FR2909293B1 - Micro-dispositif de traitement d'echantillons liquides - Google Patents

Micro-dispositif de traitement d'echantillons liquides

Info

Publication number
FR2909293B1
FR2909293B1 FR0655327A FR0655327A FR2909293B1 FR 2909293 B1 FR2909293 B1 FR 2909293B1 FR 0655327 A FR0655327 A FR 0655327A FR 0655327 A FR0655327 A FR 0655327A FR 2909293 B1 FR2909293 B1 FR 2909293B1
Authority
FR
France
Prior art keywords
micro
processing liquid
liquid samples
samples
processing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0655327A
Other languages
English (en)
Other versions
FR2909293A1 (fr
Inventor
Yves Fouillet
Laurent Davoust
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Commissariat a lEnergie Atomique et aux Energies Alternatives CEA
Original Assignee
Centre National de la Recherche Scientifique CNRS
Commissariat a lEnergie Atomique CEA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS, Commissariat a lEnergie Atomique CEA filed Critical Centre National de la Recherche Scientifique CNRS
Priority to FR0655327A priority Critical patent/FR2909293B1/fr
Priority to PCT/EP2007/063178 priority patent/WO2008068229A1/fr
Priority to EP07847689A priority patent/EP2097160B1/fr
Priority to US12/518,007 priority patent/US8444836B2/en
Priority to JP2009539723A priority patent/JP5166436B2/ja
Publication of FR2909293A1 publication Critical patent/FR2909293A1/fr
Application granted granted Critical
Publication of FR2909293B1 publication Critical patent/FR2909293B1/fr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/302—Micromixers the materials to be mixed flowing in the form of droplets
    • B01F33/3021—Micromixers the materials to be mixed flowing in the form of droplets the components to be mixed being combined in a single independent droplet, e.g. these droplets being divided by a non-miscible fluid or consisting of independent droplets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5088—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above confining liquids at a location by surface tension, e.g. virtual wells on plates, wires
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/3031—Micromixers using electro-hydrodynamic [EHD] or electro-kinetic [EKI] phenomena to mix or move the fluids
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B19/00—Machines or pumps having pertinent characteristics not provided for in, or of interest apart from, groups F04B1/00 - F04B17/00
    • F04B19/006—Micropumps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Fluid Mechanics (AREA)
  • Electrostatic Separation (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Micromachines (AREA)
  • Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
FR0655327A 2006-12-05 2006-12-05 Micro-dispositif de traitement d'echantillons liquides Expired - Fee Related FR2909293B1 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
FR0655327A FR2909293B1 (fr) 2006-12-05 2006-12-05 Micro-dispositif de traitement d'echantillons liquides
PCT/EP2007/063178 WO2008068229A1 (fr) 2006-12-05 2007-12-03 Micro-dispositif de traitement d'échantillons liquides.
EP07847689A EP2097160B1 (fr) 2006-12-05 2007-12-03 Micro-dispositif et procédé de traitement d'échantillons liquides
US12/518,007 US8444836B2 (en) 2006-12-05 2007-12-03 Microdevice for treating liquid samples
JP2009539723A JP5166436B2 (ja) 2006-12-05 2007-12-03 液体サンプルを処理するためのマイクロデバイス

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0655327A FR2909293B1 (fr) 2006-12-05 2006-12-05 Micro-dispositif de traitement d'echantillons liquides

Publications (2)

Publication Number Publication Date
FR2909293A1 FR2909293A1 (fr) 2008-06-06
FR2909293B1 true FR2909293B1 (fr) 2011-04-22

Family

ID=38198138

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0655327A Expired - Fee Related FR2909293B1 (fr) 2006-12-05 2006-12-05 Micro-dispositif de traitement d'echantillons liquides

Country Status (5)

Country Link
US (1) US8444836B2 (fr)
EP (1) EP2097160B1 (fr)
JP (1) JP5166436B2 (fr)
FR (1) FR2909293B1 (fr)
WO (1) WO2008068229A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109603939A (zh) * 2019-01-04 2019-04-12 京东方科技集团股份有限公司 极板及微流控芯片

