FR2872438B1 - Dispositif de deplacement et de traitement de volumes de liquide - Google Patents

Dispositif de deplacement et de traitement de volumes de liquide

Info

Publication number
FR2872438B1
FR2872438B1 FR0451400A FR0451400A FR2872438B1 FR 2872438 B1 FR2872438 B1 FR 2872438B1 FR 0451400 A FR0451400 A FR 0451400A FR 0451400 A FR0451400 A FR 0451400A FR 2872438 B1 FR2872438 B1 FR 2872438B1
Authority
FR
France
Prior art keywords
displacing
conductor
processing liquid
liquid volumes
liquid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0451400A
Other languages
English (en)
Other versions
FR2872438A1 (fr
Inventor
Gilles Marchand
Yves Fouillet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Commissariat a lEnergie Atomique et aux Energies Alternatives CEA
Original Assignee
Commissariat a lEnergie Atomique CEA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Commissariat a lEnergie Atomique CEA filed Critical Commissariat a lEnergie Atomique CEA
Priority to FR0451400A priority Critical patent/FR2872438B1/fr
Priority to AT05782022T priority patent/ATE531452T1/de
Priority to JP2007518668A priority patent/JP5437575B2/ja
Priority to EP20050782022 priority patent/EP1773497B1/fr
Priority to US11/631,389 priority patent/US8864967B2/en
Priority to PCT/FR2005/050527 priority patent/WO2006013303A1/fr
Publication of FR2872438A1 publication Critical patent/FR2872438A1/fr
Application granted granted Critical
Publication of FR2872438B1 publication Critical patent/FR2872438B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B01L3/502792—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics for moving individual droplets on a plate, e.g. by locally altering surface tension
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B19/00—Machines or pumps having pertinent characteristics not provided for in, or of interest apart from, groups F04B1/00 - F04B17/00
    • F04B19/006—Micropumps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/089—Virtual walls for guiding liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B01L2300/165—Specific details about hydrophobic, oleophobic surfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1816—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using induction heating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0427—Electrowetting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/206—Flow affected by fluid contact, energy field or coanda effect [e.g., pure fluid device or system]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/206—Flow affected by fluid contact, energy field or coanda effect [e.g., pure fluid device or system]
    • Y10T137/218—Means to regulate or vary operation of device
    • Y10T137/2185—To vary frequency of pulses or oscillations

Landscapes

  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Electrostatic Separation (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
FR0451400A 2004-07-01 2004-07-01 Dispositif de deplacement et de traitement de volumes de liquide Expired - Fee Related FR2872438B1 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
FR0451400A FR2872438B1 (fr) 2004-07-01 2004-07-01 Dispositif de deplacement et de traitement de volumes de liquide
AT05782022T ATE531452T1 (de) 2004-07-01 2005-06-30 Vorrichtung zur bewegung und behandlung von flüssigkeitsvolumina
JP2007518668A JP5437575B2 (ja) 2004-07-01 2005-06-30 液滴を移動させて処理するためのデバイス
EP20050782022 EP1773497B1 (fr) 2004-07-01 2005-06-30 Dispositif de deplacement et de traitement de volumes de liquide
US11/631,389 US8864967B2 (en) 2004-07-01 2005-06-30 Device for moving and treating volumes of liquid
PCT/FR2005/050527 WO2006013303A1 (fr) 2004-07-01 2005-06-30 Dispositif de deplacement et de traitement de volumes de liquide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0451400A FR2872438B1 (fr) 2004-07-01 2004-07-01 Dispositif de deplacement et de traitement de volumes de liquide

Publications (2)

Publication Number Publication Date
FR2872438A1 FR2872438A1 (fr) 2006-01-06
FR2872438B1 true FR2872438B1 (fr) 2006-09-15

Family

ID=34946391

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0451400A Expired - Fee Related FR2872438B1 (fr) 2004-07-01 2004-07-01 Dispositif de deplacement et de traitement de volumes de liquide

Country Status (6)

