HK1219485A1 - 用於 移植的受體框架 - Google Patents

用於 移植的受體框架

Info

Publication number
HK1219485A1
HK1219485A1 HK16107384.1A HK16107384A HK1219485A1 HK 1219485 A1 HK1219485 A1 HK 1219485A1 HK 16107384 A HK16107384 A HK 16107384A HK 1219485 A1 HK1219485 A1 HK 1219485A1
Authority
HK
Hong Kong
Prior art keywords
cdr
acceptor framework
grafting
cdr grafting
acceptor
Prior art date
Application number
HK16107384.1A
Other languages
English (en)
Inventor
Dominik Escher
Original Assignee
Esbatech - A Novartis Company Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esbatech - A Novartis Company Llc filed Critical Esbatech - A Novartis Company Llc
Publication of HK1219485A1 publication Critical patent/HK1219485A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
HK16107384.1A 2013-02-20 2016-06-24 用於 移植的受體框架 HK1219485A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2013/053329 WO2014127811A1 (en) 2013-02-20 2013-02-20 Acceptor framework for cdr grafting

Publications (1)

Publication Number Publication Date
HK1219485A1 true HK1219485A1 (zh) 2017-04-07

Family

ID=47740957

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16107384.1A HK1219485A1 (zh) 2013-02-20 2016-06-24 用於 移植的受體框架

Country Status (8)

Country Link
EP (1) EP2958939A1 (zh)
JP (1) JP2016506752A (zh)
CN (1) CN104884471A (zh)
AU (1) AU2013379444A1 (zh)
CA (1) CA2896174A1 (zh)
HK (1) HK1219485A1 (zh)
RU (1) RU2015139890A (zh)
WO (1) WO2014127811A1 (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11685773B2 (en) 2015-04-30 2023-06-27 Abcheck S.R.O. Method for mass humanization of rabbit antibodies

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4704362A (en) 1977-11-08 1987-11-03 Genentech, Inc. Recombinant cloning vehicle microbial polypeptide expression
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
EP0279582A3 (en) 1987-02-17 1989-10-18 Pharming B.V. Dna sequences to target proteins to the mammary gland for efficient secretion
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
US5633076A (en) 1989-12-01 1997-05-27 Pharming Bv Method of producing a transgenic bovine or transgenic bovine embryo
EP0627932B1 (en) 1992-11-04 2002-05-08 City Of Hope Antibody construct
US5827690A (en) 1993-12-20 1998-10-27 Genzyme Transgenics Corporatiion Transgenic production of antibodies in milk
US6905668B1 (en) 1998-09-25 2005-06-14 Tokyo Gas Company Limited Diagnostic agents for pancreatic exocrine function
EP2392596A3 (en) 1999-12-28 2013-11-27 ESBATech, an Alcon Biomedical Research Unit LLC Intrabodies with defined framework that is stable in a reducing environment and applications thereof
AU2001270609A1 (en) 2000-06-30 2002-01-14 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Heterodimeric fusion proteins
CN103739706B (zh) 2002-05-22 2015-11-18 艾斯巴技术-诺华有限责任公司 在胞内环境中表现出增强的稳定性的免疫球蛋白构架及其鉴定方法
CA2492524A1 (en) 2002-08-15 2004-02-26 Epitomics, Inc. Humanized rabbit antibodies
CA2533830A1 (en) 2003-08-07 2005-02-24 Epitomics, Inc. Methods for humanizing rabbit monoclonal antibodies
US7429487B2 (en) 2005-07-05 2008-09-30 Epitomics, Inc. Fusion partner for production of monoclonal rabbit antibodies
MX2009012493A (es) 2007-05-21 2010-01-20 Alder Biopharmaceuticals Inc Metodos de humanizacion de anticuerpo de conejo novedosos y anticuerpos de conejo humanizados.
WO2008144753A2 (en) * 2007-05-21 2008-11-27 Alder Biopharmaceuticals, Inc. Antibodies to tnf alpha and use thereof
MX346024B (es) * 2008-06-25 2017-03-02 Esbatech Alcon Biomed Res Unit Optimización de solubilidad de inmuno-aglutinantes.
DK3628686T3 (da) * 2008-06-25 2021-09-06 Novartis Ag Humanisering af kanin-antistoffer under anvendelse af et universelt antistof-framework
US8399624B1 (en) * 2009-06-25 2013-03-19 Esbatech, An Alcon Biomedical Research Unit Llc Acceptor framework for CDR grafting

Also Published As

Publication number Publication date
AU2013379444A1 (en) 2015-06-11
CN104884471A (zh) 2015-09-02
CA2896174A1 (en) 2014-08-28
EP2958939A1 (en) 2015-12-30
RU2015139890A (ru) 2017-03-27
WO2014127811A1 (en) 2014-08-28
JP2016506752A (ja) 2016-03-07

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