CA2722169A1 - Factor ix conjugates with extended half-lives - Google Patents
Factor ix conjugates with extended half-lives Download PDFInfo
- Publication number
- CA2722169A1 CA2722169A1 CA2722169A CA2722169A CA2722169A1 CA 2722169 A1 CA2722169 A1 CA 2722169A1 CA 2722169 A CA2722169 A CA 2722169A CA 2722169 A CA2722169 A CA 2722169A CA 2722169 A1 CA2722169 A1 CA 2722169A1
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- CA
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- Prior art keywords
- fix
- peg
- conjugate
- composition
- factor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
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Landscapes
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- Engineering & Computer Science (AREA)
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| PCT/IB2009/005763 WO2009130602A2 (en) | 2008-04-24 | 2009-04-24 | Factor ix conjugates with extended half-lives |
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| CA2670618C (en) | 2006-12-15 | 2016-10-04 | Baxter International Inc. | Factor viia- (poly) sialic acid conjugate having prolonged in vivo half-life |
| CN102497884A (zh) | 2009-07-27 | 2012-06-13 | 巴克斯特国际公司 | 凝血蛋白缀合物 |
| KR101912335B1 (ko) | 2009-07-27 | 2018-10-26 | 리폭센 테크놀로지즈 리미티드 | 비혈액 응고 단백질의 글리코폴리시알화 |
| US8642737B2 (en) | 2010-07-26 | 2014-02-04 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| CN106110311A (zh) | 2009-07-27 | 2016-11-16 | 百深公司 | 凝血蛋白缀合物 |
| US8809501B2 (en) | 2009-07-27 | 2014-08-19 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| KR20120061898A (ko) * | 2009-08-20 | 2012-06-13 | 체에스엘 베링 게엠베하 | 출혈성 장애의 치료요법 및 예방 치료에 있어서의 비정맥내 투여를 위한 알부민 융합 응고 인자 |
| GB201007357D0 (en) * | 2010-04-30 | 2010-06-16 | Leverton Licence Holdings Ltd | Conjugated factor VIII |
| GB201007356D0 (en) * | 2010-04-30 | 2010-06-16 | Leverton Licence Holdings Ltd | Conjugated factor VIIa |
| UA126265C2 (uk) * | 2010-07-09 | 2022-09-14 | Байовератів Терапьютікс Інк. | Поліпептид фактора іх і спосіб його застосування |
| HUE049352T2 (hu) | 2010-12-22 | 2020-09-28 | Baxalta GmbH | Anyagok és módszerek egy vízoldható zsírsavszármazéknak egy fehérjéhez való konjugálására |
| EP3808378A1 (en) * | 2011-05-27 | 2021-04-21 | Baxalta GmbH | Therapeutic proteins with increased half-life and methods of preparing same |
| MY190257A (en) * | 2012-04-16 | 2022-04-11 | Cantab Biopharmaceuticals Patents Ltd | Optimised subcutaneous therapeutic agents |
| MX2014015682A (es) * | 2012-06-19 | 2015-07-23 | Polytherics Ltd | Proceso novedoso para preparacion de conjugados de anticuerpo y conjugados de anticuerpo novedosos. |
| TWI750197B (zh) | 2012-09-25 | 2021-12-21 | 美商百歐維拉提夫治療公司 | Ｆｉｘ多肽的應用 |
| AR095527A1 (es) | 2013-03-15 | 2015-10-21 | Biogen Idec Inc | Formulaciones de polipéptido fc-factor ix |
| AR099340A1 (es) * | 2014-02-12 | 2016-07-13 | Novo Nordisk As | Conjugados del factor de coagulación ix |
| EA202092926A3 (ru) | 2014-03-24 | 2021-10-29 | Биовератив Терапьютикс Инк. | Лиофилизированные составы, содержащие фактор ix |
| GB2564389A (en) | 2017-07-04 | 2019-01-16 | Green Running Ltd | A system and method for utility management |
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| US5268275A (en) | 1991-05-08 | 1993-12-07 | The University Of North Carolina At Chapel Hill | Vitamin K-dependent carboxylase |
| US5621039A (en) * | 1993-06-08 | 1997-04-15 | Hallahan; Terrence W. | Factor IX- polymeric conjugates |
| US5888809A (en) | 1997-05-01 | 1999-03-30 | Icos Corporation | Hamster EF-1α transcriptional regulatory DNA |
| WO1999003496A1 (en) | 1997-07-21 | 1999-01-28 | The University Of North Carolina At Chapel Hill | Factor ix antihemophilic factor with increased clotting activity |
| AU3629800A (en) | 1999-03-16 | 2000-10-04 | Children's Hospital Of Philadelphia, The | Enhanced gamma-carboxylation of recombinant vitamin k-dependent clotting factors |
| DE60138364D1 (de) * | 2000-02-11 | 2009-05-28 | Bayer Healthcare Llc | Gerinnungsfaktor vii oder viia konjugate |
| EP1578841B2 (en) * | 2002-12-31 | 2016-10-12 | Nektar Therapeutics AL, Corporation | Maleamic acid polymer derivatives and their bioconjugates |
| WO2004060965A2 (en) * | 2002-12-31 | 2004-07-22 | Nektar Therapeutics Al, Corporation | Hydrolytically stable maleimide-terminated polymers |
| EP1581582B2 (en) * | 2003-01-06 | 2017-06-07 | Nektar Therapeutics | Thiol-selective water-soluble polmer derivatives |
