EP2229578A4 - DISCOVERING TOOL WITH MICROFLUIDIC AND INTEGRATED BIOMARKER OPTICAL DETECTION NETWORK DEVICE, AND METHODS OF USE - Google Patents

DISCOVERING TOOL WITH MICROFLUIDIC AND INTEGRATED BIOMARKER OPTICAL DETECTION NETWORK DEVICE, AND METHODS OF USE

Info

Publication number
EP2229578A4
EP2229578A4 EP08869969A EP08869969A EP2229578A4 EP 2229578 A4 EP2229578 A4 EP 2229578A4 EP 08869969 A EP08869969 A EP 08869969A EP 08869969 A EP08869969 A EP 08869969A EP 2229578 A4 EP2229578 A4 EP 2229578A4
Authority
EP
European Patent Office
Prior art keywords
methods
optical detection
array device
detection array
integrated microfluidic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP08869969A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP2229578A1 (en
Inventor
Pao-Lin Shen
Li Jiang
Kejun Jiang
Zhongzhong Chen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dynamic Throughput Inc
Original Assignee
Dynamic Throughput Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/970,451 external-priority patent/US7952705B2/en
Priority claimed from US12/191,812 external-priority patent/US20090097022A1/en
Application filed by Dynamic Throughput Inc filed Critical Dynamic Throughput Inc
Publication of EP2229578A1 publication Critical patent/EP2229578A1/en
Publication of EP2229578A4 publication Critical patent/EP2229578A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N21/658—Raman scattering enhancement Raman, e.g. surface plasmons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
    • B29D11/00—Producing optical elements, e.g. lenses or prisms
    • B29D11/0074—Production of other optical elements not provided for in B29D11/00009- B29D11/0073
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/581—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G01N33/587—Nanoparticles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0654—Lenses; Optical fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N2021/651—Cuvettes therefore

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biophysics (AREA)
  • Nanotechnology (AREA)
  • Mechanical Engineering (AREA)
  • Manufacturing & Machinery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Optical Measuring Cells (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP08869969A 2008-01-07 2008-10-31 DISCOVERING TOOL WITH MICROFLUIDIC AND INTEGRATED BIOMARKER OPTICAL DETECTION NETWORK DEVICE, AND METHODS OF USE Withdrawn EP2229578A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/970,451 US7952705B2 (en) 2007-08-24 2008-01-07 Integrated microfluidic optical device for sub-micro liter liquid sample microspectroscopy
US12/191,812 US20090097022A1 (en) 2007-08-24 2008-08-14 Discovery tool with integrated microfluidic biomarker optical detection array device and methods for use
PCT/US2008/012369 WO2009088408A1 (en) 2008-01-07 2008-10-31 Discovery tool with integrated microfluidic biomarker optical detection array device and methods for use

Publications (2)

Publication Number Publication Date
EP2229578A1 EP2229578A1 (en) 2010-09-22
EP2229578A4 true EP2229578A4 (en) 2011-02-23

Family

ID=40854774

Family Applications (1)

Application Number Title Priority Date Filing Date
EP08869969A Withdrawn EP2229578A4 (en) 2008-01-07 2008-10-31 DISCOVERING TOOL WITH MICROFLUIDIC AND INTEGRATED BIOMARKER OPTICAL DETECTION NETWORK DEVICE, AND METHODS OF USE

Country Status (6)

Country Link
EP (1) EP2229578A4 (OSRAM)
JP (1) JP2011511933A (OSRAM)
CN (1) CN101978248A (OSRAM)
AU (1) AU2008347152A1 (OSRAM)
CA (1) CA2710828A1 (OSRAM)
WO (1) WO2009088408A1 (OSRAM)

