AU2009205404B2 - Compositions and processes for improved mass spectrometry analysis - Google Patents

Compositions and processes for improved mass spectrometry analysis Download PDF

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Publication number
AU2009205404B2
AU2009205404B2 AU2009205404A AU2009205404A AU2009205404B2 AU 2009205404 B2 AU2009205404 B2 AU 2009205404B2 AU 2009205404 A AU2009205404 A AU 2009205404A AU 2009205404 A AU2009205404 A AU 2009205404A AU 2009205404 B2 AU2009205404 B2 AU 2009205404B2
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AU
Australia
Prior art keywords
mass spectrometry
matrix
substrate
acid
ascorbic acid
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AU2009205404A
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AU2009205404A1 (en
Inventor
Thomas Becker
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Agena Bioscience Inc
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Agena Bioscience Inc
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Priority to AU2014203336A priority Critical patent/AU2014203336B2/en
Assigned to AGENA BIOSCIENCE, INC. reassignment AGENA BIOSCIENCE, INC. Amend patent request/document other than specification (104) Assignors: SEQUENOM, INC.
Ceased legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6872—Methods for sequencing involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25125—Digestion or removing interfering materials

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU2009205404A 2008-01-15 2009-01-14 Compositions and processes for improved mass spectrometry analysis Ceased AU2009205404B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2014203336A AU2014203336B2 (en) 2008-01-15 2014-06-19 Compositions and processes for improved mass spectrometry analysis

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12/014,671 2008-01-15
US12/014,671 US7888127B2 (en) 2008-01-15 2008-01-15 Methods for reducing adduct formation for mass spectrometry analysis
PCT/US2009/031020 WO2009091841A2 (en) 2008-01-15 2009-01-14 Compositions and processes for improved mass spectrometry analysis

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2014203336A Division AU2014203336B2 (en) 2008-01-15 2014-06-19 Compositions and processes for improved mass spectrometry analysis

Publications (2)

Publication Number Publication Date
AU2009205404A1 AU2009205404A1 (en) 2009-07-23
AU2009205404B2 true AU2009205404B2 (en) 2014-03-20

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AU2014203336A Ceased AU2014203336B2 (en) 2008-01-15 2014-06-19 Compositions and processes for improved mass spectrometry analysis

