CA2710828A1 - Discovery tool with integrated microfluidic biomarker optical detection array device and methods for use - Google Patents
Discovery tool with integrated microfluidic biomarker optical detection array device and methods for use Download PDFInfo
- Publication number
- CA2710828A1 CA2710828A1 CA2710828A CA2710828A CA2710828A1 CA 2710828 A1 CA2710828 A1 CA 2710828A1 CA 2710828 A CA2710828 A CA 2710828A CA 2710828 A CA2710828 A CA 2710828A CA 2710828 A1 CA2710828 A1 CA 2710828A1
- Authority
- CA
- Canada
- Prior art keywords
- kinase
- protein
- sample
- protease
- enzymatic substrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 230000003287 optical effect Effects 0.000 title claims abstract description 75
- 238000000034 method Methods 0.000 title claims description 71
- 238000001514 detection method Methods 0.000 title abstract description 74
- 239000000090 biomarker Substances 0.000 title abstract description 39
- 238000001069 Raman spectroscopy Methods 0.000 claims abstract description 35
- 238000004611 spectroscopical analysis Methods 0.000 claims abstract description 9
- 108091000080 Phosphotransferase Proteins 0.000 claims description 197
- 239000000758 substrate Substances 0.000 claims description 193
- 102000020233 phosphotransferase Human genes 0.000 claims description 181
- 108090000623 proteins and genes Proteins 0.000 claims description 119
- 239000000523 sample Substances 0.000 claims description 100
- 108090000790 Enzymes Proteins 0.000 claims description 72
- 102000004169 proteins and genes Human genes 0.000 claims description 72
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 71
- 238000004416 surface enhanced Raman spectroscopy Methods 0.000 claims description 69
- 230000002255 enzymatic effect Effects 0.000 claims description 68
- 230000000694 effects Effects 0.000 claims description 55
- 102000004190 Enzymes Human genes 0.000 claims description 52
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 41
- 238000004458 analytical method Methods 0.000 claims description 30
- 229910052751 metal Inorganic materials 0.000 claims description 30
- 239000002184 metal Substances 0.000 claims description 30
- 239000002086 nanomaterial Substances 0.000 claims description 26
- 229910052710 silicon Inorganic materials 0.000 claims description 26
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 24
- 239000012530 fluid Substances 0.000 claims description 24
- 238000006366 phosphorylation reaction Methods 0.000 claims description 24
- 239000010703 silicon Substances 0.000 claims description 24
- 230000026731 phosphorylation Effects 0.000 claims description 21
- 230000027455 binding Effects 0.000 claims description 20
- 238000009739 binding Methods 0.000 claims description 19
- 238000001228 spectrum Methods 0.000 claims description 19
- 230000003993 interaction Effects 0.000 claims description 18
- 230000005284 excitation Effects 0.000 claims description 17
- 239000007788 liquid Substances 0.000 claims description 16
- 102000039446 nucleic acids Human genes 0.000 claims description 15
- 108020004707 nucleic acids Proteins 0.000 claims description 15
- 150000007523 nucleic acids Chemical class 0.000 claims description 15
- 229920001184 polypeptide Polymers 0.000 claims description 15
- 229910021420 polycrystalline silicon Inorganic materials 0.000 claims description 9
- 230000008859 change Effects 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 8
- 230000004048 modification Effects 0.000 claims description 7
- 238000012986 modification Methods 0.000 claims description 7
- 238000006911 enzymatic reaction Methods 0.000 claims description 6
- 230000015572 biosynthetic process Effects 0.000 claims description 5
- 238000005530 etching Methods 0.000 claims description 4
- 150000004676 glycans Chemical class 0.000 claims description 4
- 239000002105 nanoparticle Substances 0.000 claims description 4
- 238000000059 patterning Methods 0.000 claims description 4
- 229920002120 photoresistant polymer Polymers 0.000 claims description 4
- 238000000137 annealing Methods 0.000 claims description 3
- 238000003486 chemical etching Methods 0.000 claims description 3
- 238000003776 cleavage reaction Methods 0.000 claims description 3
- 230000008878 coupling Effects 0.000 claims description 3
- 238000010168 coupling process Methods 0.000 claims description 3
- 238000005859 coupling reaction Methods 0.000 claims description 3
- 238000005553 drilling Methods 0.000 claims description 3
- 229920001282 polysaccharide Polymers 0.000 claims description 3
- 239000005017 polysaccharide Substances 0.000 claims description 3
- 230000007017 scission Effects 0.000 claims description 3
- 102000052510 DNA-Binding Proteins Human genes 0.000 claims description 2
- 239000013068 control sample Substances 0.000 claims description 2
- 238000000151 deposition Methods 0.000 claims 2
- 101710096438 DNA-binding protein Proteins 0.000 claims 1
- 238000007599 discharging Methods 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 25
- 206010028980 Neoplasm Diseases 0.000 abstract description 23
- 201000010099 disease Diseases 0.000 abstract description 18
- 201000011510 cancer Diseases 0.000 abstract description 17
- 238000003745 diagnosis Methods 0.000 abstract description 7
- 238000011160 research Methods 0.000 abstract description 6
- 208000024172 Cardiovascular disease Diseases 0.000 abstract description 5
- 230000004952 protein activity Effects 0.000 abstract description 4
- 206010012601 diabetes mellitus Diseases 0.000 abstract description 3
- 102000035195 Peptidases Human genes 0.000 description 104
- 108091005804 Peptidases Proteins 0.000 description 104
- 239000004365 Protease Substances 0.000 description 99
- 235000019419 proteases Nutrition 0.000 description 83
- 102100022789 Calcium/calmodulin-dependent protein kinase type IV Human genes 0.000 description 77
- 101100287682 Homo sapiens CAMK2G gene Proteins 0.000 description 72
- 101100126883 Homo sapiens CAMK4 gene Proteins 0.000 description 72
- 235000018102 proteins Nutrition 0.000 description 68
- 108090000708 Proteasome Endopeptidase Complex Proteins 0.000 description 54
- 102000004245 Proteasome Endopeptidase Complex Human genes 0.000 description 54
- 102000038625 CMGCs Human genes 0.000 description 51
- 108091007913 CMGCs Proteins 0.000 description 51
- 229940088598 enzyme Drugs 0.000 description 48
- 150000001413 amino acids Chemical class 0.000 description 44
- 229940024606 amino acid Drugs 0.000 description 41
- 235000001014 amino acid Nutrition 0.000 description 41
- 230000002559 cytogenic effect Effects 0.000 description 38
- 230000002068 genetic effect Effects 0.000 description 35
- 102000043136 MAP kinase family Human genes 0.000 description 33
- 108091054455 MAP kinase family Proteins 0.000 description 33
- 238000006243 chemical reaction Methods 0.000 description 32
- 238000005259 measurement Methods 0.000 description 32
- 102000001253 Protein Kinase Human genes 0.000 description 31
- 108060006633 protein kinase Proteins 0.000 description 31
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 description 29
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 description 29
- 108091007914 CDKs Proteins 0.000 description 28
- 102000005741 Metalloproteases Human genes 0.000 description 27
- 108010006035 Metalloproteases Proteins 0.000 description 27
- 101800001224 Disintegrin Proteins 0.000 description 23
- 102100031065 Choline kinase alpha Human genes 0.000 description 22
- 210000004027 cell Anatomy 0.000 description 22
- 102100038358 Prostate-specific antigen Human genes 0.000 description 21
- 239000000126 substance Substances 0.000 description 21
- 101000777314 Homo sapiens Choline kinase alpha Proteins 0.000 description 20
- 239000010410 layer Substances 0.000 description 20
- 101800000620 Disintegrin-like Proteins 0.000 description 19
- 108010072866 Prostate-Specific Antigen Proteins 0.000 description 19
- 230000001419 dependent effect Effects 0.000 description 19
- 239000000463 material Substances 0.000 description 19
- 230000001105 regulatory effect Effects 0.000 description 19
- 108091006146 Channels Proteins 0.000 description 18
- 108060008245 Thrombospondin Proteins 0.000 description 18
- 102000002938 Thrombospondin Human genes 0.000 description 18
- -1 extractants Substances 0.000 description 17
- 102000012479 Serine Proteases Human genes 0.000 description 16
- 108010022999 Serine Proteases Proteins 0.000 description 16
- 238000003556 assay Methods 0.000 description 14
- 210000001519 tissue Anatomy 0.000 description 14
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 13
- 150000001875 compounds Chemical class 0.000 description 13
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 13
- 235000018417 cysteine Nutrition 0.000 description 13
- 210000002381 plasma Anatomy 0.000 description 13
- 235000004400 serine Nutrition 0.000 description 13
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 12
- 241000255581 Drosophila <fruit fly, genus> Species 0.000 description 12
- 101000628647 Homo sapiens Serine/threonine-protein kinase 24 Proteins 0.000 description 12
- 101710163270 Nuclease Proteins 0.000 description 12
- 102100026764 Serine/threonine-protein kinase 24 Human genes 0.000 description 12
- 235000001465 calcium Nutrition 0.000 description 12
- 229960005069 calcium Drugs 0.000 description 12
- 229910052791 calcium Inorganic materials 0.000 description 12
- 239000011575 calcium Substances 0.000 description 12
- 210000000349 chromosome Anatomy 0.000 description 12
- 229920000642 polymer Polymers 0.000 description 12
- 108020004414 DNA Proteins 0.000 description 11
- 229910019142 PO4 Inorganic materials 0.000 description 11
- 230000006907 apoptotic process Effects 0.000 description 11
- 230000003197 catalytic effect Effects 0.000 description 11
- KAKKHKRHCKCAGH-UHFFFAOYSA-L disodium;(4-nitrophenyl) phosphate;hexahydrate Chemical compound O.O.O.O.O.O.[Na+].[Na+].[O-][N+](=O)C1=CC=C(OP([O-])([O-])=O)C=C1 KAKKHKRHCKCAGH-UHFFFAOYSA-L 0.000 description 11
- 239000006166 lysate Substances 0.000 description 11
- 125000003729 nucleotide group Chemical group 0.000 description 11
- 239000010452 phosphate Substances 0.000 description 11
- 102000008130 Cyclic AMP-Dependent Protein Kinases Human genes 0.000 description 10
- 102100028554 Dual specificity tyrosine-phosphorylation-regulated kinase 1A Human genes 0.000 description 10
- 101000838016 Homo sapiens Dual specificity tyrosine-phosphorylation-regulated kinase 1A Proteins 0.000 description 10
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 description 10
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 description 10
- 108010066496 Ubiquitin-Specific Proteases Proteins 0.000 description 10
- 102000018390 Ubiquitin-Specific Proteases Human genes 0.000 description 10
- 239000002773 nucleotide Substances 0.000 description 10
- 235000012431 wafers Nutrition 0.000 description 10
- 101000600890 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) G2-specific protein kinase nimA Proteins 0.000 description 9
- 102100035044 Myosin light chain kinase, smooth muscle Human genes 0.000 description 9
- 102000003923 Protein Kinase C Human genes 0.000 description 9
- 108090000315 Protein Kinase C Proteins 0.000 description 9
- 108091008109 Pseudogenes Proteins 0.000 description 9
- 102000057361 Pseudogenes Human genes 0.000 description 9
- 108010034782 Ribosomal Protein S6 Kinases Proteins 0.000 description 9
- 102000009738 Ribosomal Protein S6 Kinases Human genes 0.000 description 9
- 239000012472 biological sample Substances 0.000 description 9
- 238000001574 biopsy Methods 0.000 description 9
- 238000010586 diagram Methods 0.000 description 9
- 239000011159 matrix material Substances 0.000 description 9
- 230000008569 process Effects 0.000 description 9
- 238000012360 testing method Methods 0.000 description 9
- 102000000584 Calmodulin Human genes 0.000 description 8
- 108010041952 Calmodulin Proteins 0.000 description 8
- 101000585344 Homo sapiens Sulfotransferase 1E1 Proteins 0.000 description 8
- 108700020796 Oncogene Proteins 0.000 description 8
- 108700026244 Open Reading Frames Proteins 0.000 description 8
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 8
- 102100029862 Sulfotransferase 1E1 Human genes 0.000 description 8
- 102000040945 Transcription factor Human genes 0.000 description 8
- 108091023040 Transcription factor Proteins 0.000 description 8
- 239000004205 dimethyl polysiloxane Substances 0.000 description 8
- 239000003814 drug Substances 0.000 description 8
- 229910052737 gold Inorganic materials 0.000 description 8
- 239000010931 gold Substances 0.000 description 8
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 8
- 238000012545 processing Methods 0.000 description 8
- 239000004065 semiconductor Substances 0.000 description 8
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 7
- 102100022749 Aminopeptidase N Human genes 0.000 description 7
- 101001059454 Homo sapiens Serine/threonine-protein kinase MARK2 Proteins 0.000 description 7
- 101710172072 Kexin Proteins 0.000 description 7
- 241000124008 Mammalia Species 0.000 description 7
- 101710198035 Myosin light chain kinase, smooth muscle Proteins 0.000 description 7
- 108010052185 Myotonin-Protein Kinase Proteins 0.000 description 7
- 102100022437 Myotonin-protein kinase Human genes 0.000 description 7
- 102100028904 Serine/threonine-protein kinase MARK2 Human genes 0.000 description 7
- 108090000787 Subtilisin Proteins 0.000 description 7
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 7
- 208000035475 disorder Diseases 0.000 description 7
- 230000006870 function Effects 0.000 description 7
- 125000000524 functional group Chemical group 0.000 description 7
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 7
- 230000000873 masking effect Effects 0.000 description 7
- 239000000203 mixture Substances 0.000 description 7
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 7
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 7
- 235000000346 sugar Nutrition 0.000 description 7
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 6
- 102100034613 Annexin A2 Human genes 0.000 description 6
- 108090000668 Annexin A2 Proteins 0.000 description 6
- 239000004971 Cross linker Substances 0.000 description 6
- 102000004157 Hydrolases Human genes 0.000 description 6
- 108090000604 Hydrolases Proteins 0.000 description 6
- 102100034866 Kallikrein-6 Human genes 0.000 description 6
- 108091034117 Oligonucleotide Proteins 0.000 description 6
- 102000006437 Proprotein Convertases Human genes 0.000 description 6
- 108010044159 Proprotein Convertases Proteins 0.000 description 6
- 102100031206 Serine/threonine-protein kinase N1 Human genes 0.000 description 6
- 102100038192 Serine/threonine-protein kinase TBK1 Human genes 0.000 description 6
- 239000000427 antigen Substances 0.000 description 6
- 108091007433 antigens Proteins 0.000 description 6
- 102000036639 antigens Human genes 0.000 description 6
- 230000008901 benefit Effects 0.000 description 6
- 238000012512 characterization method Methods 0.000 description 6
- 238000011161 development Methods 0.000 description 6
- 230000018109 developmental process Effects 0.000 description 6
- 229940079593 drug Drugs 0.000 description 6
- 238000002493 microarray Methods 0.000 description 6
- 235000019833 protease Nutrition 0.000 description 6
- 102000005962 receptors Human genes 0.000 description 6
- 108020003175 receptors Proteins 0.000 description 6
- 230000035945 sensitivity Effects 0.000 description 6
- 210000002966 serum Anatomy 0.000 description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 6
- 150000003384 small molecules Chemical class 0.000 description 6
- 238000000479 surface-enhanced Raman spectrum Methods 0.000 description 6
- 230000003612 virological effect Effects 0.000 description 6
- 101100463130 Arabidopsis thaliana PDK gene Proteins 0.000 description 5
- 102100034356 Casein kinase I isoform alpha-like Human genes 0.000 description 5
- 206010009944 Colon cancer Diseases 0.000 description 5
- 108010031042 Death-Associated Protein Kinases Proteins 0.000 description 5
- 102000005721 Death-Associated Protein Kinases Human genes 0.000 description 5
- 102100038587 Death-associated protein kinase 1 Human genes 0.000 description 5
- 102100040862 Dual specificity protein kinase CLK1 Human genes 0.000 description 5
- 101000944251 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) Calcium/calmodulin-dependent protein kinase cmkA Proteins 0.000 description 5
- 101000956145 Homo sapiens Death-associated protein kinase 1 Proteins 0.000 description 5
- 101001091385 Homo sapiens Kallikrein-6 Proteins 0.000 description 5
- 101001059982 Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 5 Proteins 0.000 description 5
- 101000701401 Homo sapiens Serine/threonine-protein kinase 38 Proteins 0.000 description 5
- 101000665442 Homo sapiens Serine/threonine-protein kinase TBK1 Proteins 0.000 description 5
- 101000595531 Homo sapiens Serine/threonine-protein kinase pim-1 Proteins 0.000 description 5
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 5
- 239000004472 Lysine Substances 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 5
- 102100028195 Mitogen-activated protein kinase kinase kinase kinase 5 Human genes 0.000 description 5
- 102000003729 Neprilysin Human genes 0.000 description 5
- 108090000028 Neprilysin Proteins 0.000 description 5
- 101100230208 Oryza sativa subsp. japonica GSK2 gene Proteins 0.000 description 5
- 206010060862 Prostate cancer Diseases 0.000 description 5
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 5
- 102100030514 Serine/threonine-protein kinase 38 Human genes 0.000 description 5
- 102100023230 Serine/threonine-protein kinase MAK Human genes 0.000 description 5
- 102100036077 Serine/threonine-protein kinase pim-1 Human genes 0.000 description 5
- 102000006467 TATA-Box Binding Protein Human genes 0.000 description 5
- 108010044281 TATA-Box Binding Protein Proteins 0.000 description 5
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 5
- 150000001412 amines Chemical class 0.000 description 5
- 125000000539 amino acid group Chemical group 0.000 description 5
- 238000013459 approach Methods 0.000 description 5
- 229910052799 carbon Inorganic materials 0.000 description 5
- 238000000576 coating method Methods 0.000 description 5
- 238000006209 dephosphorylation reaction Methods 0.000 description 5
- 229940088597 hormone Drugs 0.000 description 5
- 239000002082 metal nanoparticle Substances 0.000 description 5
- 229920003023 plastic Polymers 0.000 description 5
- 238000003752 polymerase chain reaction Methods 0.000 description 5
- 238000005086 pumping Methods 0.000 description 5
- 238000011002 quantification Methods 0.000 description 5
- 238000012216 screening Methods 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 230000014621 translational initiation Effects 0.000 description 5
- 238000005406 washing Methods 0.000 description 5
- 229910052725 zinc Inorganic materials 0.000 description 5
- 239000011701 zinc Substances 0.000 description 5
- 101150034092 ATG4 gene Proteins 0.000 description 4
- 108091023037 Aptamer Proteins 0.000 description 4
- JBRZTFJDHDCESZ-UHFFFAOYSA-N AsGa Chemical compound [As]#[Ga] JBRZTFJDHDCESZ-UHFFFAOYSA-N 0.000 description 4
- 102100032948 Aspartoacylase Human genes 0.000 description 4
- 102100025232 Calcium/calmodulin-dependent protein kinase type II subunit beta Human genes 0.000 description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
- 102100024931 Caspase-14 Human genes 0.000 description 4
- 102100034744 Cell division cycle 7-related protein kinase Human genes 0.000 description 4
- 102000001133 Fertilins Human genes 0.000 description 4
- 108010069446 Fertilins Proteins 0.000 description 4
- 102000009331 Homeodomain Proteins Human genes 0.000 description 4
- 108010048671 Homeodomain Proteins Proteins 0.000 description 4
- 101001077352 Homo sapiens Calcium/calmodulin-dependent protein kinase type II subunit beta Proteins 0.000 description 4
- 101000945740 Homo sapiens Cell division cycle 7-related protein kinase Proteins 0.000 description 4
- 101000720704 Homo sapiens Neuronal migration protein doublecortin Proteins 0.000 description 4
- 101000945272 Homo sapiens Phosphorylase b kinase regulatory subunit alpha, liver isoform Proteins 0.000 description 4
- 101000945096 Homo sapiens Ribosomal protein S6 kinase alpha-5 Proteins 0.000 description 4
- 101001026870 Homo sapiens Serine/threonine-protein kinase D1 Proteins 0.000 description 4
- 101000625846 Homo sapiens TBC domain-containing protein kinase-like protein Proteins 0.000 description 4
- 101000926525 Homo sapiens eIF-2-alpha kinase GCN2 Proteins 0.000 description 4
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 4
- 102100026753 Lymphokine-activated killer T-cell-originated protein kinase Human genes 0.000 description 4
- 102000029749 Microtubule Human genes 0.000 description 4
- 108091022875 Microtubule Proteins 0.000 description 4
- 102100027869 Moesin Human genes 0.000 description 4
- 241001529936 Murinae Species 0.000 description 4
- 102100025929 Neuronal migration protein doublecortin Human genes 0.000 description 4
- 102100021858 Nuclear receptor-binding protein Human genes 0.000 description 4
- 101100217550 Oryza sativa subsp. indica ATG4B gene Proteins 0.000 description 4
- 108010064071 Phosphorylase Kinase Proteins 0.000 description 4
- 102000014750 Phosphorylase Kinase Human genes 0.000 description 4
- 102100033548 Phosphorylase b kinase regulatory subunit alpha, liver isoform Human genes 0.000 description 4
- 102100033810 RAC-alpha serine/threonine-protein kinase Human genes 0.000 description 4
- 238000001237 Raman spectrum Methods 0.000 description 4
- 102100033645 Ribosomal protein S6 kinase alpha-5 Human genes 0.000 description 4
- 102100031075 Serine/threonine-protein kinase Chk2 Human genes 0.000 description 4
- 102100037310 Serine/threonine-protein kinase D1 Human genes 0.000 description 4
- 102100026940 Small ubiquitin-related modifier 1 Human genes 0.000 description 4
- 102100024750 TBC domain-containing protein kinase-like protein Human genes 0.000 description 4
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 4
- 239000004473 Threonine Substances 0.000 description 4
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 4
- 238000002835 absorbance Methods 0.000 description 4
- 150000001299 aldehydes Chemical class 0.000 description 4
- 230000004075 alteration Effects 0.000 description 4
- 230000004900 autophagic degradation Effects 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 239000000872 buffer Substances 0.000 description 4
- 150000001720 carbohydrates Chemical class 0.000 description 4
- 235000014633 carbohydrates Nutrition 0.000 description 4
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- 239000011248 coating agent Substances 0.000 description 4
- 208000029742 colonic neoplasm Diseases 0.000 description 4
- 230000002950 deficient Effects 0.000 description 4
- 230000030609 dephosphorylation Effects 0.000 description 4
- 238000002405 diagnostic procedure Methods 0.000 description 4
- 239000003596 drug target Substances 0.000 description 4
- 102100034175 eIF-2-alpha kinase GCN2 Human genes 0.000 description 4
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 description 4
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 description 4
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- 239000005556 hormone Substances 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- 210000004688 microtubule Anatomy 0.000 description 4
- 210000003205 muscle Anatomy 0.000 description 4
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 description 4
- 150000002924 oxiranes Chemical class 0.000 description 4
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 4
- 238000001020 plasma etching Methods 0.000 description 4
- 239000004033 plastic Substances 0.000 description 4
- 239000013641 positive control Substances 0.000 description 4
- 239000002243 precursor Substances 0.000 description 4
- 210000002307 prostate Anatomy 0.000 description 4
- 230000017854 proteolysis Effects 0.000 description 4
- 230000002797 proteolythic effect Effects 0.000 description 4
- 230000003595 spectral effect Effects 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- 238000013518 transcription Methods 0.000 description 4
- 102100036009 5'-AMP-activated protein kinase catalytic subunit alpha-2 Human genes 0.000 description 3
- 102100026802 72 kDa type IV collagenase Human genes 0.000 description 3
- 108091006112 ATPases Proteins 0.000 description 3
- 102000057290 Adenosine Triphosphatases Human genes 0.000 description 3
- 108010054404 Adenylyl-sulfate kinase Proteins 0.000 description 3
- 102100032126 Aminopeptidase B Human genes 0.000 description 3
- 239000004475 Arginine Substances 0.000 description 3
- 102100035952 Atypical kinase COQ8B, mitochondrial Human genes 0.000 description 3
- 102100032311 Aurora kinase A Human genes 0.000 description 3
- 102100032306 Aurora kinase B Human genes 0.000 description 3
- 108090001008 Avidin Proteins 0.000 description 3
- 102100037281 Beta-adrenergic receptor kinase 2 Human genes 0.000 description 3
- 102100026008 Breakpoint cluster region protein Human genes 0.000 description 3
- 102100029894 Bromodomain testis-specific protein Human genes 0.000 description 3
- 102100033641 Bromodomain-containing protein 2 Human genes 0.000 description 3
- 102100033642 Bromodomain-containing protein 3 Human genes 0.000 description 3
- 102100029895 Bromodomain-containing protein 4 Human genes 0.000 description 3
- 108010049990 CD13 Antigens Proteins 0.000 description 3
- 102100032539 Calpain-3 Human genes 0.000 description 3
- 102100030006 Calpain-5 Human genes 0.000 description 3
- 102100035023 Carboxypeptidase B2 Human genes 0.000 description 3
- 102100026548 Caspase-8 Human genes 0.000 description 3
- 102100024940 Cathepsin K Human genes 0.000 description 3
- 101710178430 Cathepsin L-like Proteins 0.000 description 3
- 102100032404 Cholinesterase Human genes 0.000 description 3
- 102100025567 Citron Rho-interacting kinase Human genes 0.000 description 3
- 108010067499 Clk dual-specificity kinases Proteins 0.000 description 3
- 241001550206 Colla Species 0.000 description 3
- 102000016917 Complement C1 Human genes 0.000 description 3
- 108010028774 Complement C1 Proteins 0.000 description 3
- 108010049894 Cyclic AMP-Dependent Protein Kinases Proteins 0.000 description 3
- 102100038111 Cyclin-dependent kinase 12 Human genes 0.000 description 3
- 102100034741 Cyclin-dependent kinase 20 Human genes 0.000 description 3
- 102100026810 Cyclin-dependent kinase 7 Human genes 0.000 description 3
- 230000004568 DNA-binding Effects 0.000 description 3
- 108090000626 DNA-directed RNA polymerases Proteins 0.000 description 3
- 102000004163 DNA-directed RNA polymerases Human genes 0.000 description 3
- 101710088194 Dehydrogenase Proteins 0.000 description 3
- 102100029588 Deoxycytidine kinase Human genes 0.000 description 3
- 108010033174 Deoxycytidine kinase Proteins 0.000 description 3
- 102100025012 Dipeptidyl peptidase 4 Human genes 0.000 description 3
- 102100040844 Dual specificity protein kinase CLK2 Human genes 0.000 description 3
- 102100040856 Dual specificity protein kinase CLK3 Human genes 0.000 description 3
- 102100040858 Dual specificity protein kinase CLK4 Human genes 0.000 description 3
- 102100036109 Dual specificity protein kinase TTK Human genes 0.000 description 3
- 102100029493 EKC/KEOPS complex subunit TP53RK Human genes 0.000 description 3
- 102100029531 Fas-activated serine/threonine kinase Human genes 0.000 description 3
- 229910005542 GaSb Inorganic materials 0.000 description 3
- 229910001218 Gallium arsenide Inorganic materials 0.000 description 3
- 229920002527 Glycogen Polymers 0.000 description 3
- 108010001483 Glycogen Synthase Proteins 0.000 description 3
- 102100038104 Glycogen synthase kinase-3 beta Human genes 0.000 description 3
- 102000001398 Granzyme Human genes 0.000 description 3
- 108060005986 Granzyme Proteins 0.000 description 3
- 102100030385 Granzyme B Human genes 0.000 description 3
- 102100038393 Granzyme H Human genes 0.000 description 3
- 101150017137 Haspin gene Proteins 0.000 description 3
- 101000783681 Homo sapiens 5'-AMP-activated protein kinase catalytic subunit alpha-2 Proteins 0.000 description 3
- 101000779572 Homo sapiens Alpha-protein kinase 3 Proteins 0.000 description 3
- 101000875775 Homo sapiens Atypical kinase COQ8B, mitochondrial Proteins 0.000 description 3
- 101000798300 Homo sapiens Aurora kinase A Proteins 0.000 description 3
- 101000806653 Homo sapiens Beta-adrenergic receptor kinase 2 Proteins 0.000 description 3
- 101000794028 Homo sapiens Bromodomain testis-specific protein Proteins 0.000 description 3
- 101000871850 Homo sapiens Bromodomain-containing protein 2 Proteins 0.000 description 3
- 101000871851 Homo sapiens Bromodomain-containing protein 3 Proteins 0.000 description 3
- 101000761467 Homo sapiens Caspase-14 Proteins 0.000 description 3
- 101000761509 Homo sapiens Cathepsin K Proteins 0.000 description 3
- 101000659223 Homo sapiens Dual specificity protein kinase TTK Proteins 0.000 description 3
- 101001009603 Homo sapiens Granzyme B Proteins 0.000 description 3
- 101000762967 Homo sapiens Lymphokine-activated killer T-cell-originated protein kinase Proteins 0.000 description 3
- 101001014223 Homo sapiens MAPK/MAK/MRK overlapping kinase Proteins 0.000 description 3
- 101000573441 Homo sapiens Misshapen-like kinase 1 Proteins 0.000 description 3
- 101001005556 Homo sapiens Mitogen-activated protein kinase kinase kinase 19 Proteins 0.000 description 3
- 101000987094 Homo sapiens Moesin Proteins 0.000 description 3
- 101000584208 Homo sapiens Myosin light chain kinase 2, skeletal/cardiac muscle Proteins 0.000 description 3
- 101001108314 Homo sapiens Nuclear receptor-binding protein Proteins 0.000 description 3
- 101000919019 Homo sapiens Probable ATP-dependent RNA helicase DDX6 Proteins 0.000 description 3
- 101000983155 Homo sapiens Protein-associating with the carboxyl-terminal domain of ezrin Proteins 0.000 description 3
- 101001096580 Homo sapiens Rhomboid domain-containing protein 2 Proteins 0.000 description 3
- 101001051709 Homo sapiens Ribosomal protein S6 kinase-related protein Proteins 0.000 description 3
- 101000826079 Homo sapiens SRSF protein kinase 3 Proteins 0.000 description 3
- 101000697600 Homo sapiens Serine/threonine-protein kinase 32B Proteins 0.000 description 3
- 101000697610 Homo sapiens Serine/threonine-protein kinase 32C Proteins 0.000 description 3
- 101000777277 Homo sapiens Serine/threonine-protein kinase Chk2 Proteins 0.000 description 3
- 101001006988 Homo sapiens Serine/threonine-protein kinase H2 Proteins 0.000 description 3
- 101000913761 Homo sapiens Serine/threonine-protein kinase ICK Proteins 0.000 description 3
- 101000601460 Homo sapiens Serine/threonine-protein kinase Nek4 Proteins 0.000 description 3
