CA2723685C - Oral administration of peripherally-acting opioid antagonists - Google Patents
Oral administration of peripherally-acting opioid antagonists Download PDFInfo
- Publication number
- CA2723685C CA2723685C CA2723685A CA2723685A CA2723685C CA 2723685 C CA2723685 C CA 2723685C CA 2723685 A CA2723685 A CA 2723685A CA 2723685 A CA2723685 A CA 2723685A CA 2723685 C CA2723685 C CA 2723685C
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- CA
- Canada
- Prior art keywords
- opioid
- medicament
- antagonist
- side effect
- opioid antagonist
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
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|---|---|---|---|
| US12686808P | 2008-05-07 | 2008-05-07 | |
| US61/126,868 | 2008-05-07 | ||
| PCT/US2009/002856 WO2009137086A1 (en) | 2008-05-07 | 2009-05-07 | Oral administration of peripherally-acting opioid antagonists |
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|---|---|
| CA2723685A1 CA2723685A1 (en) | 2009-11-12 |
| CA2723685C true CA2723685C (en) | 2016-09-27 |
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| CA2723685A Active CA2723685C (en) | 2008-05-07 | 2009-05-07 | Oral administration of peripherally-acting opioid antagonists |
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| US (1) | US20110160239A1 (enExample) |
| EP (1) | EP2300009A1 (enExample) |
| JP (1) | JP2011519930A (enExample) |
| KR (1) | KR20110004425A (enExample) |
| CN (1) | CN102014907A (enExample) |
| AU (1) | AU2009244805B2 (enExample) |
| BR (1) | BRPI0912219A2 (enExample) |
| CA (1) | CA2723685C (enExample) |
| EA (1) | EA201001643A1 (enExample) |
| IL (1) | IL208794A0 (enExample) |
| MX (1) | MX2010011727A (enExample) |
| MY (1) | MY156913A (enExample) |
| NZ (1) | NZ589733A (enExample) |
| WO (1) | WO2009137086A1 (enExample) |
| ZA (1) | ZA201007531B (enExample) |
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| SI2368553T1 (sl) | 2003-04-08 | 2015-05-29 | Progenics Pharmaceuticals, Inc. | Farmacevtske formulacije, vsebujoče metilnatrekson |
| TWI489984B (zh) | 2006-08-04 | 2015-07-01 | Wyeth Corp | 用於非經腸道傳輸化合物之配方及其用途 |
| US8524276B2 (en) * | 2010-03-11 | 2013-09-03 | Wyeth, Llc | Oral formulations and lipophilic salts of methylnaltrexone |
| MX2013003587A (es) | 2010-09-30 | 2013-05-31 | Nektar Therapeutics | Conjugados de naloxol-polietilenglicol cristalinos. |
| CN110384701A (zh) * | 2011-12-19 | 2019-10-29 | 萨利克斯药品有限公司 | 使用甲基纳曲酮口服组合物治疗和预防阿片类诱发型便秘的方法 |
| WO2015023675A2 (en) | 2013-08-12 | 2015-02-19 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded immediate release abuse deterrent pill |
| CN104546791A (zh) * | 2013-10-16 | 2015-04-29 | 辽宁亿灵科创生物医药科技有限公司 | 一种阿片受体拮抗剂的固体制剂及其制备方法 |
| US10172797B2 (en) | 2013-12-17 | 2019-01-08 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| US9492444B2 (en) | 2013-12-17 | 2016-11-15 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| CN106470999B (zh) | 2014-04-28 | 2018-11-13 | 奥佛麦德公司 | 叔丁啡二聚体及其在治疗肠胃失调中的应用 |
