JP2011519833A - 半減期が延長された第ｉｘ因子コンジュゲート - Google Patents
半減期が延長された第ｉｘ因子コンジュゲート Download PDFInfo
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- C12N9/6424—Serine endopeptidases (3.4.21)
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- A61K38/36—Blood coagulation or fibrinolysis factors
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C—CHEMISTRY; METALLURGY
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- C12Y—ENZYMES
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Landscapes
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- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
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| PCT/IB2009/005763 WO2009130602A2 (en) | 2008-04-24 | 2009-04-24 | Factor ix conjugates with extended half-lives |
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| JP2015512927A (ja) * | 2012-04-16 | 2015-04-30 | カンタブ バイオファーマシューティカルズ パテンツ リミテッド | 最適化された皮下治療薬 |
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| PT2101821E (pt) | 2006-12-15 | 2014-10-03 | Baxter Int | Fator conjugado viia-ácido (poli)siálico com prolongamento do tempo de meia vida in vivo |
| US8809501B2 (en) | 2009-07-27 | 2014-08-19 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| JP5909755B2 (ja) | 2009-07-27 | 2016-04-27 | リポクセン テクノロジーズ リミテッド | 非血液凝固タンパク質の糖ポリシアル酸化 |
| US8642737B2 (en) | 2010-07-26 | 2014-02-04 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| ES2597954T3 (es) | 2009-07-27 | 2017-01-24 | Baxalta GmbH | Conjugados de proteína de la coagulación sanguínea |
| EP3093029A1 (en) | 2009-07-27 | 2016-11-16 | Baxalta GmbH | Blood coagulation protein conjugates |
| WO2011020866A2 (en) * | 2009-08-20 | 2011-02-24 | Csl Behring Gmbh | Albumin fused coagulation factors for non-intravenous administration in the therapy and prophylactic treatment of bleeding disorders |
| GB201007356D0 (en) * | 2010-04-30 | 2010-06-16 | Leverton Licence Holdings Ltd | Conjugated factor VIIa |
| GB201007357D0 (en) * | 2010-04-30 | 2010-06-16 | Leverton Licence Holdings Ltd | Conjugated factor VIII |
| PL3552619T3 (pl) | 2010-07-09 | 2025-12-01 | Bioverativ Therapeutics Inc. | Polipeptydy czynnika ix i sposoby ich zastosowania |
| BR112013015898A2 (pt) | 2010-12-22 | 2018-06-26 | Baxter International Inc. | derivado de ácido graxo solúvel em água, e, métodos para preparar um derivado de ácido graxo e uma proteína terapêutica conjugada. |
| JP2014520094A (ja) * | 2011-05-27 | 2014-08-21 | バクスター・インターナショナル・インコーポレイテッド | 増加した半減期を有する治療用タンパク質およびそれを調製する方法 |
| EP2861261A2 (en) * | 2012-06-19 | 2015-04-22 | Polytherics Limited | Process for preparation of antibody conjugates and antibody conjugates |
| HK1213521A1 (zh) | 2012-09-25 | 2016-07-08 | Bioverativ Therapeutics Inc. | Fix多肽的應用 |
| WO2014144549A1 (en) | 2013-03-15 | 2014-09-18 | Biogen Idec Ma Inc. | Factor ix polypeptide formulations |
| AR099340A1 (es) * | 2014-02-12 | 2016-07-13 | Novo Nordisk As | Conjugados del factor de coagulación ix |
| AU2015236340B2 (en) | 2014-03-24 | 2020-02-06 | Bioverativ Therapeutics Inc. | Lyophilized factor IX formulations |
| GB2564389A (en) | 2017-07-04 | 2019-01-16 | Green Running Ltd | A system and method for utility management |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005033140A1 (ja) * | 2003-09-30 | 2005-04-14 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | 高純度血液凝固ｉｘ因子調製物およびその精製方法 |
| JP2007527382A (ja) * | 2003-07-11 | 2007-09-27 | ポリセリックス リミテッド | 複合生物学的分子及びそれらの調製 |
| WO2007126808A1 (en) * | 2006-03-31 | 2007-11-08 | Baxter International Inc | Pegylated factor viii |
| WO2007135182A2 (en) * | 2006-05-24 | 2007-11-29 | Novo Nordisk Health Care Ag | Factor ix analogues having prolonged in vivo half life |
| JP2008505119A (ja) * | 2004-06-30 | 2008-02-21 | ネクター セラピューティクス アラバマ，コーポレイション | 高分子−第ｉｘ因子部分の抱合体 |
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| US5171569A (en) | 1985-03-15 | 1992-12-15 | National Research Development Corporation | Factor IX preparations uncontaminated by plasma components or pox virus |
| US5268275A (en) | 1991-05-08 | 1993-12-07 | The University Of North Carolina At Chapel Hill | Vitamin K-dependent carboxylase |