- 101000577652 Homo sapiens Serine/threonine-protein kinase PRP4 homolog Proteins 0.000 description 3
- 101000754913 Homo sapiens Serine/threonine-protein kinase RIO2 Proteins 0.000 description 3
- 101000754911 Homo sapiens Serine/threonine-protein kinase RIO3 Proteins 0.000 description 3
- 101000693598 Homo sapiens Serine/threonine-protein kinase SBK1 Proteins 0.000 description 3
- 101000651178 Homo sapiens Striated muscle preferentially expressed protein kinase Proteins 0.000 description 3
- 101000577737 Homo sapiens U4/U6 small nuclear ribonucleoprotein Prp4 Proteins 0.000 description 3
- 101000807540 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 25 Proteins 0.000 description 3
- 101000841466 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 8 Proteins 0.000 description 3
- 101000720059 Homo sapiens Uncharacterized aarF domain-containing protein kinase 2 Proteins 0.000 description 3
- 101001046426 Homo sapiens cGMP-dependent protein kinase 1 Proteins 0.000 description 3
- 229910000673 Indium arsenide Inorganic materials 0.000 description 3
- 108010044467 Isoenzymes Proteins 0.000 description 3
- 102100034872 Kallikrein-4 Human genes 0.000 description 3
- 102100034870 Kallikrein-8 Human genes 0.000 description 3
- 102000003960 Ligases Human genes 0.000 description 3
- 108090000364 Ligases Proteins 0.000 description 3
- 102100024130 Matrix metalloproteinase-23 Human genes 0.000 description 3
- 102100026287 Misshapen-like kinase 1 Human genes 0.000 description 3
- 102100024189 Mitogen-activated protein kinase 4 Human genes 0.000 description 3
- 102100037809 Mitogen-activated protein kinase 9 Human genes 0.000 description 3
- 102100025217 Mitogen-activated protein kinase kinase kinase 19 Human genes 0.000 description 3
- 102100030788 Myosin light chain kinase 2, skeletal/cardiac muscle Human genes 0.000 description 3
- 102100023072 Neurolysin, mitochondrial Human genes 0.000 description 3
- 102100035484 Neurotrypsin Human genes 0.000 description 3
- 102100028790 Nuclear receptor-binding protein 2 Human genes 0.000 description 3
- 108091005461 Nucleic proteins Proteins 0.000 description 3
- 108010053291 Oncogene Protein v-akt Proteins 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 102000009516 Protein Serine-Threonine Kinases Human genes 0.000 description 3
- 108010009341 Protein Serine-Threonine Kinases Proteins 0.000 description 3
- 102100026829 Protein-associating with the carboxyl-terminal domain of ezrin Human genes 0.000 description 3
- 102000053067 Pyruvate Dehydrogenase Acetyl-Transferring Kinase Human genes 0.000 description 3
- 102100037470 Rhomboid domain-containing protein 2 Human genes 0.000 description 3
- 102100024914 Ribosomal protein S6 kinase-related protein Human genes 0.000 description 3
- 102100023015 SRSF protein kinase 2 Human genes 0.000 description 3
- 102100023017 SRSF protein kinase 3 Human genes 0.000 description 3
- 101000615178 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) Serine/threonine-protein kinase SKY1 Proteins 0.000 description 3
- 102100028030 Serine/threonine-protein kinase 32B Human genes 0.000 description 3
- 102100027903 Serine/threonine-protein kinase 32C Human genes 0.000 description 3
- 102100037312 Serine/threonine-protein kinase D2 Human genes 0.000 description 3
- 102100028475 Serine/threonine-protein kinase H2 Human genes 0.000 description 3
- 102100026621 Serine/threonine-protein kinase ICK Human genes 0.000 description 3
- 102100034447 Serine/threonine-protein kinase NLK Human genes 0.000 description 3
- 102100037705 Serine/threonine-protein kinase Nek4 Human genes 0.000 description 3
- 102100022090 Serine/threonine-protein kinase RIO2 Human genes 0.000 description 3
- 102100022109 Serine/threonine-protein kinase RIO3 Human genes 0.000 description 3
- 102100025554 Serine/threonine-protein kinase SBK1 Human genes 0.000 description 3
- 208000005718 Stomach Neoplasms Diseases 0.000 description 3
- 102100027659 Striated muscle preferentially expressed protein kinase Human genes 0.000 description 3
- 102100023276 Tau-tubulin kinase 2 Human genes 0.000 description 3
- 102100030141 Testis-specific serine/threonine-protein kinase 6 Human genes 0.000 description 3
- 102100026260 Titin Human genes 0.000 description 3
- 108090000340 Transaminases Proteins 0.000 description 3
- 102100028852 U4/U6 small nuclear ribonucleoprotein Prp4 Human genes 0.000 description 3
- 102000044159 Ubiquitin Human genes 0.000 description 3
- 108090000848 Ubiquitin Proteins 0.000 description 3
- 102100037179 Ubiquitin carboxyl-terminal hydrolase 25 Human genes 0.000 description 3
- 102100029088 Ubiquitin carboxyl-terminal hydrolase 8 Human genes 0.000 description 3
- 102100025993 Uncharacterized aarF domain-containing protein kinase 2 Human genes 0.000 description 3
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 description 3
- 241000700605 Viruses Species 0.000 description 3
- 108010038900 X-Pro aminopeptidase Proteins 0.000 description 3
- 101710159466 [Pyruvate dehydrogenase (acetyl-transferring)] kinase, mitochondrial Proteins 0.000 description 3
- 230000002378 acidificating effect Effects 0.000 description 3
- 125000003277 amino group Chemical group 0.000 description 3
- 239000012491 analyte Substances 0.000 description 3
- 238000003491 array Methods 0.000 description 3
- 239000002585 base Substances 0.000 description 3
- 229960002685 biotin Drugs 0.000 description 3
- 235000020958 biotin Nutrition 0.000 description 3
- 239000011616 biotin Substances 0.000 description 3
- 102100022422 cGMP-dependent protein kinase 1 Human genes 0.000 description 3
- 150000007942 carboxylates Chemical class 0.000 description 3
- 210000000845 cartilage Anatomy 0.000 description 3
- 238000006555 catalytic reaction Methods 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 210000001072 colon Anatomy 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 210000003298 dental enamel Anatomy 0.000 description 3
- 230000008034 disappearance Effects 0.000 description 3
- 230000005672 electromagnetic field Effects 0.000 description 3
- 239000003623 enhancer Substances 0.000 description 3
- 150000002148 esters Chemical class 0.000 description 3
- 239000000284 extract Substances 0.000 description 3
- 230000014509 gene expression Effects 0.000 description 3
- 229910052732 germanium Inorganic materials 0.000 description 3
- 239000003862 glucocorticoid Substances 0.000 description 3
- 229940096919 glycogen Drugs 0.000 description 3
- 229910052736 halogen Inorganic materials 0.000 description 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 3
- WPYVAWXEWQSOGY-UHFFFAOYSA-N indium antimonide Chemical compound [Sb]#[In] WPYVAWXEWQSOGY-UHFFFAOYSA-N 0.000 description 3
- RPQDHPTXJYYUPQ-UHFFFAOYSA-N indium arsenide Chemical compound [In]#[As] RPQDHPTXJYYUPQ-UHFFFAOYSA-N 0.000 description 3
- 230000010354 integration Effects 0.000 description 3
- 230000002452 interceptive effect Effects 0.000 description 3
- 108010024383 kallikrein 4 Proteins 0.000 description 3
- 229940043355 kinase inhibitor Drugs 0.000 description 3
- 238000002372 labelling Methods 0.000 description 3
- 210000004185 liver Anatomy 0.000 description 3
- 238000011068 loading method Methods 0.000 description 3
- 108020004999 messenger RNA Proteins 0.000 description 3
- 239000002207 metabolite Substances 0.000 description 3
- 229910021645 metal ion Inorganic materials 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 239000003068 molecular probe Substances 0.000 description 3
- 230000036961 partial effect Effects 0.000 description 3
- 230000007170 pathology Effects 0.000 description 3
- 230000037361 pathway Effects 0.000 description 3
- 239000000137 peptide hydrolase inhibitor Substances 0.000 description 3
- 230000035479 physiological effects, processes and functions Effects 0.000 description 3
- 238000007639 printing Methods 0.000 description 3
- 108010061151 protein kinase N Proteins 0.000 description 3
- 238000000746 purification Methods 0.000 description 3
- 210000003296 saliva Anatomy 0.000 description 3
- 235000012239 silicon dioxide Nutrition 0.000 description 3
- 229910052709 silver Inorganic materials 0.000 description 3
- 239000008279 sol Substances 0.000 description 3
- 230000009870 specific binding Effects 0.000 description 3
- 150000008163 sugars Chemical class 0.000 description 3
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 description 3
- 208000008732 thymoma Diseases 0.000 description 3
- 230000035897 transcription Effects 0.000 description 3
- 210000002700 urine Anatomy 0.000 description 3
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 2
- 102100035906 (Lyso)-N-acylphosphatidylethanolamine lipase Human genes 0.000 description 2
- 102100035905 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 Human genes 0.000 description 2
- 102100036657 26S proteasome non-ATPase regulatory subunit 7 Human genes 0.000 description 2
- 108091007507 ADAM12 Proteins 0.000 description 2
- 108091005662 ADAMTS2 Proteins 0.000 description 2
- 102000000872 ATM Human genes 0.000 description 2
- 102100033639 Acetylcholinesterase Human genes 0.000 description 2
- 102100026041 Acrosin Human genes 0.000 description 2
- 102100032534 Adenosine kinase Human genes 0.000 description 2
- 102100040149 Adenylyl-sulfate kinase Human genes 0.000 description 2
- 102100026423 Adhesion G protein-coupled receptor E5 Human genes 0.000 description 2
- 102100035991 Alpha-2-antiplasmin Human genes 0.000 description 2
- 102100020968 Alpha/beta hydrolase domain-containing protein 17B Human genes 0.000 description 2
- 102100031890 Aminopeptidase NAALADL1 Human genes 0.000 description 2
- 102100030988 Angiotensin-converting enzyme Human genes 0.000 description 2
- 102100040214 Apolipoprotein(a) Human genes 0.000 description 2
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
- 102000004580 Aspartic Acid Proteases Human genes 0.000 description 2
- 108010017640 Aspartic Acid Proteases Proteins 0.000 description 2
- 108700023155 Aspartoacylases Proteins 0.000 description 2
- 108010004586 Ataxia Telangiectasia Mutated Proteins Proteins 0.000 description 2
- 102100039341 Atrial natriuretic peptide receptor 2 Human genes 0.000 description 2
- 102100037293 Atrial natriuretic peptide-converting enzyme Human genes 0.000 description 2
- 102100035958 Atypical kinase COQ8A, mitochondrial Human genes 0.000 description 2
- 102100026630 Aurora kinase C Human genes 0.000 description 2
- 102100024507 BMP-2-inducible protein kinase Human genes 0.000 description 2
- 108091005625 BRD4 Proteins 0.000 description 2
- 229910015808 BaTe Inorganic materials 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 102100027517 Baculoviral IAP repeat-containing protein 8 Human genes 0.000 description 2
- 102100021257 Beta-secretase 1 Human genes 0.000 description 2
- 102100021277 Beta-secretase 2 Human genes 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 2
- 102000004219 Brain-derived neurotrophic factor Human genes 0.000 description 2
- 108090000715 Brain-derived neurotrophic factor Proteins 0.000 description 2
- 108091007381 CBL proteins Proteins 0.000 description 2
- 108010040340 CDC2-CDC28 Kinases Proteins 0.000 description 2
- 102000001840 CDC2-CDC28 Kinases Human genes 0.000 description 2
- 101150012716 CDK1 gene Proteins 0.000 description 2
- 102100028879 COP9 signalosome complex subunit 8 Human genes 0.000 description 2
- 102100025589 CaM kinase-like vesicle-associated protein Human genes 0.000 description 2
- 229910004813 CaTe Inorganic materials 0.000 description 2
- 102100035680 Cadherin EGF LAG seven-pass G-type receptor 2 Human genes 0.000 description 2
- 101100478890 Caenorhabditis elegans smo-1 gene Proteins 0.000 description 2
- 108010003613 Calcium-Calmodulin-Dependent Protein Kinase Type 4 Proteins 0.000 description 2
- 102000004646 Calcium-Calmodulin-Dependent Protein Kinase Type 4 Human genes 0.000 description 2
- 102100021534 Calcium/calmodulin-dependent protein kinase kinase 2 Human genes 0.000 description 2
- 102100025871 Calpain-14 Human genes 0.000 description 2
- 102100025168 Calpain-15 Human genes 0.000 description 2
- 102100032537 Calpain-2 catalytic subunit Human genes 0.000 description 2
- 102100030005 Calpain-6 Human genes 0.000 description 2
- 102100030003 Calpain-9 Human genes 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 108010051152 Carboxylesterase Proteins 0.000 description 2
- 102000013392 Carboxylesterase Human genes 0.000 description 2
- 102100036808 Carboxylesterase 3 Human genes 0.000 description 2
- 102100030621 Carboxypeptidase A4 Human genes 0.000 description 2
- 108090000201 Carboxypeptidase B2 Proteins 0.000 description 2
- 102100026679 Carboxypeptidase Q Human genes 0.000 description 2
- 102000014914 Carrier Proteins Human genes 0.000 description 2
- 102000008122 Casein Kinase I Human genes 0.000 description 2
- 108010049812 Casein Kinase I Proteins 0.000 description 2
- 102000052052 Casein Kinase II Human genes 0.000 description 2
- 108010010919 Casein Kinase II Proteins 0.000 description 2
- 102100037402 Casein kinase I isoform delta Human genes 0.000 description 2
- 108090000397 Caspase 3 Proteins 0.000 description 2
- 102100029855 Caspase-3 Human genes 0.000 description 2
- 102100025597 Caspase-4 Human genes 0.000 description 2
- 102100038916 Caspase-5 Human genes 0.000 description 2
- 102100038918 Caspase-6 Human genes 0.000 description 2
- 102100026550 Caspase-9 Human genes 0.000 description 2
- 102100021633 Cathepsin B Human genes 0.000 description 2
- 102100032219 Cathepsin D Human genes 0.000 description 2
- 102100026540 Cathepsin L2 Human genes 0.000 description 2
- 102100035654 Cathepsin S Human genes 0.000 description 2
- 102100026658 Cathepsin W Human genes 0.000 description 2
- 229910004613 CdTe Inorganic materials 0.000 description 2
- 102000011068 Cdc42 Human genes 0.000 description 2
- 102100039511 Chymotrypsin-C Human genes 0.000 description 2
- 102100023335 Chymotrypsin-like elastase family member 2A Human genes 0.000 description 2
- 102100023337 Chymotrypsin-like elastase family member 3A Human genes 0.000 description 2
- 102100023336 Chymotrypsin-like elastase family member 3B Human genes 0.000 description 2
- 101710087170 Citron rho-interacting kinase Proteins 0.000 description 2
- 102100022641 Coagulation factor IX Human genes 0.000 description 2
- 102000029816 Collagenase Human genes 0.000 description 2
- 108060005980 Collagenase Proteins 0.000 description 2
- 208000035473 Communicable disease Diseases 0.000 description 2
- 102000003706 Complement factor D Human genes 0.000 description 2
- 108090000059 Complement factor D Proteins 0.000 description 2
- 102100031673 Corneodesmosin Human genes 0.000 description 2
- 101710139375 Corneodesmosin Proteins 0.000 description 2
- 108010003591 Cyclic GMP-Dependent Protein Kinases Proteins 0.000 description 2
- 102000004654 Cyclic GMP-Dependent Protein Kinases Human genes 0.000 description 2
- 229920000089 Cyclic olefin copolymer Polymers 0.000 description 2
- 239000004713 Cyclic olefin copolymer Substances 0.000 description 2
- 108010024986 Cyclin-Dependent Kinase 2 Proteins 0.000 description 2
- 102000015792 Cyclin-Dependent Kinase 2 Human genes 0.000 description 2
- 108010025464 Cyclin-Dependent Kinase 4 Proteins 0.000 description 2
- 108010025454 Cyclin-Dependent Kinase 5 Proteins 0.000 description 2
- 108010025468 Cyclin-Dependent Kinase 6 Proteins 0.000 description 2
- 102100037912 Cyclin-dependent kinase 11A Human genes 0.000 description 2
- 102100033234 Cyclin-dependent kinase 17 Human genes 0.000 description 2
- 102100033144 Cyclin-dependent kinase 18 Human genes 0.000 description 2
- 102100036329 Cyclin-dependent kinase 3 Human genes 0.000 description 2
- 102100036252 Cyclin-dependent kinase 4 Human genes 0.000 description 2
- 102100026804 Cyclin-dependent kinase 6 Human genes 0.000 description 2
- 102100024456 Cyclin-dependent kinase 8 Human genes 0.000 description 2
- 102100024457 Cyclin-dependent kinase 9 Human genes 0.000 description 2
- 102100031685 Cyclin-dependent kinase-like 2 Human genes 0.000 description 2
- 102100031684 Cyclin-dependent kinase-like 3 Human genes 0.000 description 2
- 102100031683 Cyclin-dependent kinase-like 4 Human genes 0.000 description 2
- 102100034746 Cyclin-dependent kinase-like 5 Human genes 0.000 description 2
- 102100026805 Cyclin-dependent-like kinase 5 Human genes 0.000 description 2
- 102100026897 Cystatin-C Human genes 0.000 description 2
- 102000005927 Cysteine Proteases Human genes 0.000 description 2
- 108010005843 Cysteine Proteases Proteins 0.000 description 2
- 102100025721 Cytosolic carboxypeptidase 2 Human genes 0.000 description 2
- 102100032406 Cytosolic carboxypeptidase 6 Human genes 0.000 description 2
- 102100024829 DNA polymerase delta catalytic subunit Human genes 0.000 description 2
- 102100038606 Death-associated protein kinase 3 Human genes 0.000 description 2
- 102100037458 Dephospho-CoA kinase Human genes 0.000 description 2
- 102100034581 Dihydroorotase Human genes 0.000 description 2
- 108091000126 Dihydroorotase Proteins 0.000 description 2
- 102100031116 Disintegrin and metalloproteinase domain-containing protein 19 Human genes 0.000 description 2
- 101710121160 Disintegrin and metalloproteinase domain-containing protein 19 Proteins 0.000 description 2
- 101000938675 Dothistroma septosporum (strain NZE10 / CBS 128990) Versiconal hemiacetal acetate esterase Proteins 0.000 description 2
- 101100226059 Drosophila melanogaster Erk7 gene Proteins 0.000 description 2
- 101000945286 Drosophila melanogaster Serine/threonine-protein kinase PITSLRE Proteins 0.000 description 2
- 102100035813 E3 ubiquitin-protein ligase CBL Human genes 0.000 description 2
- 102000015782 Electron Transport Complex III Human genes 0.000 description 2
- 108010024882 Electron Transport Complex III Proteins 0.000 description 2
- 102100030377 Endoplasmic reticulum metallopeptidase 1 Human genes 0.000 description 2
- 102100030011 Endoribonuclease Human genes 0.000 description 2
- 108030001679 Endothelin-converting enzyme 1 Proteins 0.000 description 2
- 102100029113 Endothelin-converting enzyme 2 Human genes 0.000 description 2
- 102100040513 Endothelin-converting enzyme-like 1 Human genes 0.000 description 2
- 102100029727 Enteropeptidase Human genes 0.000 description 2
- 102100039353 Epoxide hydrolase 3 Human genes 0.000 description 2
- 102100039354 Epoxide hydrolase 4 Human genes 0.000 description 2
- 239000004593 Epoxy Substances 0.000 description 2
- 108090000156 Fructokinases Proteins 0.000 description 2
- 102000004961 Furin Human genes 0.000 description 2
- 102000038624 GSKs Human genes 0.000 description 2
- 108091007911 GSKs Proteins 0.000 description 2
- 229910002601 GaN Inorganic materials 0.000 description 2
- 229910005540 GaP Inorganic materials 0.000 description 2
- 102100021023 Gamma-glutamyl hydrolase Human genes 0.000 description 2
- 102100030875 Gastricsin Human genes 0.000 description 2
- 102400000921 Gastrin Human genes 0.000 description 2
- 108010052343 Gastrins Proteins 0.000 description 2
- 108010026132 Gelatinases Proteins 0.000 description 2
- 102000013382 Gelatinases Human genes 0.000 description 2
- 102000030595 Glucokinase Human genes 0.000 description 2
- 108010021582 Glucokinase Proteins 0.000 description 2
- 108010021382 Gluconokinase Proteins 0.000 description 2
- 108010051975 Glycogen Synthase Kinase 3 beta Proteins 0.000 description 2
- 102100022975 Glycogen synthase kinase-3 alpha Human genes 0.000 description 2
- 102100030386 Granzyme A Human genes 0.000 description 2
- 102100038395 Granzyme K Human genes 0.000 description 2
- 102100022087 Granzyme M Human genes 0.000 description 2
- 102000003693 Hedgehog Proteins Human genes 0.000 description 2
- 108090000031 Hedgehog Proteins Proteins 0.000 description 2
- 108090000100 Hepatocyte Growth Factor Proteins 0.000 description 2
- 102100021866 Hepatocyte growth factor Human genes 0.000 description 2
- 229910004262 HgTe Inorganic materials 0.000 description 2
- 108010033040 Histones Proteins 0.000 description 2
- 102100032827 Homeodomain-interacting protein kinase 2 Human genes 0.000 description 2
- 102100032826 Homeodomain-interacting protein kinase 3 Human genes 0.000 description 2
- 102100022603 Homeodomain-interacting protein kinase 4 Human genes 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 101000929842 Homo sapiens (Lyso)-N-acylphosphatidylethanolamine lipase Proteins 0.000 description 2
- 101000929840 Homo sapiens 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 Proteins 0.000 description 2
- 101001136696 Homo sapiens 26S proteasome non-ATPase regulatory subunit 7 Proteins 0.000 description 2
- 101000718243 Homo sapiens Adhesion G protein-coupled receptor E5 Proteins 0.000 description 2
- 101000783847 Homo sapiens Alpha/beta hydrolase domain-containing protein 17B Proteins 0.000 description 2
- 101000757160 Homo sapiens Aminopeptidase N Proteins 0.000 description 2
- 101000760943 Homo sapiens Arylacetamide deacetylase Proteins 0.000 description 2
- 101000797251 Homo sapiens Aspartoacylase Proteins 0.000 description 2
- 101000875771 Homo sapiens Atypical kinase COQ8A, mitochondrial Proteins 0.000 description 2
- 101000798306 Homo sapiens Aurora kinase B Proteins 0.000 description 2
- 101000936076 Homo sapiens Baculoviral IAP repeat-containing protein 8 Proteins 0.000 description 2
- 101000894895 Homo sapiens Beta-secretase 1 Proteins 0.000 description 2
- 101000978381 Homo sapiens C-C motif chemokine 14 Proteins 0.000 description 2
- 101000978376 Homo sapiens C-C motif chemokine 15 Proteins 0.000 description 2
- 101000916502 Homo sapiens COP9 signalosome complex subunit 8 Proteins 0.000 description 2
- 101000932896 Homo sapiens CaM kinase-like vesicle-associated protein Proteins 0.000 description 2
- 101000715674 Homo sapiens Cadherin EGF LAG seven-pass G-type receptor 2 Proteins 0.000 description 2
- 101000867692 Homo sapiens Calpain-2 catalytic subunit Proteins 0.000 description 2
- 101000867715 Homo sapiens Calpain-3 Proteins 0.000 description 2
- 101000793666 Homo sapiens Calpain-5 Proteins 0.000 description 2
- 101000793680 Homo sapiens Calpain-9 Proteins 0.000 description 2
- 101000851624 Homo sapiens Carboxylesterase 3 Proteins 0.000 description 2
- 101000983528 Homo sapiens Caspase-8 Proteins 0.000 description 2
- 101000907955 Homo sapiens Chymotrypsin-like elastase family member 2A Proteins 0.000 description 2
- 101000907964 Homo sapiens Chymotrypsin-like elastase family member 3A Proteins 0.000 description 2
- 101000907951 Homo sapiens Chymotrypsin-like elastase family member 3B Proteins 0.000 description 2
- 101000868333 Homo sapiens Cyclin-dependent kinase 1 Proteins 0.000 description 2
- 101000738403 Homo sapiens Cyclin-dependent kinase 11A Proteins 0.000 description 2
- 101000884345 Homo sapiens Cyclin-dependent kinase 12 Proteins 0.000 description 2
- 101000944358 Homo sapiens Cyclin-dependent kinase 17 Proteins 0.000 description 2
- 101000944341 Homo sapiens Cyclin-dependent kinase 18 Proteins 0.000 description 2
- 101000945708 Homo sapiens Cyclin-dependent kinase 20 Proteins 0.000 description 2
- 101000715946 Homo sapiens Cyclin-dependent kinase 3 Proteins 0.000 description 2
- 101000911952 Homo sapiens Cyclin-dependent kinase 7 Proteins 0.000 description 2
- 101000980937 Homo sapiens Cyclin-dependent kinase 8 Proteins 0.000 description 2
- 101000777764 Homo sapiens Cyclin-dependent kinase-like 2 Proteins 0.000 description 2
- 101000777768 Homo sapiens Cyclin-dependent kinase-like 3 Proteins 0.000 description 2
- 101000777775 Homo sapiens Cyclin-dependent kinase-like 4 Proteins 0.000 description 2
- 101000945692 Homo sapiens Cyclin-dependent kinase-like 5 Proteins 0.000 description 2
- 101000932634 Homo sapiens Cytosolic carboxypeptidase 2 Proteins 0.000 description 2
- 101000868785 Homo sapiens Cytosolic carboxypeptidase 6 Proteins 0.000 description 2
- 101000909198 Homo sapiens DNA polymerase delta catalytic subunit Proteins 0.000 description 2
- 101000956149 Homo sapiens Death-associated protein kinase 3 Proteins 0.000 description 2
- 101000908391 Homo sapiens Dipeptidyl peptidase 4 Proteins 0.000 description 2
- 101000756756 Homo sapiens Disintegrin and metalloproteinase domain-containing protein 28 Proteins 0.000 description 2
- 101000749291 Homo sapiens Dual specificity protein kinase CLK2 Proteins 0.000 description 2
- 101000749304 Homo sapiens Dual specificity protein kinase CLK3 Proteins 0.000 description 2
- 101000749298 Homo sapiens Dual specificity protein kinase CLK4 Proteins 0.000 description 2
- 101001063315 Homo sapiens Endoplasmic reticulum metallopeptidase 1 Proteins 0.000 description 2
- 101001012451 Homo sapiens Enteropeptidase Proteins 0.000 description 2
- 101000812391 Homo sapiens Epoxide hydrolase 3 Proteins 0.000 description 2
- 101000812405 Homo sapiens Epoxide hydrolase 4 Proteins 0.000 description 2
- 101000917570 Homo sapiens Fas-activated serine/threonine kinase Proteins 0.000 description 2
- 101000829481 Homo sapiens G protein-coupled receptor kinase 4 Proteins 0.000 description 2
- 101000829476 Homo sapiens G protein-coupled receptor kinase 5 Proteins 0.000 description 2
- 101000829473 Homo sapiens G protein-coupled receptor kinase 6 Proteins 0.000 description 2
- 101000903717 Homo sapiens Glycogen synthase kinase-3 alpha Proteins 0.000 description 2
- 101001009599 Homo sapiens Granzyme A Proteins 0.000 description 2
- 101001033000 Homo sapiens Granzyme H Proteins 0.000 description 2
- 101001033007 Homo sapiens Granzyme K Proteins 0.000 description 2
- 101000900697 Homo sapiens Granzyme M Proteins 0.000 description 2
- 101001066401 Homo sapiens Homeodomain-interacting protein kinase 2 Proteins 0.000 description 2
- 101001066389 Homo sapiens Homeodomain-interacting protein kinase 3 Proteins 0.000 description 2
- 101001045363 Homo sapiens Homeodomain-interacting protein kinase 4 Proteins 0.000 description 2
- 101000580021 Homo sapiens Inactive rhomboid protein 2 Proteins 0.000 description 2
- 101000809220 Homo sapiens Inactive ubiquitin carboxyl-terminal hydrolase 50 Proteins 0.000 description 2
- 101000605522 Homo sapiens Kallikrein-1 Proteins 0.000 description 2
- 101001091371 Homo sapiens Kallikrein-8 Proteins 0.000 description 2
- 101000971879 Homo sapiens Kell blood group glycoprotein Proteins 0.000 description 2
- 101001077840 Homo sapiens Lipid-phosphate phosphatase Proteins 0.000 description 2
- 101001064870 Homo sapiens Lon protease homolog, mitochondrial Proteins 0.000 description 2
- 101000871869 Homo sapiens Lys-63-specific deubiquitinase BRCC36 Proteins 0.000 description 2
- 101000627851 Homo sapiens Matrix metalloproteinase-23 Proteins 0.000 description 2
- 101000629400 Homo sapiens Mesoderm-specific transcript homolog protein Proteins 0.000 description 2
- 101001018300 Homo sapiens Microtubule-associated serine/threonine-protein kinase 2 Proteins 0.000 description 2
- 101001018294 Homo sapiens Microtubule-associated serine/threonine-protein kinase 3 Proteins 0.000 description 2
- 101001018298 Homo sapiens Microtubule-associated serine/threonine-protein kinase 4 Proteins 0.000 description 2
- 101000960626 Homo sapiens Mitochondrial inner membrane protease subunit 2 Proteins 0.000 description 2
- 101000577080 Homo sapiens Mitochondrial-processing peptidase subunit alpha Proteins 0.000 description 2
- 101000628949 Homo sapiens Mitogen-activated protein kinase 10 Proteins 0.000 description 2
- 101001052477 Homo sapiens Mitogen-activated protein kinase 4 Proteins 0.000 description 2
- 101000950669 Homo sapiens Mitogen-activated protein kinase 9 Proteins 0.000 description 2
- 101001018141 Homo sapiens Mitogen-activated protein kinase kinase kinase 2 Proteins 0.000 description 2
- 101001018145 Homo sapiens Mitogen-activated protein kinase kinase kinase 3 Proteins 0.000 description 2
- 101001018147 Homo sapiens Mitogen-activated protein kinase kinase kinase 4 Proteins 0.000 description 2
- 101001018196 Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Proteins 0.000 description 2
- 101001055097 Homo sapiens Mitogen-activated protein kinase kinase kinase 6 Proteins 0.000 description 2
- 101001055092 Homo sapiens Mitogen-activated protein kinase kinase kinase 7 Proteins 0.000 description 2
- 101001055091 Homo sapiens Mitogen-activated protein kinase kinase kinase 8 Proteins 0.000 description 2
- 101000929834 Homo sapiens Monoacylglycerol lipase ABHD6 Proteins 0.000 description 2
- 101001090860 Homo sapiens Myeloblastin Proteins 0.000 description 2
- 101000584177 Homo sapiens Myosin light chain kinase 3 Proteins 0.000 description 2
- 101100079343 Homo sapiens NAALADL1 gene Proteins 0.000 description 2
- 101000581940 Homo sapiens Napsin-A Proteins 0.000 description 2
- 101000602918 Homo sapiens Nicalin Proteins 0.000 description 2
- 101000577339 Homo sapiens Nuclear receptor-binding protein 2 Proteins 0.000 description 2
- 101100463123 Homo sapiens PDK3 gene Proteins 0.000 description 2
- 101100463125 Homo sapiens PDK4 gene Proteins 0.000 description 2
- 101000692672 Homo sapiens Phosphoinositide 3-kinase regulatory subunit 4 Proteins 0.000 description 2
- 101000692455 Homo sapiens Platelet-derived growth factor receptor beta Proteins 0.000 description 2
- 101000981464 Homo sapiens Presenilins-associated rhomboid-like protein, mitochondrial Proteins 0.000 description 2
- 101000633613 Homo sapiens Probable threonine protease PRSS50 Proteins 0.000 description 2
- 101000605534 Homo sapiens Prostate-specific antigen Proteins 0.000 description 2
- 101001136986 Homo sapiens Proteasome subunit beta type-8 Proteins 0.000 description 2
- 101001136981 Homo sapiens Proteasome subunit beta type-9 Proteins 0.000 description 2
- 101000677836 Homo sapiens Protein ABHD13 Proteins 0.000 description 2
- 101000995290 Homo sapiens Protein NDRG3 Proteins 0.000 description 2
- 101000995332 Homo sapiens Protein NDRG4 Proteins 0.000 description 2
- 101000908015 Homo sapiens Putative inactive carboxylesterase 4 Proteins 0.000 description 2
- 101001125116 Homo sapiens Putative serine/threonine-protein kinase PRKY Proteins 0.000 description 2
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 description 2
- 101000665873 Homo sapiens Retinol-binding protein 3 Proteins 0.000 description 2
- 101000669921 Homo sapiens Rho-associated protein kinase 2 Proteins 0.000 description 2
- 101000829506 Homo sapiens Rhodopsin kinase GRK1 Proteins 0.000 description 2
- 101000871032 Homo sapiens Rhodopsin kinase GRK7 Proteins 0.000 description 2
- 101000709006 Homo sapiens Rhomboid-related protein 2 Proteins 0.000 description 2
- 101000709003 Homo sapiens Rhomboid-related protein 3 Proteins 0.000 description 2
- 101000944921 Homo sapiens Ribosomal protein S6 kinase alpha-2 Proteins 0.000 description 2
- 101000945090 Homo sapiens Ribosomal protein S6 kinase alpha-3 Proteins 0.000 description 2
- 101000945093 Homo sapiens Ribosomal protein S6 kinase alpha-4 Proteins 0.000 description 2