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US (6) US7888127B2 (enExample)
EP (2) EP2242561B1 (enExample)
JP (3) JP5400799B2 (enExample)
KR (1) KR101733248B1 (enExample)
CN (2) CN101965221A (enExample)
AU (2) AU2009205404B2 (enExample)
CA (1) CA2711943C (enExample)
EA (1) EA017342B1 (enExample)
ES (2) ES2601359T3 (enExample)
WO (1) WO2009091841A2 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7888127B2 (en) 2008-01-15 2011-02-15 Sequenom, Inc. Methods for reducing adduct formation for mass spectrometry analysis
US8110797B2 (en) * 2009-02-06 2012-02-07 Florida State University Research Foundation, Inc. Electrospray ionization mass spectrometry methodology
JP5895694B2 (ja) * 2012-05-11 2016-03-30 株式会社島津製作所 マトリックス支援レーザ脱離イオン化質量分析用マトリックス
ES2660294T3 (es) * 2013-03-12 2018-03-21 Panacea Biomatx Inc. Método y sistema para hacer formulaciones personalizadas para los individuos
US9305756B2 (en) 2013-03-13 2016-04-05 Agena Bioscience, Inc. Preparation enhancements and methods of use for MALDI mass spectrometry
US10451544B2 (en) 2016-10-11 2019-10-22 Genotox Laboratories Methods of characterizing a urine sample
CN106483191B (zh) * 2016-10-27 2019-03-08 吉林大学 一种通过消除甜点效应提高质谱检测重复性的方法
CN108008003A (zh) * 2017-10-31 2018-05-08 北京毅新博创生物科技有限公司 改善质谱检测核酸结晶的方法及产品
CN107884466A (zh) * 2017-10-31 2018-04-06 北京毅新博创生物科技有限公司 校正质谱检测微生物样品的准确率的方法及产品
CN108051503A (zh) * 2017-10-31 2018-05-18 北京毅新博创生物科技有限公司 改善质谱检测微生物结晶的方法及产品
CN108008002A (zh) * 2017-10-31 2018-05-08 北京毅新博创生物科技有限公司 校正质谱检测核酸样品的准确率的方法及产品
CN107907585A (zh) * 2017-11-09 2018-04-13 广州禾信康源医疗科技有限公司 靶板及其制作方法
CN108845023A (zh) * 2018-03-30 2018-11-20 清华大学 一种激光解吸附离子化质谱检测方法
CN109541012A (zh) * 2018-11-23 2019-03-29 杭州汇健科技有限公司 一种用于质谱分析的通用型纳米芯片及其制备方法与应用
CN110129893A (zh) * 2019-03-25 2019-08-16 为康（苏州）基因科技有限公司 一种芯片的制备方法及其应用
KR102410207B1 (ko) * 2020-03-06 2022-06-20 주식회사 우성제약 고성능 액체 크래마토그래피-질량분석기를 이용한 타우린아미드의 정량 분석 방법
CN112316847A (zh) * 2020-11-11 2021-02-05 吉林大学 一种磷氮化合物的高温高压合成方法
CN113447560B (zh) * 2021-05-24 2022-12-09 上海交通大学 一种基于金属离子加成的小分子代谢物碎裂控制方法及应用
CN116297805A (zh) * 2023-02-28 2023-06-23 厦门金诺花生物技术有限公司 用于maldi-ms的核酸基质溶液及其制备
CN116660359A (zh) * 2023-05-19 2023-08-29 中元汇吉生物技术股份有限公司 一种质谱分析用组合物、芯片及其应用
CN117074509B (zh) * 2023-07-31 2024-04-23 广东省农业科学院农业生物基因研究中心 一种基于核壳纳米材料检测类胡萝卜素的质谱方法
CN117368300B (zh) * 2023-11-14 2024-08-09 浙江迪谱诊断技术有限公司 核酸质谱基质的试剂组合及其制备方法和应用
CN122477528A (zh) * 2023-12-28 2026-07-28 Ionoscope有限责任公司 飞行时间质谱分析器
CN118956653B (zh) * 2024-07-05 2025-03-18 齐鲁工业大学(山东省科学院) 具有降尿酸活性的益生菌、复合益生菌剂及其应用