| US5621039A (en) * | 1993-06-08 | 1997-04-15 | Hallahan; Terrence W. | Factor IX- polymeric conjugates |
| US5888809A (en) | 1997-05-01 | 1999-03-30 | Icos Corporation | Hamster EF-1α transcriptional regulatory DNA |
| US6531298B2 (en) | 1997-07-21 | 2003-03-11 | The University Of North Carolina At Chapel Hill | Factor IX antihemophilic factor with increased clotting activity |
| WO2000054787A1 (en) | 1999-03-16 | 2000-09-21 | The Children's Hospital Of Philadelphia | Enhanced gamma-carboxylation of recombinant vitamin k-dependent clotting factors |
| CA2739933A1 (en) * | 2000-02-11 | 2001-08-16 | Bayer Healthcare Llc | Factor vii or viia-like molecules |
| MXPA05007151A (es) * | 2002-12-31 | 2005-09-21 | Nektar Therapeutics Al Corp | Polimeros terminados en maleimida hidroliticamente estables. |
| JP4490369B2 (ja) * | 2002-12-31 | 2010-06-23 | ネクター セラピューティクス アラバマ，コーポレイション | マレアミド酸ポリマー誘導体及びこれらの生物学的複合体 |
| KR101207247B1 (ko) * | 2003-01-06 | 2012-12-03 | 넥타르 테라퓨틱스 | 티올-선택성 수용성 중합체 유도체 |
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- 2009-04-24 CN CN200980119877XA patent/CN102046205A/zh active Pending
- 2009-04-24 US US12/989,555 patent/US20110183906A1/en not_active Abandoned
- 2009-04-24 ES ES09734192.9T patent/ES2466340T3/es active Active
- 2009-04-24 BR BRPI0911350A patent/BRPI0911350A2/pt not_active IP Right Cessation
- 2009-04-24 AU AU2009239641A patent/AU2009239641B2/en not_active Ceased
- 2009-04-24 UA UAA201013989A patent/UA101497C2/ru unknown
- 2009-04-24 CA CA2722169A patent/CA2722169A1/en not_active Abandoned
- 2009-04-24 WO PCT/IB2009/005763 patent/WO2009130602A2/en not_active Ceased
- 2009-04-24 EP EP09734192.9A patent/EP2280734B1/en not_active Not-in-force
- 2009-04-24 MY MYPI2010004993A patent/MY158228A/en unknown
- 2009-04-24 JP JP2011505616A patent/JP2011519833A/ja active Pending
- 2009-04-24 NZ NZ588854A patent/NZ588854A/en not_active IP Right Cessation
- 2009-04-24 RU RU2010147813/15A patent/RU2496521C2/ru not_active IP Right Cessation
- 2009-04-24 KR KR1020107026368A patent/KR20110016440A/ko not_active Ceased
- 2009-04-24 MX MX2010011672A patent/MX2010011672A/es active IP Right Grant
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2010
- 2010-10-22 ZA ZA2010/07559A patent/ZA201007559B/en unknown
- 2010-10-22 NI NI201000177A patent/NI201000177A/es unknown
- 2010-10-24 IL IL208908A patent/IL208908A0/en unknown
- 2010-10-27 CR CR11763A patent/CR11763A/es not_active Application Discontinuation
- 2010-11-24 CO CO10147494A patent/CO6300965A2/es not_active Application Discontinuation
- 2010-11-24 EC EC2010010632A patent/ECSP10010632A/es unknown
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015512927A (ja) * | 2012-04-16 | 2015-04-30 | カンタブ バイオファーマシューティカルズ パテンツ リミテッド | 最適化された皮下治療薬 |
| JP2018024684A (ja) * | 2012-04-16 | 2018-02-15 | カンタブ バイオファーマシューティカルズ パテンツ リミテッド | 最適化された皮下治療薬 |
| JP2019131593A (ja) * | 2012-04-16 | 2019-08-08 | カンタブ バイオファーマシューティカルズ パテンツ リミテッド | 最適化された皮下治療薬 |
Also Published As
| Publication number | Publication date |
|---|---|
| CR11763A (es) | 2011-04-26 |
| CN102046205A (zh) | 2011-05-04 |
| NZ588854A (en) | 2011-12-22 |
| CO6300965A2 (es) | 2011-07-21 |
| NI201000177A (es) | 2011-08-29 |
| ECSP10010632A (es) | 2011-02-28 |
| MX2010011672A (es) | 2011-03-02 |
| KR20110016440A (ko) | 2011-02-17 |
| WO2009130602A3 (en) | 2010-02-11 |
| EP2280734A2 (en) | 2011-02-09 |
| DK2280734T3 (da) | 2014-05-26 |
| AU2009239641B2 (en) | 2013-11-07 |
| IL208908A0 (en) | 2011-01-31 |
| RU2496521C2 (ru) | 2013-10-27 |
| BRPI0911350A2 (pt) | 2017-12-05 |
| WO2009130602A2 (en) | 2009-10-29 |
| UA101497C2 (ru) | 2013-04-10 |
| MY158228A (en) | 2016-09-15 |
| WO2009130602A9 (en) | 2010-04-22 |
| US20110183906A1 (en) | 2011-07-28 |
| ES2466340T3 (es) | 2014-06-10 |
| AU2009239641A1 (en) | 2009-10-29 |
| RU2010147813A (ru) | 2012-05-27 |
| HK1151986A1 (en) | 2012-02-17 |
| ZA201007559B (en) | 2012-01-25 |
| EP2280734B1 (en) | 2014-02-26 |
| CA2722169A1 (en) | 2009-10-29 |
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