CA2684778C - Methods and compounds for vitamin d therapy - Google Patents
Methods and compounds for vitamin d therapy Download PDFInfo
- Publication number
- CA2684778C CA2684778C CA2684778A CA2684778A CA2684778C CA 2684778 C CA2684778 C CA 2684778C CA 2684778 A CA2684778 A CA 2684778A CA 2684778 A CA2684778 A CA 2684778A CA 2684778 C CA2684778 C CA 2684778C
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- Prior art keywords
- dihydroxyvitamin
- vitamin
- patient
- levels
- serum
- Prior art date
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- 238000007920 subcutaneous administration Methods 0.000 description 1
- 230000037072 sun protection Effects 0.000 description 1
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- 230000009885 systemic effect Effects 0.000 description 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 description 1
- 238000009475 tablet pressing Methods 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
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- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 235000010215 titanium dioxide Nutrition 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 150000005691 triesters Chemical class 0.000 description 1
- RRHXZLALVWBDKH-UHFFFAOYSA-M trimethyl-[2-(2-methylprop-2-enoyloxy)ethyl]azanium;chloride Chemical class [Cl-].CC(=C)C(=O)OCC[N+](C)(C)C RRHXZLALVWBDKH-UHFFFAOYSA-M 0.000 description 1
- 206010044697 tropical sprue Diseases 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/592—9,10-Secoergostane derivatives, e.g. ergocalciferol, i.e. vitamin D2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
- A61P5/20—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nutrition Science (AREA)
- Endocrinology (AREA)
- Physiology (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91384807P | 2007-04-25 | 2007-04-25 | |
| US60/913,848 | 2007-04-25 | ||
| PCT/US2008/061586 WO2008134518A2 (en) | 2007-04-25 | 2008-04-25 | Methods and compounds for vitamin d therapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2684778A1 CA2684778A1 (en) | 2008-11-06 |
| CA2684778C true CA2684778C (en) | 2017-09-05 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2684778A Expired - Fee Related CA2684778C (en) | 2007-04-25 | 2008-04-25 | Methods and compounds for vitamin d therapy |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US8592401B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2148685A4 (cg-RX-API-DMAC7.html) |
| JP (2) | JP5647516B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2684778C (cg-RX-API-DMAC7.html) |
| WO (1) | WO2008134518A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2904546T3 (es) | 2006-02-03 | 2022-04-05 | Opko Renal Llc | Tratamiento de la insuficiencia y deficiencia de vitamina D con 25-hidroxivitamina D2 y 25-hidroxivitamina D3 |
| SI2037936T1 (sl) | 2006-06-21 | 2014-11-28 | Opko Renal, Llc | Postopek zdravljenja in prepreäśevanja sekundarnega hiperparatiroidizma |
| PT2148661E (pt) | 2007-04-25 | 2013-03-06 | Proventiv Therapeutics Llc | Composições orais de libertação controlada compreendendo um composto de vitamina d e veículo ceroso |
| CA2684778C (en) * | 2007-04-25 | 2017-09-05 | Cytochroma Inc. | Methods and compounds for vitamin d therapy |
| CA2683628C (en) | 2007-04-25 | 2018-03-06 | Cytochroma Inc. | Method of treating vitamin d insufficiency and deficiency |
| EP2262765B1 (en) * | 2008-03-12 | 2016-03-09 | OPKO Ireland Global Holdings, Limited | Stabilized 1,25-dihydroxyvitamin d2 and method of making same |
| CA2731382C (en) * | 2008-07-24 | 2020-04-28 | Wisconsin Alumni Research Foundation | Once-a-week administration of 25-hydroxy vitamin d3 to sustain elevated steady-state pharmacokinetic blood concentration |