- 101001051723 Homo sapiens Ribosomal protein S6 kinase alpha-6 Proteins 0.000 description 2
- 101000726974 Homo sapiens Ribosomal protein S6 kinase-like 1 Proteins 0.000 description 2
- 101000654257 Homo sapiens SCY1-like protein 2 Proteins 0.000 description 2
- 101000826077 Homo sapiens SRSF protein kinase 2 Proteins 0.000 description 2
- 101000684507 Homo sapiens Sentrin-specific protease 5 Proteins 0.000 description 2
- 101000708013 Homo sapiens Sentrin-specific protease 7 Proteins 0.000 description 2
- 101000650658 Homo sapiens Serine hydrolase-like protein Proteins 0.000 description 2
- 101001041365 Homo sapiens Serine protease HTRA2, mitochondrial Proteins 0.000 description 2
- 101000998897 Homo sapiens Serine protease HTRA3 Proteins 0.000 description 2
- 101000998893 Homo sapiens Serine protease HTRA4 Proteins 0.000 description 2
- 101000661821 Homo sapiens Serine/threonine-protein kinase 17A Proteins 0.000 description 2
- 101000661819 Homo sapiens Serine/threonine-protein kinase 17B Proteins 0.000 description 2
- 101000628575 Homo sapiens Serine/threonine-protein kinase 19 Proteins 0.000 description 2
- 101000701391 Homo sapiens Serine/threonine-protein kinase 31 Proteins 0.000 description 2
- 101000701396 Homo sapiens Serine/threonine-protein kinase 33 Proteins 0.000 description 2
- 101000697608 Homo sapiens Serine/threonine-protein kinase 38-like Proteins 0.000 description 2
- 101000794043 Homo sapiens Serine/threonine-protein kinase BRSK2 Proteins 0.000 description 2
- 101000576907 Homo sapiens Serine/threonine-protein kinase MRCK gamma Proteins 0.000 description 2
- 101001123814 Homo sapiens Serine/threonine-protein kinase Nek10 Proteins 0.000 description 2
- 101000601441 Homo sapiens Serine/threonine-protein kinase Nek2 Proteins 0.000 description 2
- 101000588553 Homo sapiens Serine/threonine-protein kinase Nek9 Proteins 0.000 description 2
- 101001098464 Homo sapiens Serine/threonine-protein kinase OSR1 Proteins 0.000 description 2
- 101000729945 Homo sapiens Serine/threonine-protein kinase PLK2 Proteins 0.000 description 2
- 101000691614 Homo sapiens Serine/threonine-protein kinase PLK3 Proteins 0.000 description 2
- 101000582914 Homo sapiens Serine/threonine-protein kinase PLK4 Proteins 0.000 description 2
- 101000756066 Homo sapiens Serine/threonine-protein kinase RIO1 Proteins 0.000 description 2
- 101000654491 Homo sapiens Serine/threonine-protein kinase SIK3 Proteins 0.000 description 2
- 101000864831 Homo sapiens Serine/threonine-protein kinase Sgk3 Proteins 0.000 description 2
- 101000838578 Homo sapiens Serine/threonine-protein kinase TAO2 Proteins 0.000 description 2
- 101001036145 Homo sapiens Serine/threonine-protein kinase greatwall Proteins 0.000 description 2
- 101001001648 Homo sapiens Serine/threonine-protein kinase pim-2 Proteins 0.000 description 2
- 101001001645 Homo sapiens Serine/threonine-protein kinase pim-3 Proteins 0.000 description 2
- 101000628899 Homo sapiens Small ubiquitin-related modifier 1 Proteins 0.000 description 2
- 101100245176 Homo sapiens TP53RK gene Proteins 0.000 description 2
- 101000759318 Homo sapiens Tau-tubulin kinase 2 Proteins 0.000 description 2
- 101000772239 Homo sapiens Testis-specific serine/threonine-protein kinase 2 Proteins 0.000 description 2
- 101000794197 Homo sapiens Testis-specific serine/threonine-protein kinase 3 Proteins 0.000 description 2
- 101000794199 Homo sapiens Testis-specific serine/threonine-protein kinase 4 Proteins 0.000 description 2
- 101000794200 Homo sapiens Testis-specific serine/threonine-protein kinase 6 Proteins 0.000 description 2
- 101000795793 Homo sapiens Tetratricopeptide repeat protein 28 Proteins 0.000 description 2
- 101000649064 Homo sapiens Thyrotropin-releasing hormone-degrading ectoenzyme Proteins 0.000 description 2
- 101000637850 Homo sapiens Tolloid-like protein 2 Proteins 0.000 description 2
- 101000596093 Homo sapiens Transcription initiation factor TFIID subunit 1 Proteins 0.000 description 2
- 101000625358 Homo sapiens Transcription initiation factor TFIID subunit 2 Proteins 0.000 description 2
- 101000835093 Homo sapiens Transferrin receptor protein 1 Proteins 0.000 description 2
- 101000798698 Homo sapiens Transmembrane protease serine 7 Proteins 0.000 description 2
- 101000796738 Homo sapiens Tryptase gamma Proteins 0.000 description 2
- 101000997835 Homo sapiens Tyrosine-protein kinase JAK1 Proteins 0.000 description 2
- 101000939517 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 2 Proteins 0.000 description 2
- 101000607872 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 21 Proteins 0.000 description 2
- 101000807541 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 24 Proteins 0.000 description 2
- 101000939456 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 29 Proteins 0.000 description 2
- 101000777220 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 3 Proteins 0.000 description 2
- 101000748141 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 32 Proteins 0.000 description 2
- 101000748157 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 33 Proteins 0.000 description 2
- 101000671819 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 36 Proteins 0.000 description 2
- 101000671811 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 37 Proteins 0.000 description 2
- 101000777134 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 43 Proteins 0.000 description 2
- 101000759988 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 48 Proteins 0.000 description 2
- 101000759935 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 49 Proteins 0.000 description 2
- 101000809223 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 51 Proteins 0.000 description 2
- 101000720061 Homo sapiens Uncharacterized aarF domain-containing protein kinase 5 Proteins 0.000 description 2
- 101000638886 Homo sapiens Urokinase-type plasminogen activator Proteins 0.000 description 2
- 101000983271 Homo sapiens Xaa-Arg dipeptidase Proteins 0.000 description 2
- 101000739853 Homo sapiens [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Proteins 0.000 description 2
- 101001117143 Homo sapiens [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Proteins 0.000 description 2
- 102100026020 Hormone-sensitive lipase Human genes 0.000 description 2
- 102100039238 Hyaluronan-binding protein 2 Human genes 0.000 description 2
- 102100027537 Inactive rhomboid protein 2 Human genes 0.000 description 2
- 102100028288 Inactive serine/threonine-protein kinase VRK3 Human genes 0.000 description 2
- 102100038414 Inactive ubiquitin carboxyl-terminal hydrolase 50 Human genes 0.000 description 2
- GPXJNWSHGFTCBW-UHFFFAOYSA-N Indium phosphide Chemical compound [In]#P GPXJNWSHGFTCBW-UHFFFAOYSA-N 0.000 description 2
- 102100029228 Insulin-like growth factor-binding protein 7 Human genes 0.000 description 2
- 102000001399 Kallikrein Human genes 0.000 description 2
- 108060005987 Kallikrein Proteins 0.000 description 2
- 102100027613 Kallikrein-10 Human genes 0.000 description 2
- 102100038318 Kallikrein-12 Human genes 0.000 description 2
- 102100038315 Kallikrein-13 Human genes 0.000 description 2
- 102100038298 Kallikrein-14 Human genes 0.000 description 2
- 102100038301 Kallikrein-15 Human genes 0.000 description 2
- 102100038356 Kallikrein-2 Human genes 0.000 description 2
- 102100034868 Kallikrein-5 Human genes 0.000 description 2
- 102100021447 Kell blood group glycoprotein Human genes 0.000 description 2
- 102100040621 Kynurenine formamidase Human genes 0.000 description 2
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 2
- LRQKBLKVPFOOQJ-YFKPBYRVSA-N L-norleucine Chemical compound CCCC[C@H]([NH3+])C([O-])=O LRQKBLKVPFOOQJ-YFKPBYRVSA-N 0.000 description 2
- 102100032241 Lactotransferrin Human genes 0.000 description 2
- 229930186657 Lat Natural products 0.000 description 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 2
- 102100022118 Leukotriene A-4 hydrolase Human genes 0.000 description 2
- 102000004882 Lipase Human genes 0.000 description 2
- 108090001060 Lipase Proteins 0.000 description 2
- 239000004367 Lipase Substances 0.000 description 2
- 102100025357 Lipid-phosphate phosphatase Human genes 0.000 description 2
- 102100030817 Liver carboxylesterase 1 Human genes 0.000 description 2
- 208000019693 Lung disease Diseases 0.000 description 2
- 102100033638 Lys-63-specific deubiquitinase BRCC36 Human genes 0.000 description 2
- 102100033320 Lysosomal Pro-X carboxypeptidase Human genes 0.000 description 2
- 102100033610 MAP kinase-interacting serine/threonine-protein kinase 2 Human genes 0.000 description 2
- 102100031520 MAPK/MAK/MRK overlapping kinase Human genes 0.000 description 2
- 101150098805 MAPK6 gene Proteins 0.000 description 2
- 102100027998 Macrophage metalloelastase Human genes 0.000 description 2
- 101150024075 Mapk1 gene Proteins 0.000 description 2
- 102100024299 Maternal embryonic leucine zipper kinase Human genes 0.000 description 2
- 101710154611 Maternal embryonic leucine zipper kinase Proteins 0.000 description 2
- 108010016165 Matrix Metalloproteinase 2 Proteins 0.000 description 2
- 102000002274 Matrix Metalloproteinases Human genes 0.000 description 2
- 108010000684 Matrix Metalloproteinases Proteins 0.000 description 2
- 102000001776 Matrix metalloproteinase-9 Human genes 0.000 description 2
- 108010015302 Matrix metalloproteinase-9 Proteins 0.000 description 2
- 102100026821 Mesoderm-specific transcript homolog protein Human genes 0.000 description 2
- 229910017680 MgTe Inorganic materials 0.000 description 2
- 108010020004 Microtubule-Associated Proteins Proteins 0.000 description 2
- 102000009664 Microtubule-Associated Proteins Human genes 0.000 description 2
- 102100033252 Microtubule-associated serine/threonine-protein kinase 4 Human genes 0.000 description 2
- 102100029083 Minor histocompatibility antigen H13 Human genes 0.000 description 2
- 102100039840 Mitochondrial inner membrane protease subunit 2 Human genes 0.000 description 2
- 102100026934 Mitochondrial intermediate peptidase Human genes 0.000 description 2
- 102100025321 Mitochondrial-processing peptidase subunit alpha Human genes 0.000 description 2
- 102100024193 Mitogen-activated protein kinase 1 Human genes 0.000 description 2
- 102100026931 Mitogen-activated protein kinase 10 Human genes 0.000 description 2
- 102100037805 Mitogen-activated protein kinase 7 Human genes 0.000 description 2
- 102100037808 Mitogen-activated protein kinase 8 Human genes 0.000 description 2
- 102100033058 Mitogen-activated protein kinase kinase kinase 2 Human genes 0.000 description 2
- 102100033059 Mitogen-activated protein kinase kinase kinase 3 Human genes 0.000 description 2
- 102100033060 Mitogen-activated protein kinase kinase kinase 4 Human genes 0.000 description 2
- 102100033127 Mitogen-activated protein kinase kinase kinase 5 Human genes 0.000 description 2
- 102100026889 Mitogen-activated protein kinase kinase kinase 6 Human genes 0.000 description 2
- 102100026888 Mitogen-activated protein kinase kinase kinase 7 Human genes 0.000 description 2
- 102100026907 Mitogen-activated protein kinase kinase kinase 8 Human genes 0.000 description 2
- 102100035912 Monoacylglycerol lipase ABHD6 Human genes 0.000 description 2
- 101000780283 Mus musculus A disintegrin and metallopeptidase domain 3 Proteins 0.000 description 2
- 101100127339 Mus musculus Camkk1 gene Proteins 0.000 description 2
- 101100070645 Mus musculus Hint1 gene Proteins 0.000 description 2
- 101100295637 Mus musculus Obscn gene Proteins 0.000 description 2
- 101100268066 Mus musculus Zap70 gene Proteins 0.000 description 2
- 102100034681 Myeloblastin Human genes 0.000 description 2
- 102100030783 Myosin light chain kinase 3 Human genes 0.000 description 2
- 238000005481 NMR spectroscopy Methods 0.000 description 2
- 101150111783 NTRK1 gene Proteins 0.000 description 2
- 102100027343 Napsin-A Human genes 0.000 description 2
- 102100038940 Neuroligin-3 Human genes 0.000 description 2
- 102100034441 Neuroligin-4, X-linked Human genes 0.000 description 2
- 102100034448 Neuroligin-4, Y-linked Human genes 0.000 description 2
- 102100033174 Neutrophil elastase Human genes 0.000 description 2
- 102100037228 Nicalin Human genes 0.000 description 2
- 102100029561 Nuclear receptor-interacting protein 3 Human genes 0.000 description 2
- 108020005187 Oligonucleotide Probes Proteins 0.000 description 2
- 102100026306 Ovochymase-2 Human genes 0.000 description 2
- 108091007960 PI3Ks Proteins 0.000 description 2
- 101150020891 PRKCA gene Proteins 0.000 description 2
- 101150075026 PRKCB gene Proteins 0.000 description 2
- 101150073266 PRKCD gene Proteins 0.000 description 2
- 101150010978 PRKCE gene Proteins 0.000 description 2
- 101150001670 PRKCG gene Proteins 0.000 description 2
- 102000014160 PTEN Phosphohydrolase Human genes 0.000 description 2
- 108010011536 PTEN Phosphohydrolase Proteins 0.000 description 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 2
- 108010021592 Pantothenate kinase Proteins 0.000 description 2
- 102100024122 Pantothenate kinase 1 Human genes 0.000 description 2
- 102100027006 Paraplegin Human genes 0.000 description 2
- 108091093037 Peptide nucleic acid Proteins 0.000 description 2
- 108010043958 Peptoids Proteins 0.000 description 2
- 102000003993 Phosphatidylinositol 3-kinases Human genes 0.000 description 2
- 108090000430 Phosphatidylinositol 3-kinases Proteins 0.000 description 2
- 102100026481 Phosphoinositide 3-kinase regulatory subunit 4 Human genes 0.000 description 2
- 108700019535 Phosphoprotein Phosphatases Proteins 0.000 description 2
- 102000045595 Phosphoprotein Phosphatases Human genes 0.000 description 2
- 102100036473 Phosphoribosylformylglycinamidine synthase Human genes 0.000 description 2
- 102100038124 Plasminogen Human genes 0.000 description 2
- 102100026547 Platelet-derived growth factor receptor beta Human genes 0.000 description 2
- 102100024778 Polyserase-2 Human genes 0.000 description 2
- 102100022033 Presenilin-1 Human genes 0.000 description 2
- 102100022036 Presenilin-2 Human genes 0.000 description 2
- 102100024056 Presenilins-associated rhomboid-like protein, mitochondrial Human genes 0.000 description 2
- 101150062385 Prkch gene Proteins 0.000 description 2
- 101150009401 Prkcz gene Proteins 0.000 description 2
- 102100025974 Pro-cathepsin H Human genes 0.000 description 2
- 102100029523 Probable threonine protease PRSS50 Human genes 0.000 description 2
- 102100026534 Procathepsin L Human genes 0.000 description 2
- 102100030350 Prolactin-inducible protein Human genes 0.000 description 2
- 102100023832 Prolyl endopeptidase FAP Human genes 0.000 description 2
- 102100029500 Prostasin Human genes 0.000 description 2
- 101710180316 Protease 2 Proteins 0.000 description 2
- 102100035760 Proteasome subunit beta type-8 Human genes 0.000 description 2
- 102100035764 Proteasome subunit beta type-9 Human genes 0.000 description 2
- 102100021500 Protein ABHD13 Human genes 0.000 description 2
- 108010029485 Protein Isoforms Proteins 0.000 description 2
- 102000001708 Protein Isoforms Human genes 0.000 description 2
- 108010003506 Protein Kinase D2 Proteins 0.000 description 2
- 102100034435 Protein NDRG3 Human genes 0.000 description 2
- 102100034432 Protein NDRG4 Human genes 0.000 description 2
- 101710092489 Protein kinase 2 Proteins 0.000 description 2
- 102100027378 Prothrombin Human genes 0.000 description 2
- 102100023322 Putative inactive carboxylesterase 4 Human genes 0.000 description 2
- 102100029403 Putative serine/threonine-protein kinase PRKY Human genes 0.000 description 2
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 description 2
- 101000605535 Rattus norvegicus Tonin Proteins 0.000 description 2
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 description 2
- 108700038365 Reelin Proteins 0.000 description 2
- 102000043322 Reelin Human genes 0.000 description 2
- 102100030847 Retinal guanylyl cyclase 2 Human genes 0.000 description 2
- 102100038247 Retinol-binding protein 3 Human genes 0.000 description 2
- 102100039314 Rho-associated protein kinase 2 Human genes 0.000 description 2
- 102100023742 Rhodopsin kinase GRK1 Human genes 0.000 description 2
- 102100032686 Rhomboid-related protein 2 Human genes 0.000 description 2
- 102100032691 Rhomboid-related protein 3 Human genes 0.000 description 2
- 108091028664 Ribonucleotide Proteins 0.000 description 2
- 102100033534 Ribosomal protein S6 kinase alpha-2 Human genes 0.000 description 2
- 102100033643 Ribosomal protein S6 kinase alpha-3 Human genes 0.000 description 2
- 102100033644 Ribosomal protein S6 kinase alpha-4 Human genes 0.000 description 2
- 102100024897 Ribosomal protein S6 kinase alpha-6 Human genes 0.000 description 2
- 102100030864 Ribosomal protein S6 kinase-like 1 Human genes 0.000 description 2
- 102100031698 SCY1-like protein 2 Human genes 0.000 description 2
- 101150102102 SMT3 gene Proteins 0.000 description 2
- 102100022010 SNF-related serine/threonine-protein kinase Human genes 0.000 description 2
- 102100024472 STAM-binding protein Human genes 0.000 description 2
- 101150096255 SUMO1 gene Proteins 0.000 description 2
- 101100162195 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) AFG3 gene Proteins 0.000 description 2
- 101100408688 Schizosaccharomyces pombe (strain 972 / ATCC 24843) pmt3 gene Proteins 0.000 description 2
- 102100031318 Secernin-2 Human genes 0.000 description 2
- 102100031320 Secernin-3 Human genes 0.000 description 2
- 101710118835 Sentrin-specific protease Proteins 0.000 description 2
- 102100023655 Sentrin-specific protease 5 Human genes 0.000 description 2
- 102100023713 Sentrin-specific protease 6 Human genes 0.000 description 2
- 102100031406 Sentrin-specific protease 7 Human genes 0.000 description 2
- 102100027696 Serine hydrolase-like protein Human genes 0.000 description 2
- 102100040107 Serine protease 27 Human genes 0.000 description 2
- 102100021117 Serine protease HTRA2, mitochondrial Human genes 0.000 description 2
- 102100033196 Serine protease HTRA4 Human genes 0.000 description 2
- 102100037955 Serine/threonine-protein kinase 17A Human genes 0.000 description 2
- 102100037959 Serine/threonine-protein kinase 17B Human genes 0.000 description 2
- 102100026757 Serine/threonine-protein kinase 19 Human genes 0.000 description 2
- 102100037628 Serine/threonine-protein kinase 3 Human genes 0.000 description 2
- 102100030618 Serine/threonine-protein kinase 31 Human genes 0.000 description 2
- 102100030515 Serine/threonine-protein kinase 33 Human genes 0.000 description 2
- 102100027898 Serine/threonine-protein kinase 38-like Human genes 0.000 description 2
- 102100029891 Serine/threonine-protein kinase BRSK2 Human genes 0.000 description 2
- 102100025345 Serine/threonine-protein kinase MRCK gamma Human genes 0.000 description 2
- 102100026180 Serine/threonine-protein kinase N2 Human genes 0.000 description 2
- 102100026219 Serine/threonine-protein kinase N3 Human genes 0.000 description 2
- 102100028774 Serine/threonine-protein kinase Nek10 Human genes 0.000 description 2
- 102100037703 Serine/threonine-protein kinase Nek2 Human genes 0.000 description 2
- 102100031398 Serine/threonine-protein kinase Nek9 Human genes 0.000 description 2
- 102100037143 Serine/threonine-protein kinase OSR1 Human genes 0.000 description 2
- 102100031463 Serine/threonine-protein kinase PLK1 Human genes 0.000 description 2
- 102100031462 Serine/threonine-protein kinase PLK2 Human genes 0.000 description 2
- 102100026209 Serine/threonine-protein kinase PLK3 Human genes 0.000 description 2
- 102100030267 Serine/threonine-protein kinase PLK4 Human genes 0.000 description 2
- 102100022261 Serine/threonine-protein kinase RIO1 Human genes 0.000 description 2
- 102100031445 Serine/threonine-protein kinase SIK3 Human genes 0.000 description 2
- 102100030071 Serine/threonine-protein kinase Sgk3 Human genes 0.000 description 2
- 102100028949 Serine/threonine-protein kinase TAO2 Human genes 0.000 description 2
- 102100028234 Serine/threonine-protein kinase VRK2 Human genes 0.000 description 2
- 102100036120 Serine/threonine-protein kinase pim-2 Human genes 0.000 description 2
- 102100036119 Serine/threonine-protein kinase pim-3 Human genes 0.000 description 2
- 102100032014 Serine/threonine-protein kinase tousled-like 2 Human genes 0.000 description 2
- 102100030404 Signal peptide peptidase-like 2B Human genes 0.000 description 2
- 101710201179 Small conductance calcium-activated potassium channel protein 3 Proteins 0.000 description 2
- 101710081623 Small ubiquitin-related modifier 1 Proteins 0.000 description 2
- 229910004411 SrTe Inorganic materials 0.000 description 2
- 102100030416 Stromelysin-1 Human genes 0.000 description 2
- 102100028848 Stromelysin-2 Human genes 0.000 description 2
- 102100037942 Suppressor of tumorigenicity 14 protein Human genes 0.000 description 2
- 102100029355 Testis-specific serine/threonine-protein kinase 2 Human genes 0.000 description 2
- 102100030168 Testis-specific serine/threonine-protein kinase 3 Human genes 0.000 description 2
- 102100030167 Testis-specific serine/threonine-protein kinase 4 Human genes 0.000 description 2
- 102100036494 Testisin Human genes 0.000 description 2
- 102100031744 Tetratricopeptide repeat protein 28 Human genes 0.000 description 2
- 102100033451 Thyroid hormone receptor beta Human genes 0.000 description 2
- 102100028088 Thyrotropin-releasing hormone-degrading ectoenzyme Human genes 0.000 description 2
- 102100031997 Tolloid-like protein 2 Human genes 0.000 description 2
- 102100035222 Transcription initiation factor TFIID subunit 1 Human genes 0.000 description 2
- 102100025041 Transcription initiation factor TFIID subunit 2 Human genes 0.000 description 2
- 102100022011 Transcription intermediary factor 1-alpha Human genes 0.000 description 2
- 102100026144 Transferrin receptor protein 1 Human genes 0.000 description 2
- 102100026143 Transferrin receptor protein 2 Human genes 0.000 description 2
- 102100031989 Transmembrane protease serine 2 Human genes 0.000 description 2
- 102100032471 Transmembrane protease serine 4 Human genes 0.000 description 2
- 102100032472 Transmembrane protease serine 5 Human genes 0.000 description 2
- 102100032453 Transmembrane protease serine 7 Human genes 0.000 description 2
- 108090000631 Trypsin Proteins 0.000 description 2
- 102000004142 Trypsin Human genes 0.000 description 2
- 102100034392 Trypsin-2 Human genes 0.000 description 2
- 102100032761 Tryptase gamma Human genes 0.000 description 2
- 102100033470 Tubulointerstitial nephritis antigen Human genes 0.000 description 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 2
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 description 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 2
- 108010040002 Tumor Suppressor Proteins Proteins 0.000 description 2
- 102000001742 Tumor Suppressor Proteins Human genes 0.000 description 2
- 102100033438 Tyrosine-protein kinase JAK1 Human genes 0.000 description 2
- 102100020797 UMP-CMP kinase Human genes 0.000 description 2
- 108010005656 Ubiquitin Thiolesterase Proteins 0.000 description 2
- 102100029643 Ubiquitin carboxyl-terminal hydrolase 2 Human genes 0.000 description 2
- 102100037176 Ubiquitin carboxyl-terminal hydrolase 24 Human genes 0.000 description 2
- 102100029818 Ubiquitin carboxyl-terminal hydrolase 29 Human genes 0.000 description 2
- 102100040050 Ubiquitin carboxyl-terminal hydrolase 32 Human genes 0.000 description 2
- 102100040047 Ubiquitin carboxyl-terminal hydrolase 33 Human genes 0.000 description 2
- 102100040109 Ubiquitin carboxyl-terminal hydrolase 36 Human genes 0.000 description 2
- 102100040111 Ubiquitin carboxyl-terminal hydrolase 37 Human genes 0.000 description 2
- 102100031311 Ubiquitin carboxyl-terminal hydrolase 43 Human genes 0.000 description 2
- 102100025023 Ubiquitin carboxyl-terminal hydrolase 48 Human genes 0.000 description 2
- 102100025044 Ubiquitin carboxyl-terminal hydrolase 49 Human genes 0.000 description 2
- 102100038433 Ubiquitin carboxyl-terminal hydrolase 51 Human genes 0.000 description 2
- 102100025040 Ubiquitin carboxyl-terminal hydrolase isozyme L3 Human genes 0.000 description 2
- 102100025996 Uncharacterized aarF domain-containing protein kinase 5 Human genes 0.000 description 2
- 102100031358 Urokinase-type plasminogen activator Human genes 0.000 description 2
- 108010053099 Vascular Endothelial Growth Factor Receptor-2 Proteins 0.000 description 2
- 208000036142 Viral infection Diseases 0.000 description 2
- 102100026867 Xaa-Arg dipeptidase Human genes 0.000 description 2
- 102100039662 Xaa-Pro dipeptidase Human genes 0.000 description 2
- 229910007709 ZnTe Inorganic materials 0.000 description 2
- 102100037607 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Human genes 0.000 description 2
- 102100024148 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial Human genes 0.000 description 2
- 102100024150 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Human genes 0.000 description 2
- 102100034824 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial Human genes 0.000 description 2
- 102100034825 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial Human genes 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- UDMBCSSLTHHNCD-KQYNXXCUSA-N adenosine 5'-monophosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O UDMBCSSLTHHNCD-KQYNXXCUSA-N 0.000 description 2
- 239000000556 agonist Substances 0.000 description 2
- 239000000956 alloy Substances 0.000 description 2
- 229910045601 alloy Inorganic materials 0.000 description 2
- 108090000449 aminopeptidase B Proteins 0.000 description 2
- 230000003321 amplification Effects 0.000 description 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 2
- 125000004429 atom Chemical group 0.000 description 2
- 210000003719 b-lymphocyte Anatomy 0.000 description 2
- 150000001556 benzimidazoles Chemical class 0.000 description 2
- 230000001588 bifunctional effect Effects 0.000 description 2
- 108091008324 binding proteins Proteins 0.000 description 2
- 238000010256 biochemical assay Methods 0.000 description 2
- 238000005842 biochemical reaction Methods 0.000 description 2
- 239000012620 biological material Substances 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 210000000481 breast Anatomy 0.000 description 2
- UHYPYGJEEGLRJD-UHFFFAOYSA-N cadmium(2+);selenium(2-) Chemical compound [Se-2].[Cd+2] UHYPYGJEEGLRJD-UHFFFAOYSA-N 0.000 description 2
- 150000001718 carbodiimides Chemical class 0.000 description 2
- PFKFTWBEEFSNDU-UHFFFAOYSA-N carbonyldiimidazole Chemical class C1=CN=CN1C(=O)N1C=CN=C1 PFKFTWBEEFSNDU-UHFFFAOYSA-N 0.000 description 2
- 150000001768 cations Chemical class 0.000 description 2
- 108010051348 cdc42 GTP-Binding Protein Proteins 0.000 description 2
- 230000034303 cell budding Effects 0.000 description 2
- 238000004113 cell culture Methods 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 230000036755 cellular response Effects 0.000 description 2
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 2
- AOXOCDRNSPFDPE-UKEONUMOSA-N chembl413654 Chemical compound C([C@H](C(=O)NCC(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@@H](N)CCC(O)=O)C1=CC=C(O)C=C1 AOXOCDRNSPFDPE-UKEONUMOSA-N 0.000 description 2
- NCEXYHBECQHGNR-UHFFFAOYSA-N chembl421 Chemical compound C1=C(O)C(C(=O)O)=CC(N=NC=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-UHFFFAOYSA-N 0.000 description 2
- 229960002424 collagenase Drugs 0.000 description 2
- 239000002299 complementary DNA Substances 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 2
- 108010049285 dephospho-CoA kinase Proteins 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 229940000406 drug candidate Drugs 0.000 description 2
- 210000002472 endoplasmic reticulum Anatomy 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 108010031246 erythritol kinase Proteins 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 238000001917 fluorescence detection Methods 0.000 description 2
- 238000002376 fluorescence recovery after photobleaching Methods 0.000 description 2
- 239000007850 fluorescent dye Substances 0.000 description 2
- 230000002538 fungal effect Effects 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 230000003862 health status Effects 0.000 description 2
- 210000003630 histaminocyte Anatomy 0.000 description 2
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 2
- 108010071598 homoserine kinase Proteins 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 238000005286 illumination Methods 0.000 description 2
- 230000001976 improved effect Effects 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 239000012948 isocyanate Substances 0.000 description 2
- 150000002513 isocyanates Chemical class 0.000 description 2
- 150000002576 ketones Chemical class 0.000 description 2
- 235000019421 lipase Nutrition 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 239000003202 long acting thyroid stimulator Substances 0.000 description 2
- 108010057284 lysosomal Pro-X carboxypeptidase Proteins 0.000 description 2
- 229920002521 macromolecule Polymers 0.000 description 2
- 210000002540 macrophage Anatomy 0.000 description 2
- 101150069838 mapk-15 gene Proteins 0.000 description 2
- 239000003550 marker Substances 0.000 description 2
- 229910044991 metal oxide Inorganic materials 0.000 description 2
- 150000004706 metal oxides Chemical class 0.000 description 2
- 229930182817 methionine Natural products 0.000 description 2
- 108091005601 modified peptides Proteins 0.000 description 2
- 230000035772 mutation Effects 0.000 description 2
- 239000002061 nanopillar Substances 0.000 description 2
- 239000002063 nanoring Substances 0.000 description 2
- 239000002077 nanosphere Substances 0.000 description 2
- 230000001537 neural effect Effects 0.000 description 2
- 208000015122 neurodegenerative disease Diseases 0.000 description 2
- 108010037733 neurotrypsin Proteins 0.000 description 2
- 238000003199 nucleic acid amplification method Methods 0.000 description 2
- 230000001293 nucleolytic effect Effects 0.000 description 2
- 239000012038 nucleophile Substances 0.000 description 2
- 210000004940 nucleus Anatomy 0.000 description 2
- 239000002751 oligonucleotide probe Substances 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 230000001575 pathological effect Effects 0.000 description 2
- 238000003909 pattern recognition Methods 0.000 description 2
- 230000000737 periodic effect Effects 0.000 description 2
- 229930029653 phosphoenolpyruvate Natural products 0.000 description 2
- DTBNBXWJWCWCIK-UHFFFAOYSA-K phosphonatoenolpyruvate Chemical compound [O-]C(=O)C(=C)OP([O-])([O-])=O DTBNBXWJWCWCIK-UHFFFAOYSA-K 0.000 description 2
- 239000003757 phosphotransferase inhibitor Substances 0.000 description 2
- 238000000206 photolithography Methods 0.000 description 2
- 238000000623 plasma-assisted chemical vapour deposition Methods 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 108010056274 polo-like kinase 1 Proteins 0.000 description 2