Family Cites Families (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0612994A3 (de) * 1993-02-26 1996-03-06 Ciba Geigy Ag Matrix für die matrix-unterstützte Laserdesorptions-Massenspektroskopie.
PT840804E (pt) 1996-01-23 2000-10-31 Qiagen Genomics Inc Metodos e composicoes para a analise de moleculas de acidos nocleicos usando tecnicas de separacao por dimensoes
US6051378A (en) * 1996-03-04 2000-04-18 Genetrace Systems Inc. Methods of screening nucleic acids using mass spectrometry
DE19618032C2 (de) 1996-05-04 2000-04-13 Bruker Daltonik Gmbh Lagerfähig vorpräparierte Maldi-Probenträger
US5786146A (en) 1996-06-03 1998-07-28 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
ATE464123T1 (de) * 1997-06-20 2010-04-15 Univ New York Elektrosprühen von lösungen zur massenherstellung von chips und molekülbibliotheken
EP0990047B1 (en) 1997-07-22 2003-05-14 Qiagen Genomics, Inc. Methods and compositions for analyzing nucleic acids by mass spectrometry
DE19754978C2 (de) 1997-12-11 2000-07-13 Bruker Daltonik Gmbh Probenträger für die MALDI-Massenspektrometrie nebst Verfahren zur Herstellung der Platten und zum Aufbringen der Proben
US6723564B2 (en) * 1998-05-07 2004-04-20 Sequenom, Inc. IR MALDI mass spectrometry of nucleic acids using liquid matrices
US6037118A (en) * 1998-05-14 2000-03-14 University Of Maryland Baltimore County Viral characterization by direct detection of capsid proteins
EP1144537B1 (de) 1998-12-24 2004-03-17 Sunyx Surface Nanotechnologies GmbH Ultraphobe oberfläche
AU3040100A (en) 1998-12-24 2000-07-31 Bayer Aktiengesellschaft Method for producing an ultraphobic surface by sand blasting
DK1196129T3 (da) * 1999-06-25 2006-04-03 Az Univ Amsterdam Farmaceutiske og kosmetiske sammensætninger omfattende urocaninsyrederivater som radikalscavengers eller antioxidanter
WO2001062887A1 (en) 2000-02-23 2001-08-30 Zyomyx, Inc. Chips having elevated sample surfaces
CA2301451A1 (en) * 2000-03-20 2001-09-21 Thang T. Pham Method for analysis of analytes by mass spectrometry
DE10043042C2 (de) 2000-09-01 2003-04-17 Bruker Daltonik Gmbh Verfahren zum Belegen eines Probenträgers mit Biomolekülen für die massenspektrometrische Analyse
WO2002034197A2 (en) * 2000-10-27 2002-05-02 Microbiosciences, Inc. Micro storage, reaction and detection cells and methods and apparatus for use thereof
US20020142483A1 (en) * 2000-10-30 2002-10-03 Sequenom, Inc. Method and apparatus for delivery of submicroliter volumes onto a substrate
US20060051741A1 (en) 2002-10-04 2006-03-09 Protosera Inc. Plate for mass spectrometry, process for preparing the same and use thereof
DE10112515B4 (de) 2001-03-09 2004-02-12 Epigenomics Ag Verfahren zum Nachweis von Cytosin-Methylierungsmustern mit hoher Sensitivität
GB0120131D0 (en) 2001-08-17 2001-10-10 Micromass Ltd Maldi target plate
US20030100082A1 (en) * 2001-10-31 2003-05-29 Mary Ann Lila Methods for isolation of proanthocyanidins from flavonoid-producing cell culture
US20030141253A1 (en) * 2001-12-07 2003-07-31 Bihan Thierry Le Apparatus for efficient liquid chromatography/mass spectrometry processing
SE0202415D0 (sv) 2001-12-11 2002-08-13 Thomas Laurell Dockable processing module
WO2003071274A1 (de) 2002-02-22 2003-08-28 Sunyx Surface Nanotechnologies Gmbh Verwendung von ultraphoben oberflächen mit einer vielzahl hydrophiler bereiche zur analyse von proben
ATE349555T1 (de) 2002-03-15 2007-01-15 Epigenomics Ag Entdeckungs- und diagnoseverfahren mit 5- methylcytosin-dna-glycosylase
US20050074759A1 (en) * 2002-04-23 2005-04-07 Petersson E. James Methods for evaluation of in vitro aminoacyl tRNA production using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
JP2005526972A (ja) * 2002-05-02 2005-09-08 シファーゲン バイオシステムズ， インコーポレイテッド 多糖系ヒドロゲルをコーティングした表面を有するバイオチップ
US7105809B2 (en) * 2002-11-18 2006-09-12 3M Innovative Properties Company Microstructured polymeric substrate