Country Link
US (1) US8864967B2 (fr)
EP (1) EP1773497B1 (fr)
JP (1) JP5437575B2 (fr)
AT (1) ATE531452T1 (fr)
FR (1) FR2872438B1 (fr)
WO (1) WO2006013303A1 (fr)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006081558A2 (fr) 2005-01-28 2006-08-03 Duke University Appareils et procedes de manipulation de gouttelettes sur une carte de circuits imprimes
JP2008539759A (ja) 2005-05-11 2008-11-20 ナノリティックス・インコーポレイテッド 多数の温度で生化学的又は化学的な反応を実施する方法及び装置
US20140193807A1 (en) 2006-04-18 2014-07-10 Advanced Liquid Logic, Inc. Bead manipulation techniques
US9476856B2 (en) 2006-04-13 2016-10-25 Advanced Liquid Logic, Inc. Droplet-based affinity assays
US10078078B2 (en) 2006-04-18 2018-09-18 Advanced Liquid Logic, Inc. Bead incubation and washing on a droplet actuator
US7439014B2 (en) 2006-04-18 2008-10-21 Advanced Liquid Logic, Inc. Droplet-based surface modification and washing
US8637324B2 (en) 2006-04-18 2014-01-28 Advanced Liquid Logic, Inc. Bead incubation and washing on a droplet actuator
US8658111B2 (en) 2006-04-18 2014-02-25 Advanced Liquid Logic, Inc. Droplet actuators, modified fluids and methods
US7851184B2 (en) 2006-04-18 2010-12-14 Advanced Liquid Logic, Inc. Droplet-based nucleic acid amplification method and apparatus
US8980198B2 (en) 2006-04-18 2015-03-17 Advanced Liquid Logic, Inc. Filler fluids for droplet operations
US8716015B2 (en) 2006-04-18 2014-05-06 Advanced Liquid Logic, Inc. Manipulation of cells on a droplet actuator
WO2007123908A2 (fr) 2006-04-18 2007-11-01 Advanced Liquid Logic, Inc. Opérations en puits multiples à base de gouttelettes
US8809068B2 (en) 2006-04-18 2014-08-19 Advanced Liquid Logic, Inc. Manipulation of beads in droplets and methods for manipulating droplets
US7901947B2 (en) 2006-04-18 2011-03-08 Advanced Liquid Logic, Inc. Droplet-based particle sorting
US9675972B2 (en) 2006-05-09 2017-06-13 Advanced Liquid Logic, Inc. Method of concentrating beads in a droplet
US8685344B2 (en) 2007-01-22 2014-04-01 Advanced Liquid Logic, Inc. Surface assisted fluid loading and droplet dispensing
KR101431778B1 (ko) 2007-02-09 2014-08-20 어드밴스드 리퀴드 로직, 아이엔씨. 자성 비즈를 이용하는 액적 작동기 장치 및 방법
WO2008101194A2 (fr) 2007-02-15 2008-08-21 Advanced Liquid Logic, Inc. Détection de capacité sur un actuateur goutte
EP2126038B1 (fr) 2007-03-22 2015-01-07 Advanced Liquid Logic, Inc. Essais enzymatique pour actionneur à gouttelettes
WO2009002920A1 (fr) 2007-06-22 2008-12-31 Advanced Liquid Logic, Inc. Amplification d'acide nucléique à base de gouttelette dans un gradient de température
WO2009032863A2 (fr) 2007-09-04 2009-03-12 Advanced Liquid Logic, Inc. Actionneur de gouttelette avec substrat supérieur amélioré
CN103707643B (zh) 2007-12-23 2016-06-01 先进液体逻辑公司 液滴致动器配置以及引导液滴操作的方法
FR2930457B1 (fr) * 2008-04-24 2010-06-25 Commissariat Energie Atomique Procede de fabrication de microcanaux reconfigurables
US8852952B2 (en) 2008-05-03 2014-10-07 Advanced Liquid Logic, Inc. Method of loading a droplet actuator
EP2286228B1 (fr) 2008-05-16 2019-04-03 Advanced Liquid Logic, Inc. Dispositifs et procédés actionneurs de gouttelettes pour manipuler des billes
FR2933713B1 (fr) * 2008-07-11 2011-03-25 Commissariat Energie Atomique Procede et dispositif de manipulation et d'observation de gouttes de liquide
US8877512B2 (en) 2009-01-23 2014-11-04 Advanced Liquid Logic, Inc. Bubble formation techniques using physical or chemical features to retain a gas bubble within a droplet actuator
US8926065B2 (en) 2009-08-14 2015-01-06 Advanced Liquid Logic, Inc. Droplet actuator devices and methods
US8846414B2 (en) 2009-09-29 2014-09-30 Advanced Liquid Logic, Inc. Detection of cardiac markers on a droplet actuator
WO2011057197A2 (fr) 2009-11-06 2011-05-12 Advanced Liquid Logic, Inc. Actionneur de gouttelettes intégré pour électrophorèse sur gel et analyse moléculaire
EP2516669B1 (fr) 2009-12-21 2016-10-12 Advanced Liquid Logic, Inc. Analyses d'enzymes sur un diffuseur à gouttelettes
EP2553473A4 (fr) 2010-03-30 2016-08-10 Advanced Liquid Logic Inc Plateforme pour opérations sur des gouttelettes
US8632670B2 (en) * 2010-04-13 2014-01-21 Purdue Research Foundation Controlled flow of a thin liquid film by electrowetting
EP2588322B1 (fr) 2010-06-30 2015-06-17 Advanced Liquid Logic, Inc. Ensembles actionneurs à gouttelettes et leurs procédés de fabrication
US8982574B2 (en) * 2010-12-29 2015-03-17 Stmicroelectronics S.R.L. Contact and contactless differential I/O pads for chip-to-chip communication and wireless probing
CA2833897C (fr) 2011-05-09 2020-05-19 Advanced Liquid Logic, Inc. Retroaction microfluidique utilisant une detection d'impedance
AU2012253595B2 (en) 2011-05-10 2016-10-20 Advanced Liquid Logic, Inc. Enzyme concentration and assays
CN103733059B (zh) 2011-07-06 2016-04-06 先进流体逻辑公司 在微滴执行机构上的试剂储存
US8901043B2 (en) 2011-07-06 2014-12-02 Advanced Liquid Logic, Inc. Systems for and methods of hybrid pyrosequencing
US9513253B2 (en) 2011-07-11 2016-12-06 Advanced Liquid Logic, Inc. Droplet actuators and techniques for droplet-based enzymatic assays
US9446404B2 (en) 2011-07-25 2016-09-20 Advanced Liquid Logic, Inc. Droplet actuator apparatus and system
US8637242B2 (en) 2011-11-07 2014-01-28 Illumina, Inc. Integrated sequencing apparatuses and methods of use
WO2013078216A1 (fr) 2011-11-21 2013-05-30 Advanced Liquid Logic Inc Dosages de la glucose-6-phosphate déshydrogénase
US9223317B2 (en) 2012-06-14 2015-12-29 Advanced Liquid Logic, Inc. Droplet actuators that include molecular barrier coatings
IN2015DN00359A (fr) 2012-06-27 2015-06-12 Advanced Liquid Logic Inc
US9863913B2 (en) 2012-10-15 2018-01-09 Advanced Liquid Logic, Inc. Digital microfluidics cartridge and system for operating a flow cell
KR101598847B1 (ko) * 2014-01-23 2016-03-02 부경대학교 산학협력단 액적의 직접 충전 및 전기영동에 기반한 전기천공 기기, 장치 및 방법
CN112203767B (zh) * 2018-05-24 2023-04-11 牛津纳米孔科技公司 电润湿装置中的液滴界面

