CA2688829A1 - Novel rabbit antibody humanization methods and humanized rabbit antibodies - Google Patents
Novel rabbit antibody humanization methods and humanized rabbit antibodies Download PDFInfo
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- CA2688829A1 CA2688829A1 CA2688829A CA2688829A CA2688829A1 CA 2688829 A1 CA2688829 A1 CA 2688829A1 CA 2688829 A CA2688829 A CA 2688829A CA 2688829 A CA2688829 A CA 2688829A CA 2688829 A1 CA2688829 A1 CA 2688829A1
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| PCT/US2008/064421 WO2008144757A1 (en) | 2007-05-21 | 2008-05-21 | Novel rabbit antibody humanization methods and humanized rabbit antibodies |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9422366B2 (en) | 2008-06-25 | 2016-08-23 | Esbatech, An Alcon Biomedical Research Unit Llc | Stable and soluble antibodies inhibiting TNF alpha |
| US10570198B2 (en) | 2010-10-22 | 2020-02-25 | Novartis Ag | Stable and soluble antibodies |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
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| TW200831528A (en) | 2006-11-30 | 2008-08-01 | Astrazeneca Ab | Compounds |
| US8178101B2 (en) | 2007-05-21 | 2012-05-15 | Alderbio Holdings Inc. | Use of anti-IL-6 antibodies having specific binding properties to treat cachexia |
| US7906117B2 (en) | 2007-05-21 | 2011-03-15 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever |
| US8252286B2 (en) | 2007-05-21 | 2012-08-28 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat thrombosis |
| US9701747B2 (en) | 2007-05-21 | 2017-07-11 | Alderbio Holdings Llc | Method of improving patient survivability and quality of life by anti-IL-6 antibody administration |
| US8062864B2 (en) | 2007-05-21 | 2011-11-22 | Alderbio Holdings Llc | Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies |
| CN105001332B (zh) | 2007-05-21 | 2018-12-04 | 奥尔德生物控股有限责任公司 | 针对il-6的抗体及其用途 |
| US8404235B2 (en) | 2007-05-21 | 2013-03-26 | Alderbio Holdings Llc | Antagonists of IL-6 to raise albumin and/or lower CRP |
| CA2728004C (en) | 2008-06-25 | 2022-05-24 | Esbatech, An Alcon Biomedical Research Unit Llc | Humanization of rabbit antibodies using a universal antibody framework |
| SI2752428T1 (sl) | 2008-06-25 | 2020-03-31 | Novartis Ag | Humaniziranje zajčjih protiteles z uporabo univerzalnega ogrodja protitelesa |
| US8337847B2 (en) | 2008-11-25 | 2012-12-25 | Alderbio Holdings Llc | Methods of treating anemia using anti-IL-6 antibodies |
| US9212223B2 (en) | 2008-11-25 | 2015-12-15 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat thrombosis |
| AU2009323002B2 (en) * | 2008-11-25 | 2016-01-28 | Vitaeris Inc. | Antagonists of IL-6 to raise albumin and/or lower CRP |
| US8420089B2 (en) | 2008-11-25 | 2013-04-16 | Alderbio Holdings Llc | Antagonists of IL-6 to raise albumin and/or lower CRP |
| US8323649B2 (en) | 2008-11-25 | 2012-12-04 | Alderbio Holdings Llc | Antibodies to IL-6 and use thereof |
| US8992920B2 (en) | 2008-11-25 | 2015-03-31 | Alderbio Holdings Llc | Anti-IL-6 antibodies for the treatment of arthritis |
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| US8399624B1 (en) | 2009-06-25 | 2013-03-19 | Esbatech, An Alcon Biomedical Research Unit Llc | Acceptor framework for CDR grafting |
| CN102002104A (zh) * | 2009-08-28 | 2011-04-06 | 江苏先声药物研究有限公司 | 一种抗vegf的单克隆抗体及含有该抗体的药物组合物 |
| US9775921B2 (en) | 2009-11-24 | 2017-10-03 | Alderbio Holdings Llc | Subcutaneously administrable composition containing anti-IL-6 antibody |
