CA2711434C - Epoxy-guaiane derivatives and treatment of cancer - Google Patents

Epoxy-guaiane derivatives and treatment of cancer Download PDF

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Publication number
CA2711434C
CA2711434C CA2711434A CA2711434A CA2711434C CA 2711434 C CA2711434 C CA 2711434C CA 2711434 A CA2711434 A CA 2711434A CA 2711434 A CA2711434 A CA 2711434A CA 2711434 C CA2711434 C CA 2711434C
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CA
Canada
Prior art keywords
compound
epimer
cancer
englerin
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2711434A
Other languages
English (en)
French (fr)
Other versions
CA2711434A1 (en
Inventor
John A. Beutler
Ranjala Ratnayake
David Covell
Tanya R. Johnson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Health and Human Services
Original Assignee
US Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Department of Health and Human Services filed Critical US Department of Health and Human Services
Publication of CA2711434A1 publication Critical patent/CA2711434A1/en
Application granted granted Critical
Publication of CA2711434C publication Critical patent/CA2711434C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CA2711434A 2008-01-04 2008-12-30 Epoxy-guaiane derivatives and treatment of cancer Active CA2711434C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US1893808P 2008-01-04 2008-01-04
US61/018,938 2008-01-04
US8285008P 2008-07-23 2008-07-23
US61/082,850 2008-07-23
PCT/US2008/088529 WO2009088854A1 (en) 2008-01-04 2008-12-30 Epoxy-guaiane derivatives and treatment of cancer

Publications (2)

Publication Number Publication Date
CA2711434A1 CA2711434A1 (en) 2009-07-16
CA2711434C true CA2711434C (en) 2017-01-24

Family

ID=40380295

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2711434A Active CA2711434C (en) 2008-01-04 2008-12-30 Epoxy-guaiane derivatives and treatment of cancer

Country Status (8)

Country Link
US (1) US8410292B2 (enExample)
EP (1) EP2235021B1 (enExample)
JP (1) JP5547653B2 (enExample)
AU (1) AU2008347299C1 (enExample)
CA (1) CA2711434C (enExample)
DK (1) DK2235021T3 (enExample)
ES (1) ES2393877T3 (enExample)
WO (1) WO2009088854A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011120886A1 (en) 2010-03-29 2011-10-06 Institut Català D'investigació Química (Iciq) A process for the preparation of (-)-englerin a, and analogues and intermediates thereof
EP2474550A1 (en) * 2010-12-22 2012-07-11 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Derivatives of Englerin for the treatment of cancer
CA2860842A1 (en) * 2012-01-09 2013-07-18 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of treating or preventing insulin resistance and associated diseases and conditions
CN105025894B (zh) * 2012-11-15 2017-06-09 美国卫生和人力服务部 治疗被hiv和htlv感染的患者的方法
AU2015214189B2 (en) * 2014-02-05 2018-12-13 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Aza-epoxy-guaiane derivatives and treatment of cancer
EP3283489B1 (en) * 2015-04-13 2019-08-21 The U.S.A. As Represented By The Secretary, Department Of Health And Human Services Epoxyazulene derivatives useful for treating cancer
US11098054B2 (en) * 2017-07-06 2021-08-24 The United States of America, as represented by the Secretary, Department of Health and Human Sciences Englerin derivatives for treatment of cancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US5019369A (en) * 1984-10-22 1991-05-28 Vestar, Inc. Method of targeting tumors in humans
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
CN1704417A (zh) * 2004-05-26 2005-12-07 杭州民生药业集团有限公司 新化合物莪术醇衍生物

Also Published As

Publication number Publication date
JP5547653B2 (ja) 2014-07-16
US20100286259A1 (en) 2010-11-11
AU2008347299B2 (en) 2012-12-06
ES2393877T3 (es) 2012-12-28
EP2235021A1 (en) 2010-10-06
CA2711434A1 (en) 2009-07-16
US8410292B2 (en) 2013-04-02
WO2009088854A1 (en) 2009-07-16
AU2008347299A1 (en) 2009-07-16
AU2008347299C1 (en) 2013-08-15
JP2011508779A (ja) 2011-03-17
DK2235021T3 (da) 2012-10-08
EP2235021B1 (en) 2012-06-27

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