CA2711943C - Compositions and processes for improved mass spectrometry analysis - Google Patents
Compositions and processes for improved mass spectrometry analysis Download PDFInfo
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- CA2711943C CA2711943C CA2711943A CA2711943A CA2711943C CA 2711943 C CA2711943 C CA 2711943C CA 2711943 A CA2711943 A CA 2711943A CA 2711943 A CA2711943 A CA 2711943A CA 2711943 C CA2711943 C CA 2711943C
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- acid
- mass spectrometry
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- adduct
- substrate
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- 238000004949 mass spectrometry Methods 0.000 title claims abstract description 93
- 238000000034 method Methods 0.000 title claims abstract description 56
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- 230000008569 process Effects 0.000 title abstract description 8
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 142
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- 230000000996 additive effect Effects 0.000 claims abstract description 77
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- 238000004458 analytical method Methods 0.000 claims abstract description 35
- 239000011159 matrix material Substances 0.000 claims description 144
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- 125000000217 alkyl group Chemical group 0.000 claims description 47
- 230000015572 biosynthetic process Effects 0.000 claims description 35
- 102000039446 nucleic acids Human genes 0.000 claims description 28
- 108020004707 nucleic acids Proteins 0.000 claims description 28
- 150000007523 nucleic acids Chemical class 0.000 claims description 28
- 150000003839 salts Chemical class 0.000 claims description 24
- 125000000623 heterocyclic group Chemical group 0.000 claims description 22
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Classifications
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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- C12Q1/6872—Methods for sequencing involving mass spectrometry
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- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
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- G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25125—Digestion or removing interfering materials
Landscapes
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- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US12/014,671 US7888127B2 (en) | 2008-01-15 | 2008-01-15 | Methods for reducing adduct formation for mass spectrometry analysis |
| US12/014,671 | 2008-01-15 | ||
| PCT/US2009/031020 WO2009091841A2 (en) | 2008-01-15 | 2009-01-14 | Compositions and processes for improved mass spectrometry analysis |
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| CA2711943A1 CA2711943A1 (en) | 2009-07-23 |
| CA2711943C true CA2711943C (en) | 2018-01-02 |
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| CA2711943A Expired - Fee Related CA2711943C (en) | 2008-01-15 | 2009-01-14 | Compositions and processes for improved mass spectrometry analysis |
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| EP (2) | EP3138623B1 (enExample) |
| JP (3) | JP5400799B2 (enExample) |
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| ES (2) | ES2601359T3 (enExample) |
| WO (1) | WO2009091841A2 (enExample) |
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| US7888127B2 (en) | 2008-01-15 | 2011-02-15 | Sequenom, Inc. | Methods for reducing adduct formation for mass spectrometry analysis |
| US8110797B2 (en) | 2009-02-06 | 2012-02-07 | Florida State University Research Foundation, Inc. | Electrospray ionization mass spectrometry methodology |
| JP5895694B2 (ja) * | 2012-05-11 | 2016-03-30 | 株式会社島津製作所 | マトリックス支援レーザ脱離イオン化質量分析用マトリックス |
| EP3300015B1 (en) * | 2013-03-12 | 2019-08-14 | Panacea Biomatx Inc. | System for making customized formulations for individuals |
| US9305756B2 (en) | 2013-03-13 | 2016-04-05 | Agena Bioscience, Inc. | Preparation enhancements and methods of use for MALDI mass spectrometry |
| US10451544B2 (en) | 2016-10-11 | 2019-10-22 | Genotox Laboratories | Methods of characterizing a urine sample |
| CN106483191B (zh) * | 2016-10-27 | 2019-03-08 | 吉林大学 | 一种通过消除甜点效应提高质谱检测重复性的方法 |
| CN108008003A (zh) * | 2017-10-31 | 2018-05-08 | 北京毅新博创生物科技有限公司 | 改善质谱检测核酸结晶的方法及产品 |
| CN108051503A (zh) * | 2017-10-31 | 2018-05-18 | 北京毅新博创生物科技有限公司 | 改善质谱检测微生物结晶的方法及产品 |
| CN108008002A (zh) * | 2017-10-31 | 2018-05-08 | 北京毅新博创生物科技有限公司 | 校正质谱检测核酸样品的准确率的方法及产品 |
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