29
HK1151229A1 (en) 2012-01-27
US8415301B2 (en) 2013-04-09
US20130116181A1 (en) 2013-05-09
US9579363B2 (en) 2017-02-28
US20120040903A1 (en) 2012-02-16
HK1139051A1 (en) 2010-09-10
CN103212063B (zh) 2015-07-22
US8372809B2 (en) 2013-02-12
EA201500552A1 (ru) 2016-07-29
CY1116925T1 (el) 2017-04-05
IL208992A (en) 2013-09-30
SI2288373T1 (sl) 2015-12-31
SG191587A1 (en) 2013-07-31
US9205132B2 (en) 2015-12-08
EP2829280A1 (en) 2015-01-28
ES2546287T3 (es) 2015-09-22
IL247351A0 (en) 2016-09-29
HRP20150845T1 (hr) 2015-11-06
PT2288373E (pt) 2015-10-19
IL208992A0 (en) 2011-01-31
CA2724540A1 (en) 2009-11-19
GB2462221A (en) 2010-02-03
EP2288373B1 (en) 2015-06-24
IL228244A (en) 2016-10-31
US9066916B2 (en) 2015-06-30
GB0908432D0 (en) 2009-06-24
GB2462221B (en) 2010-09-01
HK1140693A1 (en) 2010-10-22

Similar Documents

Publication Publication Date Title
GB2459983B (en) Methods of treating dyspnea associated with acute heart failure
EP2288366A4 (en) METHOD FOR TREATING CHRONIC HEART FAILURE
ZA201006648B (en) Methods of treatment
AP3536A (en) Method of treating atrial fibrillation
IL207752A0 (en) Methods of treating inflammation
IL212348A0 (en) Treatment method
EP2331564A4 (en) PROCESS FOR TREATMENT OF IGNITION
GB2475018B (en) Water treatment methods
EP2493309A4 (en) METHODS OF TREATING OR PREVENTING ACUTE ERYTHEMA
IL208069A0 (en) Methods for treating psoriasis
EP2350641A4 (en) Methods of Treatment
IL219565A0 (en) Method for treating heart failure with stresscopin-like peptides
VN25747A1 (en) Method of water treatment
GB0806047D0 (en) Treatment of heart failure
ZA201007680B (en) Method of treating metalliferrous materials
HK1139051B (en) Methods of treating dyspnea associated with acute heart failure
GB0822435D0 (en) Method of treating chronic heart failure
GB0804320D0 (en) Treatment of heart failure
GB0816662D0 (en) Treatment of heart failure
ZA201101773B (en) Compositions and methods for treating heart failure
GB0823435D0 (en) Method of treatment
PL386606A1 (pl) Sposób barwienia drewna
ZA201006046B (en) Methods of treating inflammation
GB0814856D0 (en) A method of treating wood
ZA201102198B (en) Treatment method

Legal Events

Date Code Title Description
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1139051

Country of ref document: HK

REG Reference to a national code

Ref country code: HK

Ref legal event code: GR

Ref document number: 1139051

Country of ref document: HK

PCNP Patent ceased through non-payment of renewal fee

Effective date: 20180515