- 208000030151 polycystic kidney disease 3 with or without polycystic liver disease Diseases 0.000 description 2
- 102000040430 polynucleotide Human genes 0.000 description 2
- 108091033319 polynucleotide Proteins 0.000 description 2
- 239000002157 polynucleotide Substances 0.000 description 2
- 230000004481 post-translational protein modification Effects 0.000 description 2
- 230000035935 pregnancy Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000000069 prophylactic effect Effects 0.000 description 2
- 230000007055 protein processing involved in protein targeting to mitochondrion Effects 0.000 description 2
- RXWNCPJZOCPEPQ-NVWDDTSBSA-N puromycin Chemical compound C1=CC(OC)=CC=C1C[C@H](N)C(=O)N[C@H]1[C@@H](O)[C@H](N2C3=NC=NC(=C3N=C2)N(C)C)O[C@@H]1CO RXWNCPJZOCPEPQ-NVWDDTSBSA-N 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 230000000241 respiratory effect Effects 0.000 description 2
- 239000002336 ribonucleotide Substances 0.000 description 2
- 239000005060 rubber Substances 0.000 description 2
- 239000012488 sample solution Substances 0.000 description 2
- SBIBMFFZSBJNJF-UHFFFAOYSA-N selenium;zinc Chemical compound [Se]=[Zn] SBIBMFFZSBJNJF-UHFFFAOYSA-N 0.000 description 2
- 210000000582 semen Anatomy 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 108020001482 shikimate kinase Proteins 0.000 description 2
- 230000011664 signaling Effects 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 239000004332 silver Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000012306 spectroscopic technique Methods 0.000 description 2
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- 108010077917 tau-tubulin kinase Proteins 0.000 description 2
- 210000001138 tear Anatomy 0.000 description 2
- 210000001550 testis Anatomy 0.000 description 2
- 239000010409 thin film Substances 0.000 description 2
- 125000003396 thiol group Chemical group [H]S* 0.000 description 2
- 210000001541 thymus gland Anatomy 0.000 description 2
- 102000014898 transaminase activity proteins Human genes 0.000 description 2
- 230000002103 transcriptional effect Effects 0.000 description 2
- 108010071511 transcriptional intermediary factor 1 Proteins 0.000 description 2
- 230000009466 transformation Effects 0.000 description 2
- 230000001052 transient effect Effects 0.000 description 2
- 239000012588 trypsin Substances 0.000 description 2
- 102000003298 tumor necrosis factor receptor Human genes 0.000 description 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 2
- 108010016317 ubiquitin-aldehyde Proteins 0.000 description 2
- PGOHTUIFYSHAQG-LJSDBVFPSA-N (2S)-6-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-1-[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-sulfanylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-carboxybutanoyl]amino]-5-oxopentanoyl]amino]hexanoic acid Chemical compound CSCC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(O)=O PGOHTUIFYSHAQG-LJSDBVFPSA-N 0.000 description 1
- ZPAVDMSDYRVQJR-BQBZGAKWSA-N (2s)-5-[[(2r)-1-(carboxymethylamino)-1-oxo-3-sulfanylpropan-2-yl]amino]-2-formamido-5-oxopentanoic acid Chemical compound OC(=O)CNC(=O)[C@H](CS)NC(=O)CC[C@@H](C(O)=O)NC=O ZPAVDMSDYRVQJR-BQBZGAKWSA-N 0.000 description 1
- UKAUYVFTDYCKQA-UHFFFAOYSA-N -2-Amino-4-hydroxybutanoic acid Natural products OC(=O)C(N)CCO UKAUYVFTDYCKQA-UHFFFAOYSA-N 0.000 description 1
- DELJNDWGTWHHFA-UHFFFAOYSA-N 1-azaniumylpropyl(hydroxy)phosphinate Chemical compound CCC(N)P(O)(O)=O DELJNDWGTWHHFA-UHFFFAOYSA-N 0.000 description 1
- UHDGCWIWMRVCDJ-UHFFFAOYSA-N 1-beta-D-Xylofuranosyl-NH-Cytosine Natural products O=C1N=C(N)C=CN1C1C(O)C(O)C(CO)O1 UHDGCWIWMRVCDJ-UHFFFAOYSA-N 0.000 description 1
- 108010023317 1-phosphofructokinase Proteins 0.000 description 1
- 150000003923 2,5-pyrrolediones Chemical class 0.000 description 1
- 102100027962 2-5A-dependent ribonuclease Human genes 0.000 description 1
- 108010000834 2-5A-dependent ribonuclease Proteins 0.000 description 1
- QZDDFQLIQRYMBV-UHFFFAOYSA-N 2-[3-nitro-2-(2-nitrophenyl)-4-oxochromen-8-yl]acetic acid Chemical compound OC(=O)CC1=CC=CC(C(C=2[N+]([O-])=O)=O)=C1OC=2C1=CC=CC=C1[N+]([O-])=O QZDDFQLIQRYMBV-UHFFFAOYSA-N 0.000 description 1
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
- DIDGPCDGNMIUNX-UUOKFMHZSA-N 2-amino-9-[(2r,3r,4s,5r)-5-(dihydroxyphosphinothioyloxymethyl)-3,4-dihydroxyoxolan-2-yl]-3h-purin-6-one Chemical compound C1=2NC(N)=NC(=O)C=2N=CN1[C@@H]1O[C@H](COP(O)(O)=S)[C@@H](O)[C@H]1O DIDGPCDGNMIUNX-UUOKFMHZSA-N 0.000 description 1
- 102100032282 26S proteasome non-ATPase regulatory subunit 14 Human genes 0.000 description 1
- BYIRZDTVVMWWFI-UHFFFAOYSA-N 2h-pteridin-1-ylmethanol Chemical compound C1=CN=C2N(CO)CN=CC2=N1 BYIRZDTVVMWWFI-UHFFFAOYSA-N 0.000 description 1
- 101710128662 3-mercaptopyruvate sulfurtransferase Proteins 0.000 description 1
- QHKABHOOEWYVLI-UHFFFAOYSA-N 3-methyl-2-oxobutanoic acid Chemical compound CC(C)C(=O)C(O)=O QHKABHOOEWYVLI-UHFFFAOYSA-N 0.000 description 1
- NCGICGYLBXGBGN-UHFFFAOYSA-N 3-morpholin-4-yl-1-oxa-3-azonia-2-azanidacyclopent-3-en-5-imine;hydrochloride Chemical compound Cl.[N-]1OC(=N)C=[N+]1N1CCOCC1 NCGICGYLBXGBGN-UHFFFAOYSA-N 0.000 description 1
- OSJPPGNTCRNQQC-UWTATZPHSA-N 3-phospho-D-glyceric acid Chemical compound OC(=O)[C@H](O)COP(O)(O)=O OSJPPGNTCRNQQC-UWTATZPHSA-N 0.000 description 1
- VUTBELPREDJDDH-UHFFFAOYSA-N 4-amino-5-hydroxymethyl-2-methylpyrimidine Chemical compound CC1=NC=C(CO)C(N)=N1 VUTBELPREDJDDH-UHFFFAOYSA-N 0.000 description 1
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 1
- GUDJFFQZIISQJB-UHFFFAOYSA-N 4-cyano-5-(3,5-dichloropyridin-4-yl)sulfanyl-n-(4-methylsulfonylphenyl)thiophene-2-carboxamide Chemical compound C1=CC(S(=O)(=O)C)=CC=C1NC(=O)C(S1)=CC(C#N)=C1SC1=C(Cl)C=NC=C1Cl GUDJFFQZIISQJB-UHFFFAOYSA-N 0.000 description 1
- 101710169336 5'-deoxyadenosine deaminase Proteins 0.000 description 1
- OOXNYFKPOPJIOT-UHFFFAOYSA-N 5-(3-bromophenyl)-7-(6-morpholin-4-ylpyridin-3-yl)pyrido[2,3-d]pyrimidin-4-amine;dihydrochloride Chemical compound Cl.Cl.C=12C(N)=NC=NC2=NC(C=2C=NC(=CC=2)N2CCOCC2)=CC=1C1=CC=CC(Br)=C1 OOXNYFKPOPJIOT-UHFFFAOYSA-N 0.000 description 1
- PQGCEDQWHSBAJP-TXICZTDVSA-N 5-O-phosphono-alpha-D-ribofuranosyl diphosphate Chemical compound O[C@H]1[C@@H](O)[C@@H](O[P@](O)(=O)OP(O)(O)=O)O[C@@H]1COP(O)(O)=O PQGCEDQWHSBAJP-TXICZTDVSA-N 0.000 description 1
- 108090000713 5-dehydro-2-deoxygluconokinases Proteins 0.000 description 1
- OLVVOVIFTBSBBH-KVTDHHQDSA-N 5-methylthioribose Chemical compound CSC[C@H]1O[C@@H](O)[C@H](O)[C@@H]1O OLVVOVIFTBSBBH-KVTDHHQDSA-N 0.000 description 1
- 102100027399 A disintegrin and metalloproteinase with thrombospondin motifs 2 Human genes 0.000 description 1
- 102100027401 A disintegrin and metalloproteinase with thrombospondin motifs 3 Human genes 0.000 description 1
- 102100027400 A disintegrin and metalloproteinase with thrombospondin motifs 4 Human genes 0.000 description 1
- 102100032638 A disintegrin and metalloproteinase with thrombospondin motifs 5 Human genes 0.000 description 1
- 102100032632 A disintegrin and metalloproteinase with thrombospondin motifs 6 Human genes 0.000 description 1
- 102100032639 A disintegrin and metalloproteinase with thrombospondin motifs 7 Human genes 0.000 description 1
- 102100032635 A disintegrin and metalloproteinase with thrombospondin motifs 8 Human genes 0.000 description 1
- 102100032650 A disintegrin and metalloproteinase with thrombospondin motifs 9 Human genes 0.000 description 1
- 102000029791 ADAM Human genes 0.000 description 1
- 108091022885 ADAM Proteins 0.000 description 1
- 102100026007 ADAM DEC1 Human genes 0.000 description 1
- 108091007505 ADAM17 Proteins 0.000 description 1
- 108091005661 ADAMTS3 Proteins 0.000 description 1
- 108091005664 ADAMTS4 Proteins 0.000 description 1
- 108091005663 ADAMTS5 Proteins 0.000 description 1
- 108091005665 ADAMTS6 Proteins 0.000 description 1
- 108091005667 ADAMTS7 Proteins 0.000 description 1
- 108091005666 ADAMTS8 Proteins 0.000 description 1
- 108091005669 ADAMTS9 Proteins 0.000 description 1
- 102100026381 ADP-dependent glucokinase Human genes 0.000 description 1
- 108010058598 ADP-dependent glucokinase Proteins 0.000 description 1
- 102100034215 AFG3-like protein 2 Human genes 0.000 description 1
- 108010011376 AMP-Activated Protein Kinases Proteins 0.000 description 1
- 102000014156 AMP-Activated Protein Kinases Human genes 0.000 description 1
- 102000007566 ATP-Dependent Proteases Human genes 0.000 description 1
- 101710157736 ATP-dependent 6-phosphofructokinase Proteins 0.000 description 1
- 101710200244 ATP-dependent 6-phosphofructokinase isozyme 2 Proteins 0.000 description 1
- 108050001496 ATP-dependent Clp protease proteolytic subunit Proteins 0.000 description 1
- 102100021222 ATP-dependent Clp protease proteolytic subunit, mitochondrial Human genes 0.000 description 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 108010092060 Acetate kinase Proteins 0.000 description 1
- 102000000452 Acetyl-CoA carboxylase Human genes 0.000 description 1
- 108010016219 Acetyl-CoA carboxylase Proteins 0.000 description 1
- 108091005508 Acid proteases Proteins 0.000 description 1
- 108090000107 Acrosin Proteins 0.000 description 1
- 108700016155 Acyl transferases Proteins 0.000 description 1
- 102100032488 Acylamino-acid-releasing enzyme Human genes 0.000 description 1
- 102100036664 Adenosine deaminase Human genes 0.000 description 1
- 108010076278 Adenosine kinase Proteins 0.000 description 1
- 108030003722 Adenosylcobinamide kinases Proteins 0.000 description 1
- 108020000543 Adenylate kinase Proteins 0.000 description 1
- 108030003773 Allose kinases Proteins 0.000 description 1
- 102100033804 Alpha-protein kinase 2 Human genes 0.000 description 1
- 102100033806 Alpha-protein kinase 3 Human genes 0.000 description 1
- 102100038046 Alpha/beta hydrolase domain-containing protein 17A Human genes 0.000 description 1
- 208000012186 Alzheimer disease 3 Diseases 0.000 description 1
- 208000026833 Alzheimer disease 4 Diseases 0.000 description 1
- 102100025981 Aminoacylase-1 Human genes 0.000 description 1
- 101710143180 Aminoacylase-1 Proteins 0.000 description 1
- 101710099461 Aminopeptidase N Proteins 0.000 description 1
- 102100040141 Aminopeptidase O Human genes 0.000 description 1
- 102000001921 Aminopeptidase P Human genes 0.000 description 1
- 102100040181 Aminopeptidase Q Human genes 0.000 description 1
- 206010059245 Angiopathy Diseases 0.000 description 1
- 102100035765 Angiotensin-converting enzyme 2 Human genes 0.000 description 1
- 108090000975 Angiotensin-converting enzyme 2 Proteins 0.000 description 1
- 241000219194 Arabidopsis Species 0.000 description 1
- 101100110023 Arabidopsis thaliana ASK8 gene Proteins 0.000 description 1
- 101001044245 Arabidopsis thaliana Insulin-degrading enzyme-like 1, peroxisomal Proteins 0.000 description 1
- 101100207331 Arabidopsis thaliana TPPI gene Proteins 0.000 description 1
- 108010020366 Arginine kinase Proteins 0.000 description 1
- 102100024624 Arylacetamide deacetylase Human genes 0.000 description 1
- 108010018854 Arylformamidase Proteins 0.000 description 1
- 102100023927 Asparagine synthetase [glutamine-hydrolyzing] Human genes 0.000 description 1
- 102000030431 Asparaginyl endopeptidase Human genes 0.000 description 1
- 102000030907 Aspartate Carbamoyltransferase Human genes 0.000 description 1
- 102100033261 Aspartyl aminopeptidase Human genes 0.000 description 1
- 102100027710 Astacin-like metalloendopeptidase Human genes 0.000 description 1
- 206010003594 Ataxia telangiectasia Diseases 0.000 description 1
- 102100039339 Atrial natriuretic peptide receptor 1 Human genes 0.000 description 1
- 101710133555 Atrial natriuretic peptide-converting enzyme Proteins 0.000 description 1
- 108090000749 Aurora kinase B Proteins 0.000 description 1
- 108090000805 Aurora kinase C Proteins 0.000 description 1
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 101710151325 B2 protein Proteins 0.000 description 1
- FTOVXSOBNPWTSH-UHFFFAOYSA-N BCR-47 Natural products C12=CC=CC=C1C1=CC3=CC=CC=C3C3=C1C2=CC=C3 FTOVXSOBNPWTSH-UHFFFAOYSA-N 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 108010027344 Basic Helix-Loop-Helix Transcription Factors Proteins 0.000 description 1
- 102000018720 Basic Helix-Loop-Helix Transcription Factors Human genes 0.000 description 1
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 description 1
- 102100021738 Beta-adrenergic receptor kinase 1 Human genes 0.000 description 1
- 108010015248 Beta-glucoside kinase Proteins 0.000 description 1
- 101710150190 Beta-secretase 2 Proteins 0.000 description 1
- 235000018185 Betula X alpestris Nutrition 0.000 description 1
- 235000018212 Betula X uliginosa Nutrition 0.000 description 1
- 108010018763 Biotin carboxylase Proteins 0.000 description 1
- 102100027058 Bleomycin hydrolase Human genes 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 102100028728 Bone morphogenetic protein 1 Human genes 0.000 description 1
- 101001091591 Bos taurus Kininogen-1 Proteins 0.000 description 1
- 101000782236 Bothrops leucurus Thrombin-like enzyme leucurobin Proteins 0.000 description 1
- 102100022046 Brain-specific serine protease 4 Human genes 0.000 description 1
- FERIUCNNQQJTOY-UHFFFAOYSA-M Butyrate Chemical compound CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 description 1
- 108700024126 Butyrate kinases Proteins 0.000 description 1
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Natural products CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 1
- 108010053652 Butyrylcholinesterase Proteins 0.000 description 1
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 description 1
- XMWRBQBLMFGWIX-UHFFFAOYSA-N C60 fullerene Chemical compound C12=C3C(C4=C56)=C7C8=C5C5=C9C%10=C6C6=C4C1=C1C4=C6C6=C%10C%10=C9C9=C%11C5=C8C5=C8C7=C3C3=C7C2=C1C1=C2C4=C6C4=C%10C6=C9C9=C%11C5=C5C8=C3C3=C7C1=C1C2=C4C6=C2C9=C5C3=C12 XMWRBQBLMFGWIX-UHFFFAOYSA-N 0.000 description 1
- 102100022361 CAAX prenyl protease 1 homolog Human genes 0.000 description 1
- 102100025752 CASP8 and FADD-like apoptosis regulator Human genes 0.000 description 1
- QCMYYKRYFNMIEC-UHFFFAOYSA-N COP(O)=O Chemical class COP(O)=O QCMYYKRYFNMIEC-UHFFFAOYSA-N 0.000 description 1
- 102100021824 COP9 signalosome complex subunit 5 Human genes 0.000 description 1
- 102100028372 COP9 signalosome complex subunit 6 Human genes 0.000 description 1
- 101000708016 Caenorhabditis elegans Sentrin-specific protease Proteins 0.000 description 1
- 101100029886 Caenorhabditis elegans lov-1 gene Proteins 0.000 description 1
- 101100042630 Caenorhabditis elegans sin-3 gene Proteins 0.000 description 1
- 102000004631 Calcineurin Human genes 0.000 description 1
- 108010042955 Calcineurin Proteins 0.000 description 1
- 102000005701 Calcium-Binding Proteins Human genes 0.000 description 1
- 108010045403 Calcium-Binding Proteins Proteins 0.000 description 1
- 102100033086 Calcium/calmodulin-dependent protein kinase type 1 Human genes 0.000 description 1
- 241000189662 Calla Species 0.000 description 1
- 102000003895 Calpain-1 Human genes 0.000 description 1
- 108090000236 Calpain-1 Proteins 0.000 description 1
- 102100025465 Calpain-10 Human genes 0.000 description 1
- 108090000451 Calpain-10 Proteins 0.000 description 1
- 102100025456 Calpain-11 Human genes 0.000 description 1
- 101710165505 Calpain-11 Proteins 0.000 description 1
- 102100025462 Calpain-12 Human genes 0.000 description 1
- 108050003161 Calpain-12 Proteins 0.000 description 1
- 102000014271 Calpain-13 Human genes 0.000 description 1
- 108050003159 Calpain-13 Proteins 0.000 description 1
- 101710165502 Calpain-14 Proteins 0.000 description 1
- 101710165503 Calpain-15 Proteins 0.000 description 1
- 108030001375 Calpain-3 Proteins 0.000 description 1
- 101710099825 Calpain-5 Proteins 0.000 description 1
- 101710099824 Calpain-6 Proteins 0.000 description 1
- 102100030010 Calpain-7 Human genes 0.000 description 1
- 101710099823 Calpain-7 Proteins 0.000 description 1
- 102100030004 Calpain-8 Human genes 0.000 description 1
- 208000022526 Canavan disease Diseases 0.000 description 1
- 241000282465 Canis Species 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 101710132601 Capsid protein Proteins 0.000 description 1
- 101710201076 Carboxylesterase 1 Proteins 0.000 description 1
- 102100030614 Carboxypeptidase A2 Human genes 0.000 description 1
- 102100026794 Carboxypeptidase A5 Human genes 0.000 description 1
- 102100026793 Carboxypeptidase A6 Human genes 0.000 description 1
- 102100026678 Carboxypeptidase N catalytic chain Human genes 0.000 description 1
- 101710093167 Carboxypeptidase Q Proteins 0.000 description 1
- 108010006303 Carboxypeptidases Proteins 0.000 description 1
- 102000005367 Carboxypeptidases Human genes 0.000 description 1
- 208000005623 Carcinogenesis Diseases 0.000 description 1
- QRYRORQUOLYVBU-VBKZILBWSA-N Carnosic acid Natural products CC([C@@H]1CC2)(C)CCC[C@]1(C(O)=O)C1=C2C=C(C(C)C)C(O)=C1O QRYRORQUOLYVBU-VBKZILBWSA-N 0.000 description 1
- 108010087806 Carnosine Proteins 0.000 description 1
- 102000005403 Casein Kinases Human genes 0.000 description 1
- 108010031425 Casein Kinases Proteins 0.000 description 1
- 101710160185 Casein kinase I isoform delta Proteins 0.000 description 1
- 102100037398 Casein kinase I isoform epsilon Human genes 0.000 description 1
- 102100037397 Casein kinase I isoform gamma-1 Human genes 0.000 description 1
- 102100023060 Casein kinase I isoform gamma-2 Human genes 0.000 description 1
- 102100023067 Casein kinase I isoform gamma-3 Human genes 0.000 description 1
- 108010076119 Caseins Proteins 0.000 description 1
- 102000011632 Caseins Human genes 0.000 description 1
- 108090000425 Caspase 6 Proteins 0.000 description 1
- 108090000567 Caspase 7 Proteins 0.000 description 1
- 102100035904 Caspase-1 Human genes 0.000 description 1
- 108090000426 Caspase-1 Proteins 0.000 description 1
- 102000004068 Caspase-10 Human genes 0.000 description 1
- 108090000572 Caspase-10 Proteins 0.000 description 1
- 102000004066 Caspase-12 Human genes 0.000 description 1
- 108090000570 Caspase-12 Proteins 0.000 description 1
- 108090001132 Caspase-14 Proteins 0.000 description 1
- 102100032616 Caspase-2 Human genes 0.000 description 1
- 108090000552 Caspase-2 Proteins 0.000 description 1
- 101710090338 Caspase-4 Proteins 0.000 description 1
- 101710090333 Caspase-5 Proteins 0.000 description 1
- 102100038902 Caspase-7 Human genes 0.000 description 1
- 108090000538 Caspase-8 Proteins 0.000 description 1
- 108090000566 Caspase-9 Proteins 0.000 description 1
- 102000011727 Caspases Human genes 0.000 description 1
- 108010076667 Caspases Proteins 0.000 description 1
- 108090000712 Cathepsin B Proteins 0.000 description 1
- 102000003902 Cathepsin C Human genes 0.000 description 1
- 108090000267 Cathepsin C Proteins 0.000 description 1
- 108090000258 Cathepsin D Proteins 0.000 description 1
- 102100032215 Cathepsin E Human genes 0.000 description 1
- 102100025953 Cathepsin F Human genes 0.000 description 1
- 102100025975 Cathepsin G Human genes 0.000 description 1
- 108090000619 Cathepsin H Proteins 0.000 description 1
- 108090000624 Cathepsin L Proteins 0.000 description 1
- 101710169274 Cathepsin L2 Proteins 0.000 description 1
- 108090000613 Cathepsin S Proteins 0.000 description 1
- 108010061112 Cathepsin W Proteins 0.000 description 1
- 102100026657 Cathepsin Z Human genes 0.000 description 1
- 102100036158 Ceramide kinase Human genes 0.000 description 1
- 108010017573 Ceramide kinase Proteins 0.000 description 1
- 206010008111 Cerebral haemorrhage Diseases 0.000 description 1
- 241000288673 Chiroptera Species 0.000 description 1
- 108010018888 Choline kinase Proteins 0.000 description 1
- 108090000322 Cholinesterases Proteins 0.000 description 1
- 108090000746 Chymosin Proteins 0.000 description 1
- 108090000205 Chymotrypsin C Proteins 0.000 description 1
- 102100035371 Chymotrypsin-like elastase family member 1 Human genes 0.000 description 1
- 102100023338 Chymotrypsin-like elastase family member 2B Human genes 0.000 description 1
- 102100039501 Chymotrypsinogen B Human genes 0.000 description 1
- 240000004307 Citrus medica Species 0.000 description 1
- 102100023804 Coagulation factor VII Human genes 0.000 description 1
- 102100029117 Coagulation factor X Human genes 0.000 description 1
- 102100030563 Coagulation factor XI Human genes 0.000 description 1
- 102100027995 Collagenase 3 Human genes 0.000 description 1
- 102100030152 Complement C1r subcomponent-like protein Human genes 0.000 description 1
- 108090000955 Complement C2 Proteins 0.000 description 1
- 102000004381 Complement C2 Human genes 0.000 description 1
- 102100034622 Complement factor B Human genes 0.000 description 1
- 102100035431 Complement factor I Human genes 0.000 description 1
- 108010002947 Connectin Proteins 0.000 description 1
- 108091035707 Consensus sequence Proteins 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 101710199851 Copy number protein Proteins 0.000 description 1
- 102000004420 Creatine Kinase Human genes 0.000 description 1
- 108010042126 Creatine kinase Proteins 0.000 description 1
- 108010068192 Cyclin A Proteins 0.000 description 1
- 108010068150 Cyclin B Proteins 0.000 description 1
- 102000002427 Cyclin B Human genes 0.000 description 1
- 102100025191 Cyclin-A2 Human genes 0.000 description 1
- 108010025461 Cyclin-Dependent Kinase 9 Proteins 0.000 description 1
- 102100023263 Cyclin-dependent kinase 10 Human genes 0.000 description 1
- 101710179260 Cyclin-dependent kinase 12 Proteins 0.000 description 1
- 102100038113 Cyclin-dependent kinase 14 Human genes 0.000 description 1
- 102100033250 Cyclin-dependent kinase 15 Human genes 0.000 description 1
- 102100033245 Cyclin-dependent kinase 16 Human genes 0.000 description 1
- 102100033145 Cyclin-dependent kinase 19 Human genes 0.000 description 1
- 101710084687 Cyclin-dependent kinase 2 homolog Proteins 0.000 description 1
- 101710179325 Cyclin-dependent kinase 20 Proteins 0.000 description 1
- 101710106276 Cyclin-dependent kinase 7 Proteins 0.000 description 1
- 102100031679 Cyclin-dependent kinase-like 1 Human genes 0.000 description 1
- 101710178929 Cyclin-dependent kinase-like 1 Proteins 0.000 description 1
- 102000003903 Cyclin-dependent kinases Human genes 0.000 description 1
- 108090000266 Cyclin-dependent kinases Proteins 0.000 description 1
- 108010061642 Cystatin C Proteins 0.000 description 1
- 102100021901 Cysteine protease ATG4A Human genes 0.000 description 1
- 102100021903 Cysteine protease ATG4B Human genes 0.000 description 1
- 102100021902 Cysteine protease ATG4C Human genes 0.000 description 1
- 102100027713 Cysteine protease ATG4D Human genes 0.000 description 1
- UHDGCWIWMRVCDJ-PSQAKQOGSA-N Cytidine Natural products O=C1N=C(N)C=CN1[C@@H]1[C@@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-PSQAKQOGSA-N 0.000 description 1
- 101710171534 Cytochrome b-c1 complex subunit 1, mitochondrial Proteins 0.000 description 1
- 102100039924 Cytochrome b-c1 complex subunit 1, mitochondrial Human genes 0.000 description 1
- 102100039441 Cytochrome b-c1 complex subunit 2, mitochondrial Human genes 0.000 description 1
- 102100028183 Cytohesin-interacting protein Human genes 0.000 description 1
- 102100034560 Cytosol aminopeptidase Human genes 0.000 description 1
- 108010071840 Cytosol nonspecific dipeptidase Proteins 0.000 description 1
- 102100025707 Cytosolic carboxypeptidase 3 Human genes 0.000 description 1
- 102100031007 Cytosolic non-specific dipeptidase Human genes 0.000 description 1
- GSXOAOHZAIYLCY-UHFFFAOYSA-N D-F6P Natural products OCC(=O)C(O)C(O)C(O)COP(O)(O)=O GSXOAOHZAIYLCY-UHFFFAOYSA-N 0.000 description 1
- 150000008574 D-amino acids Chemical class 0.000 description 1
- 108010000214 D-ribulokinase Proteins 0.000 description 1
- 102000053602 DNA Human genes 0.000 description 1
- 108020003215 DNA Probes Proteins 0.000 description 1
- 230000004544 DNA amplification Effects 0.000 description 1
- 239000003298 DNA probe Substances 0.000 description 1
- 108010006124 DNA-Activated Protein Kinase Proteins 0.000 description 1
- 102000005768 DNA-Activated Protein Kinase Human genes 0.000 description 1
- 108700020911 DNA-Binding Proteins Proteins 0.000 description 1
- 102100022204 DNA-dependent protein kinase catalytic subunit Human genes 0.000 description 1
- 108010058222 Deoxyguanosine kinase Proteins 0.000 description 1
- 108030003689 Deoxynucleoside kinases Proteins 0.000 description 1
- 102100040561 Deubiquitinase OTUD6B Human genes 0.000 description 1
- 108010086291 Deubiquitinating Enzyme CYLD Proteins 0.000 description 1
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 description 1
- 102000011107 Diacylglycerol Kinase Human genes 0.000 description 1
- 108010062677 Diacylglycerol Kinase Proteins 0.000 description 1
- 101001031598 Dictyostelium discoideum Probable serine/threonine-protein kinase fhkC Proteins 0.000 description 1
- 102100036238 Dihydropyrimidinase Human genes 0.000 description 1
- 102100024426 Dihydropyrimidinase-related protein 2 Human genes 0.000 description 1
- 102100024425 Dihydropyrimidinase-related protein 3 Human genes 0.000 description 1
- 102100024443 Dihydropyrimidinase-related protein 4 Human genes 0.000 description 1
- 102100024441 Dihydropyrimidinase-related protein 5 Human genes 0.000 description 1
- 102100020743 Dipeptidase 1 Human genes 0.000 description 1
- 102100029858 Dipeptidase 2 Human genes 0.000 description 1
- 102100029857 Dipeptidase 3 Human genes 0.000 description 1
- 108090001081 Dipeptidases Proteins 0.000 description 1
- 102000004860 Dipeptidases Human genes 0.000 description 1
- 108010067722 Dipeptidyl Peptidase 4 Proteins 0.000 description 1
- 102100036966 Dipeptidyl aminopeptidase-like protein 6 Human genes 0.000 description 1
- 102100029921 Dipeptidyl peptidase 1 Human genes 0.000 description 1
- 102100020751 Dipeptidyl peptidase 2 Human genes 0.000 description 1
- 102100020750 Dipeptidyl peptidase 3 Human genes 0.000 description 1
- 102100036968 Dipeptidyl peptidase 8 Human genes 0.000 description 1
- 102100036969 Dipeptidyl peptidase 9 Human genes 0.000 description 1
- 101710087012 Dipeptidyl-peptidase 7 Proteins 0.000 description 1
- 102100031112 Disintegrin and metalloproteinase domain-containing protein 12 Human genes 0.000 description 1
- 102100031113 Disintegrin and metalloproteinase domain-containing protein 15 Human genes 0.000 description 1
- 101710121363 Disintegrin and metalloproteinase domain-containing protein 15 Proteins 0.000 description 1
- 102100031111 Disintegrin and metalloproteinase domain-containing protein 17 Human genes 0.000 description 1
- 102100031098 Disintegrin and metalloproteinase domain-containing protein 18 Human genes 0.000 description 1
- 101710121158 Disintegrin and metalloproteinase domain-containing protein 18 Proteins 0.000 description 1
- 102100024361 Disintegrin and metalloproteinase domain-containing protein 9 Human genes 0.000 description 1
- 101710116121 Disintegrin and metalloproteinase domain-containing protein 9 Proteins 0.000 description 1
- 101100108136 Drosophila melanogaster Adck1 gene Proteins 0.000 description 1
- 101100020292 Drosophila melanogaster Pitslre gene Proteins 0.000 description 1
- 101100410039 Drosophila melanogaster Rpn8 gene Proteins 0.000 description 1
- 101000939518 Drosophila melanogaster Ubiquitin carboxyl-terminal hydrolase Usp2 Proteins 0.000 description 1
- 101100291385 Drosophila melanogaster p38a gene Proteins 0.000 description 1
- 102100029638 Dual serine/threonine and tyrosine protein kinase Human genes 0.000 description 1
- 102100023112 Dual specificity tyrosine-phosphorylation-regulated kinase 4 Human genes 0.000 description 1
- 108091035710 E-box Proteins 0.000 description 1
- 102100029505 E3 ubiquitin-protein ligase TRIM33 Human genes 0.000 description 1
- 108700034637 EC 3.2.-.- Proteins 0.000 description 1
- 108060006698 EGF receptor Proteins 0.000 description 1
- 101710171276 EKC/KEOPS complex subunit TP53RK Proteins 0.000 description 1
- 101150099213 ERN2 gene Proteins 0.000 description 1
- 101710088791 Elongation factor 2 Proteins 0.000 description 1
- 101100059559 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) nimX gene Proteins 0.000 description 1
- 102100021597 Endoplasmic reticulum aminopeptidase 2 Human genes 0.000 description 1
- 102100039328 Endoplasmin Human genes 0.000 description 1
- 102100030013 Endoribonuclease Human genes 0.000 description 1
- 101710199605 Endoribonuclease Proteins 0.000 description 1
- 102000048186 Endothelin-converting enzyme 1 Human genes 0.000 description 1
- 102100029112 Endothelin-converting enzyme 1 Human genes 0.000 description 1
- 108050004623 Endothelin-converting enzyme-like 1 Proteins 0.000 description 1
- 108010001687 Enterotoxin Receptors Proteins 0.000 description 1
- 102000000820 Enterotoxin Receptors Human genes 0.000 description 1
- 101710181478 Envelope glycoprotein GP350 Proteins 0.000 description 1
- 102100025403 Epoxide hydrolase 1 Human genes 0.000 description 1
- 101710167546 Epoxide hydrolase 1 Proteins 0.000 description 1
- 241000283086 Equidae Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 108090000371 Esterases Proteins 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 241000206602 Eukaryota Species 0.000 description 1
- 108010089790 Eukaryotic Initiation Factor-3 Proteins 0.000 description 1
- 102100034255 Eukaryotic translation initiation factor 3 subunit F Human genes 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 108050001049 Extracellular proteins Proteins 0.000 description 1
- 102100026130 Extracellular tyrosine-protein kinase PKDCC Human genes 0.000 description 1
- 108010076282 Factor IX Proteins 0.000 description 1
- 108010023321 Factor VII Proteins 0.000 description 1
- 108010014173 Factor X Proteins 0.000 description 1
- 108010074864 Factor XI Proteins 0.000 description 1
- 108010080865 Factor XII Proteins 0.000 description 1
- 102000000429 Factor XII Human genes 0.000 description 1
- 108010074860 Factor Xa Proteins 0.000 description 1
- 101710117201 Fas-activated serine/threonine kinase Proteins 0.000 description 1
- 241000282324 Felis Species 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 102100037813 Focal adhesion kinase 1 Human genes 0.000 description 1
- 101001076781 Fructilactobacillus sanfranciscensis (strain ATCC 27651 / DSM 20451 / JCM 5668 / CCUG 30143 / KCTC 3205 / NCIMB 702811 / NRRL B-3934 / L-12) Ribose-5-phosphate isomerase A Proteins 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- 206010017533 Fungal infection Diseases 0.000 description 1
- 108090001126 Furin Proteins 0.000 description 1
- 101150111025 Furin gene Proteins 0.000 description 1
- 102100023734 G protein-coupled receptor kinase 4 Human genes 0.000 description 1
- 102100023685 G protein-coupled receptor kinase 5 Human genes 0.000 description 1
- 102100023686 G protein-coupled receptor kinase 6 Human genes 0.000 description 1
- 108091004242 G-Protein-Coupled Receptor Kinase 1 Proteins 0.000 description 1
