FR2909293B1 - Micro-dispositif de traitement d'echantillons liquides - Google Patents

Micro-dispositif de traitement d'echantillons liquides

Info

Publication number
FR2909293B1
FR2909293B1 FR0655327A FR0655327A FR2909293B1 FR 2909293 B1 FR2909293 B1 FR 2909293B1 FR 0655327 A FR0655327 A FR 0655327A FR 0655327 A FR0655327 A FR 0655327A FR 2909293 B1 FR2909293 B1 FR 2909293B1
Authority
FR
France
Prior art keywords
micro
processing liquid
liquid samples
samples
processing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0655327A
Other languages
English (en)
Other versions
FR2909293A1 (fr
Inventor
Yves Fouillet
Laurent Davoust
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Commissariat a lEnergie Atomique et aux Energies Alternatives CEA
Original Assignee
Centre National de la Recherche Scientifique CNRS
Commissariat a lEnergie Atomique CEA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS, Commissariat a lEnergie Atomique CEA filed Critical Centre National de la Recherche Scientifique CNRS
Priority to FR0655327A priority Critical patent/FR2909293B1/fr
Priority to JP2009539723A priority patent/JP5166436B2/ja
Priority to US12/518,007 priority patent/US8444836B2/en
Priority to PCT/EP2007/063178 priority patent/WO2008068229A1/fr
Priority to EP07847689A priority patent/EP2097160B1/fr
Publication of FR2909293A1 publication Critical patent/FR2909293A1/fr
Application granted granted Critical
Publication of FR2909293B1 publication Critical patent/FR2909293B1/fr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/302—Micromixers the materials to be mixed flowing in the form of droplets
    • B01F33/3021—Micromixers the materials to be mixed flowing in the form of droplets the components to be mixed being combined in a single independent droplet, e.g. these droplets being divided by a non-miscible fluid or consisting of independent droplets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5088—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above confining liquids at a location by surface tension, e.g. virtual wells on plates, wires
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/3031—Micromixers using electro-hydrodynamic [EHD] or electro-kinetic [EKI] phenomena to mix or move the fluids
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B19/00—Machines or pumps having pertinent characteristics not provided for in, or of interest apart from, groups F04B1/00 - F04B17/00
    • F04B19/006—Micropumps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Fluid Mechanics (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Mechanical Engineering (AREA)
  • Clinical Laboratory Science (AREA)
  • Electrostatic Separation (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Micromachines (AREA)
  • Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
FR0655327A 2006-12-05 2006-12-05 Micro-dispositif de traitement d'echantillons liquides Expired - Fee Related FR2909293B1 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
FR0655327A FR2909293B1 (fr) 2006-12-05 2006-12-05 Micro-dispositif de traitement d'echantillons liquides
JP2009539723A JP5166436B2 (ja) 2006-12-05 2007-12-03 液体サンプルを処理するためのマイクロデバイス
US12/518,007 US8444836B2 (en) 2006-12-05 2007-12-03 Microdevice for treating liquid samples
PCT/EP2007/063178 WO2008068229A1 (fr) 2006-12-05 2007-12-03 Micro-dispositif de traitement d'échantillons liquides.
EP07847689A EP2097160B1 (fr) 2006-12-05 2007-12-03 Micro-dispositif et procédé de traitement d'échantillons liquides

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0655327A FR2909293B1 (fr) 2006-12-05 2006-12-05 Micro-dispositif de traitement d'echantillons liquides

Publications (2)

Publication Number Publication Date
FR2909293A1 FR2909293A1 (fr) 2008-06-06
FR2909293B1 true FR2909293B1 (fr) 2011-04-22

Family

ID=38198138

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0655327A Expired - Fee Related FR2909293B1 (fr) 2006-12-05 2006-12-05 Micro-dispositif de traitement d'echantillons liquides

Country Status (5)

Country Link
US (1) US8444836B2 (fr)
EP (1) EP2097160B1 (fr)
JP (1) JP5166436B2 (fr)
FR (1) FR2909293B1 (fr)
WO (1) WO2008068229A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109603939A (zh) * 2019-01-04 2019-04-12 京东方科技集团股份有限公司 极板及微流控芯片