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US7329545B2 (en) 2002-09-24 2008-02-12 Duke University Methods for sampling a liquid flow
US8349276B2 (en) 2002-09-24 2013-01-08 Duke University Apparatuses and methods for manipulating droplets on a printed circuit board
US8734003B2 (en) * 2005-09-15 2014-05-27 Alcatel Lucent Micro-chemical mixing
US20140193807A1 (en) 2006-04-18 2014-07-10 Advanced Liquid Logic, Inc. Bead manipulation techniques
US8658111B2 (en) 2006-04-18 2014-02-25 Advanced Liquid Logic, Inc. Droplet actuators, modified fluids and methods
WO2007123908A2 (fr) 2006-04-18 2007-11-01 Advanced Liquid Logic, Inc. Opérations en puits multiples à base de gouttelettes
US8809068B2 (en) 2006-04-18 2014-08-19 Advanced Liquid Logic, Inc. Manipulation of beads in droplets and methods for manipulating droplets
US8637324B2 (en) 2006-04-18 2014-01-28 Advanced Liquid Logic, Inc. Bead incubation and washing on a droplet actuator
US10078078B2 (en) 2006-04-18 2018-09-18 Advanced Liquid Logic, Inc. Bead incubation and washing on a droplet actuator
US8716015B2 (en) 2006-04-18 2014-05-06 Advanced Liquid Logic, Inc. Manipulation of cells on a droplet actuator
US7439014B2 (en) 2006-04-18 2008-10-21 Advanced Liquid Logic, Inc. Droplet-based surface modification and washing
US9675972B2 (en) 2006-05-09 2017-06-13 Advanced Liquid Logic, Inc. Method of concentrating beads in a droplet
US8685344B2 (en) 2007-01-22 2014-04-01 Advanced Liquid Logic, Inc. Surface assisted fluid loading and droplet dispensing
EP2111554B1 (fr) 2007-02-09 2013-05-08 Advanced Liquid Logic, Inc. Dispositifs actionneurs de gouttelettes et procédés employant des perles magnétiques
US8872527B2 (en) * 2007-02-15 2014-10-28 Advanced Liquid Logic, Inc. Capacitance detection in a droplet actuator
US8268246B2 (en) 2007-08-09 2012-09-18 Advanced Liquid Logic Inc PCB droplet actuator fabrication
US8702938B2 (en) * 2007-09-04 2014-04-22 Advanced Liquid Logic, Inc. Droplet actuator with improved top substrate
WO2009052123A2 (fr) * 2007-10-17 2009-04-23 Advanced Liquid Logic, Inc. Schémas de détection à multiplexage destinés à un actionneur à gouttelettes
WO2009052321A2 (fr) * 2007-10-18 2009-04-23 Advanced Liquid Logic, Inc. Actionneurs de gouttelettes, systèmes et procédés
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FR2930457B1 (fr) * 2008-04-24 2010-06-25 Commissariat Energie Atomique Procede de fabrication de microcanaux reconfigurables
US8852952B2 (en) 2008-05-03 2014-10-07 Advanced Liquid Logic, Inc. Method of loading a droplet actuator
EP2286228B1 (fr) 2008-05-16 2019-04-03 Advanced Liquid Logic, Inc. Dispositifs et procédés actionneurs de gouttelettes pour manipuler des billes
FR2936167A1 (fr) * 2008-09-23 2010-03-26 Commissariat Energie Atomique Micro-dispositif d'analyse d'echantillons liquides.
US8877512B2 (en) 2009-01-23 2014-11-04 Advanced Liquid Logic, Inc. Bubble formation techniques using physical or chemical features to retain a gas bubble within a droplet actuator
US20130146459A1 (en) * 2009-06-16 2013-06-13 Massachusetts Institute Of Technology Multiphase non-linear electrokinetic devices
