JP4969060B2 - 自動分析装置 - Google Patents
自動分析装置 Download PDFInfo
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- JP4969060B2 JP4969060B2 JP2005167632A JP2005167632A JP4969060B2 JP 4969060 B2 JP4969060 B2 JP 4969060B2 JP 2005167632 A JP2005167632 A JP 2005167632A JP 2005167632 A JP2005167632 A JP 2005167632A JP 4969060 B2 JP4969060 B2 JP 4969060B2
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- UBAZGMLMVVQSCD-UHFFFAOYSA-N carbon dioxide;molecular oxygen Chemical compound O=O.O=C=O UBAZGMLMVVQSCD-UHFFFAOYSA-N 0.000 description 2
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/08—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
- B01F33/302—Micromixers the materials to be mixed flowing in the form of droplets
- B01F33/3021—Micromixers the materials to be mixed flowing in the form of droplets the components to be mixed being combined in a single independent droplet, e.g. these droplets being divided by a non-miscible fluid or consisting of independent droplets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
- B01F33/3031—Micromixers using electro-hydrodynamic [EHD] or electro-kinetic [EKI] phenomena to mix or move the fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
- B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0803—Disc shape
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/089—Virtual walls for guiding liquids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
- B01L2400/0427—Electrowetting
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N2035/1027—General features of the devices
- G01N2035/1034—Transferring microquantities of liquid
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- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Fluid Mechanics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Description
50で検出し、結果を制御装置12に送信する。
81を形成している。また電極a18,a19,a20の部分は測光領域である。
22は、分注後洗浄ポート26に移動し、洗浄水でプローブ内面,外面を洗浄される。
a18,a19,a20に固定されて、第1反応時間の5分間液滴は保持される。
48まで搬送される。第2反応液の液滴70は撥水膜62,69との表面力により、排液ポート48の内部に入り込み、オイル71との比重の違いで浮き上がる。浮き上がった廃液73は排液チューブ47に吸引されて排出される。
Claims (7)
- 所定間隔で対向させ、間隙に液体を保持する少なくとも1対の板状部材を備えた液体搬送機構であって、
前記少なくとも1対の板状部材の少なくとも一方に、液体を搬送する方向に沿って複数の電極を所定間隔で配置した液体搬送路を複数備え、
かつ該液体搬送路には、少なくともサンプル液体を搬送するサンプル搬送路と、該サンプル搬送路に試薬を供給する試薬搬送路と、を備えた液体搬送機構と、
前記サンプル搬送路に検体を供給する検体分配機構と、
前記試薬搬送路に試薬を供給する試薬分配機構と、
前記液体搬送路中での検体と試薬の反応を光学的に分析する測定機構と、
を備え、
更に、前記試薬分配機構が前記サンプル搬送路に試薬を供給する位置より、前記検体分配機構が前記サンプル搬送路に検体を供給する位置の側に、前記検体分配機構から供給された複数の検体を保持し、かつ保持している検体を前記サンプル搬送路に複数の位置で供給する搬送路を備えたバッファ電極列を備えたことを特徴とする自動分析装置。 - 請求項1記載の自動分析装置において、
前記サンプル搬送路は異なる検体を並行して搬送できるよう複数設けられ、前記バッファ電極列は、複数の該サンプル搬送路間で連結されていることを特徴とする自動分析装置。 - 請求項2記載の自動分析装置において、
前記バッファ電極列は並行して複数設けられ、更に複数のバッファ電極列を接続する少なくとも1列の電極列を備えたことを特徴とする自動分析装置。 - 請求項2または3記載の自動分析装置において、
前記バッファ電極列には複数回分の分析が実行可能な検体を蓄えることが可能なサンプル溜めが接続されていることを特徴とする自動分析装置。 - 請求項1〜4のいずれかに記載の自動分析装置において、
前記測定機構での分析結果に基づき、再検査の要否を判断する判断手段と、
該判断手段が特定検体の特定分析項目での再検査が必要と判断した場合は、前記バッファ電極列に保持された前記特定検体と同一の検体が前記サンプル搬送路に搬送されるようにバッファ電極列を制御する制御手段とを備えたことを特徴とする自動分析装置。 - 請求項5に記載の自動分析装置において、
前記検体分配機構の近傍に検体の希釈液を供給する希釈液供給機構を備え、
該検体分配機構がサンプル搬送路に検体を供給する際に、該希釈液供給機構が該サンプル搬送路に希釈液を供給することにより、希釈した検体をサンプル搬送路内で生成し、希釈された検体を前記バッファ電極列に保持するよう制御する制御手段を備えたことを特徴とする自動分析装置。 - 請求項1〜6のいずれかに記載の自動分析装置において、
前記サンプル搬送路は放射状に形成され、かつ前記試薬搬送路は、該サンプル搬送路を横断して、複数の該サンプル搬送路に試薬を供給可能に形成されていることを特徴とする自動分析装置。
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2005167632A JP4969060B2 (ja) | 2005-06-08 | 2005-06-08 | 自動分析装置 |
PCT/JP2006/311278 WO2006132211A1 (ja) | 2005-06-08 | 2006-06-06 | 自動分析装置 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2005167632A JP4969060B2 (ja) | 2005-06-08 | 2005-06-08 | 自動分析装置 |
Publications (2)
Publication Number | Publication Date |
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JP2006343163A JP2006343163A (ja) | 2006-12-21 |
JP4969060B2 true JP4969060B2 (ja) | 2012-07-04 |
Family
ID=37498412
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP2005167632A Expired - Fee Related JP4969060B2 (ja) | 2005-06-08 | 2005-06-08 | 自動分析装置 |
Country Status (2)
Country | Link |
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JP (1) | JP4969060B2 (ja) |
