ES2393877T3 - Derivados de epoxi-guayano y tratamiento del cáncer - Google Patents

Derivados de epoxi-guayano y tratamiento del cáncer Download PDF

Info

Publication number
ES2393877T3
ES2393877T3 ES08869946T ES08869946T ES2393877T3 ES 2393877 T3 ES2393877 T3 ES 2393877T3 ES 08869946 T ES08869946 T ES 08869946T ES 08869946 T ES08869946 T ES 08869946T ES 2393877 T3 ES2393877 T3 ES 2393877T3
Authority
ES
Spain
Prior art keywords
compound
epimer
cancer
halo
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES08869946T
Other languages
English (en)
Spanish (es)
Inventor
John A. Beutler
Ranjala Ratnayake
David Covell
Tanya R. Johnson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
United States Department of Health and Human Services
Original Assignee
United States Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by United States Department of Health and Human Services filed Critical United States Department of Health and Human Services
Application granted granted Critical
Publication of ES2393877T3 publication Critical patent/ES2393877T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
ES08869946T 2008-01-04 2008-12-30 Derivados de epoxi-guayano y tratamiento del cáncer Active ES2393877T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US82850P 1998-04-23
US1893808P 2008-01-04 2008-01-04
US18938P 2008-01-04
US8285008P 2008-07-23 2008-07-23
PCT/US2008/088529 WO2009088854A1 (en) 2008-01-04 2008-12-30 Epoxy-guaiane derivatives and treatment of cancer

Publications (1)

Publication Number Publication Date
ES2393877T3 true ES2393877T3 (es) 2012-12-28

Family

ID=40380295

Family Applications (1)

Application Number Title Priority Date Filing Date
ES08869946T Active ES2393877T3 (es) 2008-01-04 2008-12-30 Derivados de epoxi-guayano y tratamiento del cáncer

Country Status (8)

Country Link
US (1) US8410292B2 (enExample)
EP (1) EP2235021B1 (enExample)
JP (1) JP5547653B2 (enExample)
AU (1) AU2008347299C1 (enExample)
CA (1) CA2711434C (enExample)
DK (1) DK2235021T3 (enExample)
ES (1) ES2393877T3 (enExample)
WO (1) WO2009088854A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011120886A1 (en) 2010-03-29 2011-10-06 Institut Català D'investigació Química (Iciq) A process for the preparation of (-)-englerin a, and analogues and intermediates thereof
EP2474550A1 (en) * 2010-12-22 2012-07-11 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Derivatives of Englerin for the treatment of cancer
AU2013208308B2 (en) * 2012-01-09 2017-03-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of treating or preventing insulin resistance and associated diseases and conditions
CA2891294A1 (en) * 2012-11-15 2014-05-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of treating patients infected with hiv and htlv
CA2938971C (en) * 2014-02-05 2022-03-15 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Aza-epoxy-guaiane derivatives and treatment of cancer
DK3283489T3 (da) * 2015-04-13 2019-11-18 Us Health Epoxyazulenderivater, som kan anvendes til behandling af cancer
EP3649133B1 (en) * 2017-07-06 2022-02-23 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Englerin derivatives for treatment of cancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US5019369A (en) 1984-10-22 1991-05-28 Vestar, Inc. Method of targeting tumors in humans
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
CN1704417A (zh) 2004-05-26 2005-12-07 杭州民生药业集团有限公司 新化合物莪术醇衍生物

Also Published As

Publication number Publication date
JP5547653B2 (ja) 2014-07-16
WO2009088854A1 (en) 2009-07-16
AU2008347299C1 (en) 2013-08-15
JP2011508779A (ja) 2011-03-17
CA2711434A1 (en) 2009-07-16
EP2235021B1 (en) 2012-06-27
AU2008347299B2 (en) 2012-12-06
EP2235021A1 (en) 2010-10-06
AU2008347299A1 (en) 2009-07-16
US8410292B2 (en) 2013-04-02
DK2235021T3 (da) 2012-10-08
US20100286259A1 (en) 2010-11-11
CA2711434C (en) 2017-01-24

Similar Documents

Publication Publication Date Title
Rinehart et al. Didemnins and tunichlorin: novel natural products from the marine tunicate Trididemnum solidum
ES2268068T3 (es) Derivado de geldanamicina util para el tratamiento del cancer.
ES2336937T3 (es) Sintesis de epotilonas, sus intermedios, analogos y usos.
AU725724B2 (en) Artemisinin dimer compounds having anticancer activity
AU2008347299C1 (en) Epoxy-guaiane derivatives and treatment of cancer
Cen et al. Development of tacrine-bifendate conjugates with improved cholinesterase inhibitory and pro-cognitive efficacy and reduced hepatotoxicity
ES2880029T3 (es) Derivados de anfotericina B
JP2002505682A (ja) パクリタクセルの可溶性プロドラッグ
WO1997031921A1 (en) Immunosuppressive compounds and methods
US6569893B2 (en) Amino acid derivatives of triptolide compounds as immune modulators and anticancer agents
JPH0665675B2 (ja) 新規なブリオスタチン４〜８
Lee et al. Investigation of amino acid conjugates of (S)-1-[1-(4-aminobenzoyl)-2, 3-dihydro-1H-indol-6-sulfonyl]-4-phenyl-imidazolidin-2-one (DW2282) as water soluble anticancer prodrugs
CN101289482A (zh) 藤黄酸苷衍生物和类似物及其制备方法和用途
US6586464B2 (en) Artemisinin analogs having antimalarial, antiproliferative, and antitumor activities and chemoselective methods of making the same
KR20100026030A (ko) 항암 유효성분 추출물, 그 추출방법 및 이를 이용한 항암제
ITMI941112A1 (it) Alcaloidi da mappia foetida, loro uso e formulazioni che li contengono
WO2008133387A1 (en) New acyclic triterpenoids compound, and pharmaceutical composition comprising alpinia katsumadai extract or acyclic triterpenoids compounds isolated from the same
CZ303386B6 (cs) N-deacetylthiokolchicinové deriváty
SK10562002A3 (sk) Polosyntetické taxány, farmaceutický prostriedok s ich obsahom a ich použitie
USRE38117E1 (en) Trioxane dimer compound having antiproliferative and antitumor activities
KR100615971B1 (ko) 개구린 5로부터 합성 및 제조된 항암 펩타이드 유도체
US6153756A (en) Soluble prodrugs of paclitaxel
AU730722B2 (en) Trioxane dimer compounds having antiproliferative and antitumor activities
Golec Androgen receptor N-terminal domain antagonists: synthesis, SAR, and animal studies
ES2914325T3 (es) Derivados de englerina para el tratamiento del cáncer