- 102100036858 GPI-anchor transamidase Human genes 0.000 description 1
- 102000001267 GSK3 Human genes 0.000 description 1
- 108060006662 GSK3 Proteins 0.000 description 1
- 208000017462 Galactosialidosis Diseases 0.000 description 1
- 102000002464 Galactosidases Human genes 0.000 description 1
- 108010093031 Galactosidases Proteins 0.000 description 1
- 108090001072 Gastricsin Proteins 0.000 description 1
- 208000018522 Gastrointestinal disease Diseases 0.000 description 1
- 102100033264 Geranylgeranyl transferase type-1 subunit beta Human genes 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- 102100033424 Glutamine-fructose-6-phosphate aminotransferase [isomerizing] 2 Human genes 0.000 description 1
- 102100029846 Glutaminyl-peptide cyclotransferase Human genes 0.000 description 1
- 102100025783 Glutamyl aminopeptidase Human genes 0.000 description 1
- 102100034063 Glutathione hydrolase 7 Human genes 0.000 description 1
- 102100025527 Glutathione hydrolase light chain 2 Human genes 0.000 description 1
- 102100025591 Glycerate kinase Human genes 0.000 description 1
- 102000057621 Glycerol kinases Human genes 0.000 description 1
- 108700016170 Glycerol kinases Proteins 0.000 description 1
- 108010014905 Glycogen Synthase Kinase 3 Proteins 0.000 description 1
- 102000002254 Glycogen Synthase Kinase 3 Human genes 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- 102000051366 Glycosyltransferases Human genes 0.000 description 1
- 108700023372 Glycosyltransferases Proteins 0.000 description 1
- 206010072579 Granulomatosis with polyangiitis Diseases 0.000 description 1
- 101710113220 Granzyme H Proteins 0.000 description 1
- 108010043121 Green Fluorescent Proteins Proteins 0.000 description 1
- 102000004144 Green Fluorescent Proteins Human genes 0.000 description 1
- 108010012029 Guanine Deaminase Proteins 0.000 description 1
- 102000013587 Guanine deaminase Human genes 0.000 description 1
- 102100039218 Guanine deaminase Human genes 0.000 description 1
- 108020004202 Guanylate Kinase Proteins 0.000 description 1
- 101710191387 Guanylate cyclase 2D Proteins 0.000 description 1
- 102100022662 Guanylyl cyclase C Human genes 0.000 description 1
- 102100030488 HEAT repeat-containing protein 6 Human genes 0.000 description 1
- 108010043026 HGF activator Proteins 0.000 description 1
- 102100034051 Heat shock protein HSP 90-alpha Human genes 0.000 description 1
- 102100032510 Heat shock protein HSP 90-beta Human genes 0.000 description 1
- 102100023043 Heat shock protein beta-8 Human genes 0.000 description 1
- 102000003745 Hepatocyte Growth Factor Human genes 0.000 description 1
- 102100031465 Hepatocyte growth factor activator Human genes 0.000 description 1
- 102000004989 Hepsin Human genes 0.000 description 1
- 108090001101 Hepsin Proteins 0.000 description 1
- 108010084680 Heterogeneous-Nuclear Ribonucleoprotein K Proteins 0.000 description 1
- 102000005548 Hexokinase Human genes 0.000 description 1
- 102100029237 Hexokinase-4 Human genes 0.000 description 1
- 108700040460 Hexokinases Proteins 0.000 description 1
- 108010072039 Histidine kinase Proteins 0.000 description 1
- 102100032822 Homeodomain-interacting protein kinase 1 Human genes 0.000 description 1
- 101000590281 Homo sapiens 26S proteasome non-ATPase regulatory subunit 14 Proteins 0.000 description 1
- 101000600756 Homo sapiens 3-phosphoinositide-dependent protein kinase 1 Proteins 0.000 description 1
- 101000627872 Homo sapiens 72 kDa type IV collagenase Proteins 0.000 description 1
- 101000719904 Homo sapiens ADAM DEC1 Proteins 0.000 description 1
- 101000780591 Homo sapiens AFG3-like protein 2 Proteins 0.000 description 1
- 101000750222 Homo sapiens ATP-dependent Clp protease proteolytic subunit, mitochondrial Proteins 0.000 description 1
- 101000801359 Homo sapiens Acetylcholinesterase Proteins 0.000 description 1
- 101000798584 Homo sapiens Acylamino-acid-releasing enzyme Proteins 0.000 description 1
- 101000783712 Homo sapiens Alpha-2-antiplasmin Proteins 0.000 description 1
- 101000779565 Homo sapiens Alpha-protein kinase 2 Proteins 0.000 description 1
- 101000742837 Homo sapiens Alpha/beta hydrolase domain-containing protein 17A Proteins 0.000 description 1
- 101000775829 Homo sapiens Aminopeptidase B Proteins 0.000 description 1
- 101000889627 Homo sapiens Aminopeptidase O Proteins 0.000 description 1
- 101000889673 Homo sapiens Aminopeptidase Q Proteins 0.000 description 1
- 101000889990 Homo sapiens Apolipoprotein(a) Proteins 0.000 description 1
- 101000975992 Homo sapiens Asparagine synthetase [glutamine-hydrolyzing] Proteins 0.000 description 1
- 101000927708 Homo sapiens Aspartyl aminopeptidase Proteins 0.000 description 1
- 101000936739 Homo sapiens Astacin-like metalloendopeptidase Proteins 0.000 description 1
- 101000961044 Homo sapiens Atrial natriuretic peptide receptor 1 Proteins 0.000 description 1
- 101000961040 Homo sapiens Atrial natriuretic peptide receptor 2 Proteins 0.000 description 1
- 101000952934 Homo sapiens Atrial natriuretic peptide-converting enzyme Proteins 0.000 description 1
- 101000765862 Homo sapiens Aurora kinase C Proteins 0.000 description 1
- 101000762370 Homo sapiens BMP-2-inducible protein kinase Proteins 0.000 description 1
- 101000751445 Homo sapiens Beta-adrenergic receptor kinase 1 Proteins 0.000 description 1
- 101000894883 Homo sapiens Beta-secretase 2 Proteins 0.000 description 1
- 101000984541 Homo sapiens Bleomycin hydrolase Proteins 0.000 description 1
- 101000695352 Homo sapiens Bone morphogenetic protein 1 Proteins 0.000 description 1
- 101000896891 Homo sapiens Brain-specific serine protease 4 Proteins 0.000 description 1
- 101000794024 Homo sapiens Bromodomain-containing protein 4 Proteins 0.000 description 1
- 101000914211 Homo sapiens CASP8 and FADD-like apoptosis regulator Proteins 0.000 description 1
- 101000896048 Homo sapiens COP9 signalosome complex subunit 5 Proteins 0.000 description 1
- 101000860047 Homo sapiens COP9 signalosome complex subunit 6 Proteins 0.000 description 1
- 101000944250 Homo sapiens Calcium/calmodulin-dependent protein kinase type 1 Proteins 0.000 description 1
- 101000933733 Homo sapiens Calpain-14 Proteins 0.000 description 1
- 101000934071 Homo sapiens Calpain-15 Proteins 0.000 description 1
- 101000793671 Homo sapiens Calpain-6 Proteins 0.000 description 1
- 101000793675 Homo sapiens Calpain-8 Proteins 0.000 description 1
- 101000772572 Homo sapiens Carboxypeptidase A4 Proteins 0.000 description 1
- 101000910789 Homo sapiens Carboxypeptidase A5 Proteins 0.000 description 1
- 101000910782 Homo sapiens Carboxypeptidase A6 Proteins 0.000 description 1
- 101000946518 Homo sapiens Carboxypeptidase B2 Proteins 0.000 description 1
- 101000910843 Homo sapiens Carboxypeptidase N catalytic chain Proteins 0.000 description 1
- 101000910846 Homo sapiens Carboxypeptidase Q Proteins 0.000 description 1
- 101000859758 Homo sapiens Cartilage-associated protein Proteins 0.000 description 1
- 101000994694 Homo sapiens Casein kinase I isoform alpha-like Proteins 0.000 description 1
- 101001026336 Homo sapiens Casein kinase I isoform delta Proteins 0.000 description 1
- 101001026376 Homo sapiens Casein kinase I isoform epsilon Proteins 0.000 description 1
- 101001026384 Homo sapiens Casein kinase I isoform gamma-1 Proteins 0.000 description 1
- 101001049881 Homo sapiens Casein kinase I isoform gamma-2 Proteins 0.000 description 1
- 101001049879 Homo sapiens Casein kinase I isoform gamma-3 Proteins 0.000 description 1
- 101000933112 Homo sapiens Caspase-4 Proteins 0.000 description 1
- 101000741072 Homo sapiens Caspase-5 Proteins 0.000 description 1
- 101000741087 Homo sapiens Caspase-6 Proteins 0.000 description 1
- 101000741014 Homo sapiens Caspase-7 Proteins 0.000 description 1
- 101000983523 Homo sapiens Caspase-9 Proteins 0.000 description 1
- 101000898449 Homo sapiens Cathepsin B Proteins 0.000 description 1
- 101000869010 Homo sapiens Cathepsin D Proteins 0.000 description 1
- 101000869031 Homo sapiens Cathepsin E Proteins 0.000 description 1
- 101000933218 Homo sapiens Cathepsin F Proteins 0.000 description 1
- 101000933179 Homo sapiens Cathepsin G Proteins 0.000 description 1
- 101000983577 Homo sapiens Cathepsin L2 Proteins 0.000 description 1
- 101000740970 Homo sapiens Cathepsin O Proteins 0.000 description 1
- 101000910988 Homo sapiens Cathepsin W Proteins 0.000 description 1
- 101000910979 Homo sapiens Cathepsin Z Proteins 0.000 description 1
- 101000943274 Homo sapiens Cholinesterase Proteins 0.000 description 1
- 101000889306 Homo sapiens Chymotrypsin-C Proteins 0.000 description 1
- 101000737684 Homo sapiens Chymotrypsin-like elastase family member 1 Proteins 0.000 description 1
- 101000907961 Homo sapiens Chymotrypsin-like elastase family member 2B Proteins 0.000 description 1
- 101000889273 Homo sapiens Chymotrypsinogen B Proteins 0.000 description 1
- 101000856200 Homo sapiens Citron Rho-interacting kinase Proteins 0.000 description 1
- 101000898006 Homo sapiens Cocaine esterase Proteins 0.000 description 1
- 101000577887 Homo sapiens Collagenase 3 Proteins 0.000 description 1
- 101000794267 Homo sapiens Complement C1r subcomponent-like protein Proteins 0.000 description 1
- 101000710032 Homo sapiens Complement factor B Proteins 0.000 description 1
- 101000737565 Homo sapiens Complement factor I Proteins 0.000 description 1
- 101000908138 Homo sapiens Cyclin-dependent kinase 10 Proteins 0.000 description 1
- 101000884374 Homo sapiens Cyclin-dependent kinase 14 Proteins 0.000 description 1
- 101000944355 Homo sapiens Cyclin-dependent kinase 15 Proteins 0.000 description 1
- 101000944357 Homo sapiens Cyclin-dependent kinase 16 Proteins 0.000 description 1
- 101000944345 Homo sapiens Cyclin-dependent kinase 19 Proteins 0.000 description 1
- 101000980930 Homo sapiens Cyclin-dependent kinase 9 Proteins 0.000 description 1
- 101000912205 Homo sapiens Cystatin-C Proteins 0.000 description 1
- 101000753414 Homo sapiens Cysteine protease ATG4A Proteins 0.000 description 1
- 101000753468 Homo sapiens Cysteine protease ATG4B Proteins 0.000 description 1
- 101000753453 Homo sapiens Cysteine protease ATG4C Proteins 0.000 description 1
- 101000936854 Homo sapiens Cysteine protease ATG4D Proteins 0.000 description 1
- 101000875170 Homo sapiens Cytochrome P450 2A6 Proteins 0.000 description 1
- 101000746756 Homo sapiens Cytochrome b-c1 complex subunit 2, mitochondrial Proteins 0.000 description 1
- 101000916686 Homo sapiens Cytohesin-interacting protein Proteins 0.000 description 1
- 101000924389 Homo sapiens Cytosol aminopeptidase Proteins 0.000 description 1
- 101000932588 Homo sapiens Cytosolic carboxypeptidase 3 Proteins 0.000 description 1
- 101000919690 Homo sapiens Cytosolic non-specific dipeptidase Proteins 0.000 description 1
- 101000619536 Homo sapiens DNA-dependent protein kinase catalytic subunit Proteins 0.000 description 1
- 101000613797 Homo sapiens Deubiquitinase OTUD6B Proteins 0.000 description 1
- 101000930818 Homo sapiens Dihydropyrimidinase Proteins 0.000 description 1
- 101001053503 Homo sapiens Dihydropyrimidinase-related protein 2 Proteins 0.000 description 1
- 101001053501 Homo sapiens Dihydropyrimidinase-related protein 3 Proteins 0.000 description 1
- 101001053490 Homo sapiens Dihydropyrimidinase-related protein 4 Proteins 0.000 description 1
- 101001053479 Homo sapiens Dihydropyrimidinase-related protein 5 Proteins 0.000 description 1
- 101000932213 Homo sapiens Dipeptidase 1 Proteins 0.000 description 1
- 101000864123 Homo sapiens Dipeptidase 2 Proteins 0.000 description 1
- 101000864130 Homo sapiens Dipeptidase 3 Proteins 0.000 description 1
- 101000804935 Homo sapiens Dipeptidyl aminopeptidase-like protein 6 Proteins 0.000 description 1
- 101000793922 Homo sapiens Dipeptidyl peptidase 1 Proteins 0.000 description 1
- 101000931862 Homo sapiens Dipeptidyl peptidase 3 Proteins 0.000 description 1
- 101000804947 Homo sapiens Dipeptidyl peptidase 8 Proteins 0.000 description 1
- 101000804945 Homo sapiens Dipeptidyl peptidase 9 Proteins 0.000 description 1
- 101000689653 Homo sapiens Disintegrin and metalloproteinase domain-containing protein 20 Proteins 0.000 description 1
- 101000689659 Homo sapiens Disintegrin and metalloproteinase domain-containing protein 21 Proteins 0.000 description 1
- 101000756722 Homo sapiens Disintegrin and metalloproteinase domain-containing protein 22 Proteins 0.000 description 1
- 101000756727 Homo sapiens Disintegrin and metalloproteinase domain-containing protein 23 Proteins 0.000 description 1
- 101000756746 Homo sapiens Disintegrin and metalloproteinase domain-containing protein 29 Proteins 0.000 description 1
- 101000720046 Homo sapiens Disintegrin and metalloproteinase domain-containing protein 30 Proteins 0.000 description 1
- 101000720047 Homo sapiens Disintegrin and metalloproteinase domain-containing protein 32 Proteins 0.000 description 1
- 101000720049 Homo sapiens Disintegrin and metalloproteinase domain-containing protein 33 Proteins 0.000 description 1
- 101000832771 Homo sapiens Disintegrin and metalloproteinase domain-containing protein 7 Proteins 0.000 description 1
- 101000832767 Homo sapiens Disintegrin and metalloproteinase domain-containing protein 8 Proteins 0.000 description 1
- 101000832769 Homo sapiens Disintegrin and metalloproteinase domain-containing protein 9 Proteins 0.000 description 1
- 101000865739 Homo sapiens Dual serine/threonine and tyrosine protein kinase Proteins 0.000 description 1
- 101000749294 Homo sapiens Dual specificity protein kinase CLK1 Proteins 0.000 description 1
- 101001049983 Homo sapiens Dual specificity tyrosine-phosphorylation-regulated kinase 4 Proteins 0.000 description 1
- 101000634991 Homo sapiens E3 ubiquitin-protein ligase TRIM33 Proteins 0.000 description 1
- 101000898718 Homo sapiens Endoplasmic reticulum aminopeptidase 2 Proteins 0.000 description 1
- 101000812663 Homo sapiens Endoplasmin Proteins 0.000 description 1
- 101001010783 Homo sapiens Endoribonuclease Proteins 0.000 description 1
- 101000841259 Homo sapiens Endothelin-converting enzyme 1 Proteins 0.000 description 1
- 101000841255 Homo sapiens Endothelin-converting enzyme 2 Proteins 0.000 description 1
- 101000967016 Homo sapiens Endothelin-converting enzyme-like 1 Proteins 0.000 description 1
- 101000691796 Homo sapiens Extracellular tyrosine-protein kinase PKDCC Proteins 0.000 description 1
- 101000878536 Homo sapiens Focal adhesion kinase 1 Proteins 0.000 description 1
- 101001071309 Homo sapiens GPI-anchor transamidase Proteins 0.000 description 1
- 101001071129 Homo sapiens Geranylgeranyl transferase type-1 subunit beta Proteins 0.000 description 1
- 101000997966 Homo sapiens Glutamine-fructose-6-phosphate aminotransferase [isomerizing] 2 Proteins 0.000 description 1
- 101000585315 Homo sapiens Glutaminyl-peptide cyclotransferase Proteins 0.000 description 1
- 101000719019 Homo sapiens Glutamyl aminopeptidase Proteins 0.000 description 1
- 101000926240 Homo sapiens Glutathione hydrolase 7 Proteins 0.000 description 1
- 101000856496 Homo sapiens Glutathione hydrolase light chain 2 Proteins 0.000 description 1
- 101000899808 Homo sapiens Guanylyl cyclase C Proteins 0.000 description 1
- 101000990566 Homo sapiens HEAT repeat-containing protein 6 Proteins 0.000 description 1
- 101001016865 Homo sapiens Heat shock protein HSP 90-alpha Proteins 0.000 description 1
- 101001016856 Homo sapiens Heat shock protein HSP 90-beta Proteins 0.000 description 1
- 101001047341 Homo sapiens Heat shock protein beta-8 Proteins 0.000 description 1
- 101001066338 Homo sapiens Hepatocyte growth factor activator Proteins 0.000 description 1
- 101001066435 Homo sapiens Hepatocyte growth factor-like protein Proteins 0.000 description 1
- 101000726740 Homo sapiens Homeobox protein cut-like 1 Proteins 0.000 description 1
- 101001066404 Homo sapiens Homeodomain-interacting protein kinase 1 Proteins 0.000 description 1
- 101001035951 Homo sapiens Hyaluronan-binding protein 2 Proteins 0.000 description 1
- 101000599573 Homo sapiens InaD-like protein Proteins 0.000 description 1
- 101000919167 Homo sapiens Inactive carboxypeptidase-like protein X2 Proteins 0.000 description 1
- 101000983515 Homo sapiens Inactive caspase-12 Proteins 0.000 description 1
- 101000926208 Homo sapiens Inactive glutathione hydrolase 2 Proteins 0.000 description 1
- 101000610630 Homo sapiens Inactive serine protease 35 Proteins 0.000 description 1
- 101000705915 Homo sapiens Inactive serine protease 54 Proteins 0.000 description 1
- 101000649963 Homo sapiens Inactive serine/threonine-protein kinase VRK3 Proteins 0.000 description 1
- 101000734676 Homo sapiens Inactive tyrosine-protein kinase PEAK1 Proteins 0.000 description 1
- 101000741965 Homo sapiens Inactive tyrosine-protein kinase PRAG1 Proteins 0.000 description 1
- 101000809239 Homo sapiens Inactive ubiquitin carboxyl-terminal hydrolase 53 Proteins 0.000 description 1
- 101001008919 Homo sapiens Kallikrein-10 Proteins 0.000 description 1
- 101000605516 Homo sapiens Kallikrein-12 Proteins 0.000 description 1
- 101000605514 Homo sapiens Kallikrein-13 Proteins 0.000 description 1
- 101000605520 Homo sapiens Kallikrein-14 Proteins 0.000 description 1
- 101000605518 Homo sapiens Kallikrein-15 Proteins 0.000 description 1
- 101000605528 Homo sapiens Kallikrein-2 Proteins 0.000 description 1
- 101001091379 Homo sapiens Kallikrein-5 Proteins 0.000 description 1
- 101001091388 Homo sapiens Kallikrein-7 Proteins 0.000 description 1
- 101001091356 Homo sapiens Kallikrein-9 Proteins 0.000 description 1
- 101000614145 Homo sapiens Kynurenine formamidase Proteins 0.000 description 1
- 101001063370 Homo sapiens Legumain Proteins 0.000 description 1
- 101001005155 Homo sapiens Leishmanolysin-like peptidase Proteins 0.000 description 1
- 101001137975 Homo sapiens Leucyl-cystinyl aminopeptidase Proteins 0.000 description 1
- 101000619898 Homo sapiens Leukotriene A-4 hydrolase Proteins 0.000 description 1
- 101000938676 Homo sapiens Liver carboxylesterase 1 Proteins 0.000 description 1
- 101001005245 Homo sapiens Lon protease homolog 2, peroxisomal Proteins 0.000 description 1
- 101000742901 Homo sapiens Lysophosphatidylserine lipase ABHD12 Proteins 0.000 description 1
- 101001018978 Homo sapiens MAP kinase-interacting serine/threonine-protein kinase 2 Proteins 0.000 description 1
- 101000590679 Homo sapiens MPN domain-containing protein Proteins 0.000 description 1
- 101000577881 Homo sapiens Macrophage metalloelastase Proteins 0.000 description 1
- 101001055956 Homo sapiens Mannan-binding lectin serine protease 1 Proteins 0.000 description 1
- 101001056015 Homo sapiens Mannan-binding lectin serine protease 2 Proteins 0.000 description 1
- 101000990912 Homo sapiens Matrilysin Proteins 0.000 description 1
- 101001011906 Homo sapiens Matrix metalloproteinase-14 Proteins 0.000 description 1
- 101001011884 Homo sapiens Matrix metalloproteinase-15 Proteins 0.000 description 1
- 101001011886 Homo sapiens Matrix metalloproteinase-16 Proteins 0.000 description 1
- 101001011896 Homo sapiens Matrix metalloproteinase-19 Proteins 0.000 description 1
- 101001013139 Homo sapiens Matrix metalloproteinase-20 Proteins 0.000 description 1
- 101001013142 Homo sapiens Matrix metalloproteinase-21 Proteins 0.000 description 1
- 101000627858 Homo sapiens Matrix metalloproteinase-24 Proteins 0.000 description 1
- 101000627854 Homo sapiens Matrix metalloproteinase-26 Proteins 0.000 description 1
- 101000627860 Homo sapiens Matrix metalloproteinase-27 Proteins 0.000 description 1
- 101000627861 Homo sapiens Matrix metalloproteinase-28 Proteins 0.000 description 1
- 101000990902 Homo sapiens Matrix metalloproteinase-9 Proteins 0.000 description 1
- 101000798109 Homo sapiens Melanotransferrin Proteins 0.000 description 1
- 101000581514 Homo sapiens Membrane-bound transcription factor site-2 protease Proteins 0.000 description 1
- 101000991619 Homo sapiens Meprin A subunit alpha Proteins 0.000 description 1
- 101000991618 Homo sapiens Meprin A subunit beta Proteins 0.000 description 1
- 101000578762 Homo sapiens Methionine aminopeptidase 1D, mitochondrial Proteins 0.000 description 1
- 101000979001 Homo sapiens Methionine aminopeptidase 2 Proteins 0.000 description 1
- 101000988591 Homo sapiens Minor histocompatibility antigen H13 Proteins 0.000 description 1
- 101000960590 Homo sapiens Mitochondrial inner membrane protease subunit 1 Proteins 0.000 description 1
- 101000628925 Homo sapiens Mitochondrial intermediate peptidase Proteins 0.000 description 1
- 101000576973 Homo sapiens Mitochondrial-processing peptidase subunit beta Proteins 0.000 description 1
- 101000628967 Homo sapiens Mitogen-activated protein kinase 11 Proteins 0.000 description 1
- 101000950687 Homo sapiens Mitogen-activated protein kinase 7 Proteins 0.000 description 1
- 101000950695 Homo sapiens Mitogen-activated protein kinase 8 Proteins 0.000 description 1
- 101001059991 Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 1 Proteins 0.000 description 1
- 101001059990 Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 2 Proteins 0.000 description 1
- 101001012646 Homo sapiens Monoglyceride lipase Proteins 0.000 description 1
- 101001030197 Homo sapiens Myelin transcription factor 1 Proteins 0.000 description 1
- 101001022780 Homo sapiens Myosin light chain kinase, smooth muscle Proteins 0.000 description 1
- 101001128148 Homo sapiens N-acetylated-alpha-linked acidic dipeptidase 2 Proteins 0.000 description 1
- 101000797269 Homo sapiens N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) Proteins 0.000 description 1
- 101001123834 Homo sapiens Neprilysin Proteins 0.000 description 1
- 101000601394 Homo sapiens Neuroendocrine convertase 2 Proteins 0.000 description 1
- 101000603239 Homo sapiens Neuroligin-1 Proteins 0.000 description 1
- 101000603173 Homo sapiens Neuroligin-2 Proteins 0.000 description 1
- 101000603172 Homo sapiens Neuroligin-3 Proteins 0.000 description 1
- 101000996111 Homo sapiens Neuroligin-4, X-linked Proteins 0.000 description 1
- 101000996109 Homo sapiens Neuroligin-4, Y-linked Proteins 0.000 description 1
- 101001023733 Homo sapiens Neurotrypsin Proteins 0.000 description 1
- 101000990908 Homo sapiens Neutrophil collagenase Proteins 0.000 description 1
- 101000851058 Homo sapiens Neutrophil elastase Proteins 0.000 description 1
- 101000721835 Homo sapiens Nuclear pore complex protein Nup98-Nup96 Proteins 0.000 description 1
- 101000633310 Homo sapiens Nuclear receptor-interacting protein 3 Proteins 0.000 description 1
- 101000721380 Homo sapiens OTU domain-containing protein 1 Proteins 0.000 description 1
- 101000721382 Homo sapiens OTU domain-containing protein 3 Proteins 0.000 description 1
- 101000721384 Homo sapiens OTU domain-containing protein 4 Proteins 0.000 description 1
- 101000721386 Homo sapiens OTU domain-containing protein 5 Proteins 0.000 description 1
- 101000613787 Homo sapiens OTU domain-containing protein 6A Proteins 0.000 description 1
- 101001121386 Homo sapiens Ovochymase-1 Proteins 0.000 description 1
- 101001121388 Homo sapiens Ovochymase-2 Proteins 0.000 description 1
- 101000598781 Homo sapiens Oxidative stress-responsive serine-rich protein 1 Proteins 0.000 description 1
- 101000982939 Homo sapiens PAN2-PAN3 deadenylation complex catalytic subunit PAN2 Proteins 0.000 description 1
- 101100243116 Homo sapiens PDK1 gene Proteins 0.000 description 1
- 101100244966 Homo sapiens PRKX gene Proteins 0.000 description 1
- 101000677825 Homo sapiens Palmitoyl-protein thioesterase ABHD10, mitochondrial Proteins 0.000 description 1
- 101000610209 Homo sapiens Pappalysin-2 Proteins 0.000 description 1
- 101000606728 Homo sapiens Pepsin A-3 Proteins 0.000 description 1
- 101000606748 Homo sapiens Pepsin A-5 Proteins 0.000 description 1
- 101000801684 Homo sapiens Phospholipid-transporting ATPase ABCA1 Proteins 0.000 description 1
- 101001136034 Homo sapiens Phosphoribosylformylglycinamidine synthase Proteins 0.000 description 1
- 101001091365 Homo sapiens Plasma kallikrein Proteins 0.000 description 1
- 101000906619 Homo sapiens Polyribonucleotide 5'-hydroxyl-kinase Clp1 Proteins 0.000 description 1
- 101000687782 Homo sapiens Polyserase-2 Proteins 0.000 description 1
- 101001105683 Homo sapiens Pre-mRNA-processing-splicing factor 8 Proteins 0.000 description 1
- 101000617536 Homo sapiens Presenilin-1 Proteins 0.000 description 1
- 101000617546 Homo sapiens Presenilin-2 Proteins 0.000 description 1
- 101000933173 Homo sapiens Pro-cathepsin H Proteins 0.000 description 1
- 101000919183 Homo sapiens Probable carboxypeptidase X1 Proteins 0.000 description 1
- 101000745667 Homo sapiens Probable serine carboxypeptidase CPVL Proteins 0.000 description 1
- 101000598806 Homo sapiens Probable tRNA N6-adenosine threonylcarbamoyltransferase Proteins 0.000 description 1
- 101000808592 Homo sapiens Probable ubiquitin carboxyl-terminal hydrolase FAF-X Proteins 0.000 description 1
- 101000808590 Homo sapiens Probable ubiquitin carboxyl-terminal hydrolase FAF-Y Proteins 0.000 description 1
- 101000983583 Homo sapiens Procathepsin L Proteins 0.000 description 1
- 101000983170 Homo sapiens Proliferation-associated protein 2G4 Proteins 0.000 description 1
- 101000684208 Homo sapiens Prolyl endopeptidase FAP Proteins 0.000 description 1
- 101001095240 Homo sapiens Prolyl endopeptidase-like Proteins 0.000 description 1
- 101001072067 Homo sapiens Proprotein convertase subtilisin/kexin type 4 Proteins 0.000 description 1
- 101001072081 Homo sapiens Proprotein convertase subtilisin/kexin type 5 Proteins 0.000 description 1
- 101001098833 Homo sapiens Proprotein convertase subtilisin/kexin type 6 Proteins 0.000 description 1
- 101001098872 Homo sapiens Proprotein convertase subtilisin/kexin type 7 Proteins 0.000 description 1
- 101001098868 Homo sapiens Proprotein convertase subtilisin/kexin type 9 Proteins 0.000 description 1
- 101001125574 Homo sapiens Prostasin Proteins 0.000 description 1
- 101000610781 Homo sapiens Proteasome subunit alpha type-2 Proteins 0.000 description 1
- 101001136888 Homo sapiens Proteasome subunit alpha type-3 Proteins 0.000 description 1
- 101000577424 Homo sapiens Proteasome subunit alpha type-4 Proteins 0.000 description 1
- 101001124667 Homo sapiens Proteasome subunit alpha type-5 Proteins 0.000 description 1
- 101001090813 Homo sapiens Proteasome subunit alpha type-6 Proteins 0.000 description 1
- 101001105486 Homo sapiens Proteasome subunit alpha type-7 Proteins 0.000 description 1
- 101000612692 Homo sapiens Proteasome subunit alpha-type 8 Proteins 0.000 description 1
- 101000611053 Homo sapiens Proteasome subunit beta type-2 Proteins 0.000 description 1
- 101001089120 Homo sapiens Proteasome subunit beta type-3 Proteins 0.000 description 1
- 101000592466 Homo sapiens Proteasome subunit beta type-4 Proteins 0.000 description 1
- 101000735881 Homo sapiens Proteasome subunit beta type-5 Proteins 0.000 description 1
- 101000735893 Homo sapiens Proteasome subunit beta type-6 Proteins 0.000 description 1
- 101001136954 Homo sapiens Proteasome subunit beta type-7 Proteins 0.000 description 1
- 101000677831 Homo sapiens Protein ABHD11 Proteins 0.000 description 1
- 101000677768 Homo sapiens Protein ABHD12B Proteins 0.000 description 1
- 101000760638 Homo sapiens Protein ABHD16B Proteins 0.000 description 1
- 101000677895 Homo sapiens Protein ABHD8 Proteins 0.000 description 1
- 101000761460 Homo sapiens Protein CASP Proteins 0.000 description 1
- 101000979748 Homo sapiens Protein NDRG1 Proteins 0.000 description 1
- 101000836974 Homo sapiens Protein O-mannose kinase Proteins 0.000 description 1
- 101000716750 Homo sapiens Protein SCAF11 Proteins 0.000 description 1
- 101001051767 Homo sapiens Protein kinase C beta type Proteins 0.000 description 1
- 101001026864 Homo sapiens Protein kinase C gamma type Proteins 0.000 description 1
- 101000971404 Homo sapiens Protein kinase C iota type Proteins 0.000 description 1
- 101000971468 Homo sapiens Protein kinase C zeta type Proteins 0.000 description 1
- 101000613717 Homo sapiens Protein odd-skipped-related 1 Proteins 0.000 description 1
- 101000651439 Homo sapiens Prothrombin Proteins 0.000 description 1
- 101000592517 Homo sapiens Puromycin-sensitive aminopeptidase Proteins 0.000 description 1
- 101001091615 Homo sapiens Putative protein KRIP1 Proteins 0.000 description 1
- 101000741737 Homo sapiens Putative serine protease 42 Proteins 0.000 description 1
- 101000741739 Homo sapiens Putative serine protease 45 Proteins 0.000 description 1
- 101000777204 Homo sapiens Putative ubiquitin carboxyl-terminal hydrolase 41 Proteins 0.000 description 1
- 101000779418 Homo sapiens RAC-alpha serine/threonine-protein kinase Proteins 0.000 description 1
- 101000798015 Homo sapiens RAC-beta serine/threonine-protein kinase Proteins 0.000 description 1
- 101000798007 Homo sapiens RAC-gamma serine/threonine-protein kinase Proteins 0.000 description 1
- 101000686246 Homo sapiens Ras-related protein R-Ras Proteins 0.000 description 1
- 101000606545 Homo sapiens Receptor-type tyrosine-protein phosphatase F Proteins 0.000 description 1
- 101000899806 Homo sapiens Retinal guanylyl cyclase 1 Proteins 0.000 description 1
- 101001009847 Homo sapiens Retinal guanylyl cyclase 2 Proteins 0.000 description 1
- 101000574648 Homo sapiens Retinoid-inducible serine carboxypeptidase Proteins 0.000 description 1
- 101000669917 Homo sapiens Rho-associated protein kinase 1 Proteins 0.000 description 1
- 101000708979 Homo sapiens Rhomboid-related protein 1 Proteins 0.000 description 1
- 101000944909 Homo sapiens Ribosomal protein S6 kinase alpha-1 Proteins 0.000 description 1
- 101001051707 Homo sapiens Ribosomal protein S6 kinase delta-1 Proteins 0.000 description 1
- 101000617778 Homo sapiens SNF-related serine/threonine-protein kinase Proteins 0.000 description 1
- 101000832248 Homo sapiens STAM-binding protein Proteins 0.000 description 1
- 101000701497 Homo sapiens STE20/SPS1-related proline-alanine-rich protein kinase Proteins 0.000 description 1
- 101000654339 Homo sapiens Secernin-2 Proteins 0.000 description 1
- 101000654301 Homo sapiens Secernin-3 Proteins 0.000 description 1
- 101000684497 Homo sapiens Sentrin-specific protease 2 Proteins 0.000 description 1
- 101000684503 Homo sapiens Sentrin-specific protease 3 Proteins 0.000 description 1
- 101000684514 Homo sapiens Sentrin-specific protease 6 Proteins 0.000 description 1
- 101000708009 Homo sapiens Sentrin-specific protease 8 Proteins 0.000 description 1
- 101000604981 Homo sapiens Serine beta-lactamase-like protein LACTB, mitochondrial Proteins 0.000 description 1
- 101001069710 Homo sapiens Serine protease 23 Proteins 0.000 description 1
- 101000610616 Homo sapiens Serine protease 27 Proteins 0.000 description 1
- 101000610626 Homo sapiens Serine protease 33 Proteins 0.000 description 1
- 101000619121 Homo sapiens Serine protease 48 Proteins 0.000 description 1
- 101000705949 Homo sapiens Serine protease 57 Proteins 0.000 description 1
