AU2008347299C1 - Epoxy-guaiane derivatives and treatment of cancer - Google Patents

Epoxy-guaiane derivatives and treatment of cancer Download PDF

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Publication number
AU2008347299C1
AU2008347299C1 AU2008347299A AU2008347299A AU2008347299C1 AU 2008347299 C1 AU2008347299 C1 AU 2008347299C1 AU 2008347299 A AU2008347299 A AU 2008347299A AU 2008347299 A AU2008347299 A AU 2008347299A AU 2008347299 C1 AU2008347299 C1 AU 2008347299C1
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AU
Australia
Prior art keywords
compound
epimer
cancer
englerin
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2008347299A
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English (en)
Other versions
AU2008347299B2 (en
AU2008347299A1 (en
Inventor
John A. Beutler
David Covell
Tanya R. Johnson
Ranjala Ratnayake
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Health and Human Services
Original Assignee
Government of the United States of America
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Government of the United States of America filed Critical Government of the United States of America
Publication of AU2008347299A1 publication Critical patent/AU2008347299A1/en
Publication of AU2008347299B2 publication Critical patent/AU2008347299B2/en
Application granted granted Critical
Publication of AU2008347299C1 publication Critical patent/AU2008347299C1/en
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AU2008347299A 2008-01-04 2008-12-30 Epoxy-guaiane derivatives and treatment of cancer Active AU2008347299C1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US1893808P 2008-01-04 2008-01-04
US61/018,938 2008-01-04
US8285008P 2008-07-23 2008-07-23
US61/082,850 2008-07-23
PCT/US2008/088529 WO2009088854A1 (en) 2008-01-04 2008-12-30 Epoxy-guaiane derivatives and treatment of cancer

Publications (3)

Publication Number Publication Date
AU2008347299A1 AU2008347299A1 (en) 2009-07-16
AU2008347299B2 AU2008347299B2 (en) 2012-12-06
AU2008347299C1 true AU2008347299C1 (en) 2013-08-15

Family

ID=40380295

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2008347299A Active AU2008347299C1 (en) 2008-01-04 2008-12-30 Epoxy-guaiane derivatives and treatment of cancer

Country Status (8)

Country Link
US (1) US8410292B2 (enExample)
EP (1) EP2235021B1 (enExample)
JP (1) JP5547653B2 (enExample)
AU (1) AU2008347299C1 (enExample)
CA (1) CA2711434C (enExample)
DK (1) DK2235021T3 (enExample)
ES (1) ES2393877T3 (enExample)
WO (1) WO2009088854A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011120886A1 (en) 2010-03-29 2011-10-06 Institut Català D'investigació Química (Iciq) A process for the preparation of (-)-englerin a, and analogues and intermediates thereof
EP2474550A1 (en) * 2010-12-22 2012-07-11 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Derivatives of Englerin for the treatment of cancer
AU2013208308B2 (en) 2012-01-09 2017-03-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of treating or preventing insulin resistance and associated diseases and conditions
EP2919776B1 (en) * 2012-11-15 2017-02-01 The U.S.A. as represented by the Secretary, Department of Health and Human Services Methods of treating patients infected with hiv and htlv
EP3102581B1 (en) * 2014-02-05 2018-05-02 The United States of America, as represented by The Secretary, Department of Health & Human Services Aza-epoxy-guaiane derivatives and treatment of cancer
US10287297B2 (en) 2015-04-13 2019-05-14 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Epoxyazulene derivatives useful for treating cancer and diabetes
JP7367936B2 (ja) * 2017-07-06 2023-10-24 アメリカ合衆国 癌の治療のためのエングレリン誘導体

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1749830A1 (en) * 2004-05-26 2007-02-07 Hangzhou Minsheng Pharmaceuticals Co., Ltd. Curcumol derivatives, the compositions comprising the same and the use of the same in the manufacture of medicament

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4501728A (en) * 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US5019369A (en) 1984-10-22 1991-05-28 Vestar, Inc. Method of targeting tumors in humans
US4837028A (en) * 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1749830A1 (en) * 2004-05-26 2007-02-07 Hangzhou Minsheng Pharmaceuticals Co., Ltd. Curcumol derivatives, the compositions comprising the same and the use of the same in the manufacture of medicament

Also Published As

Publication number Publication date
AU2008347299B2 (en) 2012-12-06
JP5547653B2 (ja) 2014-07-16
CA2711434C (en) 2017-01-24
US8410292B2 (en) 2013-04-02
JP2011508779A (ja) 2011-03-17
US20100286259A1 (en) 2010-11-11
ES2393877T3 (es) 2012-12-28
CA2711434A1 (en) 2009-07-16
EP2235021B1 (en) 2012-06-27
WO2009088854A1 (en) 2009-07-16
AU2008347299A1 (en) 2009-07-16
EP2235021A1 (en) 2010-10-06
DK2235021T3 (da) 2012-10-08

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DA2 Applications for amendment section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 19 FEB 2013 .

DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 19 FEB 2013

FGA Letters patent sealed or granted (standard patent)