| GB0316294D0 (en) * | 2003-07-11 | 2003-08-13 | Polytherics Ltd | Conjugated biological molecules and their preparation |
| EP2380985B1 (en) | 2003-09-23 | 2014-01-01 | University of North Carolina at Chapel Hill | Cells expressing vitamin K epoxide reductase and use thereof |
| WO2005033140A1 (ja) * | 2003-09-30 | 2005-04-14 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | 高純度血液凝固ｉｘ因子調製物およびその精製方法 |
| ATE466074T1 (de) | 2003-10-14 | 2010-05-15 | Baxter Int | Vkorc1 (vitamin k epoxide recycling polypeptide), ein therapeutisches ziel für coumarin und deren derivate |
| US20060040856A1 (en) * | 2003-12-03 | 2006-02-23 | Neose Technologies, Inc. | Glycopegylated factor IX |
| KR101146160B1 (ko) * | 2004-06-30 | 2012-07-16 | 넥타르 테라퓨틱스 | 중합체인자 ｉｘ 부분의 접합체 |
| EP1819829A1 (en) | 2004-12-08 | 2007-08-22 | ICOS Corporation | Recombinant method for making multimeric proteins |
| ES2397530T3 (es) | 2005-02-28 | 2013-03-07 | Baxter International Inc. | Coexpresión recombinante de la subunidad 1 de la epóxido reductasa de la vitamina K para mejorar la expresión de proteína dependiente de la vitamina K |
| AU2005329450A1 (en) | 2005-03-15 | 2006-09-28 | University Of North Carolina At Chapel Hill | Methods and compositions for producing active Vitamin K-dependent proteins |
| EP1891231A4 (en) * | 2005-05-25 | 2011-06-22 | Novo Nordisk As | GLYCOPEGYLATED FACTOR IX |
| CA2647314A1 (en) * | 2006-03-31 | 2007-11-08 | Baxter International Inc. | Pegylated factor viii |
| KR20090013816A (ko) * | 2006-05-24 | 2009-02-05 | 노보 노르디스크 헬스 케어 악티엔게젤샤프트 | 연장된 생체내 반감기를 갖는 인자 ⅸ 유사체 |
| JP5737821B2 (ja) * | 2006-08-17 | 2015-06-17 | 一夫 大橋 | 血友病ｂ治療剤及びその製造方法 |
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2009
- 2009-04-24 WO PCT/IB2009/005763 patent/WO2009130602A2/en not_active Ceased
- 2009-04-24 ES ES09734192.9T patent/ES2466340T3/es active Active
- 2009-04-24 UA UAA201013989A patent/UA101497C2/ru unknown
- 2009-04-24 CN CN200980119877XA patent/CN102046205A/zh active Pending
- 2009-04-24 KR KR1020107026368A patent/KR20110016440A/ko not_active Ceased
- 2009-04-24 MY MYPI2010004993A patent/MY158228A/en unknown
- 2009-04-24 MX MX2010011672A patent/MX2010011672A/es active IP Right Grant
- 2009-04-24 NZ NZ588854A patent/NZ588854A/en not_active IP Right Cessation
- 2009-04-24 DK DK09734192.9T patent/DK2280734T3/da active
- 2009-04-24 CA CA2722169A patent/CA2722169A1/en not_active Abandoned
- 2009-04-24 AU AU2009239641A patent/AU2009239641B2/en not_active Ceased
- 2009-04-24 BR BRPI0911350A patent/BRPI0911350A2/pt not_active IP Right Cessation
- 2009-04-24 JP JP2011505616A patent/JP2011519833A/ja active Pending
- 2009-04-24 EP EP09734192.9A patent/EP2280734B1/en not_active Not-in-force
- 2009-04-24 RU RU2010147813/15A patent/RU2496521C2/ru not_active IP Right Cessation
- 2009-04-24 US US12/989,555 patent/US20110183906A1/en not_active Abandoned
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2010
- 2010-10-22 NI NI201000177A patent/NI201000177A/es unknown
- 2010-10-22 ZA ZA2010/07559A patent/ZA201007559B/en unknown
- 2010-10-24 IL IL208908A patent/IL208908A0/en unknown
- 2010-10-27 CR CR11763A patent/CR11763A/es not_active Application Discontinuation
- 2010-11-24 CO CO10147494A patent/CO6300965A2/es not_active Application Discontinuation
- 2010-11-24 EC EC2010010632A patent/ECSP10010632A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CR11763A (es) | 2011-04-26 |
| ES2466340T3 (es) | 2014-06-10 |
| KR20110016440A (ko) | 2011-02-17 |
| RU2010147813A (ru) | 2012-05-27 |
| US20110183906A1 (en) | 2011-07-28 |
| IL208908A0 (en) | 2011-01-31 |
| AU2009239641A1 (en) | 2009-10-29 |
| BRPI0911350A2 (pt) | 2017-12-05 |
| EP2280734B1 (en) | 2014-02-26 |
| MX2010011672A (es) | 2011-03-02 |
| ZA201007559B (en) | 2012-01-25 |
| WO2009130602A2 (en) | 2009-10-29 |
| NI201000177A (es) | 2011-08-29 |
| AU2009239641B2 (en) | 2013-11-07 |
| CO6300965A2 (es) | 2011-07-21 |
| HK1151986A1 (en) | 2012-02-17 |
| EP2280734A2 (en) | 2011-02-09 |
| ECSP10010632A (es) | 2011-02-28 |
| UA101497C2 (ru) | 2013-04-10 |
| WO2009130602A3 (en) | 2010-02-11 |
| RU2496521C2 (ru) | 2013-10-27 |
| MY158228A (en) | 2016-09-15 |
| DK2280734T3 (da) | 2014-05-26 |
| NZ588854A (en) | 2011-12-22 |
| WO2009130602A9 (en) | 2010-04-22 |
| CN102046205A (zh) | 2011-05-04 |
| JP2011519833A (ja) | 2011-07-14 |
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