CA2709928A1 - Droplet actuator configurations and methods of conducting droplet operations - Google Patents
Droplet actuator configurations and methods of conducting droplet operations Download PDFInfo
- Publication number
- CA2709928A1 CA2709928A1 CA2709928A CA2709928A CA2709928A1 CA 2709928 A1 CA2709928 A1 CA 2709928A1 CA 2709928 A CA2709928 A CA 2709928A CA 2709928 A CA2709928 A CA 2709928A CA 2709928 A1 CA2709928 A1 CA 2709928A1
- Authority
- CA
- Canada
- Prior art keywords
- droplet
- electrode
- electrodes
- actuator
- field gradient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/52—Containers specially adapted for storing or dispensing a reagent
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
- B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
- B01L3/502792—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics for moving individual droplets on a plate, e.g. by locally altering surface tension
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
- B01F33/302—Micromixers the materials to be mixed flowing in the form of droplets
- B01F33/3021—Micromixers the materials to be mixed flowing in the form of droplets the components to be mixed being combined in a single independent droplet, e.g. these droplets being divided by a non-miscible fluid or consisting of independent droplets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
- B01F33/3031—Micromixers using electro-hydrodynamic [EHD] or electro-kinetic [EKI] phenomena to mix or move the fluids
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B19/00—Machines or pumps having pertinent characteristics not provided for in, or of interest apart from, groups F04B1/00 - F04B17/00
- F04B19/006—Micropumps
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
- B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0605—Metering of fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/14—Process control and prevention of errors
- B01L2200/143—Quality control, feedback systems
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- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/16—Reagents, handling or storing thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0819—Microarrays; Biochips
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/089—Virtual walls for guiding liquids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
- B01L2400/0427—Electrowetting
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0688—Valves, specific forms thereof surface tension valves, capillary stop, capillary break
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/0241—Drop counters; Drop formers
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Clinical Laboratory Science (AREA)
- Analytical Chemistry (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Physics & Mathematics (AREA)
- Fluid Mechanics (AREA)
- Medicinal Chemistry (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Coating Apparatus (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Application Of Or Painting With Fluid Materials (AREA)
- Electrostatic Spraying Apparatus (AREA)
- Particle Formation And Scattering Control In Inkjet Printers (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1648007P | 2007-12-23 | 2007-12-23 | |
| US61/016,480 | 2007-12-23 | ||
| US1661807P | 2007-12-26 | 2007-12-26 | |
| US61/016,618 | 2007-12-26 | ||
| PCT/US2008/088205 WO2009086403A2 (en) | 2007-12-23 | 2008-12-23 | Droplet actuator configurations and methods of conducting droplet operations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2709928A1 true CA2709928A1 (en) | 2009-07-09 |
Family
ID=40825079