CN1774511B (zh) 2002-11-27 2013-08-21 斯昆诺有限公司 用于序列变异检测和发现的基于断裂的方法和系统
US20040122598A1 (en) * 2002-12-18 2004-06-24 Ecker David J. Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent in food products and cosmetics thereby
US6822230B2 (en) 2002-12-23 2004-11-23 Agilent Technologies, Inc. Matrix-assisted laser desorption/ionization sample holders and methods of using the same
DE112004000250T5 (de) 2003-02-10 2006-02-16 Waters Investments Ltd., New Castle Probenaufbereitungsplatte für die Massenspektrometrie
JP4074921B2 (ja) 2003-03-14 2008-04-16 日本電気株式会社 質量分析システムおよび分析方法
US7442542B2 (en) 2003-03-24 2008-10-28 Agency For Science, Technology And Research Shallow multi-well plastic chip for thermal multiplexing
US6891156B2 (en) 2003-04-30 2005-05-10 Perkin Elmer Instruments Llc Sample plate for matrix-assisted laser desorption and ionization mass spectrometry
US20060183128A1 (en) 2003-08-12 2006-08-17 Epigenomics Ag Methods and compositions for differentiating tissues for cell types using epigenetic markers
WO2005033663A2 (en) 2003-09-30 2005-04-14 Sequenom, Inc. Methods of making substrates for mass spectrometry analysis and related devices
JP4532874B2 (ja) * 2003-10-07 2010-08-25 キヤノン株式会社 質量分析可能な原子群を構成単位とする鎖状構造を有する分子に対して付加情報を付与して、情報記録コードとして利用する方法
WO2005064330A1 (en) * 2003-12-23 2005-07-14 Applera Corporation Improved matrix with noise reduction additive and disposable target containing the same
WO2005065307A2 (en) 2003-12-31 2005-07-21 Ionwerks, Inc. Maldi-im-ortho-tof mass spectrometry with simultaneaous positive and negative mode detection
JP2005221250A (ja) 2004-02-03 2005-08-18 Jeol Ltd 質量スペクトルの解析方法および装置
US20050178959A1 (en) 2004-02-18 2005-08-18 Viorica Lopez-Avila Methods and compositions for assessing a sample by maldi mass spectrometry
US7985424B2 (en) * 2004-04-20 2011-07-26 Dendritic Nanotechnologies Inc. Dendritic polymers with enhanced amplification and interior functionality
US20060023808A1 (en) * 2004-05-17 2006-02-02 Hajivandi Mahbod R Compositions, kits, and methods for calibration in mass spectrometry
US20060243899A1 (en) * 2004-05-24 2006-11-02 Shimadzu Corporation Method for selective measurement of specific substances from a mixture by maldi mass spectrometry
CA2518706A1 (en) 2004-09-09 2006-03-09 Simon Fraser University Method and apparatus for coupling an analyte supply to an electrodynamic droplet processor
US20060214104A1 (en) * 2004-10-26 2006-09-28 Invitrogen Corporation Compositions and methods for analyzing biomolecules using mass spectroscopy
ATE491938T1 (de) 2004-10-29 2011-01-15 Japan Science & Tech Agency Substrat für maldi-tof-ms und massenspektrometrisches verfahren unter verwendung davon
US20060094065A1 (en) * 2004-10-30 2006-05-04 Viorica Lopez-Avila Methods of analyzing a sample by MALDI-mass spectrometry
EP1817430B1 (en) 2004-11-29 2009-09-16 Klinikum der Universität Regensburg Means and methods for detecting methylated dna
KR100544860B1 (ko) 2005-02-07 2006-01-24 (주)프로테오니크 시료 플레이트 및 이의 제조방법
WO2006113671A2 (en) 2005-04-15 2006-10-26 Oncomethylome Sciences, S.A. Methylation markers for diagnosis and treatment of cancers
US7351959B2 (en) 2005-05-13 2008-04-01 Applera Corporation Mass analyzer systems and methods for their operation
US20080023630A1 (en) 2005-11-22 2008-01-31 Ciphergen Biosystems Inc. Polymer probe doped with conductive material for mass spectrometry
GB0524782D0 (en) * 2005-12-05 2006-01-11 Chiron Srl Analysis of samples
EP1814137A3 (en) 2006-01-27 2008-04-23 Sony DADC Austria AG Mass spectrometry target assembly
JP4732951B2 (ja) * 2006-05-22 2011-07-27 株式会社島津製作所 Ｍａｌｄｉ用サンプル調製方法及び質量分析方法
EP3260556B1 (en) 2006-05-31 2019-07-31 Sequenom, Inc. Methods for the extraction of nucleic acid from a sample