- 101000785063 Homo sapiens Serine-protein kinase ATM Proteins 0.000 description 1
- 101000628578 Homo sapiens Serine/threonine-protein kinase 16 Proteins 0.000 description 1
- 101000880439 Homo sapiens Serine/threonine-protein kinase 3 Proteins 0.000 description 1
- 101000697591 Homo sapiens Serine/threonine-protein kinase 32A Proteins 0.000 description 1
- 101000701395 Homo sapiens Serine/threonine-protein kinase 35 Proteins 0.000 description 1
- 101000701405 Homo sapiens Serine/threonine-protein kinase 36 Proteins 0.000 description 1
- 101000880431 Homo sapiens Serine/threonine-protein kinase 4 Proteins 0.000 description 1
- 101000880461 Homo sapiens Serine/threonine-protein kinase 40 Proteins 0.000 description 1
- 101000984753 Homo sapiens Serine/threonine-protein kinase B-raf Proteins 0.000 description 1
- 101000695043 Homo sapiens Serine/threonine-protein kinase BRSK1 Proteins 0.000 description 1
- 101000885387 Homo sapiens Serine/threonine-protein kinase DCLK2 Proteins 0.000 description 1
- 101000885383 Homo sapiens Serine/threonine-protein kinase DCLK3 Proteins 0.000 description 1
- 101001047642 Homo sapiens Serine/threonine-protein kinase LATS1 Proteins 0.000 description 1
- 101001047637 Homo sapiens Serine/threonine-protein kinase LATS2 Proteins 0.000 description 1
- 101000691459 Homo sapiens Serine/threonine-protein kinase N2 Proteins 0.000 description 1
- 101000691455 Homo sapiens Serine/threonine-protein kinase N3 Proteins 0.000 description 1
- 101001123812 Homo sapiens Serine/threonine-protein kinase Nek11 Proteins 0.000 description 1
- 101000601456 Homo sapiens Serine/threonine-protein kinase Nek3 Proteins 0.000 description 1
- 101000601467 Homo sapiens Serine/threonine-protein kinase Nek5 Proteins 0.000 description 1
- 101000588540 Homo sapiens Serine/threonine-protein kinase Nek6 Proteins 0.000 description 1
- 101000588545 Homo sapiens Serine/threonine-protein kinase Nek7 Proteins 0.000 description 1
- 101000588548 Homo sapiens Serine/threonine-protein kinase Nek8 Proteins 0.000 description 1
- 101000628562 Homo sapiens Serine/threonine-protein kinase STK11 Proteins 0.000 description 1
- 101000864806 Homo sapiens Serine/threonine-protein kinase Sgk2 Proteins 0.000 description 1
- 101000607332 Homo sapiens Serine/threonine-protein kinase ULK2 Proteins 0.000 description 1
- 101000607339 Homo sapiens Serine/threonine-protein kinase ULK3 Proteins 0.000 description 1
- 101000809308 Homo sapiens Serine/threonine-protein kinase ULK4 Proteins 0.000 description 1
- 101000649931 Homo sapiens Serine/threonine-protein kinase VRK2 Proteins 0.000 description 1
- 101000637839 Homo sapiens Serine/threonine-protein kinase tousled-like 1 Proteins 0.000 description 1
- 101000637847 Homo sapiens Serine/threonine-protein kinase tousled-like 2 Proteins 0.000 description 1
- 101000702393 Homo sapiens Signal peptide peptidase-like 2B Proteins 0.000 description 1
- 101000828788 Homo sapiens Signal peptide peptidase-like 3 Proteins 0.000 description 1
- 101000990915 Homo sapiens Stromelysin-1 Proteins 0.000 description 1
- 101000577874 Homo sapiens Stromelysin-2 Proteins 0.000 description 1
- 101000577877 Homo sapiens Stromelysin-3 Proteins 0.000 description 1
- 101000661807 Homo sapiens Suppressor of tumorigenicity 14 protein Proteins 0.000 description 1
- 101000662997 Homo sapiens TRAF2 and NCK-interacting protein kinase Proteins 0.000 description 1
- 101000759314 Homo sapiens Tau-tubulin kinase 1 Proteins 0.000 description 1
- 101000772231 Homo sapiens Testis-specific serine/threonine-protein kinase 1 Proteins 0.000 description 1
- 101000714168 Homo sapiens Testisin Proteins 0.000 description 1
- 101000794213 Homo sapiens Thymus-specific serine protease Proteins 0.000 description 1
- 101000904152 Homo sapiens Transcription factor E2F1 Proteins 0.000 description 1
- 101001050288 Homo sapiens Transcription factor Jun Proteins 0.000 description 1
- 101000753286 Homo sapiens Transcription intermediary factor 1-beta Proteins 0.000 description 1
- 101000802105 Homo sapiens Transducin-like enhancer protein 2 Proteins 0.000 description 1
- 101000835086 Homo sapiens Transferrin receptor protein 2 Proteins 0.000 description 1
- 101000796673 Homo sapiens Transformation/transcription domain-associated protein Proteins 0.000 description 1
- 101000598055 Homo sapiens Transmembrane protease serine 11A Proteins 0.000 description 1
- 101000637853 Homo sapiens Transmembrane protease serine 11F Proteins 0.000 description 1
- 101000798715 Homo sapiens Transmembrane protease serine 12 Proteins 0.000 description 1
- 101000638154 Homo sapiens Transmembrane protease serine 2 Proteins 0.000 description 1
- 101000798702 Homo sapiens Transmembrane protease serine 4 Proteins 0.000 description 1
- 101000798704 Homo sapiens Transmembrane protease serine 5 Proteins 0.000 description 1
- 101000798710 Homo sapiens Transmembrane protease serine 9 Proteins 0.000 description 1
- 101000766332 Homo sapiens Tribbles homolog 1 Proteins 0.000 description 1
- 101000766349 Homo sapiens Tribbles homolog 2 Proteins 0.000 description 1
- 101000766345 Homo sapiens Tribbles homolog 3 Proteins 0.000 description 1
- 101000848014 Homo sapiens Trypsin-2 Proteins 0.000 description 1
- 101000847952 Homo sapiens Trypsin-3 Proteins 0.000 description 1
- 101000795085 Homo sapiens Tryptase beta-2 Proteins 0.000 description 1
- 101000796737 Homo sapiens Tryptase delta Proteins 0.000 description 1
- 101000800288 Homo sapiens Tubulointerstitial nephritis antigen Proteins 0.000 description 1
- 101000800287 Homo sapiens Tubulointerstitial nephritis antigen-like Proteins 0.000 description 1
- 101000997832 Homo sapiens Tyrosine-protein kinase JAK2 Proteins 0.000 description 1
- 101001087394 Homo sapiens Tyrosine-protein phosphatase non-receptor type 1 Proteins 0.000 description 1
- 101000836261 Homo sapiens U4/U6.U5 tri-snRNP-associated protein 2 Proteins 0.000 description 1
- 101001138544 Homo sapiens UMP-CMP kinase Proteins 0.000 description 1
- 101000809261 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 11 Proteins 0.000 description 1
- 101000760210 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 12 Proteins 0.000 description 1
- 101000760229 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 13 Proteins 0.000 description 1
- 101000841471 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 15 Proteins 0.000 description 1
- 101000644815 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 16 Proteins 0.000 description 1
- 101000761569 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 17 Proteins 0.000 description 1
- 101000644843 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 19 Proteins 0.000 description 1
- 101000607865 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 20 Proteins 0.000 description 1
- 101000807524 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 22 Proteins 0.000 description 1
- 101000807533 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 26 Proteins 0.000 description 1
- 101000939135 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 27 Proteins 0.000 description 1
- 101000939467 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 28 Proteins 0.000 description 1
- 101000748132 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 30 Proteins 0.000 description 1
- 101000748137 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 31 Proteins 0.000 description 1
- 101000748161 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 34 Proteins 0.000 description 1
- 101000671814 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 38 Proteins 0.000 description 1
- 101000777206 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 40 Proteins 0.000 description 1
- 101000777138 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 42 Proteins 0.000 description 1
- 101000777120 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 44 Proteins 0.000 description 1
- 101000760243 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 45 Proteins 0.000 description 1
- 101000759984 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 46 Proteins 0.000 description 1
- 101000759994 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 47 Proteins 0.000 description 1
- 101000643890 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 5 Proteins 0.000 description 1
- 101000643895 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 6 Proteins 0.000 description 1
- 101000759918 Homo sapiens Ubiquitin carboxyl-terminal hydrolase isozyme L3 Proteins 0.000 description 1
- 101000809126 Homo sapiens Ubiquitin carboxyl-terminal hydrolase isozyme L5 Proteins 0.000 description 1
- 101000720948 Homo sapiens Ubiquitin thioesterase OTUB2 Proteins 0.000 description 1
- 101000644847 Homo sapiens Ubl carboxyl-terminal hydrolase 18 Proteins 0.000 description 1
- 101000934581 Homo sapiens Valacyclovir hydrolase Proteins 0.000 description 1
- 101000851007 Homo sapiens Vascular endothelial growth factor receptor 2 Proteins 0.000 description 1
- 101001105816 Homo sapiens Vitamin K-dependent protein Z Proteins 0.000 description 1
- 101000666519 Homo sapiens Xaa-Pro aminopeptidase 3 Proteins 0.000 description 1
- 101001117146 Homo sapiens [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial Proteins 0.000 description 1
- 101000994496 Homo sapiens cAMP-dependent protein kinase catalytic subunit alpha Proteins 0.000 description 1
- 101000944219 Homo sapiens cAMP-dependent protein kinase catalytic subunit beta Proteins 0.000 description 1
- 101000944207 Homo sapiens cAMP-dependent protein kinase catalytic subunit gamma Proteins 0.000 description 1
- 101001046427 Homo sapiens cGMP-dependent protein kinase 2 Proteins 0.000 description 1
- 241000713772 Human immunodeficiency virus 1 Species 0.000 description 1
- 101710163637 Hyaluronan-binding protein 2 Proteins 0.000 description 1
- 108010052919 Hydroxyethylthiazole kinase Proteins 0.000 description 1
- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 description 1
- 208000029663 Hypophosphatemia Diseases 0.000 description 1
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 1
- 101150057269 IKBKB gene Proteins 0.000 description 1
- 108010042653 IgA receptor Proteins 0.000 description 1
- 102100037978 InaD-like protein Human genes 0.000 description 1
- 102100029326 Inactive carboxypeptidase-like protein X2 Human genes 0.000 description 1
- 102100026556 Inactive caspase-12 Human genes 0.000 description 1
- 102100034061 Inactive glutathione hydrolase 2 Human genes 0.000 description 1
- 102100040339 Inactive serine protease 35 Human genes 0.000 description 1
- 102100031071 Inactive serine protease 54 Human genes 0.000 description 1
- 102100040173 Inactive serine/threonine-protein kinase TEX14 Human genes 0.000 description 1
- 101710193551 Inactive serine/threonine-protein kinase TEX14 Proteins 0.000 description 1
- 101710123193 Inactive serine/threonine-protein kinase VRK3 Proteins 0.000 description 1
- 102100034687 Inactive tyrosine-protein kinase PEAK1 Human genes 0.000 description 1
- 102100038659 Inactive tyrosine-protein kinase PRAG1 Human genes 0.000 description 1
- 102100038425 Inactive ubiquitin carboxyl-terminal hydrolase 53 Human genes 0.000 description 1
- 108010001139 Inosine kinase Proteins 0.000 description 1
- 108010001127 Insulin Receptor Proteins 0.000 description 1
- 102100036721 Insulin receptor Human genes 0.000 description 1
- 102100021496 Insulin-degrading enzyme Human genes 0.000 description 1
- 108090000828 Insulysin Proteins 0.000 description 1
- 102100034170 Interferon-induced, double-stranded RNA-activated protein kinase Human genes 0.000 description 1
- 101710089751 Interferon-induced, double-stranded RNA-activated protein kinase Proteins 0.000 description 1
- 102000000589 Interleukin-1 Human genes 0.000 description 1
- 108010002352 Interleukin-1 Proteins 0.000 description 1
- 208000005016 Intestinal Neoplasms Diseases 0.000 description 1
- 102100033903 Isoaspartyl peptidase/L-asparaginase Human genes 0.000 description 1
- 101710197042 Isoaspartyl peptidase/L-asparaginase Proteins 0.000 description 1
- 102100038297 Kallikrein-1 Human genes 0.000 description 1
- 101710115801 Kallikrein-10 Proteins 0.000 description 1
- 101710115809 Kallikrein-12 Proteins 0.000 description 1
- 101710115806 Kallikrein-14 Proteins 0.000 description 1
- 101710115873 Kallikrein-15 Proteins 0.000 description 1
- 101710176220 Kallikrein-2 Proteins 0.000 description 1
- 101710176223 Kallikrein-5 Proteins 0.000 description 1
- 101710176224 Kallikrein-6 Proteins 0.000 description 1
- 101710176225 Kallikrein-8 Proteins 0.000 description 1
- 102100034876 Kallikrein-9 Human genes 0.000 description 1
- 108010025815 Kanamycin Kinase Proteins 0.000 description 1
- 102100023418 Ketohexokinase Human genes 0.000 description 1
- 108010062852 Ketohexokinase Proteins 0.000 description 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 1
- 150000008575 L-amino acids Chemical class 0.000 description 1
- 108030003738 L-arabinokinases Proteins 0.000 description 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
- 102100040648 L-fucose kinase Human genes 0.000 description 1
- 108090000324 L-fuculokinases Proteins 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- UKAUYVFTDYCKQA-VKHMYHEASA-N L-homoserine Chemical compound OC(=O)[C@@H](N)CCO UKAUYVFTDYCKQA-VKHMYHEASA-N 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- QEFRNWWLZKMPFJ-ZXPFJRLXSA-N L-methionine (R)-S-oxide Chemical compound C[S@@](=O)CC[C@H]([NH3+])C([O-])=O QEFRNWWLZKMPFJ-ZXPFJRLXSA-N 0.000 description 1
- QEFRNWWLZKMPFJ-UHFFFAOYSA-N L-methionine sulphoxide Natural products CS(=O)CCC(N)C(O)=O QEFRNWWLZKMPFJ-UHFFFAOYSA-N 0.000 description 1
- XNSAINXGIQZQOO-UHFFFAOYSA-N L-pyroglutamyl-L-histidyl-L-proline amide Natural products NC(=O)C1CCCN1C(=O)C(NC(=O)C1NC(=O)CC1)CC1=CN=CN1 XNSAINXGIQZQOO-UHFFFAOYSA-N 0.000 description 1
- 125000002842 L-seryl group Chemical group O=C([*])[C@](N([H])[H])([H])C([H])([H])O[H] 0.000 description 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 1
- 108030003782 L-xylulokinases Proteins 0.000 description 1
- 108010063045 Lactoferrin Proteins 0.000 description 1
- 101710128836 Large T antigen Proteins 0.000 description 1
- 102100030985 Legumain Human genes 0.000 description 1
- 241000594011 Leuciscus leuciscus Species 0.000 description 1
- 102100020872 Leucyl-cystinyl aminopeptidase Human genes 0.000 description 1
- 108010033266 Lipoprotein(a) Proteins 0.000 description 1
- 108010070802 Lombricine kinase Proteins 0.000 description 1
- 102100025889 Lon protease homolog 2, peroxisomal Human genes 0.000 description 1
- 102100031955 Lon protease homolog, mitochondrial Human genes 0.000 description 1
- 206010025323 Lymphomas Diseases 0.000 description 1
- 102100038056 Lysophosphatidylserine lipase ABHD12 Human genes 0.000 description 1
- 102100034069 MAP kinase-activated protein kinase 2 Human genes 0.000 description 1
- 102100028397 MAP kinase-activated protein kinase 3 Human genes 0.000 description 1
- 102100028396 MAP kinase-activated protein kinase 5 Human genes 0.000 description 1
- 101710138999 MAP kinase-interacting serine/threonine-protein kinase 2 Proteins 0.000 description 1
- 108010041955 MAP-kinase-activated kinase 2 Proteins 0.000 description 1
- 108010041980 MAP-kinase-activated kinase 3 Proteins 0.000 description 1
- 108010041164 MAP-kinase-activated kinase 5 Proteins 0.000 description 1
- 101150043871 MAPK7 gene Proteins 0.000 description 1
- 101150060910 MMEL1 gene Proteins 0.000 description 1
- 108091007144 MMP23A Proteins 0.000 description 1
- 102100032496 MPN domain-containing protein Human genes 0.000 description 1
- 108010043901 Macrolide 2'-kinase Proteins 0.000 description 1
- 108030001712 Macrophage elastases Proteins 0.000 description 1
- 102100026046 Mannan-binding lectin serine protease 2 Human genes 0.000 description 1
- 108010015328 Mannokinase Proteins 0.000 description 1
- 102000009112 Mannose-Binding Lectin Human genes 0.000 description 1
- 108010087870 Mannose-Binding Lectin Proteins 0.000 description 1
- 102000004318 Matrilysin Human genes 0.000 description 1
- 102100030417 Matrilysin Human genes 0.000 description 1
- 108090000855 Matrilysin Proteins 0.000 description 1
- 108010091175 Matriptase Proteins 0.000 description 1
- 108010076497 Matrix Metalloproteinase 10 Proteins 0.000 description 1
- 108010016160 Matrix Metalloproteinase 3 Proteins 0.000 description 1
- 102100030216 Matrix metalloproteinase-14 Human genes 0.000 description 1
- 102100030201 Matrix metalloproteinase-15 Human genes 0.000 description 1
- 102100030200 Matrix metalloproteinase-16 Human genes 0.000 description 1
- 102000004054 Matrix metalloproteinase-17 Human genes 0.000 description 1
- 108090000585 Matrix metalloproteinase-17 Proteins 0.000 description 1
- 102100030218 Matrix metalloproteinase-19 Human genes 0.000 description 1
- 102100029693 Matrix metalloproteinase-20 Human genes 0.000 description 1
- 102100024129 Matrix metalloproteinase-24 Human genes 0.000 description 1
- 102100024131 Matrix metalloproteinase-25 Human genes 0.000 description 1
- 102100024128 Matrix metalloproteinase-26 Human genes 0.000 description 1
- 102100024132 Matrix metalloproteinase-27 Human genes 0.000 description 1
- 102100026799 Matrix metalloproteinase-28 Human genes 0.000 description 1
- 102100030412 Matrix metalloproteinase-9 Human genes 0.000 description 1
- 102100032239 Melanotransferrin Human genes 0.000 description 1
- 102000018697 Membrane Proteins Human genes 0.000 description 1
- 108010052285 Membrane Proteins Proteins 0.000 description 1
- 102100024197 Membrane metallo-endopeptidase-like 1 Human genes 0.000 description 1
- 102100027382 Membrane-bound transcription factor site-2 protease Human genes 0.000 description 1
- 108090000265 Meprin A Proteins 0.000 description 1
- 102100030882 Meprin A subunit alpha Human genes 0.000 description 1
- 102100030876 Meprin A subunit beta Human genes 0.000 description 1
- 101000761459 Mesocricetus auratus Calcium-dependent serine proteinase Proteins 0.000 description 1
- PESQCPHRXOFIPX-RYUDHWBXSA-N Met-Tyr Chemical compound CSCC[C@H](N)C(=O)N[C@H](C(O)=O)CC1=CC=C(O)C=C1 PESQCPHRXOFIPX-RYUDHWBXSA-N 0.000 description 1
- 101000859568 Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS) Carbamoyl-phosphate synthase Proteins 0.000 description 1
- 102100028398 Methionine aminopeptidase 1D, mitochondrial Human genes 0.000 description 1
- 102100023174 Methionine aminopeptidase 2 Human genes 0.000 description 1
- 102100022259 Mevalonate kinase Human genes 0.000 description 1
- 108700040132 Mevalonate kinases Proteins 0.000 description 1
- 102100033253 Microtubule-associated serine/threonine-protein kinase 2 Human genes 0.000 description 1
- 102100033251 Microtubule-associated serine/threonine-protein kinase 3 Human genes 0.000 description 1
- 102100039842 Mitochondrial inner membrane protease subunit 1 Human genes 0.000 description 1
- 108010047660 Mitochondrial intermediate peptidase Proteins 0.000 description 1
- 102100025298 Mitochondrial-processing peptidase subunit beta Human genes 0.000 description 1
- 108700027649 Mitogen-Activated Protein Kinase 3 Proteins 0.000 description 1
- 108700027647 Mitogen-Activated Protein Kinase 6 Proteins 0.000 description 1
- 108700027650 Mitogen-Activated Protein Kinase 7 Proteins 0.000 description 1
- 108700027648 Mitogen-Activated Protein Kinase 8 Proteins 0.000 description 1
- 108700027653 Mitogen-Activated Protein Kinase 9 Proteins 0.000 description 1
- 102100026929 Mitogen-activated protein kinase 11 Human genes 0.000 description 1
- 108700015928 Mitogen-activated protein kinase 13 Proteins 0.000 description 1
- 102100023482 Mitogen-activated protein kinase 14 Human genes 0.000 description 1
- 101710203984 Mitogen-activated protein kinase 14A Proteins 0.000 description 1
- 101710166115 Mitogen-activated protein kinase 2 Proteins 0.000 description 1
- 102100024192 Mitogen-activated protein kinase 3 Human genes 0.000 description 1
- 101710166114 Mitogen-activated protein kinase 4 Proteins 0.000 description 1
- 102100037801 Mitogen-activated protein kinase 6 Human genes 0.000 description 1
- 102100038243 Mitogen-activated protein kinase kinase kinase 10 Human genes 0.000 description 1
- 102100028199 Mitogen-activated protein kinase kinase kinase kinase 1 Human genes 0.000 description 1
- 102100028192 Mitogen-activated protein kinase kinase kinase kinase 2 Human genes 0.000 description 1
- 101710144533 Mitogen-activated protein kinase kinase kinase kinase 2 Proteins 0.000 description 1
- 101710143037 Mitogen-activated protein kinase p38a Proteins 0.000 description 1
- 108010006519 Molecular Chaperones Proteins 0.000 description 1
- 102100029814 Monoglyceride lipase Human genes 0.000 description 1
- 108091006675 Monovalent cation:proton antiporter-2 Proteins 0.000 description 1
- 108091006676 Monovalent cation:proton antiporter-3 Proteins 0.000 description 1
- 102000007474 Multiprotein Complexes Human genes 0.000 description 1
- 108010085220 Multiprotein Complexes Proteins 0.000 description 1
- 101000715673 Mus musculus Cadherin EGF LAG seven-pass G-type receptor 2 Proteins 0.000 description 1
- 101100452374 Mus musculus Ikbke gene Proteins 0.000 description 1
- 101000613791 Mus musculus OTU domain-containing protein 6A Proteins 0.000 description 1
- 101100297651 Mus musculus Pim2 gene Proteins 0.000 description 1
- 101100410041 Mus musculus Psmd7 gene Proteins 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- 102100038893 Myelin transcription factor 1 Human genes 0.000 description 1
- 108010084498 Myosin Heavy Chains Proteins 0.000 description 1
- 102000005604 Myosin Heavy Chains Human genes 0.000 description 1
- 102000016349 Myosin Light Chains Human genes 0.000 description 1
- 108010067385 Myosin Light Chains Proteins 0.000 description 1
- 206010068871 Myotonic dystrophy Diseases 0.000 description 1
- PESQCPHRXOFIPX-UHFFFAOYSA-N N-L-methionyl-L-tyrosine Natural products CSCCC(N)C(=O)NC(C(O)=O)CC1=CC=C(O)C=C1 PESQCPHRXOFIPX-UHFFFAOYSA-N 0.000 description 1
- 108700026495 N-Myc Proto-Oncogene Proteins 0.000 description 1
- 102100035286 N-acetyl-D-glucosamine kinase Human genes 0.000 description 1
- 102100031895 N-acetylated-alpha-linked acidic dipeptidase 2 Human genes 0.000 description 1
- 108010032040 N-acetylglucosamine kinase Proteins 0.000 description 1
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 description 1
- 102100032946 N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) Human genes 0.000 description 1
- 108010029147 N-acylmannosamine kinase Proteins 0.000 description 1
- CQOVPNPJLQNMDC-UHFFFAOYSA-N N-beta-alanyl-L-histidine Natural products NCCC(=O)NC(C(O)=O)CC1=CN=CN1 CQOVPNPJLQNMDC-UHFFFAOYSA-N 0.000 description 1
- GHAZCVNUKKZTLG-UHFFFAOYSA-N N-ethyl-succinimide Natural products CCN1C(=O)CCC1=O GHAZCVNUKKZTLG-UHFFFAOYSA-N 0.000 description 1
- HDFGOPSGAURCEO-UHFFFAOYSA-N N-ethylmaleimide Chemical compound CCN1C(=O)C=CC1=O HDFGOPSGAURCEO-UHFFFAOYSA-N 0.000 description 1
- 102100030124 N-myc proto-oncogene protein Human genes 0.000 description 1
- JLEBZPBDRKPWTD-TURQNECASA-O N-ribosylnicotinamide Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](CO)O2)O)=C1 JLEBZPBDRKPWTD-TURQNECASA-O 0.000 description 1
- 108010049175 N-substituted Glycines Proteins 0.000 description 1
- XJLXINKUBYWONI-NNYOXOHSSA-O NADP(+) Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-NNYOXOHSSA-O 0.000 description 1
- ACFIXJIJDZMPPO-NNYOXOHSSA-J NADPH(4-) Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP([O-])(=O)OP([O-])(=O)OC[C@@H]2[C@H]([C@@H](OP([O-])([O-])=O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 ACFIXJIJDZMPPO-NNYOXOHSSA-J 0.000 description 1
- 102100031911 NEDD8 Human genes 0.000 description 1
- 108700004934 NEDD8 Proteins 0.000 description 1
- 101150107958 NEDD8 gene Proteins 0.000 description 1
- 101150060710 NPR1 gene Proteins 0.000 description 1
- 101150117329 NTRK3 gene Proteins 0.000 description 1
- 102100021850 Nardilysin Human genes 0.000 description 1
- 108090000970 Nardilysin Proteins 0.000 description 1
- 241000772415 Neovison vison Species 0.000 description 1
- 102100028782 Neprilysin Human genes 0.000 description 1
- 208000012902 Nervous system disease Diseases 0.000 description 1
- 102100037732 Neuroendocrine convertase 2 Human genes 0.000 description 1
- 102100038992 Neuroligin-1 Human genes 0.000 description 1
- 102100038939 Neuroligin-2 Human genes 0.000 description 1
- 101710083717 Neuroligin-4, X-linked Proteins 0.000 description 1
- 101710137815 Neuroligin-4, Y-linked Proteins 0.000 description 1
- 208000025966 Neurological disease Diseases 0.000 description 1
- 108090000812 Neurolysin Proteins 0.000 description 1
- 101100018566 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) tif-1 gene Proteins 0.000 description 1
- 102100030411 Neutrophil collagenase Human genes 0.000 description 1
- 102000056189 Neutrophil collagenases Human genes 0.000 description 1
- 108030001564 Neutrophil collagenases Proteins 0.000 description 1
- 108010094052 Nik related kinase Proteins 0.000 description 1
- 102100034340 Nik-related protein kinase Human genes 0.000 description 1
- 102000007999 Nuclear Proteins Human genes 0.000 description 1
- 108010089610 Nuclear Proteins Proteins 0.000 description 1
- 102100025372 Nuclear pore complex protein Nup98-Nup96 Human genes 0.000 description 1
- 101710127265 Nuclear receptor-binding protein Proteins 0.000 description 1
- 101710171988 Nuclear receptor-binding protein 2 Proteins 0.000 description 1
- 102100029585 Nuclear receptor-interacting protein 2 Human genes 0.000 description 1
- 101710140546 Nuclear receptor-interacting protein 2 Proteins 0.000 description 1
- 101710140545 Nuclear receptor-interacting protein 3 Proteins 0.000 description 1
- 108020004711 Nucleic Acid Probes Proteins 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 108010011356 Nucleoside phosphotransferase Proteins 0.000 description 1
- 102100025195 OTU domain-containing protein 1 Human genes 0.000 description 1
- 102100025196 OTU domain-containing protein 3 Human genes 0.000 description 1
- 102100025193 OTU domain-containing protein 4 Human genes 0.000 description 1
- 102100025194 OTU domain-containing protein 5 Human genes 0.000 description 1
- 102100040564 OTU domain-containing protein 6A Human genes 0.000 description 1
- 102100030127 Obscurin Human genes 0.000 description 1
- 101710194880 Obscurin Proteins 0.000 description 1
- 102000043276 Oncogene Human genes 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 101100230207 Oryza sativa subsp. japonica GSK1 gene Proteins 0.000 description 1
- 101100532088 Oryza sativa subsp. japonica RUB2 gene Proteins 0.000 description 1
- 101100532090 Oryza sativa subsp. japonica RUB3 gene Proteins 0.000 description 1
- 102100026305 Ovochymase-1 Human genes 0.000 description 1
- 108090000854 Oxidoreductases Proteins 0.000 description 1
- 102000004316 Oxidoreductases Human genes 0.000 description 1
- 102100027016 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 Human genes 0.000 description 1
- 102000002131 PAS domains Human genes 0.000 description 1
- 108050009469 PAS domains Proteins 0.000 description 1
- 108010014971 PDZ-binding kinase Proteins 0.000 description 1
- 150000005857 PFAS Chemical class 0.000 description 1
- 108010033253 PHEX Phosphate Regulating Neutral Endopeptidase Proteins 0.000 description 1
- 102000007057 PHEX Phosphate Regulating Neutral Endopeptidase Human genes 0.000 description 1
- 102000038030 PI3Ks Human genes 0.000 description 1
- 101150057803 PRSS37 gene Proteins 0.000 description 1
- 108010081575 PTEN-induced putative kinase Proteins 0.000 description 1
- 102100021498 Palmitoyl-protein thioesterase ABHD10, mitochondrial Human genes 0.000 description 1
- 108010067372 Pancreatic elastase Proteins 0.000 description 1
- 102000016387 Pancreatic elastase Human genes 0.000 description 1
- 102100040154 Pappalysin-2 Human genes 0.000 description 1
- 241000051107 Paraechinus aethiopicus Species 0.000 description 1
- 206010033892 Paraplegia Diseases 0.000 description 1
- 101710083869 Paraplegin Proteins 0.000 description 1
- 208000018737 Parkinson disease Diseases 0.000 description 1
- 102000018546 Paxillin Human genes 0.000 description 1
- ACNHBCIZLNNLRS-UHFFFAOYSA-N Paxilline 1 Natural products N1C2=CC=CC=C2C2=C1C1(C)C3(C)CCC4OC(C(C)(O)C)C(=O)C=C4C3(O)CCC1C2 ACNHBCIZLNNLRS-UHFFFAOYSA-N 0.000 description 1
- 102100039657 Pepsin A-3 Human genes 0.000 description 1
- 102100039652 Pepsin A-5 Human genes 0.000 description 1
- 108010047320 Pepsinogen A Proteins 0.000 description 1
- 102000005877 Peptide Initiation Factors Human genes 0.000 description 1
- 108010044843 Peptide Initiation Factors Proteins 0.000 description 1
- 108090000882 Peptidyl-Dipeptidase A Proteins 0.000 description 1
- 229940122907 Phosphatase inhibitor Drugs 0.000 description 1
- 102100024634 Phosphatidylserine lipase ABHD16A Human genes 0.000 description 1
- 101710193683 Phosphatidylserine lipase ABHD16A Proteins 0.000 description 1
- 108010022684 Phosphofructokinase-1 Proteins 0.000 description 1
- 102000012435 Phosphofructokinase-1 Human genes 0.000 description 1
- 108010069341 Phosphofructokinases Proteins 0.000 description 1
- 102000001105 Phosphofructokinases Human genes 0.000 description 1
- 102000011755 Phosphoglycerate Kinase Human genes 0.000 description 1
- 102100024279 Phosphomevalonate kinase Human genes 0.000 description 1
- 108030004873 Phosphoribosylformylglycinamidine synthases Proteins 0.000 description 1
- 108010073135 Phosphorylases Proteins 0.000 description 1
- 102000009097 Phosphorylases Human genes 0.000 description 1
- 108090000316 Pitrilysin Proteins 0.000 description 1
- 108090000113 Plasma Kallikrein Proteins 0.000 description 1
- 102100034869 Plasma kallikrein Human genes 0.000 description 1
- 108010051456 Plasminogen Proteins 0.000 description 1
- 108010038512 Platelet-Derived Growth Factor Proteins 0.000 description 1
- 102000010780 Platelet-Derived Growth Factor Human genes 0.000 description 1
- 102100037596 Platelet-derived growth factor subunit A Human genes 0.000 description 1
- 102100023504 Polyribonucleotide 5'-hydroxyl-kinase Clp1 Human genes 0.000 description 1
- 101710148859 Polyserase-2 Proteins 0.000 description 1
- 102100021231 Pre-mRNA-processing-splicing factor 8 Human genes 0.000 description 1
- 108010036933 Presenilin-1 Proteins 0.000 description 1
- 108010036908 Presenilin-2 Proteins 0.000 description 1
- 241000288906 Primates Species 0.000 description 1
- 101710087463 Probable 3-mercaptopyruvate sulfurtransferase Proteins 0.000 description 1
- 101710145642 Probable Xaa-Pro aminopeptidase P Proteins 0.000 description 1
- 102100027191 Probable aminopeptidase NPEPL1 Human genes 0.000 description 1
- 101710159900 Probable aminopeptidase NPEPL1 Proteins 0.000 description 1
- 102100029401 Probable carboxypeptidase X1 Human genes 0.000 description 1
- 102100038770 Probable inactive serine protease 37 Human genes 0.000 description 1