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2709928A Abandoned CA2709928A1 (en) | 2007-12-23 | 2008-12-23 | Droplet actuator configurations and methods of conducting droplet operations |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20100270156A1 (enExample) |
| EP (1) | EP2237955A4 (enExample) |
| JP (1) | JP5462183B2 (enExample) |
| KR (1) | KR20100100974A (enExample) |
| CN (2) | CN103707643B (enExample) |
| AU (1) | AU2008345138B2 (enExample) |
| BR (1) | BRPI0821734A2 (enExample) |
| CA (1) | CA2709928A1 (enExample) |
| MX (1) | MX2010007034A (enExample) |
| WO (1) | WO2009086403A2 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11110000B2 (en) | 2012-04-10 | 2021-09-07 | Eyenovia, Inc. | Spray ejector mechanisms and devices providing charge isolation and controllable droplet charge, and low dosage volume ophthalmic administration |
| US11260416B2 (en) | 2012-05-15 | 2022-03-01 | Eyenovia, Inc. | Ejector devices, methods, drivers, and circuits therefor |
Families Citing this family (106)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL1859330T3 (pl) | 2005-01-28 | 2013-01-31 | Univ Duke | Urządzenia i sposoby manipulacji kropelkami na płytkach obwodów drukowanych |
| US20140193807A1 (en) | 2006-04-18 | 2014-07-10 | Advanced Liquid Logic, Inc. | Bead manipulation techniques |
| US8658111B2 (en) | 2006-04-18 | 2014-02-25 | Advanced Liquid Logic, Inc. | Droplet actuators, modified fluids and methods |
| US7439014B2 (en) | 2006-04-18 | 2008-10-21 | Advanced Liquid Logic, Inc. | Droplet-based surface modification and washing |
| US8637324B2 (en) | 2006-04-18 | 2014-01-28 | Advanced Liquid Logic, Inc. | Bead incubation and washing on a droplet actuator |
| US10078078B2 (en) | 2006-04-18 | 2018-09-18 | Advanced Liquid Logic, Inc. | Bead incubation and washing on a droplet actuator |
| US8809068B2 (en) | 2006-04-18 | 2014-08-19 | Advanced Liquid Logic, Inc. | Manipulation of beads in droplets and methods for manipulating droplets |
| US9675972B2 (en) | 2006-05-09 | 2017-06-13 | Advanced Liquid Logic, Inc. | Method of concentrating beads in a droplet |
| US8685344B2 (en) | 2007-01-22 | 2014-04-01 | Advanced Liquid Logic, Inc. | Surface assisted fluid loading and droplet dispensing |
| EP2111554B1 (en) | 2007-02-09 | 2013-05-08 | Advanced Liquid Logic, Inc. | Droplet actuator devices and methods employing magnetic beads |
| WO2008101194A2 (en) | 2007-02-15 | 2008-08-21 | Advanced Liquid Logic, Inc. | Capacitance detection in a droplet actuator |
| US8702938B2 (en) | 2007-09-04 | 2014-04-22 | Advanced Liquid Logic, Inc. | Droplet actuator with improved top substrate |
| EP2237955A4 (en) | 2007-12-23 | 2016-04-20 | Advanced Liquid Logic Inc | DROPLET FORMATION ACTUATOR CONFIGURATIONS, AND METHODS OF PERFORMING DROPLET FORMING OPERATIONS |
| US8852952B2 (en) | 2008-05-03 | 2014-10-07 | Advanced Liquid Logic, Inc. | Method of loading a droplet actuator |
| EP2286228B1 (en) | 2008-05-16 | 2019-04-03 | Advanced Liquid Logic, Inc. | Droplet actuator devices and methods for manipulating beads |
| FR2933315B1 (fr) * | 2008-07-07 | 2012-02-10 | Commissariat Energie Atomique | Dispositif microfluidique de deplacement de liquide |
| US8364315B2 (en) * | 2008-08-13 | 2013-01-29 | Advanced Liquid Logic Inc. | Methods, systems, and products for conducting droplet operations |
| US20110297547A1 (en) * | 2009-01-14 | 2011-12-08 | National Chiao Tung University | Virtual channel platform |
| US8877512B2 (en) * | 2009-01-23 | 2014-11-04 | Advanced Liquid Logic, Inc. | Bubble formation techniques using physical or chemical features to retain a gas bubble within a droplet actuator |
| US8926065B2 (en) | 2009-08-14 | 2015-01-06 | Advanced Liquid Logic, Inc. | Droplet actuator devices and methods |