| WO2011066369A2 (en) | 2009-11-24 | 2011-06-03 | Alder Biopharmaceuticals, Inc. | Antagonists of il-6 to raise albumin and/or lower crp |
| MX2012006626A (es) * | 2009-12-22 | 2012-06-25 | Hoffmann La Roche | Agregacion dependiente de secuencia. |
| EP2518084B1 (en) * | 2009-12-25 | 2016-11-30 | Sekisui Medical Co., Ltd. | Method for measuring human insulin and measurement reagent |
| RU2012147249A (ru) | 2010-04-07 | 2014-05-20 | Эббви Инк. | TNF-α- СВЯЗЫВАЮЩИЕ БЕЛКИ |
| ES2847891T3 (es) | 2010-11-23 | 2021-08-04 | Vitaeris Inc | Anticuerpos anti-IL-6 para el tratamiento de la mucositis oral |
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| ES2709654T3 (es) | 2011-04-29 | 2019-04-17 | Apexigen Inc | Anticuerpos anti-CD40 y métodos de uso |
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| JP6193220B2 (ja) | 2011-05-20 | 2017-09-06 | アルダーバイオ・ホールディングズ・エルエルシー | 形質転換されたピキア・パストリス（Ｐｉｃｈｉａｐａｓｔｏｒｉｓ）などの微生物における抗体などのマルチサブユニットタンパク質の高純度生産 |
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| EP2744903B1 (en) | 2011-08-19 | 2018-10-10 | AlderBio Holdings LLC | Multi-copy strategy for high-titer and high-purity production of multi-subunit proteins such as a antibodies in transformed microbes such as pichia pastoris |
| KR102270618B1 (ko) | 2012-10-30 | 2021-06-30 | 아펙시젠, 인코포레이티드 | 항-cd40 항체 및 사용 방법 |
| AU2013378628A1 (en) | 2013-02-15 | 2015-06-11 | Esbatech - A Novartis Company Llc | Acceptor framework for CDR grafting |
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- 2008-05-21 TW TW097118659A patent/TWI609965B/zh not_active IP Right Cessation
- 2008-05-21 US US12/124,723 patent/US20090104187A1/en not_active Abandoned
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- 2008-05-21 KR KR1020097026659A patent/KR20100028571A/ko not_active Ceased
- 2008-05-21 CA CA2688829A patent/CA2688829A1/en not_active Abandoned
- 2008-05-21 TW TW097118657A patent/TWI501976B/zh not_active IP Right Cessation
- 2008-05-21 WO PCT/US2008/064421 patent/WO2008144757A1/en not_active Ceased
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- 2009-11-19 IL IL202232A patent/IL202232A/en active IP Right Grant
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9422366B2 (en) | 2008-06-25 | 2016-08-23 | Esbatech, An Alcon Biomedical Research Unit Llc | Stable and soluble antibodies inhibiting TNF alpha |
| US10100111B2 (en) | 2008-06-25 | 2018-10-16 | Esbatech, An Alcon Biomedical Research Unit Llc | Stable and soluble antibodies inhibiting TNF alpha |
| US11578123B2 (en) | 2008-06-25 | 2023-02-14 | Novartis Ag | Stable and soluble antibodies inhibiting TNFα |
| US10570198B2 (en) | 2010-10-22 | 2020-02-25 | Novartis Ag | Stable and soluble antibodies |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20100028571A (ko) | 2010-03-12 |
| TW200911826A (en) | 2009-03-16 |
| TWI609965B (zh) | 2018-01-01 |
| AU2008254578A1 (en) | 2008-11-27 |
| IL202232A0 (en) | 2010-06-16 |
| TW200902720A (en) | 2009-01-16 |
| MX343879B (es) | 2016-11-25 |
| KR20160005134A (ko) | 2016-01-13 |
| NZ601583A (en) | 2013-08-30 |
| US20090104187A1 (en) | 2009-04-23 |
| JP2010528589A (ja) | 2010-08-26 |
| EP2162469A4 (en) | 2012-08-01 |
| NO20093386L (no) | 2010-02-18 |
| AU2008254578B2 (en) | 2013-06-06 |
| NZ581418A (en) | 2012-08-31 |
| KR20170036814A (ko) | 2017-04-03 |
| MX2009012493A (es) | 2010-01-20 |
| JP5859202B2 (ja) | 2016-02-10 |
| TWI501976B (zh) | 2015-10-01 |
| EP2162469A1 (en) | 2010-03-17 |
| IL202232A (en) | 2015-11-30 |
| WO2008144757A1 (en) | 2008-11-27 |
| CN101868477A (zh) | 2010-10-20 |
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