US8926065B2 (en) 2009-08-14 2015-01-06 Advanced Liquid Logic, Inc. Droplet actuator devices and methods
WO2011057197A2 (fr) 2009-11-06 2011-05-12 Advanced Liquid Logic, Inc. Actionneur de gouttelettes intégré pour électrophorèse sur gel et analyse moléculaire
EP2516669B1 (fr) 2009-12-21 2016-10-12 Advanced Liquid Logic, Inc. Analyses d'enzymes sur un diffuseur à gouttelettes
WO2011126892A2 (fr) 2010-03-30 2011-10-13 Advanced Liquid Logic, Inc. Plateforme pour opérations sur des gouttelettes
WO2012012090A2 (fr) 2010-06-30 2012-01-26 Advanced Liquid Logic, Inc. Ensembles actionneurs à gouttelettes et leurs procédés de fabrication
WO2012107101A1 (fr) * 2011-02-11 2012-08-16 Commissariat à l'énergie atomique et aux énergies alternatives Procédé et microsystème pour détecter des analytes présents dans des gouttelettes de liquide.
TWI419738B (zh) * 2011-03-18 2013-12-21 Ind Tech Res Inst 微粒子輸送器
WO2012154745A2 (fr) 2011-05-09 2012-11-15 Advanced Liquid Logic, Inc. Rétroaction microfluidique utilisant une détection d'impédance
US9140635B2 (en) 2011-05-10 2015-09-22 Advanced Liquid Logic, Inc. Assay for measuring enzymatic modification of a substrate by a glycoprotein having enzymatic activity
AU2012279420A1 (en) 2011-07-06 2014-01-30 Advanced Liquid Logic Inc Reagent storage on a droplet actuator
US8901043B2 (en) 2011-07-06 2014-12-02 Advanced Liquid Logic, Inc. Systems for and methods of hybrid pyrosequencing
US9513253B2 (en) 2011-07-11 2016-12-06 Advanced Liquid Logic, Inc. Droplet actuators and techniques for droplet-based enzymatic assays
US9446404B2 (en) 2011-07-25 2016-09-20 Advanced Liquid Logic, Inc. Droplet actuator apparatus and system
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WO2013078216A1 (fr) 2011-11-21 2013-05-30 Advanced Liquid Logic Inc Dosages de la glucose-6-phosphate déshydrogénase
RU2489202C1 (ru) * 2012-04-27 2013-08-10 Владимир Иванович Клешканов Мелкодисперсная эмульсия на основе воды и водонерастворимых веществ и способ ее получения
US9223317B2 (en) 2012-06-14 2015-12-29 Advanced Liquid Logic, Inc. Droplet actuators that include molecular barrier coatings
JP6222671B2 (ja) 2012-06-27 2017-11-01 アドバンスト リキッド ロジック インコーポレイテッドＡｄｖａｎｃｅｄ Ｌｉｑｕｉｄ Ｌｏｇｉｃ， Ｉｎｃ． 泡形成を低減するための技術および液滴アクチュエーターの設計
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CN105435664B (zh) * 2014-09-12 2018-06-29 杭州华安生物技术有限公司 一种抗原乳化器
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CN109126917B (zh) * 2018-10-09 2020-04-10 京东方科技集团股份有限公司 微流控芯片及其驱动方法
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CN116585756B (zh) * 2023-07-19 2023-09-22 山东第一医科大学附属省立医院(山东省立医院) 一种适用于单分子采样设备及样本存储装置

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109603939A (zh) * 2019-01-04 2019-04-12 京东方科技集团股份有限公司 极板及微流控芯片
CN109603939B (zh) * 2019-01-04 2021-08-31 京东方科技集团股份有限公司 极板及微流控芯片

Also Published As

Publication number Publication date
FR2909293A1 (fr) 2008-06-06
JP2010511506A (ja) 2010-04-15
WO2008068229A1 (fr) 2008-06-12
EP2097160B1 (fr) 2013-04-03
US8444836B2 (en) 2013-05-21
EP2097160A1 (fr) 2009-09-09
US20100320088A1 (en) 2010-12-23
JP5166436B2 (ja) 2013-03-21

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Effective date: 20160831