| JP5610258B2 (ja) * | 2009-09-09 | 2014-10-22 | 国立大学法人 筑波大学 | 送液装置 |
| WO2011057197A2 (en) | 2009-11-06 | 2011-05-12 | Advanced Liquid Logic, Inc. | Integrated droplet actuator for gel electrophoresis and molecular analysis |
| EP2516669B1 (en) | 2009-12-21 | 2016-10-12 | Advanced Liquid Logic, Inc. | Enzyme assays on a droplet actuator |
| US8685325B2 (en) * | 2010-03-09 | 2014-04-01 | Sparkle Power Inc. | Field-programmable lab-on-a-chip based on microelectrode array architecture |
| US9248450B2 (en) | 2010-03-30 | 2016-02-02 | Advanced Liquid Logic, Inc. | Droplet operations platform |
| EP2567213B1 (en) | 2010-05-05 | 2018-01-24 | The Governing Council of the Universtiy of Toronto | Method of processing dried samples using digital microfluidic device |
| US9011662B2 (en) | 2010-06-30 | 2015-04-21 | Advanced Liquid Logic, Inc. | Droplet actuator assemblies and methods of making same |
| US20120006681A1 (en) * | 2010-07-06 | 2012-01-12 | Kaler Karan V I S | Controlled Dispensing of Ultrafine, Variable Volume, Emulsion Droplets |
| US20130168250A1 (en) * | 2010-09-16 | 2013-07-04 | Advanced Liquid Logic Inc | Droplet Actuator Systems, Devices and Methods |
| US20130068622A1 (en) * | 2010-11-24 | 2013-03-21 | Michael John Schertzer | Method and apparatus for real-time monitoring of droplet composition in microfluidic devices |
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2008
- 2008-12-23 EP EP08868761.1A patent/EP2237955A4/en not_active Withdrawn
- 2008-12-23 WO PCT/US2008/088205 patent/WO2009086403A2/en not_active Ceased
- 2008-12-23 KR KR1020107015759A patent/KR20100100974A/ko not_active Ceased
- 2008-12-23 JP JP2010539943A patent/JP5462183B2/ja not_active Expired - Fee Related
- 2008-12-23 BR BRPI0821734A patent/BRPI0821734A2/pt not_active IP Right Cessation
- 2008-12-23 AU AU2008345138A patent/AU2008345138B2/en not_active Ceased
- 2008-12-23 CN CN201310415655.0A patent/CN103707643B/zh not_active Expired - Fee Related
- 2008-12-23 CN CN2008801272542A patent/CN101945767B/zh not_active Expired - Fee Related
- 2008-12-23 US US12/682,830 patent/US20100270156A1/en not_active Abandoned
- 2008-12-23 CA CA2709928A patent/CA2709928A1/en not_active Abandoned
- 2008-12-23 MX MX2010007034A patent/MX2010007034A/es active IP Right Grant
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| US11110000B2 (en) | 2012-04-10 | 2021-09-07 | Eyenovia, Inc. | Spray ejector mechanisms and devices providing charge isolation and controllable droplet charge, and low dosage volume ophthalmic administration |
| US12029682B2 (en) | 2012-04-10 | 2024-07-09 | Eyenovia, Inc. | Spray ejector mechanisms and devices providing charge isolation and controllable droplet charge, and low dosage volume ophthalmic administration |
| US11260416B2 (en) | 2012-05-15 | 2022-03-01 | Eyenovia, Inc. | Ejector devices, methods, drivers, and circuits therefor |
Also Published As
| Publication number | Publication date |
|---|---|
| US20150174578A1 (en) | 2015-06-25 |
| AU2008345138A1 (en) | 2009-07-09 |
| BRPI0821734A2 (pt) | 2022-10-25 |
| WO2009086403A3 (en) | 2009-10-22 |
| JP5462183B2 (ja) | 2014-04-02 |
| CN101945767B (zh) | 2013-10-30 |
| EP2237955A4 (en) | 2016-04-20 |
| WO2009086403A2 (en) | 2009-07-09 |
| US20100270156A1 (en) | 2010-10-28 |
| US9630180B2 (en) | 2017-04-25 |
| AU2008345138B2 (en) | 2014-05-29 |
| CN103707643A (zh) | 2014-04-09 |
| JP2011508224A (ja) | 2011-03-10 |
| EP2237955A2 (en) | 2010-10-13 |
| KR20100100974A (ko) | 2010-09-15 |
| CN101945767A (zh) | 2011-01-12 |
| CN103707643B (zh) | 2016-06-01 |
| MX2010007034A (es) | 2010-09-14 |
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