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US7329545B2 (en) * 2002-09-24 2008-02-12 Duke University Methods for sampling a liquid flow
CN101146595B (zh) 2005-01-28 2012-07-04 杜克大学 用于在印刷电路板上操作液滴的装置和方法
US8734003B2 (en) * 2005-09-15 2014-05-27 Alcatel Lucent Micro-chemical mixing
US20140193807A1 (en) 2006-04-18 2014-07-10 Advanced Liquid Logic, Inc. Bead manipulation techniques
US8637324B2 (en) 2006-04-18 2014-01-28 Advanced Liquid Logic, Inc. Bead incubation and washing on a droplet actuator
US8658111B2 (en) 2006-04-18 2014-02-25 Advanced Liquid Logic, Inc. Droplet actuators, modified fluids and methods
WO2009140671A2 (fr) 2008-05-16 2009-11-19 Advanced Liquid Logic, Inc. Dispositifs et procédés actionneurs de gouttelettes pour manipuler des billes
US7439014B2 (en) 2006-04-18 2008-10-21 Advanced Liquid Logic, Inc. Droplet-based surface modification and washing
US10078078B2 (en) 2006-04-18 2018-09-18 Advanced Liquid Logic, Inc. Bead incubation and washing on a droplet actuator
US8809068B2 (en) 2006-04-18 2014-08-19 Advanced Liquid Logic, Inc. Manipulation of beads in droplets and methods for manipulating droplets
WO2007123908A2 (fr) 2006-04-18 2007-11-01 Advanced Liquid Logic, Inc. Opérations en puits multiples à base de gouttelettes
US8716015B2 (en) 2006-04-18 2014-05-06 Advanced Liquid Logic, Inc. Manipulation of cells on a droplet actuator
US9675972B2 (en) 2006-05-09 2017-06-13 Advanced Liquid Logic, Inc. Method of concentrating beads in a droplet
WO2008091848A2 (fr) * 2007-01-22 2008-07-31 Advanced Liquid Logic, Inc. Chargement de fluide assisté en surface et distribution de gouttelette
CA2712863C (fr) 2007-02-09 2015-01-06 Advanced Liquid Logic, Inc. Dispositifs actionneurs de gouttelettes et procedes employant des perles magnetiques
WO2008101194A2 (fr) 2007-02-15 2008-08-21 Advanced Liquid Logic, Inc. Détection de capacité sur un actuateur goutte
US8268246B2 (en) 2007-08-09 2012-09-18 Advanced Liquid Logic Inc PCB droplet actuator fabrication
WO2009032863A2 (fr) 2007-09-04 2009-03-12 Advanced Liquid Logic, Inc. Actionneur de gouttelette avec substrat supérieur amélioré
US20100236928A1 (en) * 2007-10-17 2010-09-23 Advanced Liquid Logic, Inc. Multiplexed Detection Schemes for a Droplet Actuator
WO2009052321A2 (fr) * 2007-10-18 2009-04-23 Advanced Liquid Logic, Inc. Actionneurs de gouttelettes, systèmes et procédés
MX2010007034A (es) * 2007-12-23 2010-09-14 Advanced Liquid Logic Inc Configuraciones para eyector de gotas y metodos para realizar operaciones de gota.
FR2930457B1 (fr) * 2008-04-24 2010-06-25 Commissariat Energie Atomique Procede de fabrication de microcanaux reconfigurables
WO2009137415A2 (fr) 2008-05-03 2009-11-12 Advanced Liquid Logic, Inc. Réactif et préparation, charge et stockage d'échantillon
FR2936167A1 (fr) * 2008-09-23 2010-03-26 Commissariat Energie Atomique Micro-dispositif d'analyse d'echantillons liquides.
US8877512B2 (en) 2009-01-23 2014-11-04 Advanced Liquid Logic, Inc. Bubble formation techniques using physical or chemical features to retain a gas bubble within a droplet actuator
US20130146459A1 (en) * 2009-06-16 2013-06-13 Massachusetts Institute Of Technology Multiphase non-linear electrokinetic devices
US8926065B2 (en) 2009-08-14 2015-01-06 Advanced Liquid Logic, Inc. Droplet actuator devices and methods
WO2011057197A2 (fr) 2009-11-06 2011-05-12 Advanced Liquid Logic, Inc. Actionneur de gouttelettes intégré pour électrophorèse sur gel et analyse moléculaire
EP2516669B1 (fr) 2009-12-21 2016-10-12 Advanced Liquid Logic, Inc. Analyses d'enzymes sur un diffuseur à gouttelettes
