AU2009239641B2 - Factor IX conjugates with extended half-lives - Google Patents
Factor IX conjugates with extended half-lives Download PDFInfo
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- AU2009239641B2 AU2009239641B2 AU2009239641A AU2009239641A AU2009239641B2 AU 2009239641 B2 AU2009239641 B2 AU 2009239641B2 AU 2009239641 A AU2009239641 A AU 2009239641A AU 2009239641 A AU2009239641 A AU 2009239641A AU 2009239641 B2 AU2009239641 B2 AU 2009239641B2
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- Prior art keywords
- fix
- peg
- conjugate
- factor
- composition
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- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
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- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
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- C—CHEMISTRY; METALLURGY
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- C12Y—ENZYMES
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Landscapes
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- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| PCT/IB2009/005763 WO2009130602A2 (en) | 2008-04-24 | 2009-04-24 | Factor ix conjugates with extended half-lives |
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| US8809501B2 (en) | 2009-07-27 | 2014-08-19 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| JP5909755B2 (ja) | 2009-07-27 | 2016-04-27 | リポクセン テクノロジーズ リミテッド | 非血液凝固タンパク質の糖ポリシアル酸化 |
| US8642737B2 (en) | 2010-07-26 | 2014-02-04 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| ES2597954T3 (es) | 2009-07-27 | 2017-01-24 | Baxalta GmbH | Conjugados de proteína de la coagulación sanguínea |
| EP3093029A1 (en) | 2009-07-27 | 2016-11-16 | Baxalta GmbH | Blood coagulation protein conjugates |
| WO2011020866A2 (en) * | 2009-08-20 | 2011-02-24 | Csl Behring Gmbh | Albumin fused coagulation factors for non-intravenous administration in the therapy and prophylactic treatment of bleeding disorders |
| GB201007356D0 (en) * | 2010-04-30 | 2010-06-16 | Leverton Licence Holdings Ltd | Conjugated factor VIIa |
| GB201007357D0 (en) * | 2010-04-30 | 2010-06-16 | Leverton Licence Holdings Ltd | Conjugated factor VIII |
| PL3552619T3 (pl) | 2010-07-09 | 2025-12-01 | Bioverativ Therapeutics Inc. | Polipeptydy czynnika ix i sposoby ich zastosowania |
| BR112013015898A2 (pt) | 2010-12-22 | 2018-06-26 | Baxter International Inc. | derivado de ácido graxo solúvel em água, e, métodos para preparar um derivado de ácido graxo e uma proteína terapêutica conjugada. |
| JP2014520094A (ja) * | 2011-05-27 | 2014-08-21 | バクスター・インターナショナル・インコーポレイテッド | 増加した半減期を有する治療用タンパク質およびそれを調製する方法 |
| MY190257A (en) | 2012-04-16 | 2022-04-11 | Cantab Biopharmaceuticals Patents Ltd | Optimised subcutaneous therapeutic agents |
| EP2861261A2 (en) * | 2012-06-19 | 2015-04-22 | Polytherics Limited | Process for preparation of antibody conjugates and antibody conjugates |
| HK1213521A1 (zh) | 2012-09-25 | 2016-07-08 | Bioverativ Therapeutics Inc. | Fix多肽的應用 |
| WO2014144549A1 (en) | 2013-03-15 | 2014-09-18 | Biogen Idec Ma Inc. | Factor ix polypeptide formulations |
| AR099340A1 (es) * | 2014-02-12 | 2016-07-13 | Novo Nordisk As | Conjugados del factor de coagulación ix |
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| US5268275A (en) | 1991-05-08 | 1993-12-07 | The University Of North Carolina At Chapel Hill | Vitamin K-dependent carboxylase |
| US5621039A (en) * | 1993-06-08 | 1997-04-15 | Hallahan; Terrence W. | Factor IX- polymeric conjugates |
| US5888809A (en) | 1997-05-01 | 1999-03-30 | Icos Corporation | Hamster EF-1α transcriptional regulatory DNA |
| US6531298B2 (en) | 1997-07-21 | 2003-03-11 | The University Of North Carolina At Chapel Hill | Factor IX antihemophilic factor with increased clotting activity |
| WO2000054787A1 (en) | 1999-03-16 | 2000-09-21 | The Children's Hospital Of Philadelphia | Enhanced gamma-carboxylation of recombinant vitamin k-dependent clotting factors |
| CA2739933A1 (en) * | 2000-02-11 | 2001-08-16 | Bayer Healthcare Llc | Factor vii or viia-like molecules |
| MXPA05007151A (es) * | 2002-12-31 | 2005-09-21 | Nektar Therapeutics Al Corp | Polimeros terminados en maleimida hidroliticamente estables. |
| JP4490369B2 (ja) * | 2002-12-31 | 2010-06-23 | ネクター セラピューティクス アラバマ，コーポレイション | マレアミド酸ポリマー誘導体及びこれらの生物学的複合体 |
| KR101207247B1 (ko) * | 2003-01-06 | 2012-12-03 | 넥타르 테라퓨틱스 | 티올-선택성 수용성 중합체 유도체 |
| GB0316294D0 (en) * | 2003-07-11 | 2003-08-13 | Polytherics Ltd | Conjugated biological molecules and their preparation |