- 102100039310 Probable serine carboxypeptidase CPVL Human genes 0.000 description 1
- 102100037775 Probable tRNA N6-adenosine threonylcarbamoyltransferase Human genes 0.000 description 1
- 102100038603 Probable ubiquitin carboxyl-terminal hydrolase FAF-X Human genes 0.000 description 1
- 102100038600 Probable ubiquitin carboxyl-terminal hydrolase FAF-Y Human genes 0.000 description 1
- 108010050808 Procollagen Proteins 0.000 description 1
- 101710187242 Prolactin-inducible protein homolog Proteins 0.000 description 1
- 102100026899 Proliferation-associated protein 2G4 Human genes 0.000 description 1
- 102100034014 Prolyl 3-hydroxylase 3 Human genes 0.000 description 1
- 102100037822 Prolyl endopeptidase-like Human genes 0.000 description 1
- 108090001084 Propionate kinases Proteins 0.000 description 1
- 102100036371 Proprotein convertase subtilisin/kexin type 4 Human genes 0.000 description 1
- 102100036365 Proprotein convertase subtilisin/kexin type 5 Human genes 0.000 description 1
- 102100038946 Proprotein convertase subtilisin/kexin type 6 Human genes 0.000 description 1
- 102100038950 Proprotein convertase subtilisin/kexin type 7 Human genes 0.000 description 1
- 102100038955 Proprotein convertase subtilisin/kexin type 9 Human genes 0.000 description 1
- 208000004403 Prostatic Hyperplasia Diseases 0.000 description 1
- 101710180313 Protease 3 Proteins 0.000 description 1
- 101710180012 Protease 7 Proteins 0.000 description 1
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 description 1
- 102100040364 Proteasome subunit alpha type-2 Human genes 0.000 description 1
- 102100035908 Proteasome subunit alpha type-3 Human genes 0.000 description 1
- 102100028813 Proteasome subunit alpha type-4 Human genes 0.000 description 1
- 102100029270 Proteasome subunit alpha type-5 Human genes 0.000 description 1
- 102100034664 Proteasome subunit alpha type-6 Human genes 0.000 description 1
- 102100021201 Proteasome subunit alpha type-7 Human genes 0.000 description 1
- 102100040972 Proteasome subunit alpha-type 8 Human genes 0.000 description 1
- 102100040400 Proteasome subunit beta type-2 Human genes 0.000 description 1
- 102100033755 Proteasome subunit beta type-3 Human genes 0.000 description 1
- 102100033190 Proteasome subunit beta type-4 Human genes 0.000 description 1
- 102100036127 Proteasome subunit beta type-5 Human genes 0.000 description 1
- 102100036128 Proteasome subunit beta type-6 Human genes 0.000 description 1
- 102100035763 Proteasome subunit beta type-7 Human genes 0.000 description 1
- 102100021499 Protein ABHD11 Human genes 0.000 description 1
- 102100021513 Protein ABHD12B Human genes 0.000 description 1
- 102100024651 Protein ABHD16B Human genes 0.000 description 1
- 102100021505 Protein ABHD8 Human genes 0.000 description 1
- 101800004937 Protein C Proteins 0.000 description 1
- 102000017975 Protein C Human genes 0.000 description 1
- 108010015499 Protein Kinase C-theta Proteins 0.000 description 1
- 102000001892 Protein Kinase C-theta Human genes 0.000 description 1
- 102000055027 Protein Methyltransferases Human genes 0.000 description 1
- 108700040121 Protein Methyltransferases Proteins 0.000 description 1
- 102100024980 Protein NDRG1 Human genes 0.000 description 1
- 102100028655 Protein O-mannose kinase Human genes 0.000 description 1
- 229940096437 Protein S Drugs 0.000 description 1
- 108010066124 Protein S Proteins 0.000 description 1
- 102100020876 Protein SCAF11 Human genes 0.000 description 1
- 101710092490 Protein kinase 3 Proteins 0.000 description 1
- 102100024923 Protein kinase C beta type Human genes 0.000 description 1
- 102100037314 Protein kinase C gamma type Human genes 0.000 description 1
- 102100021557 Protein kinase C iota type Human genes 0.000 description 1
- 102100021538 Protein kinase C zeta type Human genes 0.000 description 1
- 102000017332 Protein kinase C, delta Human genes 0.000 description 1
- 108050005326 Protein kinase C, delta Proteins 0.000 description 1
- 102000015840 Protein kinase C, epsilon Human genes 0.000 description 1
- 108050004067 Protein kinase C, epsilon Proteins 0.000 description 1
- 102000017336 Protein kinase C, eta Human genes 0.000 description 1
- 108050005320 Protein kinase C, eta Proteins 0.000 description 1
- 108010094028 Prothrombin Proteins 0.000 description 1
- 108010024221 Proto-Oncogene Proteins c-bcr Proteins 0.000 description 1
- 102000016971 Proto-Oncogene Proteins c-kit Human genes 0.000 description 1
- 108010014608 Proto-Oncogene Proteins c-kit Proteins 0.000 description 1
- 241001323319 Psen Species 0.000 description 1
- 101150094745 Ptk2b gene Proteins 0.000 description 1
- 102100033192 Puromycin-sensitive aminopeptidase Human genes 0.000 description 1
- 102100035879 Putative protein KRIP1 Human genes 0.000 description 1
- 102100038765 Putative serine protease 42 Human genes 0.000 description 1
- 102100038786 Putative serine protease 45 Human genes 0.000 description 1
- 102100031285 Putative ubiquitin carboxyl-terminal hydrolase 41 Human genes 0.000 description 1
- 101710148009 Putative uracil phosphoribosyltransferase Proteins 0.000 description 1
- 108010070648 Pyridoxal Kinase Proteins 0.000 description 1
- 102100038517 Pyridoxal kinase Human genes 0.000 description 1
- 102000013009 Pyruvate Kinase Human genes 0.000 description 1
- 108020005115 Pyruvate Kinase Proteins 0.000 description 1
- 102100032315 RAC-beta serine/threonine-protein kinase Human genes 0.000 description 1
- 102100032314 RAC-gamma serine/threonine-protein kinase Human genes 0.000 description 1
- 102000009572 RNA Polymerase II Human genes 0.000 description 1
- 108010009460 RNA Polymerase II Proteins 0.000 description 1
- 238000003841 Raman measurement Methods 0.000 description 1
- 102000057707 Ran binding domains Human genes 0.000 description 1
- 108700001248 Ran binding domains Proteins 0.000 description 1
- 102100024683 Ras-related protein R-Ras Human genes 0.000 description 1
- 101000603238 Rattus norvegicus Neuroligin-1 Proteins 0.000 description 1
- 101100406666 Rattus norvegicus Yod1 gene Proteins 0.000 description 1
- 102000004278 Receptor Protein-Tyrosine Kinases Human genes 0.000 description 1
- 108090000873 Receptor Protein-Tyrosine Kinases Proteins 0.000 description 1
- 108091005682 Receptor kinases Proteins 0.000 description 1
- 102100039663 Receptor-type tyrosine-protein phosphatase F Human genes 0.000 description 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 1
- 101150057388 Reln gene Proteins 0.000 description 1
- 102100022663 Retinal guanylyl cyclase 1 Human genes 0.000 description 1
- 101710181632 Retinal guanylyl cyclase 2 Proteins 0.000 description 1
- 102100025483 Retinoid-inducible serine carboxypeptidase Human genes 0.000 description 1
- 108010041974 Rhamnulokinase Proteins 0.000 description 1
- 108010053823 Rho Guanine Nucleotide Exchange Factors Proteins 0.000 description 1
- 102100039313 Rho-associated protein kinase 1 Human genes 0.000 description 1
- 108090000799 Rhodopsin kinases Proteins 0.000 description 1
- 102100032681 Rhomboid-related protein 1 Human genes 0.000 description 1
- 102100020783 Ribokinase Human genes 0.000 description 1
- 102000003861 Ribosomal protein S6 Human genes 0.000 description 1
- 108090000221 Ribosomal protein S6 Proteins 0.000 description 1
- 102100033536 Ribosomal protein S6 kinase alpha-1 Human genes 0.000 description 1
- 102100024913 Ribosomal protein S6 kinase delta-1 Human genes 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- 102000000395 SH3 domains Human genes 0.000 description 1
- 108050008861 SH3 domains Proteins 0.000 description 1
- 101150055709 SNF1 gene Proteins 0.000 description 1
- 108010048463 SNF1-related protein kinases Proteins 0.000 description 1
- 101710190447 SRSF protein kinase 2 Proteins 0.000 description 1
- 101710181165 STAM-binding protein Proteins 0.000 description 1
- 108010044012 STAT1 Transcription Factor Proteins 0.000 description 1
- 102000004265 STAT2 Transcription Factor Human genes 0.000 description 1
- 108010081691 STAT2 Transcription Factor Proteins 0.000 description 1
- 108010017324 STAT3 Transcription Factor Proteins 0.000 description 1
- 102000005886 STAT4 Transcription Factor Human genes 0.000 description 1
- 108010019992 STAT4 Transcription Factor Proteins 0.000 description 1
- 108010029477 STAT5 Transcription Factor Proteins 0.000 description 1
- 102100030491 STE20/SPS1-related proline-alanine-rich protein kinase Human genes 0.000 description 1
- 102000051619 SUMO-1 Human genes 0.000 description 1
- 101100177159 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) HAC1 gene Proteins 0.000 description 1
- 101800001700 Saposin-D Proteins 0.000 description 1
- 206010039491 Sarcoma Diseases 0.000 description 1
- 239000002262 Schiff base Substances 0.000 description 1
- 150000004753 Schiff bases Chemical class 0.000 description 1
- 101710186589 Secernin-2 Proteins 0.000 description 1
- 101710186591 Secernin-3 Proteins 0.000 description 1
- 102000013008 Semaphorin-3A Human genes 0.000 description 1
- 108010090319 Semaphorin-3A Proteins 0.000 description 1
- 102100023646 Sentrin-specific protease 2 Human genes 0.000 description 1
- 102100023645 Sentrin-specific protease 3 Human genes 0.000 description 1
- 101710147719 Sentrin-specific protease 6 Proteins 0.000 description 1
- 102100031407 Sentrin-specific protease 8 Human genes 0.000 description 1
- 102100038230 Serine beta-lactamase-like protein LACTB, mitochondrial Human genes 0.000 description 1
- 102100032491 Serine protease 1 Human genes 0.000 description 1
- 101710151387 Serine protease 1 Proteins 0.000 description 1
- 102100033835 Serine protease 23 Human genes 0.000 description 1
- 101710197422 Serine protease 27 Proteins 0.000 description 1
- 102100040342 Serine protease 33 Human genes 0.000 description 1
- 102100022638 Serine protease 48 Human genes 0.000 description 1
- 102100031056 Serine protease 57 Human genes 0.000 description 1
- 102100033197 Serine protease HTRA3 Human genes 0.000 description 1
- 102100020824 Serine-protein kinase ATM Human genes 0.000 description 1
- 102100029666 Serine/arginine-rich splicing factor 2 Human genes 0.000 description 1
- 101710123513 Serine/arginine-rich splicing factor 2 Proteins 0.000 description 1
- 101710113029 Serine/threonine-protein kinase Proteins 0.000 description 1
- 102100026758 Serine/threonine-protein kinase 16 Human genes 0.000 description 1
- 102100028032 Serine/threonine-protein kinase 32A Human genes 0.000 description 1
- 102100030620 Serine/threonine-protein kinase 35 Human genes 0.000 description 1
- 102100030513 Serine/threonine-protein kinase 36 Human genes 0.000 description 1
- 102100037629 Serine/threonine-protein kinase 4 Human genes 0.000 description 1
- 102100037627 Serine/threonine-protein kinase 40 Human genes 0.000 description 1
- 102100028623 Serine/threonine-protein kinase BRSK1 Human genes 0.000 description 1
- 102100037311 Serine/threonine-protein kinase D3 Human genes 0.000 description 1
- 102100039775 Serine/threonine-protein kinase DCLK2 Human genes 0.000 description 1
- 102100039774 Serine/threonine-protein kinase DCLK3 Human genes 0.000 description 1
- 102100024031 Serine/threonine-protein kinase LATS1 Human genes 0.000 description 1
- 102100024043 Serine/threonine-protein kinase LATS2 Human genes 0.000 description 1
- 101710169366 Serine/threonine-protein kinase MAK Proteins 0.000 description 1
- 102100025347 Serine/threonine-protein kinase MRCK beta Human genes 0.000 description 1
- 101710137266 Serine/threonine-protein kinase MRCK beta Proteins 0.000 description 1
- 101710175706 Serine/threonine-protein kinase NLK Proteins 0.000 description 1
- 102100028775 Serine/threonine-protein kinase Nek11 Human genes 0.000 description 1
- 102100037706 Serine/threonine-protein kinase Nek3 Human genes 0.000 description 1
- 102100037702 Serine/threonine-protein kinase Nek5 Human genes 0.000 description 1
- 102100031401 Serine/threonine-protein kinase Nek6 Human genes 0.000 description 1
- 102100031400 Serine/threonine-protein kinase Nek7 Human genes 0.000 description 1
- 102100029938 Serine/threonine-protein kinase SMG1 Human genes 0.000 description 1
- 101710085356 Serine/threonine-protein kinase SMG1 Proteins 0.000 description 1
- 102100026715 Serine/threonine-protein kinase STK11 Human genes 0.000 description 1
- 101710106944 Serine/threonine-protein kinase TBK1 Proteins 0.000 description 1
- 102100039987 Serine/threonine-protein kinase ULK2 Human genes 0.000 description 1
- 102100039985 Serine/threonine-protein kinase ULK3 Human genes 0.000 description 1
- 102100038455 Serine/threonine-protein kinase ULK4 Human genes 0.000 description 1
- 102100028235 Serine/threonine-protein kinase VRK1 Human genes 0.000 description 1
- 101710196244 Serine/threonine-protein kinase VRK1 Proteins 0.000 description 1
- 101710196279 Serine/threonine-protein kinase VRK2 Proteins 0.000 description 1
- 101710177325 Serine/threonine-protein kinase chk-2 Proteins 0.000 description 1
- 102100039278 Serine/threonine-protein kinase greatwall Human genes 0.000 description 1
- 102100032015 Serine/threonine-protein kinase tousled-like 1 Human genes 0.000 description 1
- 101710098559 Serine/threonine-protein kinase tousled-like 2 Proteins 0.000 description 1
- 101710175988 Signal peptide peptidase-like 2B Proteins 0.000 description 1
- 102100026820 Signal peptide peptidase-like 2C Human genes 0.000 description 1
- 108050005903 Signal peptide peptidase-like 2C Proteins 0.000 description 1
- 102100029904 Signal transducer and activator of transcription 1-alpha/beta Human genes 0.000 description 1
- 102100024040 Signal transducer and activator of transcription 3 Human genes 0.000 description 1
- 102100024481 Signal transducer and activator of transcription 5A Human genes 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 108020004459 Small interfering RNA Proteins 0.000 description 1
- 101710188689 Small, acid-soluble spore protein 1 Proteins 0.000 description 1
- 101710188693 Small, acid-soluble spore protein 2 Proteins 0.000 description 1
- 101710166422 Small, acid-soluble spore protein A Proteins 0.000 description 1
- 101710166404 Small, acid-soluble spore protein C Proteins 0.000 description 1
- 101710174019 Small, acid-soluble spore protein C1 Proteins 0.000 description 1
- 101710174017 Small, acid-soluble spore protein C2 Proteins 0.000 description 1
- 101710174574 Small, acid-soluble spore protein gamma-type Proteins 0.000 description 1
- 208000032930 Spastic paraplegia Diseases 0.000 description 1
- 102100027662 Sphingosine kinase 2 Human genes 0.000 description 1
- 108010055297 Sterol Esterase Proteins 0.000 description 1
- 108010090804 Streptavidin Proteins 0.000 description 1
- 102100028847 Stromelysin-3 Human genes 0.000 description 1
- 102000001435 Synapsin Human genes 0.000 description 1
- 108050009621 Synapsin Proteins 0.000 description 1
- 230000006044 T cell activation Effects 0.000 description 1
- 108091008874 T cell receptors Proteins 0.000 description 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 description 1
- 102100033130 T-box transcription factor T Human genes 0.000 description 1
- 101710086566 T-box transcription factor T Proteins 0.000 description 1
- 108090000925 TNF receptor-associated factor 2 Proteins 0.000 description 1
- 102100034779 TRAF family member-associated NF-kappa-B activator Human genes 0.000 description 1
- 102100037671 TRAF2 and NCK-interacting protein kinase Human genes 0.000 description 1
- 102000018679 Tacrolimus Binding Proteins Human genes 0.000 description 1
- 108010027179 Tacrolimus Binding Proteins Proteins 0.000 description 1
- 108010006785 Taq Polymerase Proteins 0.000 description 1
- 102100023277 Tau-tubulin kinase 1 Human genes 0.000 description 1
- 102100029350 Testis-specific serine/threonine-protein kinase 1 Human genes 0.000 description 1
- 101710116860 Testis-specific serine/threonine-protein kinase 6 Proteins 0.000 description 1
- 108050003829 Testisin Proteins 0.000 description 1
- 101150050472 Tfr2 gene Proteins 0.000 description 1
- 108700031954 Tgfb1i1/Leupaxin/TGFB1I1 Proteins 0.000 description 1
- 101001099217 Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) Triosephosphate isomerase Proteins 0.000 description 1
- 102000030766 Thiamin Pyrophosphokinase Human genes 0.000 description 1
- 108010001088 Thiamin pyrophosphokinase Proteins 0.000 description 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-N Thiophosphoric acid Chemical class OP(O)(S)=O RYYWUUFWQRZTIU-UHFFFAOYSA-N 0.000 description 1
- 102100036407 Thioredoxin Human genes 0.000 description 1
- 108010000499 Thromboplastin Proteins 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 102000006601 Thymidine Kinase Human genes 0.000 description 1
- 108020004440 Thymidine kinase Proteins 0.000 description 1
- 102100037357 Thymidylate kinase Human genes 0.000 description 1
- 102100030138 Thymus-specific serine protease Human genes 0.000 description 1
- AUYYCJSJGJYCDS-LBPRGKRZSA-N Thyrolar Chemical compound IC1=CC(C[C@H](N)C(O)=O)=CC(I)=C1OC1=CC=C(O)C(I)=C1 AUYYCJSJGJYCDS-LBPRGKRZSA-N 0.000 description 1
- 239000000627 Thyrotropin-Releasing Hormone Substances 0.000 description 1
- 102400000336 Thyrotropin-releasing hormone Human genes 0.000 description 1
- 101800004623 Thyrotropin-releasing hormone Proteins 0.000 description 1
- 102000003978 Tissue Plasminogen Activator Human genes 0.000 description 1
- 108090000373 Tissue Plasminogen Activator Proteins 0.000 description 1
- 102100030859 Tissue factor Human genes 0.000 description 1
- 101710183280 Topoisomerase Proteins 0.000 description 1
- 102000003929 Transaminases Human genes 0.000 description 1
- 230000010632 Transcription Factor Activity Effects 0.000 description 1
- 102100023132 Transcription factor Jun Human genes 0.000 description 1
- 102100022012 Transcription intermediary factor 1-beta Human genes 0.000 description 1
- 102100034697 Transducin-like enhancer protein 2 Human genes 0.000 description 1
- 102000004338 Transferrin Human genes 0.000 description 1
- 108090000901 Transferrin Proteins 0.000 description 1
- 102100032762 Transformation/transcription domain-associated protein Human genes 0.000 description 1
- 102100026145 Transitional endoplasmic reticulum ATPase Human genes 0.000 description 1
- 101710132062 Transitional endoplasmic reticulum ATPase Proteins 0.000 description 1
- 102100037025 Transmembrane protease serine 11D Human genes 0.000 description 1
- 101710172763 Transmembrane protease serine 11D Proteins 0.000 description 1
- 102100032006 Transmembrane protease serine 11F Human genes 0.000 description 1
- 102100032469 Transmembrane protease serine 12 Human genes 0.000 description 1
- 102100032467 Transmembrane protease serine 13 Human genes 0.000 description 1
- 101710144006 Transmembrane protease serine 13 Proteins 0.000 description 1
- 101710081844 Transmembrane protease serine 2 Proteins 0.000 description 1
- 102100032454 Transmembrane protease serine 3 Human genes 0.000 description 1
- 101710081843 Transmembrane protease serine 3 Proteins 0.000 description 1
- 101710081835 Transmembrane protease serine 4 Proteins 0.000 description 1
- 101710081833 Transmembrane protease serine 5 Proteins 0.000 description 1
- 102100032452 Transmembrane protease serine 6 Human genes 0.000 description 1
- 101710081839 Transmembrane protease serine 6 Proteins 0.000 description 1
- 102100032468 Transmembrane protease serine 9 Human genes 0.000 description 1
- 102100026387 Tribbles homolog 1 Human genes 0.000 description 1
- 102100026394 Tribbles homolog 2 Human genes 0.000 description 1
- 102100026390 Tribbles homolog 3 Human genes 0.000 description 1
- 102100040411 Tripeptidyl-peptidase 2 Human genes 0.000 description 1
- 101710119665 Trypsin-1 Proteins 0.000 description 1
- 101710119666 Trypsin-2 Proteins 0.000 description 1
- 102100034396 Trypsin-3 Human genes 0.000 description 1
- 102000001400 Tryptase Human genes 0.000 description 1
- 108060005989 Tryptase Proteins 0.000 description 1
- 102100029637 Tryptase beta-2 Human genes 0.000 description 1
- 102100032760 Tryptase delta Human genes 0.000 description 1
- 101710185398 Tubulointerstitial nephritis antigen Proteins 0.000 description 1
- 102100033469 Tubulointerstitial nephritis antigen-like Human genes 0.000 description 1
- 108010047933 Tumor Necrosis Factor alpha-Induced Protein 3 Proteins 0.000 description 1
- 102000044209 Tumor Suppressor Genes Human genes 0.000 description 1
- 108700025716 Tumor Suppressor Genes Proteins 0.000 description 1
- 102100024596 Tumor necrosis factor alpha-induced protein 3 Human genes 0.000 description 1
- 102100033444 Tyrosine-protein kinase JAK2 Human genes 0.000 description 1
- 102100033001 Tyrosine-protein phosphatase non-receptor type 1 Human genes 0.000 description 1
- 102100033019 Tyrosine-protein phosphatase non-receptor type 11 Human genes 0.000 description 1
- 101710116241 Tyrosine-protein phosphatase non-receptor type 11 Proteins 0.000 description 1
- 102100027243 U4/U6.U5 tri-snRNP-associated protein 2 Human genes 0.000 description 1
- 108020000553 UMP kinase Proteins 0.000 description 1
- 101710100179 UMP-CMP kinase Proteins 0.000 description 1
- 101710119674 UMP-CMP kinase 2, mitochondrial Proteins 0.000 description 1
- 101150020913 USP7 gene Proteins 0.000 description 1
- 102100038462 Ubiquitin carboxyl-terminal hydrolase 11 Human genes 0.000 description 1
- 102100024662 Ubiquitin carboxyl-terminal hydrolase 12 Human genes 0.000 description 1
- 102100024720 Ubiquitin carboxyl-terminal hydrolase 13 Human genes 0.000 description 1
- 102100029164 Ubiquitin carboxyl-terminal hydrolase 15 Human genes 0.000 description 1
- 102100024922 Ubiquitin carboxyl-terminal hydrolase 17 Human genes 0.000 description 1
- 102100020728 Ubiquitin carboxyl-terminal hydrolase 19 Human genes 0.000 description 1
- 102100039920 Ubiquitin carboxyl-terminal hydrolase 20 Human genes 0.000 description 1
- 102100039918 Ubiquitin carboxyl-terminal hydrolase 21 Human genes 0.000 description 1
- 102100037184 Ubiquitin carboxyl-terminal hydrolase 22 Human genes 0.000 description 1
- 102100037180 Ubiquitin carboxyl-terminal hydrolase 26 Human genes 0.000 description 1
- 102100029736 Ubiquitin carboxyl-terminal hydrolase 27 Human genes 0.000 description 1
- 102100029821 Ubiquitin carboxyl-terminal hydrolase 28 Human genes 0.000 description 1
- 102100031287 Ubiquitin carboxyl-terminal hydrolase 3 Human genes 0.000 description 1
- 102100040052 Ubiquitin carboxyl-terminal hydrolase 30 Human genes 0.000 description 1
- 102100040096 Ubiquitin carboxyl-terminal hydrolase 34 Human genes 0.000 description 1
- 102100040108 Ubiquitin carboxyl-terminal hydrolase 38 Human genes 0.000 description 1
- 102100031284 Ubiquitin carboxyl-terminal hydrolase 40 Human genes 0.000 description 1
- 102100031310 Ubiquitin carboxyl-terminal hydrolase 42 Human genes 0.000 description 1
- 102100031306 Ubiquitin carboxyl-terminal hydrolase 44 Human genes 0.000 description 1
- 102100024718 Ubiquitin carboxyl-terminal hydrolase 45 Human genes 0.000 description 1
- 102100025025 Ubiquitin carboxyl-terminal hydrolase 46 Human genes 0.000 description 1
- 102100025029 Ubiquitin carboxyl-terminal hydrolase 47 Human genes 0.000 description 1
- 102100021017 Ubiquitin carboxyl-terminal hydrolase 5 Human genes 0.000 description 1
- 102100021015 Ubiquitin carboxyl-terminal hydrolase 6 Human genes 0.000 description 1
- 102100021013 Ubiquitin carboxyl-terminal hydrolase 7 Human genes 0.000 description 1
- 102100037587 Ubiquitin carboxyl-terminal hydrolase BAP1 Human genes 0.000 description 1
- 101710138903 Ubiquitin carboxyl-terminal hydrolase BAP1 Proteins 0.000 description 1
- 102100024250 Ubiquitin carboxyl-terminal hydrolase CYLD Human genes 0.000 description 1
- 102100038443 Ubiquitin carboxyl-terminal hydrolase isozyme L5 Human genes 0.000 description 1
- 102100025914 Ubiquitin thioesterase OTUB2 Human genes 0.000 description 1
- 108700011958 Ubiquitin-Specific Peptidase 7 Proteins 0.000 description 1
- 102000002082 Ubiquitin-associated domains Human genes 0.000 description 1
- 108050009411 Ubiquitin-associated domains Proteins 0.000 description 1
- 229940126752 Ubiquitin-specific protease 7 inhibitor Drugs 0.000 description 1
- 102100020726 Ubl carboxyl-terminal hydrolase 18 Human genes 0.000 description 1
- 102000007410 Uridine kinase Human genes 0.000 description 1
- 102100025139 Valacyclovir hydrolase Human genes 0.000 description 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
- 108010030681 Viomycin kinase Proteins 0.000 description 1
- 229930003316 Vitamin D Natural products 0.000 description 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 1
- 229930003448 Vitamin K Natural products 0.000 description 1
- 102000004210 Vitamin K Epoxide Reductases Human genes 0.000 description 1
- 108090000779 Vitamin K Epoxide Reductases Proteins 0.000 description 1
- 102100028885 Vitamin K-dependent protein S Human genes 0.000 description 1
- 102100021208 Vitamin K-dependent protein Z Human genes 0.000 description 1
- 101150007909 Wnk4 gene Proteins 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 102100038359 Xaa-Pro aminopeptidase 3 Human genes 0.000 description 1
- 241000269368 Xenopus laevis Species 0.000 description 1
- 101100273808 Xenopus laevis cdk1-b gene Proteins 0.000 description 1
- 102100029089 Xylulose kinase Human genes 0.000 description 1
- 108030005454 [Tau protein] kinases Proteins 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000004308 accommodation Effects 0.000 description 1
- 108020002494 acetyltransferase Proteins 0.000 description 1
- 102000005421 acetyltransferase Human genes 0.000 description 1
- 125000003647 acryloyl group Chemical group O=C([*])C([H])=C([H])[H] 0.000 description 1
- 238000010263 activity profiling Methods 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 102000045404 acyltransferase activity proteins Human genes 0.000 description 1
- 108700014220 acyltransferase activity proteins Proteins 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000001800 adrenalinergic effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 150000001350 alkyl halides Chemical class 0.000 description 1
- 108090000183 alpha-2-Antiplasmin Proteins 0.000 description 1
- VREFGVBLTWBCJP-UHFFFAOYSA-N alprazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NN=C2CN=C1C1=CC=CC=C1 VREFGVBLTWBCJP-UHFFFAOYSA-N 0.000 description 1
- 238000005576 amination reaction Methods 0.000 description 1
- 201000008266 amyotrophic lateral sclerosis type 2 Diseases 0.000 description 1
- 150000008064 anhydrides Chemical class 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000000692 anti-sense effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
- 238000000149 argon plasma sintering Methods 0.000 description 1
- 101150066673 artI gene Proteins 0.000 description 1
- 108010055066 asparaginylendopeptidase Proteins 0.000 description 1
- 235000003704 aspartic acid Nutrition 0.000 description 1
- 239000005441 aurora Substances 0.000 description 1
- 150000001541 aziridines Chemical class 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 239000012965 benzophenone Substances 0.000 description 1
- 150000008366 benzophenones Chemical class 0.000 description 1
- BGWGXPAPYGQALX-ARQDHWQXSA-N beta-D-fructofuranose 6-phosphate Chemical compound OC[C@@]1(O)O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O BGWGXPAPYGQALX-ARQDHWQXSA-N 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- 229940125385 biologic drug Drugs 0.000 description 1
- 239000013060 biological fluid Substances 0.000 description 1
- 230000031018 biological processes and functions Effects 0.000 description 1
- PFYXSUNOLOJMDX-UHFFFAOYSA-N bis(2,5-dioxopyrrolidin-1-yl) carbonate Chemical compound O=C1CCC(=O)N1OC(=O)ON1C(=O)CCC1=O PFYXSUNOLOJMDX-UHFFFAOYSA-N 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 229940077737 brain-derived neurotrophic factor Drugs 0.000 description 1
- 210000004899 c-terminal region Anatomy 0.000 description 1
- 102100029402 cAMP-dependent protein kinase catalytic subunit PRKX Human genes 0.000 description 1
- 102100032791 cAMP-dependent protein kinase catalytic subunit alpha Human genes 0.000 description 1
- 102100033065 cAMP-dependent protein kinase catalytic subunit beta Human genes 0.000 description 1
- 102100033064 cAMP-dependent protein kinase catalytic subunit gamma Human genes 0.000 description 1
- 102100022421 cGMP-dependent protein kinase 2 Human genes 0.000 description 1
- WUKWITHWXAAZEY-UHFFFAOYSA-L calcium difluoride Chemical compound [F-].[F-].[Ca+2] WUKWITHWXAAZEY-UHFFFAOYSA-L 0.000 description 1
- 229910001634 calcium fluoride Inorganic materials 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- 230000036952 cancer formation Effects 0.000 description 1
- 238000005251 capillar electrophoresis Methods 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000011852 carbon nanoparticle Substances 0.000 description 1
- 239000002041 carbon nanotube Substances 0.000 description 1
- 229910021393 carbon nanotube Inorganic materials 0.000 description 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 1
- 231100000504 carcinogenesis Toxicity 0.000 description 1
- 229940044199 carnosine Drugs 0.000 description 1
- CQOVPNPJLQNMDC-ZETCQYMHSA-N carnosine Chemical compound [NH3+]CCC(=O)N[C@H](C([O-])=O)CC1=CNC=N1 CQOVPNPJLQNMDC-ZETCQYMHSA-N 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 238000000423 cell based assay Methods 0.000 description 1
- 230000022131 cell cycle Effects 0.000 description 1
- 230000032823 cell division Effects 0.000 description 1
- 230000003915 cell function Effects 0.000 description 1
- 239000013592 cell lysate Substances 0.000 description 1
- 230000036978 cell physiology Effects 0.000 description 1
- 230000010001 cellular homeostasis Effects 0.000 description 1
- 208000015114 central nervous system disease Diseases 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 229940106189 ceramide Drugs 0.000 description 1
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 description 1
- 210000003679 cervix uteri Anatomy 0.000 description 1
- 125000003636 chemical group Chemical group 0.000 description 1
- 238000000701 chemical imaging Methods 0.000 description 1
- 238000001311 chemical methods and process Methods 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- FZFAMSAMCHXGEF-UHFFFAOYSA-N chloro formate Chemical compound ClOC=O FZFAMSAMCHXGEF-UHFFFAOYSA-N 0.000 description 1
- 229940048961 cholinesterase Drugs 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 208000025302 chronic primary adrenal insufficiency Diseases 0.000 description 1
- 101150116749 chuk gene Proteins 0.000 description 1
- 229940080701 chymosin Drugs 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 229940105774 coagulation factor ix Drugs 0.000 description 1
- 229940105772 coagulation factor vii Drugs 0.000 description 1
- 229940105756 coagulation factor x Drugs 0.000 description 1