| WO2010045558A1 (en) * | 2008-10-17 | 2010-04-22 | Fresenius Medical Care Holdings, Inc. | Method of determining a phosphorus binder dosage for a dialysis patient |
| WO2010094810A1 (en) * | 2009-02-23 | 2010-08-26 | N.V. Organon | Pharmaceutical compositions and methods for treating tuberculosis |
| CN105796530A (zh) * | 2010-03-29 | 2016-07-27 | 赛特克罗公司 | 用于降低甲状旁腺水平的方法和组合物 |
| KR101847947B1 (ko) | 2013-03-15 | 2018-05-28 | 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 | 안정화되고 변형된 비타민 ｄ 방출 제형 |
| JP2017523220A (ja) * | 2014-08-07 | 2017-08-17 | オプコ アイルランド グローバル ホールディングス リミテッド | ２５−ヒドロキシビタミンｄを用いる補助的療法 |
| US10220047B2 (en) | 2014-08-07 | 2019-03-05 | Opko Ireland Global Holdings, Ltd. | Adjunctive therapy with 25-hydroxyvitamin D and articles therefor |
| CL2015003047A1 (es) * | 2015-10-15 | 2016-06-17 | Univ Chile | Método ex vivo para detectar precozmente injuria renal aguda en pacientes críticos, que comprende la mediciom en una muestra de tres proteinas como biomarcadores, factor de crecimiento fibroblástico 23, klotho y eritropoyetina |
| UA129792C2 (uk) | 2016-03-28 | 2025-08-06 | Ейрджен Фарма Лтд. | Способи лікування вітаміном d |
| KR102354954B1 (ko) | 2016-04-04 | 2022-01-24 | 오메자 엘엘씨 | 어유 국소 조성물 |
| WO2025094144A1 (en) | 2023-11-02 | 2025-05-08 | Eirgen Pharma Ltd. | Controlling loss of kidney function |
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| ES2904546T3 (es) | 2006-02-03 | 2022-04-05 | Opko Renal Llc | Tratamiento de la insuficiencia y deficiencia de vitamina D con 25-hidroxivitamina D2 y 25-hidroxivitamina D3 |
| SI2037936T1 (sl) | 2006-06-21 | 2014-11-28 | Opko Renal, Llc | Postopek zdravljenja in prepreäśevanja sekundarnega hiperparatiroidizma |
| FI3225243T3 (fi) | 2007-04-25 | 2025-10-13 | Opko Renal Llc | Menetelmä sekundaarisen hyperparatyreoosin turvalliseen ja tehokkaaseen hoitoon ja ehkäisyyn kroonisen munuaistaudin yhteydessä |
| CA2684778C (en) * | 2007-04-25 | 2017-09-05 | Cytochroma Inc. | Methods and compounds for vitamin d therapy |
| PT2148661E (pt) | 2007-04-25 | 2013-03-06 | Proventiv Therapeutics Llc | Composições orais de libertação controlada compreendendo um composto de vitamina d e veículo ceroso |
| CA2731382C (en) | 2008-07-24 | 2020-04-28 | Wisconsin Alumni Research Foundation | Once-a-week administration of 25-hydroxy vitamin d3 to sustain elevated steady-state pharmacokinetic blood concentration |
-
2008
- 2008-04-25 CA CA2684778A patent/CA2684778C/en not_active Expired - Fee Related
- 2008-04-25 US US12/597,224 patent/US8592401B2/en not_active Expired - Fee Related
- 2008-04-25 EP EP08746915A patent/EP2148685A4/en not_active Withdrawn
- 2008-04-25 WO PCT/US2008/061586 patent/WO2008134518A2/en not_active Ceased
- 2008-04-25 JP JP2010506521A patent/JP5647516B2/ja not_active Expired - Fee Related
-
2013
- 2013-11-11 US US14/076,932 patent/US20140066415A1/en not_active Abandoned
-
2014
- 2014-09-12 JP JP2014186879A patent/JP5952363B2/ja not_active Expired - Fee Related
-
2016
- 2016-10-10 US US15/289,935 patent/US20170027962A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20100204189A1 (en) | 2010-08-12 |
| US20170027962A1 (en) | 2017-02-02 |
| WO2008134518A2 (en) | 2008-11-06 |
| JP2010525079A (ja) | 2010-07-22 |
| JP2015013888A (ja) | 2015-01-22 |
| WO2008134518A3 (en) | 2009-12-30 |
| JP5952363B2 (ja) | 2016-07-13 |
| CA2684778A1 (en) | 2008-11-06 |
| JP5647516B2 (ja) | 2014-12-24 |
| EP2148685A4 (en) | 2010-07-28 |
| EP2148685A2 (en) | 2010-02-03 |
| US20140066415A1 (en) | 2014-03-06 |
| US8592401B2 (en) | 2013-11-26 |
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