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US9855735B2 (en) 2009-11-23 2018-01-02 Cyvek, Inc. Portable microfluidic assay devices and methods of manufacture and use
US9500645B2 (en) 2009-11-23 2016-11-22 Cyvek, Inc. Micro-tube particles for microfluidic assays and methods of manufacture
US9700889B2 (en) 2009-11-23 2017-07-11 Cyvek, Inc. Methods and systems for manufacture of microarray assay systems, conducting microfluidic assays, and monitoring and scanning to obtain microfluidic assay results
US10065403B2 (en) 2009-11-23 2018-09-04 Cyvek, Inc. Microfluidic assay assemblies and methods of manufacture
US9759718B2 (en) 2009-11-23 2017-09-12 Cyvek, Inc. PDMS membrane-confined nucleic acid and antibody/antigen-functionalized microlength tube capture elements, and systems employing them, and methods of their use
WO2011063408A1 (en) 2009-11-23 2011-05-26 Cyvek, Inc. Method and apparatus for performing assays
JP2013528379A (ja) * 2010-05-21 2013-07-11 オームクス コーポレーション Ｐｓａ酵素活性アッセイによる癌の検出
CA2830103C (en) * 2011-03-15 2020-03-24 National Research Council Of Canada Microfluidic system having monolithic nanoplasmonic structures
CA2830533C (en) 2011-03-22 2020-02-18 Cyvek, Inc. Microfluidic devices and methods of manufacture and use
WO2012165837A2 (ko) * 2011-05-29 2012-12-06 한국화학연구원 라만 분석 기반 고속 다중 약물 고속 스크리닝 장치
KR102114734B1 (ko) 2012-03-08 2020-05-25 싸이벡, 아이엔씨 미세유체 분석 장치용 마이크로튜브 입자 및 제조방법
TWI542839B (zh) * 2012-11-30 2016-07-21 凱特伊夫公司 氣體包體總成及系統
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EP2942390B1 (en) * 2014-05-07 2017-10-04 Commissariat À L'Énergie Atomique Et Aux Énergies Alternatives Green microalgae lacking a functional DYRKP-1 gene, for use for increased production of feedstock
JP6491425B2 (ja) * 2014-05-21 2019-03-27 Ｔｏｗａ株式会社 電子部品パッケージ側面撮影装置
KR101626045B1 (ko) * 2014-07-29 2016-06-01 경희대학교 산학협력단 눈물 방울을 이용한 바이러스 감염진단 방법 및 기기
JP6441172B2 (ja) * 2015-06-12 2018-12-19 浜松ホトニクス株式会社 表面増強ラマン散乱ユニット
JP6441174B2 (ja) * 2015-06-18 2018-12-19 浜松ホトニクス株式会社 表面増強ラマン散乱ユニット
CN104880391B (zh) * 2015-06-23 2018-03-06 好来化工(中山)有限公司 用于检测唾液中颗粒物质的装置
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CN107144620A (zh) * 2017-03-31 2017-09-08 兰州百源基因技术有限公司 糖尿病肾病检测标志物
CN107179309B (zh) * 2017-05-22 2019-06-07 厦门大学 一种精氨酸激酶的检测方法
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CN108982826B (zh) * 2018-09-28 2024-03-26 广东工业大学 一种斑马鱼检测纳米颗粒对胚胎毒性的测试装置和测试方法
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CN110327996B (zh) * 2019-09-03 2019-12-24 中国科学院上海高等研究院 微流控芯片、微流控系统及红外微流控分析方法
CN112626200B (zh) * 2021-01-12 2022-07-22 复旦大学附属妇产科医院 血清微囊泡-天冬酰胺内肽酶假基因1在子宫内膜异位症诊断及复发预测中的用途
US20220236261A1 (en) * 2021-01-26 2022-07-28 IceMos Technology Limited Semiconductor Device Providing a Biosensor to Test for Pathogen
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CN114034683A (zh) * 2021-12-01 2022-02-11 吉林大学 一种快速诊断1型糖尿病的多重免疫芯片及其制备方法和应用
JPWO2023106372A1 (OSRAM) * 2021-12-08 2023-06-15
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See also references of WO2009088408A1 *
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Also Published As

Publication number Publication date
JP2011511933A (ja) 2011-04-14
WO2009088408A1 (en) 2009-07-16
CN101978248A (zh) 2011-02-16
EP2229578A1 (en) 2010-09-22
CA2710828A1 (en) 2009-07-16
AU2008347152A1 (en) 2009-07-16

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