| DE602004025157D1 (de) | 2003-09-23 | 2010-03-04 | Univ North Carolina | Zellen, die Vitamin-K-Reduktase und Vitamin-K-abhängiges Protein coexprimieren und deren Anwendung zur Verbesserung der Produktivität von diesem Vitamin-K-abhängigen Protein |
| WO2005033140A1 (ja) * | 2003-09-30 | 2005-04-14 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | 高純度血液凝固ｉｘ因子調製物およびその精製方法 |
| DE602004026897D1 (de) | 2003-10-14 | 2010-06-10 | Baxter Healthcare Sa | Vkorc1 (vitamin k epoxide recycling polypeptide), ein therapeutisches ziel für coumarin und deren derivate |
| US20060040856A1 (en) * | 2003-12-03 | 2006-02-23 | Neose Technologies, Inc. | Glycopegylated factor IX |
| CA2571292C (en) * | 2004-06-30 | 2013-05-21 | Nektar Therapeutics Al, Corporation | Polymer-factor ix moiety conjugates |
| WO2006063292A1 (en) | 2004-12-08 | 2006-06-15 | Icos Corporation | Recombinant method for making multimeric proteins |
| PL1853700T3 (pl) | 2005-02-28 | 2013-05-31 | Baxalta Inc | Koekspresja przez rekombinowanie podjednostki 1 reduktazy epoksydu witaminy K w celu poprawy ekspresji białka zależnego od witaminy K |
| CA2601574C (en) | 2005-03-15 | 2014-12-02 | University Of North Carolina At Chapel Hill | Methods and compositions for producing active vitamin k-dependent proteins |
| EP2975135A1 (en) * | 2005-05-25 | 2016-01-20 | Novo Nordisk A/S | Glycopegylated factor IX |
| AU2007245190B2 (en) * | 2006-03-31 | 2011-07-21 | Takeda Pharmaceutical Company Limited | Pegylated factor VIII |
| JP5737821B2 (ja) * | 2006-08-17 | 2015-06-17 | 一夫 大橋 | 血友病ｂ治療剤及びその製造方法 |
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2009
- 2009-04-24 DK DK09734192.9T patent/DK2280734T3/da active
- 2009-04-24 CN CN200980119877XA patent/CN102046205A/zh active Pending
- 2009-04-24 US US12/989,555 patent/US20110183906A1/en not_active Abandoned
- 2009-04-24 ES ES09734192.9T patent/ES2466340T3/es active Active
- 2009-04-24 BR BRPI0911350A patent/BRPI0911350A2/pt not_active IP Right Cessation
- 2009-04-24 AU AU2009239641A patent/AU2009239641B2/en not_active Ceased
- 2009-04-24 UA UAA201013989A patent/UA101497C2/ru unknown
- 2009-04-24 CA CA2722169A patent/CA2722169A1/en not_active Abandoned
- 2009-04-24 WO PCT/IB2009/005763 patent/WO2009130602A2/en not_active Ceased
- 2009-04-24 EP EP09734192.9A patent/EP2280734B1/en not_active Not-in-force
- 2009-04-24 MY MYPI2010004993A patent/MY158228A/en unknown
- 2009-04-24 JP JP2011505616A patent/JP2011519833A/ja active Pending
- 2009-04-24 NZ NZ588854A patent/NZ588854A/en not_active IP Right Cessation
- 2009-04-24 RU RU2010147813/15A patent/RU2496521C2/ru not_active IP Right Cessation
- 2009-04-24 KR KR1020107026368A patent/KR20110016440A/ko not_active Ceased
- 2009-04-24 MX MX2010011672A patent/MX2010011672A/es active IP Right Grant
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2010
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- 2010-10-22 NI NI201000177A patent/NI201000177A/es unknown
- 2010-10-24 IL IL208908A patent/IL208908A0/en unknown
- 2010-10-27 CR CR11763A patent/CR11763A/es not_active Application Discontinuation
- 2010-11-24 CO CO10147494A patent/CO6300965A2/es not_active Application Discontinuation
- 2010-11-24 EC EC2010010632A patent/ECSP10010632A/es unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007135182A2 (en) * | 2006-05-24 | 2007-11-29 | Novo Nordisk Health Care Ag | Factor ix analogues having prolonged in vivo half life |
Also Published As
| Publication number | Publication date |
|---|---|
| CR11763A (es) | 2011-04-26 |
| CN102046205A (zh) | 2011-05-04 |
| NZ588854A (en) | 2011-12-22 |
| CO6300965A2 (es) | 2011-07-21 |
| NI201000177A (es) | 2011-08-29 |
| ECSP10010632A (es) | 2011-02-28 |
| MX2010011672A (es) | 2011-03-02 |
| KR20110016440A (ko) | 2011-02-17 |
| WO2009130602A3 (en) | 2010-02-11 |
| EP2280734A2 (en) | 2011-02-09 |
| DK2280734T3 (da) | 2014-05-26 |
| IL208908A0 (en) | 2011-01-31 |
| RU2496521C2 (ru) | 2013-10-27 |
| BRPI0911350A2 (pt) | 2017-12-05 |
| WO2009130602A2 (en) | 2009-10-29 |
| JP2011519833A (ja) | 2011-07-14 |
| UA101497C2 (ru) | 2013-04-10 |
| MY158228A (en) | 2016-09-15 |
| WO2009130602A9 (en) | 2010-04-22 |
| US20110183906A1 (en) | 2011-07-28 |
| ES2466340T3 (es) | 2014-06-10 |
| AU2009239641A1 (en) | 2009-10-29 |
| RU2010147813A (ru) | 2012-05-27 |
| HK1151986A1 (en) | 2012-02-17 |
| ZA201007559B (en) | 2012-01-25 |
| EP2280734B1 (en) | 2014-02-26 |
| CA2722169A1 (en) | 2009-10-29 |
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