EP2038426A2 (en) 2006-06-16 2009-03-25 Sequenom, Inc. Methods and compositions for the amplification, detection and quantification of nucleic acid from a sample
US8262900B2 (en) 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US12054776B2 (en) 2007-07-23 2024-08-06 The Chinese University Of Hong Kong Diagnosing fetal chromosomal aneuploidy using massively parallel genomic sequencing
WO2009032779A2 (en) 2007-08-29 2009-03-12 Sequenom, Inc. Methods and compositions for the size-specific seperation of nucleic acid from a sample
WO2009032781A2 (en) 2007-08-29 2009-03-12 Sequenom, Inc. Methods and compositions for universal size-specific polymerase chain reaction
EA201000427A1 (ru) 2007-10-04 2010-10-29 Хэлсион Молекулар Секвенирование нуклеиново-кислотных полимеров с использованием электронной микроскопии
EP2217930B1 (en) 2007-10-24 2013-03-06 Tallinn University Of Technology Maldi ms-based high-throughput screening method for substances inhibiting aggregation of alzheimer's amyloid beta peptides
US7888127B2 (en) 2008-01-15 2011-02-15 Sequenom, Inc. Methods for reducing adduct formation for mass spectrometry analysis
WO2009120808A2 (en) 2008-03-26 2009-10-01 Sequenom, Inc. Restriction endonuclease enhanced polymorphic sequence detection
EP2106858B1 (en) 2008-03-31 2011-11-02 Sony DADC Austria AG Substrate and target plate
US20110229877A1 (en) 2008-07-07 2011-09-22 Oxford Nanopore Technologies Limited Enzyme-pore constructs
EP3103871B1 (en) 2008-09-16 2020-07-29 Sequenom, Inc. Processes for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for fetal nucleic acid quantification
US8476013B2 (en) 2008-09-16 2013-07-02 Sequenom, Inc. Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
JP2010078482A (ja) 2008-09-26 2010-04-08 Fujifilm Corp 質量分析用基板および質量分析方法
US10927415B2 (en) 2008-11-26 2021-02-23 The Johns Hopkins University Methods for identifying cancer risk
JP5317054B2 (ja) 2008-12-26 2013-10-16 大日本塗料株式会社 質量分析用基板及びその製造方法並びに質量分析法
US8771948B2 (en) 2009-04-03 2014-07-08 Sequenom, Inc. Nucleic acid preparation compositions and methods
US20110028333A1 (en) 2009-05-01 2011-02-03 Brown University Diagnosing, prognosing, and early detection of cancers by dna methylation profiling
US10388403B2 (en) 2010-01-19 2019-08-20 Verinata Health, Inc. Analyzing copy number variation in the detection of cancer
SG185544A1 (en) 2010-05-14 2012-12-28 Fluidigm Corp Nucleic acid isolation methods
CN103080197B (zh) 2010-07-30 2015-10-07 索尼公司 具有玻璃样表面的聚合物衬底和由所述聚合物衬底制成的芯片
EP2416345A1 (en) 2010-08-06 2012-02-08 Philips Intellectual Property & Standards GmbH Particle-based matrix carriers for mass spectrometry
US8610058B2 (en) 2010-11-03 2013-12-17 University Of North Texas Silver and silver nanoparticle MALDI matrix utilizing online soft landing ion mobility
WO2012149339A2 (en) 2011-04-29 2012-11-01 Sequenom, Inc. Quantification of a minority nucleic acid species
GB2493179B (en) 2011-07-26 2018-09-05 Kratos Analytical Ltd MALDI sample preparation methods and targets
US9136099B2 (en) 2012-07-04 2015-09-15 Sony Dadc Austria Ag Method and substrates for forming crystals
US9305756B2 (en) 2013-03-13 2016-04-05 Agena Bioscience, Inc. Preparation enhancements and methods of use for MALDI mass spectrometry
US20160184820A1 (en) 2013-08-14 2016-06-30 Sony Dadc Austria Ag Microfluidic device

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Ayorinde FO, Bezabeh DZ, Delves IG. Rapid Commun Mass Spectrom. 2003;17(15):1735-42 *
O'Brien BA et al. Mass Spectrometric Screening for Polyphenolic Protein Adducts. Proceedings of the 50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, Florida, June 2-6, 2002. Pages 409-410 *
ZHU YF et al. The effect of ammonium salt and matrix in the detection of DNA by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Rapid Commun Mass Spectrom. 1996;10:1591-96 *

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