| AU2015290098B2 (en) | 2014-07-17 | 2018-11-01 | Pharmaceutical Manufacturing Research Services, Inc. | Immediate release abuse deterrent liquid fill dosage form |
| AU2015336065A1 (en) | 2014-10-20 | 2017-05-04 | Pharmaceutical Manufacturing Research Services, Inc. | Extended release abuse deterrent liquid fill dosage form |
| WO2017092638A1 (zh) * | 2015-12-01 | 2017-06-08 | 江苏恒瑞医药股份有限公司 | 阿片样受体拮抗剂类衍生物、其制备方法及其在医药上的应用 |
| CN107033154B (zh) | 2016-02-02 | 2020-02-04 | 上海瀚迈生物医药科技有限公司 | 阿片受体拮抗剂缀合物及其应用 |
| CN109134479A (zh) * | 2017-06-27 | 2019-01-04 | 石家庄蒎格医药科技有限公司 | 结晶聚乙二醇纳洛酮草酸盐及制备方法 |
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| US6451806B2 (en) * | 1999-09-29 | 2002-09-17 | Adolor Corporation | Methods and compositions involving opioids and antagonists thereof |
| CZ299726B6 (cs) * | 1999-11-01 | 2008-11-05 | Lécivo pro lécení zácpy a syndromu dráždivého tracníku | |
| US7056500B2 (en) * | 2001-10-18 | 2006-06-06 | Nektar Therapeutics Al, Corporation | Polymer conjugates of opioid antagonists |
| CN1925875A (zh) * | 2003-12-16 | 2007-03-07 | 尼克塔治疗亚拉巴马公司 | 化学改性的小分子 |
| US20060182692A1 (en) * | 2003-12-16 | 2006-08-17 | Fishburn C S | Chemically modified small molecules |
| CN101466381B (zh) * | 2006-04-21 | 2012-11-14 | 尼克塔治疗公司 | 吗啡酮的立体选择性还原 |
| CN101534827A (zh) * | 2006-11-07 | 2009-09-16 | 尼克塔治疗亚拉巴马公司 | 阿片样物质激动剂和阿片样物质拮抗剂的剂型和联合给药 |
-
2009
- 2009-05-07 BR BRPI0912219A patent/BRPI0912219A2/pt not_active Application Discontinuation
- 2009-05-07 US US12/991,229 patent/US20110160239A1/en not_active Abandoned
- 2009-05-07 MY MYPI2010005212A patent/MY156913A/en unknown
- 2009-05-07 WO PCT/US2009/002856 patent/WO2009137086A1/en not_active Ceased
- 2009-05-07 NZ NZ589733A patent/NZ589733A/xx unknown
- 2009-05-07 EP EP09743073A patent/EP2300009A1/en not_active Withdrawn
- 2009-05-07 KR KR1020107024868A patent/KR20110004425A/ko not_active Ceased
- 2009-05-07 AU AU2009244805A patent/AU2009244805B2/en active Active
- 2009-05-07 JP JP2011508513A patent/JP2011519930A/ja active Pending
- 2009-05-07 CN CN2009801164862A patent/CN102014907A/zh active Pending
- 2009-05-07 EA EA201001643A patent/EA201001643A1/ru unknown
- 2009-05-07 CA CA2723685A patent/CA2723685C/en active Active
- 2009-05-07 MX MX2010011727A patent/MX2010011727A/es not_active Application Discontinuation
-
2010
- 2010-10-18 IL IL208794A patent/IL208794A0/en unknown
- 2010-10-21 ZA ZA2010/07531A patent/ZA201007531B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL208794A0 (en) | 2010-12-30 |
| AU2009244805A1 (en) | 2009-11-12 |
| KR20110004425A (ko) | 2011-01-13 |
| EP2300009A1 (en) | 2011-03-30 |
| JP2011519930A (ja) | 2011-07-14 |
| NZ589733A (en) | 2012-07-27 |
| ZA201007531B (en) | 2012-03-28 |
| BRPI0912219A2 (pt) | 2015-10-06 |
| CA2723685A1 (en) | 2009-11-12 |
| CN102014907A (zh) | 2011-04-13 |
| MX2010011727A (es) | 2010-11-30 |
| WO2009137086A1 (en) | 2009-11-12 |
| EA201001643A1 (ru) | 2011-06-30 |
| AU2009244805B2 (en) | 2013-01-10 |
| US20110160239A1 (en) | 2011-06-30 |
| MY156913A (en) | 2016-04-15 |
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