- 230000000536 complexating effect Effects 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 238000006482 condensation reaction Methods 0.000 description 1
- 230000021615 conjugation Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 239000012228 culture supernatant Substances 0.000 description 1
- 230000001351 cycling effect Effects 0.000 description 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 1
- 230000003436 cytoskeletal effect Effects 0.000 description 1
- 230000001086 cytosolic effect Effects 0.000 description 1
- 108010000742 dTMP kinase Proteins 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 108010034075 decysin Proteins 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 108010007340 deoxyadenosine kinase Proteins 0.000 description 1
- 239000005547 deoxyribonucleotide Substances 0.000 description 1
- 125000002637 deoxyribonucleotide group Chemical group 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 229910052805 deuterium Inorganic materials 0.000 description 1
- 229950006137 dexfosfoserine Drugs 0.000 description 1
- 150000004845 diazirines Chemical class 0.000 description 1
- 150000008049 diazo compounds Chemical class 0.000 description 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-O diazynium Chemical class [NH+]#N IJGRMHOSHXDMSA-UHFFFAOYSA-O 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 208000010643 digestive system disease Diseases 0.000 description 1
- 229940090124 dipeptidyl peptidase 4 (dpp-4) inhibitors for blood glucose lowering Drugs 0.000 description 1
- 239000001177 diphosphate Substances 0.000 description 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 description 1
- 235000011180 diphosphates Nutrition 0.000 description 1
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 description 1
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 101150081549 eif3f gene Proteins 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 238000005566 electron beam evaporation Methods 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 108010044215 ethanolamine kinase Proteins 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 210000002744 extracellular matrix Anatomy 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 210000001508 eye Anatomy 0.000 description 1
- 208000008805 familial cylindromatosis Diseases 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000010408 film Substances 0.000 description 1
- 238000001215 fluorescent labelling Methods 0.000 description 1
- 229940014144 folate Drugs 0.000 description 1
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 108010083136 fucokinase Proteins 0.000 description 1
- 229910003472 fullerene Inorganic materials 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 108010062699 gamma-Glutamyl Hydrolase Proteins 0.000 description 1
- 206010017758 gastric cancer Diseases 0.000 description 1
- 208000018685 gastrointestinal system disease Diseases 0.000 description 1
- 108091008053 gene clusters Proteins 0.000 description 1
- 238000011223 gene expression profiling Methods 0.000 description 1
- 102000034356 gene-regulatory proteins Human genes 0.000 description 1
- 108091006104 gene-regulatory proteins Proteins 0.000 description 1
- 210000004602 germ cell Anatomy 0.000 description 1
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 125000000404 glutamine group Chemical group N[C@@H](CCC(N)=O)C(=O)* 0.000 description 1
- 108010086476 glycerate kinase Proteins 0.000 description 1
- 108700014210 glycosyltransferase activity proteins Proteins 0.000 description 1
- 239000005090 green fluorescent protein Substances 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 239000000122 growth hormone Substances 0.000 description 1
- 230000010005 growth-factor like effect Effects 0.000 description 1
- BPMFZUMJYQTVII-UHFFFAOYSA-N guanidinoacetic acid Chemical compound NC(=N)NCC(O)=O BPMFZUMJYQTVII-UHFFFAOYSA-N 0.000 description 1
- 102000009543 guanyl-nucleotide exchange factor activity proteins Human genes 0.000 description 1
- 102000006638 guanylate kinase Human genes 0.000 description 1
- 125000005179 haloacetyl group Chemical group 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 210000002216 heart Anatomy 0.000 description 1
- 238000003505 heat denaturation Methods 0.000 description 1
- 208000009429 hemophilia B Diseases 0.000 description 1
- 210000003494 hepatocyte Anatomy 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- 150000002402 hexoses Chemical class 0.000 description 1
- 150000002429 hydrazines Chemical class 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 229960002591 hydroxyproline Drugs 0.000 description 1
- 108010002685 hygromycin-B kinase Proteins 0.000 description 1
- 150000002463 imidates Chemical class 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 208000026278 immune system disease Diseases 0.000 description 1
- 238000009169 immunotherapy Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 230000000937 inactivator Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 108091022911 insulin-like growth factor binding Proteins 0.000 description 1
- 102000028416 insulin-like growth factor binding Human genes 0.000 description 1
- 108010044426 integrins Proteins 0.000 description 1
- 102000006495 integrins Human genes 0.000 description 1
- 238000009830 intercalation Methods 0.000 description 1
- 239000000543 intermediate Substances 0.000 description 1
- 201000002313 intestinal cancer Diseases 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 230000037041 intracellular level Effects 0.000 description 1
- 238000006192 iodination reaction Methods 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- ODBLHEXUDAPZAU-UHFFFAOYSA-N isocitric acid Chemical compound OC(=O)C(O)C(C(O)=O)CC(O)=O ODBLHEXUDAPZAU-UHFFFAOYSA-N 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 150000002540 isothiocyanates Chemical class 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- 208000032799 juvenile amyotrophic lateral sclerosis type 2 Diseases 0.000 description 1
- 230000000366 juvenile effect Effects 0.000 description 1
- 150000004715 keto acids Chemical class 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 208000017169 kidney disease Diseases 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 108010072713 leukotriene A4 hydrolase Proteins 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 108700041430 link Proteins 0.000 description 1
- FCCDDURTIIUXBY-UHFFFAOYSA-N lipoamide Chemical compound NC(=O)CCCCC1CCSS1 FCCDDURTIIUXBY-UHFFFAOYSA-N 0.000 description 1
- 238000001459 lithography Methods 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 238000004020 luminiscence type Methods 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 210000004880 lymph fluid Anatomy 0.000 description 1
- 230000001926 lymphatic effect Effects 0.000 description 1
- 210000003563 lymphoid tissue Anatomy 0.000 description 1
- 230000002132 lysosomal effect Effects 0.000 description 1
- 230000002101 lytic effect Effects 0.000 description 1
- 238000003754 machining Methods 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000036210 malignancy Effects 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 230000008774 maternal effect Effects 0.000 description 1
- 108090000440 matrix metalloproteinase 25 Proteins 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 201000001441 melanoma Diseases 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 229910001092 metal group alloy Inorganic materials 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 238000001465 metallisation Methods 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 1
- 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 description 1
- LSBDJGANJWONSP-UHFFFAOYSA-N methyl 3-chloro-5-[1-(3-chloro-4-methoxy-5-methoxycarbonylphenyl)-6-methoxy-6-oxohex-1-enyl]-2-methoxybenzoate Chemical compound C=1C(Cl)=C(OC)C(C(=O)OC)=CC=1C(=CCCCC(=O)OC)C1=CC(Cl)=C(OC)C(C(=O)OC)=C1 LSBDJGANJWONSP-UHFFFAOYSA-N 0.000 description 1
- LSDPWZHWYPCBBB-UHFFFAOYSA-O methylsulfide anion Chemical compound [SH2+]C LSDPWZHWYPCBBB-UHFFFAOYSA-O 0.000 description 1
- 108091070501 miRNA Proteins 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 230000003228 microsomal effect Effects 0.000 description 1
- 238000001634 microspectroscopy Methods 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000001700 mitochondrial membrane Anatomy 0.000 description 1
- 239000003226 mitogen Substances 0.000 description 1
- 230000004001 molecular interaction Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 229910021421 monocrystalline silicon Inorganic materials 0.000 description 1
- 210000001616 monocyte Anatomy 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 238000010172 mouse model Methods 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 201000009340 myotonic dystrophy type 1 Diseases 0.000 description 1
- GNOLWGAJQVLBSM-UHFFFAOYSA-N n,n,5,7-tetramethyl-1,2,3,4-tetrahydronaphthalen-1-amine Chemical compound C1=C(C)C=C2C(N(C)C)CCCC2=C1C GNOLWGAJQVLBSM-UHFFFAOYSA-N 0.000 description 1
- NFVJNJQRWPQVOA-UHFFFAOYSA-N n-[2-chloro-5-(trifluoromethyl)phenyl]-2-[3-(4-ethyl-5-ethylsulfanyl-1,2,4-triazol-3-yl)piperidin-1-yl]acetamide Chemical compound CCN1C(SCC)=NN=C1C1CN(CC(=O)NC=2C(=CC=C(C=2)C(F)(F)F)Cl)CCC1 NFVJNJQRWPQVOA-UHFFFAOYSA-N 0.000 description 1
- 239000002114 nanocomposite Substances 0.000 description 1
- 239000002073 nanorod Substances 0.000 description 1
- 239000002070 nanowire Substances 0.000 description 1
- 102000027424 natriuretic peptide receptors Human genes 0.000 description 1
- 108091008599 natriuretic peptide receptors Proteins 0.000 description 1
- 238000013188 needle biopsy Methods 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 230000004770 neurodegeneration Effects 0.000 description 1
- 230000000626 neurodegenerative effect Effects 0.000 description 1
- 108090001073 neuroligin 3 Proteins 0.000 description 1
- 239000002858 neurotransmitter agent Substances 0.000 description 1
- 210000000440 neutrophil Anatomy 0.000 description 1
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 229910052755 nonmetal Inorganic materials 0.000 description 1
- 230000009871 nonspecific binding Effects 0.000 description 1
- 239000002853 nucleic acid probe Substances 0.000 description 1
- UPWHZOYYXHKXLQ-BGPJRJDNSA-N nucleoside triphosphate Chemical compound C[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O UPWHZOYYXHKXLQ-BGPJRJDNSA-N 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 108010062832 ovochymase Proteins 0.000 description 1
- 230000036542 oxidative stress Effects 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 108090000155 pancreatic elastase II Proteins 0.000 description 1
- 230000003071 parasitic effect Effects 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- ACNHBCIZLNNLRS-UBGQALKQSA-N paxilline Chemical compound N1C2=CC=CC=C2C2=C1[C@]1(C)[C@@]3(C)CC[C@@H]4O[C@H](C(C)(O)C)C(=O)C=C4[C@]3(O)CC[C@H]1C2 ACNHBCIZLNNLRS-UBGQALKQSA-N 0.000 description 1
- 239000000813 peptide hormone Substances 0.000 description 1
- 102000014187 peptide receptors Human genes 0.000 description 1
- 108010011903 peptide receptors Proteins 0.000 description 1
- KHIWWQKSHDUIBK-UHFFFAOYSA-N periodic acid Chemical compound OI(=O)(=O)=O KHIWWQKSHDUIBK-UHFFFAOYSA-N 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- BULVZWIRKLYCBC-UHFFFAOYSA-N phorate Chemical compound CCOP(=S)(OCC)SCSCC BULVZWIRKLYCBC-UHFFFAOYSA-N 0.000 description 1
- 108010006451 phosphomethylpyrimidine kinase Proteins 0.000 description 1
- 108091000116 phosphomevalonate kinase Proteins 0.000 description 1
- 150000008298 phosphoramidates Chemical class 0.000 description 1
- 108010080971 phosphoribulokinase Proteins 0.000 description 1
- 230000000865 phosphorylative effect Effects 0.000 description 1
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 235000002949 phytic acid Nutrition 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 108010025221 plasma protein Z Proteins 0.000 description 1
- 238000009832 plasma treatment Methods 0.000 description 1
- 108010017843 platelet-derived growth factor A Proteins 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 201000008542 polycystic kidney disease 2 Diseases 0.000 description 1
- 108020000161 polyphosphate kinase Proteins 0.000 description 1
- 229920005591 polysilicon Polymers 0.000 description 1
- 230000026341 positive regulation of angiogenesis Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 125000001844 prenyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 108010028075 procathepsin L Proteins 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 108010067415 progelatinase Proteins 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 108010066823 proline dipeptidase Proteins 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 108010026579 prorenin processing enzyme Proteins 0.000 description 1
- KSIRMUMXJFWKAC-FHJHOUOTSA-N prostaglandin A3 Chemical compound CC\C=C/C[C@H](O)\C=C\[C@H]1C=CC(=O)[C@@H]1C\C=C/CCCC(O)=O KSIRMUMXJFWKAC-FHJHOUOTSA-N 0.000 description 1
- 108010031970 prostasin Proteins 0.000 description 1
- 208000023958 prostate neoplasm Diseases 0.000 description 1
- 125000006239 protecting group Chemical group 0.000 description 1
- 239000011253 protective coating Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000011241 protective layer Substances 0.000 description 1
- 238000000159 protein binding assay Methods 0.000 description 1
- 229960000856 protein c Drugs 0.000 description 1
- 108010091338 protein kinase C nu Proteins 0.000 description 1
- 229940039716 prothrombin Drugs 0.000 description 1
- XNSAINXGIQZQOO-SRVKXCTJSA-N protirelin Chemical compound NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H]1NC(=O)CC1)CC1=CN=CN1 XNSAINXGIQZQOO-SRVKXCTJSA-N 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 229950010131 puromycin Drugs 0.000 description 1
- 239000010453 quartz Substances 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 239000011535 reaction buffer Substances 0.000 description 1
- 238000003753 real-time PCR Methods 0.000 description 1
- 102000027426 receptor tyrosine kinases Human genes 0.000 description 1
- 108091008598 receptor tyrosine kinases Proteins 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000004043 responsiveness Effects 0.000 description 1
- 210000001525 retina Anatomy 0.000 description 1
- 125000002652 ribonucleotide group Chemical group 0.000 description 1
- 108020002667 ribulokinase Proteins 0.000 description 1
- 208000007442 rickets Diseases 0.000 description 1
- 238000007788 roughening Methods 0.000 description 1
- 101150024074 rub1 gene Proteins 0.000 description 1
- 108010093322 s-formylglutathione hydrolase Proteins 0.000 description 1
- 102000028528 s-formylglutathione hydrolase Human genes 0.000 description 1
- 210000003079 salivary gland Anatomy 0.000 description 1
- 239000003566 sealing material Substances 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000011896 sensitive detection Methods 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 108010031009 signal peptide peptidase Proteins 0.000 description 1
- 102000034285 signal transducing proteins Human genes 0.000 description 1
- 108091006024 signal transducing proteins Proteins 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 239000002210 silicon-based material Substances 0.000 description 1
- 125000005373 siloxane group Chemical group [SiH2](O*)* 0.000 description 1
- 238000004557 single molecule detection Methods 0.000 description 1
- 210000002027 skeletal muscle Anatomy 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 229940126586 small molecule drug Drugs 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 108010086290 sphinganine kinase Proteins 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 201000011549 stomach cancer Diseases 0.000 description 1
- 238000013517 stratification Methods 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 108010041757 streptomycin 6-kinase Proteins 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical class ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000003746 surface roughness Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000002207 thermal evaporation Methods 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
- 230000001026 thromboplastic effect Effects 0.000 description 1
- 229940034199 thyrotropin-releasing hormone Drugs 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
- 238000004324 time-proportional phase incrementation Methods 0.000 description 1
- 230000030968 tissue homeostasis Effects 0.000 description 1
- 210000002105 tongue Anatomy 0.000 description 1
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
- 230000026683 transduction Effects 0.000 description 1
- 238000010361 transduction Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 239000012581 transferrin Substances 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 230000005945 translocation Effects 0.000 description 1
- 229940126836 transmembrane protease serine 6 synthesis reducer Drugs 0.000 description 1
- 102000035160 transmembrane proteins Human genes 0.000 description 1
- 108091005703 transmembrane proteins Proteins 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 108010039189 tripeptidyl-peptidase 2 Proteins 0.000 description 1
- JLEXUIVKURIPFI-UHFFFAOYSA-N tris phosphate Chemical compound OP(O)(O)=O.OCC(N)(CO)CO JLEXUIVKURIPFI-UHFFFAOYSA-N 0.000 description 1
- 239000000107 tumor biomarker Substances 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 239000000439 tumor marker Substances 0.000 description 1
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 101150062288 ubiB gene Proteins 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 235000019168 vitamin K Nutrition 0.000 description 1
- 239000011712 vitamin K Substances 0.000 description 1
- 150000003721 vitamin K derivatives Chemical class 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- 229940046010 vitamin k Drugs 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000002676 xenobiotic agent Substances 0.000 description 1
- 230000002034 xenobiotic effect Effects 0.000 description 1
- 229910052724 xenon Inorganic materials 0.000 description 1
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 1
- 108091022915 xylulokinase Proteins 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/65—Raman scattering
- G01N21/658—Raman scattering enhancement Raman, e.g. surface plasmons
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
- B29D11/00—Producing optical elements, e.g. lenses or prisms
- B29D11/0074—Production of other optical elements not provided for in B29D11/00009- B29D11/0073
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/581—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
- G01N33/587—Nanoparticles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0636—Integrated biosensor, microarrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0654—Lenses; Optical fibres
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0877—Flow chambers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/65—Raman scattering
- G01N2021/651—Cuvettes therefore
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Organic Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Dispersion Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Food Science & Technology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Cell Biology (AREA)
- Ophthalmology & Optometry (AREA)
- Biophysics (AREA)
- Nanotechnology (AREA)
- Mechanical Engineering (AREA)
- Manufacturing & Machinery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Optical Measuring Cells (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/970,451 | 2008-01-07 | ||
| US11/970,451 US7952705B2 (en) | 2007-08-24 | 2008-01-07 | Integrated microfluidic optical device for sub-micro liter liquid sample microspectroscopy |
| US12/191,812 | 2008-08-14 | ||
| US12/191,812 US20090097022A1 (en) | 2007-08-24 | 2008-08-14 | Discovery tool with integrated microfluidic biomarker optical detection array device and methods for use |
| PCT/US2008/012369 WO2009088408A1 (en) | 2008-01-07 | 2008-10-31 | Discovery tool with integrated microfluidic biomarker optical detection array device and methods for use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2710828A1 true CA2710828A1 (en) | 2009-07-16 |
Family
ID=40854774
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2710828A Abandoned CA2710828A1 (en) | 2008-01-07 | 2008-10-31 | Discovery tool with integrated microfluidic biomarker optical detection array device and methods for use |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP2229578A4 (OSRAM) |
| JP (1) | JP2011511933A (OSRAM) |
| CN (1) | CN101978248A (OSRAM) |
| AU (1) | AU2008347152A1 (OSRAM) |
| CA (1) | CA2710828A1 (OSRAM) |
| WO (1) | WO2009088408A1 (OSRAM) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012122628A1 (en) * | 2011-03-15 | 2012-09-20 | National Research Council Of Canada | Microfluidic system having monolithic nanoplasmonic structures |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9651568B2 (en) | 2009-11-23 | 2017-05-16 | Cyvek, Inc. | Methods and systems for epi-fluorescent monitoring and scanning for microfluidic assays |
| US9855735B2 (en) | 2009-11-23 | 2018-01-02 | Cyvek, Inc. | Portable microfluidic assay devices and methods of manufacture and use |
| US9500645B2 (en) | 2009-11-23 | 2016-11-22 | Cyvek, Inc. | Micro-tube particles for microfluidic assays and methods of manufacture |
| US9700889B2 (en) | 2009-11-23 | 2017-07-11 | Cyvek, Inc. | Methods and systems for manufacture of microarray assay systems, conducting microfluidic assays, and monitoring and scanning to obtain microfluidic assay results |
| US10065403B2 (en) | 2009-11-23 | 2018-09-04 | Cyvek, Inc. | Microfluidic assay assemblies and methods of manufacture |
| US9759718B2 (en) | 2009-11-23 | 2017-09-12 | Cyvek, Inc. | PDMS membrane-confined nucleic acid and antibody/antigen-functionalized microlength tube capture elements, and systems employing them, and methods of their use |
| WO2011063408A1 (en) | 2009-11-23 | 2011-05-26 | Cyvek, Inc. | Method and apparatus for performing assays |
| JP2013528379A (ja) * | 2010-05-21 | 2013-07-11 | オームクス コーポレーション | Psa酵素活性アッセイによる癌の検出 |
| CA2830533C (en) | 2011-03-22 | 2020-02-18 | Cyvek, Inc. | Microfluidic devices and methods of manufacture and use |
| WO2012165837A2 (ko) * | 2011-05-29 | 2012-12-06 | 한국화학연구원 | 라만 분석 기반 고속 다중 약물 고속 스크리닝 장치 |
| KR102114734B1 (ko) | 2012-03-08 | 2020-05-25 | 싸이벡, 아이엔씨 | 미세유체 분석 장치용 마이크로튜브 입자 및 제조방법 |
| TWI542839B (zh) * | 2012-11-30 | 2016-07-21 | 凱特伊夫公司 | 氣體包體總成及系統 |
| US20160003732A1 (en) | 2013-03-14 | 2016-01-07 | Hewlett-Packard Development Company, L.P. | Devices to detect a substance and methods of producing such a device |
| CN103499534B (zh) | 2013-07-25 | 2015-09-09 | 中国科学院苏州纳米技术与纳米仿生研究所 | 高灵敏太赫兹微流通道传感器及其制备方法 |
| EP2878373A1 (en) * | 2013-11-29 | 2015-06-03 | IMEC vzw | Capillary flow plasmonic sensor |
| EP2942390B1 (en) * | 2014-05-07 | 2017-10-04 | Commissariat À L'Énergie Atomique Et Aux Énergies Alternatives | Green microalgae lacking a functional DYRKP-1 gene, for use for increased production of feedstock |
| JP6491425B2 (ja) * | 2014-05-21 | 2019-03-27 | Towa株式会社 | 電子部品パッケージ側面撮影装置 |
| KR101626045B1 (ko) * | 2014-07-29 | 2016-06-01 | 경희대학교 산학협력단 | 눈물 방울을 이용한 바이러스 감염진단 방법 및 기기 |
| JP6441172B2 (ja) * | 2015-06-12 | 2018-12-19 | 浜松ホトニクス株式会社 | 表面増強ラマン散乱ユニット |
| JP6441174B2 (ja) * | 2015-06-18 | 2018-12-19 | 浜松ホトニクス株式会社 | 表面増強ラマン散乱ユニット |
| CN104880391B (zh) * | 2015-06-23 | 2018-03-06 | 好来化工(中山)有限公司 | 用于检测唾液中颗粒物质的装置 |
| EP3347694B8 (en) * | 2015-07-01 | 2021-04-21 | Horiba Instruments Incorporated | Cuvette assembly for optical microscopy of nanoparticles in liquids |
| US10228367B2 (en) | 2015-12-01 | 2019-03-12 | ProteinSimple | Segmented multi-use automated assay cartridge |
| WO2018017123A1 (en) | 2016-07-22 | 2018-01-25 | Hewlett-Packard Development Company, L.P. | Substrate supported sel stage and housing |
| CN107144620A (zh) * | 2017-03-31 | 2017-09-08 | 兰州百源基因技术有限公司 | 糖尿病肾病检测标志物 |
| CN107179309B (zh) * | 2017-05-22 | 2019-06-07 | 厦门大学 | 一种精氨酸激酶的检测方法 |
| CA3091774A1 (en) * | 2018-02-20 | 2019-08-29 | EMULATE, Inc. | Human microphysiological cell system for liver disease conversion with prov 1-18585 and prov 2-19154 |
| CN108982826B (zh) * | 2018-09-28 | 2024-03-26 | 广东工业大学 | 一种斑马鱼检测纳米颗粒对胚胎毒性的测试装置和测试方法 |
| WO2020122951A1 (en) * | 2018-12-14 | 2020-06-18 | Hewlett-Packard Development Company, L.P. | An analysis chip |
| DE102019100256A1 (de) * | 2019-01-07 | 2020-07-09 | Als Automated Lab Solutions Gmbh | Probengefäß mit einer Kavität zur Aufnahme einer Probe |
| GB2582619A (en) * | 2019-03-28 | 2020-09-30 | Sumitomo Chemical Co | Enzyme linked assay methods and apparatuses |
| CN110327996B (zh) * | 2019-09-03 | 2019-12-24 | 中国科学院上海高等研究院 | 微流控芯片、微流控系统及红外微流控分析方法 |
| CN112626200B (zh) * | 2021-01-12 | 2022-07-22 | 复旦大学附属妇产科医院 | 血清微囊泡-天冬酰胺内肽酶假基因1在子宫内膜异位症诊断及复发预测中的用途 |
| US20220236261A1 (en) * | 2021-01-26 | 2022-07-28 | IceMos Technology Limited | Semiconductor Device Providing a Biosensor to Test for Pathogen |
| US12222316B2 (en) | 2021-01-26 | 2025-02-11 | IceMos Technology Limited | Semiconductor device providing a biosensor to test for pathogen |
| CN114034683A (zh) * | 2021-12-01 | 2022-02-11 | 吉林大学 | 一种快速诊断1型糖尿病的多重免疫芯片及其制备方法和应用 |
| JPWO2023106372A1 (OSRAM) * | 2021-12-08 | 2023-06-15 | ||
| CN115931827B (zh) * | 2023-01-31 | 2025-07-25 | 中国科学技术大学 | 一种类免疫sers夹心法检测ndka蛋白的方法 |
| WO2025163244A1 (en) * | 2024-01-29 | 2025-08-07 | Oulun Yliopisto | Protein detection apparatus and method |
| CN117844932B (zh) * | 2024-03-07 | 2024-06-11 | 珠海圣美生物诊断技术有限公司 | 人类3号和10号染色体异常细胞检测试剂盒及其制备方法 |
| CN119534418B (zh) * | 2024-09-05 | 2025-06-20 | 东南大学 | 一种基于点击化学反应和表面增强拉曼光谱的单细胞酶活成像检测系统及其应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001524808A (ja) * | 1996-12-10 | 2001-12-04 | ジーントレイス・システムズ・インコーポレイテッド | 放出可能な不揮発性の質量標識分子 |
| US20040005582A1 (en) * | 2000-08-10 | 2004-01-08 | Nanobiodynamics, Incorporated | Biospecific desorption microflow systems and methods for studying biospecific interactions and their modulators |
| US7033910B2 (en) * | 2001-09-12 | 2006-04-25 | Reveo, Inc. | Method of fabricating multi layer MEMS and microfluidic devices |
| US7795388B2 (en) * | 2001-11-08 | 2010-09-14 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration (Nasa) | Versatile platform for nanotechnology based on circular permutations of chaperonin protein |
| US7355716B2 (en) * | 2002-01-24 | 2008-04-08 | The General Hospital Corporation | Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands |
| AU2003267583A1 (en) * | 2002-09-19 | 2004-04-08 | The Chancellor, Master And Scholars Of The University Of Oxford | Molecular arrays and single molecule detection |
| US7138330B2 (en) * | 2002-09-27 | 2006-11-21 | Medtronic Minimed, Inc. | High reliability multilayer circuit substrates and methods for their formation |
| US6975402B2 (en) * | 2002-11-19 | 2005-12-13 | Sandia National Laboratories | Tunable light source for use in photoacoustic spectrometers |
| US20060068412A1 (en) * | 2004-03-05 | 2006-03-30 | Cha-Mei Tang | Integrated multistep bioprocessor and sensor |
| JP4806411B2 (ja) * | 2004-05-19 | 2011-11-02 | ブィピー ホールディング、エルエルシー | 可視光レーザ励起ビーム及びラマン分光検出器と共に使用する光センサ、及び分析物の化学基を検出する方法 |
| US20060046277A1 (en) * | 2004-09-01 | 2006-03-02 | Belyaev Alexander S | Protein kinase and phosphatase substrates and multiplex assays for identifying their activities |
| US20060115536A1 (en) * | 2004-11-12 | 2006-06-01 | Board Of Regents, The University Of Texas System | Glycerin based synthesis of silver nanoparticles and nanowires |
| US7599057B2 (en) * | 2005-10-17 | 2009-10-06 | Sword Diagnostics, Inc. | Method and apparatus for detection of biological organisms using Raman scattering |
| GB0606088D0 (en) * | 2006-03-27 | 2006-05-03 | E2V Biosensors Ltd | Improved serrs substrate |
-
2008
- 2008-10-31 CA CA2710828A patent/CA2710828A1/en not_active Abandoned
- 2008-10-31 JP JP2010541421A patent/JP2011511933A/ja active Pending
- 2008-10-31 CN CN2008801245973A patent/CN101978248A/zh active Pending
- 2008-10-31 WO PCT/US2008/012369 patent/WO2009088408A1/en not_active Ceased
- 2008-10-31 EP EP08869969A patent/EP2229578A4/en not_active Withdrawn
- 2008-10-31 AU AU2008347152A patent/AU2008347152A1/en not_active Abandoned
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012122628A1 (en) * | 2011-03-15 | 2012-09-20 | National Research Council Of Canada | Microfluidic system having monolithic nanoplasmonic structures |
| US9291567B2 (en) | 2011-03-15 | 2016-03-22 | Lidija Malic | Microfluidic system having monolithic nanoplasmonic structures |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2011511933A (ja) | 2011-04-14 |
| EP2229578A4 (en) | 2011-02-23 |
| WO2009088408A1 (en) | 2009-07-16 |
| CN101978248A (zh) | 2011-02-16 |
| EP2229578A1 (en) | 2010-09-22 |
| AU2008347152A1 (en) | 2009-07-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2710828A1 (en) | Discovery tool with integrated microfluidic biomarker optical detection array device and methods for use | |
| US20090097022A1 (en) | Discovery tool with integrated microfluidic biomarker optical detection array device and methods for use | |
| CN103988082B (zh) | 试样分析芯片和试样分析方法以及基因分析方法 | |
| Aldewachi et al. | Gold nanoparticle-based colorimetric biosensors | |
| EP2919910B1 (en) | In vitro capture and analysis of circulating tumor cells | |
| JP5140386B2 (ja) | マイクロ流路内混合方法および装置 | |
| Yu et al. | Sensitive detection of MMP9 enzymatic activities in single cell-encapsulated microdroplets as an assay of cancer cell invasiveness | |
| WO2010026950A1 (ja) | Dna検出装置、及びdna検出デバイス、並びにdna検出方法 | |
| CN107076740A (zh) | 标靶分子的检测方法及其中所用的试剂盒 | |
| TW202020457A (zh) | 流體槽及與其相關之方法 | |
| JP2013113679A (ja) | マイクロチップ及びマイクロチップの製造方法 | |
| JP2016059347A (ja) | 細胞内の核酸の解析方法ならびにそのためのシステムおよびキット | |
| JP2008151770A (ja) | マイクロ流路チップ | |
| US20120064516A1 (en) | Nucleic acid amplifiction reaction apparatus, substrate for nucleic acid amplification reaction apparatus, and nucleic acid amplification reaction method | |
| Fan et al. | Nucleic acid substrate-independent DNA polymerization on the exosome membrane: a mechanism study and application in exosome analysis | |
| JP2007017354A (ja) | 化学反応検出システム | |
| US20250164470A1 (en) | Evaluation method, complex, and kit | |
| US20220186297A1 (en) | Ultrasensitive biosensor methods | |
| US20170023583A1 (en) | Multiplex enzyme assay using mass spectrometer-based flow cytometer | |
| JP2014070991A (ja) | 複数試料を分析するための試料分析チップとその分析装置 | |
| CN114829625B (zh) | 检测方法 | |
| Zhao et al. | Method for the accurate preparation of cell-spiking standards | |
| Zhao et al. | Biosensors for single-cell proteomic characterization | |
| Wu et al. | Biochemical analysis techniques integrated on microfluidic chips and their applications | |
| JP2017053650A (ja) | 試料分析チップ、試料分析方法及び試料分析装置 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued | ||
| FZDE | Discontinued |
Effective date: 20121031 |