WO2011126892A2 (fr) 2010-03-30 2011-10-13 Advanced Liquid Logic, Inc. Plateforme pour opérations sur des gouttelettes
EP2588322B1 (fr) 2010-06-30 2015-06-17 Advanced Liquid Logic, Inc. Ensembles actionneurs à gouttelettes et leurs procédés de fabrication
JP5822953B2 (ja) * 2011-02-11 2015-11-25 コミサリア ア レネルジィ アトミーク エ オ ゼネ ルジイ アルテアナティーフＣｏｍｍｉｓｓａｒｉａｔａ Ｌ’Ｅｎｅｒｇｉｅ Ａｔｏｍｉｑｕｅ Ｅｔ Ａｕｘ Ｅｎｅｒｇｉｅｓ Ａｌｔｅｒｎａｔｉｖｅｓ 液滴中に存在する検体を検出するための方法およびマイクロシステム
TWI419738B (zh) * 2011-03-18 2013-12-21 Ind Tech Res Inst 微粒子輸送器
EP2707131B1 (fr) 2011-05-09 2019-04-24 Advanced Liquid Logic, Inc. Rétroaction microfluidique utilisant une détection d'impédance
EP2707724A4 (fr) 2011-05-10 2015-01-21 Advanced Liquid Logic Inc Concentration d'enzymes et dosages
CA2840949A1 (fr) 2011-07-06 2013-01-10 Advanced Liquid Logic Inc Stockage de reactifs sur un actionneur de manipulation de gouttelettes
US8901043B2 (en) 2011-07-06 2014-12-02 Advanced Liquid Logic, Inc. Systems for and methods of hybrid pyrosequencing
WO2013009927A2 (fr) 2011-07-11 2013-01-17 Advanced Liquid Logic, Inc. Actionneurs de gouttelettes et techniques pour dosages à base de gouttelettes
US9446404B2 (en) 2011-07-25 2016-09-20 Advanced Liquid Logic, Inc. Droplet actuator apparatus and system
CA2854023A1 (fr) 2011-11-07 2013-05-16 Illumina, Inc. Appareils de sequencage integre et procedes d'utilisation
FR2982176B1 (fr) * 2011-11-09 2014-01-10 Commissariat Energie Atomique Dispositif et procede de manipulation des gouttes
US10731199B2 (en) 2011-11-21 2020-08-04 Advanced Liquid Logic, Inc. Glucose-6-phosphate dehydrogenase assays
RU2489202C1 (ru) * 2012-04-27 2013-08-10 Владимир Иванович Клешканов Мелкодисперсная эмульсия на основе воды и водонерастворимых веществ и способ ее получения
US9223317B2 (en) 2012-06-14 2015-12-29 Advanced Liquid Logic, Inc. Droplet actuators that include molecular barrier coatings
BR112014032727B1 (pt) 2012-06-27 2021-12-14 Illumina France Método e sistema para realizar operações de gotícula em uma gotícula em um atuador de gotículas para redução da formação de bolhas
US9863913B2 (en) 2012-10-15 2018-01-09 Advanced Liquid Logic, Inc. Digital microfluidics cartridge and system for operating a flow cell
CN105435664B (zh) * 2014-09-12 2018-06-29 杭州华安生物技术有限公司 一种抗原乳化器
CN104275115A (zh) * 2014-09-30 2015-01-14 博奥赛斯（天津）生物科技有限公司 一种免疫抗原预处理方法
JP5825618B1 (ja) * 2015-02-06 2015-12-02 秋田県 電界撹拌用電極及びこれを用いた電界撹拌方法
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US11061015B2 (en) * 2015-08-28 2021-07-13 Sharp Life Science (Eu) Limited Droplet microfluidic device and methods of sensing the results of an assay therein
CN109126917B (zh) * 2018-10-09 2020-04-10 京东方科技集团股份有限公司 微流控芯片及其驱动方法
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CN111920395B (zh) * 2020-07-22 2024-04-09 上海掌门科技有限公司 一种脉搏采集装置
CN116585756B (zh) * 2023-07-19 2023-09-22 山东第一医科大学附属省立医院(山东省立医院) 一种适用于单分子采样设备及样本存储装置
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Publication number Priority date Publication date Assignee Title
CN109603939A (zh) * 2019-01-04 2019-04-12 京东方科技集团股份有限公司 极板及微流控芯片
CN109603939B (zh) * 2019-01-04 2021-08-31 京东方科技集团股份有限公司 极板及微流控芯片

Also Published As

Publication number Publication date
JP2010511506A (ja) 2010-04-15
US8444836B2 (en) 2013-05-21
EP2097160A1 (fr) 2009-09-09
US20100320088A1 (en) 2010-12-23
FR2909293A1 (fr) 2008-06-06
EP2097160B1 (fr) 2013-04-03
WO2008068229A1 (fr) 2008-06-12
JP5166436B2 (ja) 2013-03-21

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Effective date: 20160831