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FR2543320B1 (fr) * 1983-03-23 1986-01-31 Thomson Csf Dispositif indicateur a commande electrique de deplacement d'un fluide
FI980874A (fi) * 1998-04-20 1999-10-21 Wallac Oy Menetelmä ja laite pienten nestemäärien kemiallisen analyysin suorittamiseksi
US6565727B1 (en) * 1999-01-25 2003-05-20 Nanolytics, Inc. Actuators for microfluidics without moving parts
US6777245B2 (en) * 2000-06-09 2004-08-17 Advalytix Ag Process for manipulation of small quantities of matter
US20040231987A1 (en) * 2001-11-26 2004-11-25 Keck Graduate Institute Method, apparatus and article for microfluidic control via electrowetting, for chemical, biochemical and biological assays and the like
FR2841063B1 (fr) * 2002-06-18 2004-09-17 Commissariat Energie Atomique Dispositif de deplacement de petits volumes de liquide le long d'un micro-catenaire par des forces electrostatiques
US6911132B2 (en) * 2002-09-24 2005-06-28 Duke University Apparatus for manipulating droplets by electrowetting-based techniques

Also Published As

Publication number Publication date
EP1773497A1 (fr) 2007-04-18
US8864967B2 (en) 2014-10-21
JP5437575B2 (ja) 2014-03-12
US20080302431A1 (en) 2008-12-11
JP2008504124A (ja) 2008-02-14
FR2872438A1 (fr) 2006-01-06
EP1773497B1 (fr) 2011-11-02
WO2006013303A1 (fr) 2006-02-09
ATE531452T1 (de) 2011-11-15

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