WO (1) | WO2006132211A1 (ja) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8349276B2 (en) | 2002-09-24 | 2013-01-08 | Duke University | Apparatuses and methods for manipulating droplets on a printed circuit board |
US9476856B2 (en) | 2006-04-13 | 2016-10-25 | Advanced Liquid Logic, Inc. | Droplet-based affinity assays |
US20140193807A1 (en) | 2006-04-18 | 2014-07-10 | Advanced Liquid Logic, Inc. | Bead manipulation techniques |
US7727723B2 (en) | 2006-04-18 | 2010-06-01 | Advanced Liquid Logic, Inc. | Droplet-based pyrosequencing |
US8809068B2 (en) | 2006-04-18 | 2014-08-19 | Advanced Liquid Logic, Inc. | Manipulation of beads in droplets and methods for manipulating droplets |
US8637324B2 (en) | 2006-04-18 | 2014-01-28 | Advanced Liquid Logic, Inc. | Bead incubation and washing on a droplet actuator |
US7439014B2 (en) | 2006-04-18 | 2008-10-21 | Advanced Liquid Logic, Inc. | Droplet-based surface modification and washing |
US7901947B2 (en) | 2006-04-18 | 2011-03-08 | Advanced Liquid Logic, Inc. | Droplet-based particle sorting |
US10078078B2 (en) | 2006-04-18 | 2018-09-18 | Advanced Liquid Logic, Inc. | Bead incubation and washing on a droplet actuator |
US9046514B2 (en) | 2007-02-09 | 2015-06-02 | Advanced Liquid Logic, Inc. | Droplet actuator devices and methods employing magnetic beads |
AU2008237017B2 (en) * | 2007-04-10 | 2013-10-24 | Advanced Liquid Logic, Inc. | Droplet dispensing device and methods |
MX2010007034A (es) | 2007-12-23 | 2010-09-14 | Advanced Liquid Logic Inc | Configuraciones para eyector de gotas y metodos para realizar operaciones de gota. |
WO2009137415A2 (en) | 2008-05-03 | 2009-11-12 | Advanced Liquid Logic, Inc. | Reagent and sample preparation, loading, and storage |
US8926065B2 (en) | 2009-08-14 | 2015-01-06 | Advanced Liquid Logic, Inc. | Droplet actuator devices and methods |
JP5610258B2 (ja) * | 2009-09-09 | 2014-10-22 | 国立大学法人 筑波大学 | 送液装置 |
WO2011057197A2 (en) | 2009-11-06 | 2011-05-12 | Advanced Liquid Logic, Inc. | Integrated droplet actuator for gel electrophoresis and molecular analysis |
EP2516669B1 (en) | 2009-12-21 | 2016-10-12 | Advanced Liquid Logic, Inc. | Enzyme assays on a droplet actuator |
CA2833897C (en) | 2011-05-09 | 2020-05-19 | Advanced Liquid Logic, Inc. | Microfluidic feedback using impedance detection |
WO2013009927A2 (en) | 2011-07-11 | 2013-01-17 | Advanced Liquid Logic, Inc. | Droplet actuators and techniques for droplet-based assays |
US10731199B2 (en) | 2011-11-21 | 2020-08-04 | Advanced Liquid Logic, Inc. | Glucose-6-phosphate dehydrogenase assays |
BR112014032727B1 (pt) | 2012-06-27 | 2021-12-14 | Illumina France | Método e sistema para realizar operações de gotícula em uma gotícula em um atuador de gotículas para redução da formação de bolhas |
US9863913B2 (en) | 2012-10-15 | 2018-01-09 | Advanced Liquid Logic, Inc. | Digital microfluidics cartridge and system for operating a flow cell |
CN113842962B (zh) * | 2021-10-19 | 2023-02-17 | 安图实验仪器(郑州)有限公司 | 基于电润湿的浓度均一化微流控芯片及浓度均一化方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2590678B2 (ja) * | 1992-11-30 | 1997-03-12 | 株式会社島津製作所 | 生化学自動分析装置 |
JP3229915B2 (ja) * | 1995-01-19 | 2001-11-19 | 日本電子株式会社 | 生化学自動分析装置 |
JP3558898B2 (ja) * | 1998-11-05 | 2004-08-25 | 株式会社日立製作所 | 自動分析装置及び自動分析方法 |
US6565727B1 (en) * | 1999-01-25 | 2003-05-20 | Nanolytics, Inc. | Actuators for microfluidics without moving parts |
JP2002090375A (ja) * | 2000-09-12 | 2002-03-27 | A & T:Kk | 臨床検査システムおよび臨床検査システムの制御方法 |
US6911132B2 (en) * | 2002-09-24 | 2005-06-28 | Duke University | Apparatus for manipulating droplets by electrowetting-based techniques |
-
2005
- 2005-06-08 JP JP2005167632A patent/JP4969060B2/ja not_active Expired - Fee Related
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2006
- 2006-06-06 WO PCT/JP2006/311278 patent/WO2006132211A1/ja active Application Filing
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Publication number | Publication date |
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WO2006132211A1 (ja) | 2006-12-14 |
JP2006343163A (ja) | 2006-12-21 |
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