CA2677264C - Compositions and methods for the treatment of metabolic disorders - Google Patents
Compositions and methods for the treatment of metabolic disorders Download PDFInfo
- Publication number
- CA2677264C CA2677264C CA2677264A CA2677264A CA2677264C CA 2677264 C CA2677264 C CA 2677264C CA 2677264 A CA2677264 A CA 2677264A CA 2677264 A CA2677264 A CA 2677264A CA 2677264 C CA2677264 C CA 2677264C
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- Canada
- Prior art keywords
- compound
- propylpyridin
- thiazol
- substituted
- metabolic disorder
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- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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| US9090601B2 (en) | 2009-01-30 | 2015-07-28 | Millennium Pharmaceuticals, Inc. | Thiazole derivatives |
| US8796314B2 (en) | 2009-01-30 | 2014-08-05 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
| CA2750935A1 (en) | 2009-01-30 | 2010-08-12 | Millennium Pharmaceuticals, Inc. | Heteroaryls and their use as pi3k inhibitors |
| WO2011140190A1 (en) | 2010-05-05 | 2011-11-10 | Infinity Pharmaceuticals | Tetrazolones as inhibitors of fatty acid synthase |
| US8450350B2 (en) | 2010-05-05 | 2013-05-28 | Infinity Pharmaceuticals, Inc. | Triazoles as inhibitors of fatty acid synthase |
| EP2603216A4 (en) | 2010-08-11 | 2013-12-18 | Millennium Pharm Inc | HETEROARYLE AND USES THEREOF |
| EP2603214A4 (en) | 2010-08-11 | 2013-12-18 | Millennium Pharm Inc | HETEROARYLE AND USES THEREOF |
| WO2012021611A1 (en) | 2010-08-11 | 2012-02-16 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
| BR112013006272A2 (pt) | 2010-09-17 | 2019-09-24 | Purdue Pharma Lp | compostos de piridina e seus usos |
| EP2625294A4 (en) * | 2010-10-07 | 2014-03-26 | Univ Columbia | PROCESS FOR TREATING TUMORS WITH A P53 MUTATION |
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| AU2012209295B2 (en) * | 2011-01-25 | 2016-06-30 | The Regents Of The University Of Michigan | Bcl-2/Bcl-xL inhibitors and therapeutic methods using the same |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013110007A1 (en) * | 2012-01-18 | 2013-07-25 | The Trustees Of Columbia University In The City Of New York | USE OF FATOSTATIN FOR TREATING CANCER HAVING A p53 MUTATION |
| CN104662028B (zh) | 2012-06-25 | 2017-05-24 | 托马斯杰弗逊大学 | 对具有异常的脂肪生成信号的癌症进行治疗的组合物和方法 |
| US20140275178A1 (en) * | 2013-03-13 | 2014-09-18 | Musc Foundation For Research Development | Thiazole compounds, compositions and methods for treatment of degenerative diseases and disorders |
| TR201809185T4 (tr) * | 2013-08-28 | 2018-07-23 | Medivation Tech Llc | Heterosiklik bileşikler ve kullanım yöntemleri. |
| JP2016534124A (ja) * | 2013-08-29 | 2016-11-04 | ベイラー カレッジ オブ メディスンＢａｙｌｏｒ Ｃｏｌｌｅｇｅ Ｏｆ Ｍｅｄｉｃｉｎｅ | 代謝並びに体重関連疾患の処置のための組成物および方法 |
| BR112016018691A2 (pt) * | 2014-02-14 | 2017-08-08 | Univ British Columbia | Compostos do domínio de ligação ao dna (dbd) de receptor de andrógeno humano como terapêuticos e métodos para seu uso |
| WO2016073826A1 (en) * | 2014-11-07 | 2016-05-12 | Fgh Biotech, Inc. | Synthesis of fatostatin based polycyclic compounds |
| WO2016105491A1 (en) * | 2014-12-23 | 2016-06-30 | Fgh Biotech | Compositions of fatostatin based heterocyclic compounds and uses thereof |
| US10532987B2 (en) * | 2015-02-17 | 2020-01-14 | Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Science | Compounds and methods for inducing browning of white adipose tissue |
| US10183015B2 (en) | 2015-03-04 | 2019-01-22 | Medivation Technologies Llc | Heterocyclic compounds and methods of use |
| US10189826B2 (en) | 2015-03-04 | 2019-01-29 | Medivation Technologies Llc | Heterocyclic compounds and methods of use |
| EP3307317B1 (en) * | 2015-05-29 | 2019-09-04 | Changiz Taghibiglou | Polypeptides to treat skin conditions associated with overproduction of sebum |
| WO2017079721A1 (en) * | 2015-11-06 | 2017-05-11 | The Children's Hospital Of Philadelphia | Compositions and methods for the treatment of fatty acid metabolism disorders |
| US12496283B2 (en) | 2016-04-19 | 2025-12-16 | Axcess Global Sciences, Llc | Administration of R-beta-hydroxybutyrate and related compounds in humans |
| US12329734B2 (en) | 2017-12-19 | 2025-06-17 | Axcess Global Sciences, Llc | Use of S-beta-hydroxybutyrate compounds for induction and maintenance of flow |
| US12109182B2 (en) | 2016-04-19 | 2024-10-08 | Axcess Global Sciences, Llc | Administration of R-beta-hydroxybutyrate and related compounds in humans |
| US11944598B2 (en) | 2017-12-19 | 2024-04-02 | Axcess Global Sciences, Llc | Compositions containing s-beta-hydroxybutyrate or non-racemic mixtures enriched with the s-enatiomer |
| KR102498741B1 (ko) | 2016-04-29 | 2023-02-10 | 에프지에이치 바이오테크 인코포레이티드 | 질환 치료용 이-치환된 피라졸 화합물 |
| EP3510027B1 (en) * | 2016-09-07 | 2022-11-02 | FGH BioTech, Inc. | Di-substituted pyrazole compounds for the treatment of diseases |
| KR101869308B1 (ko) * | 2017-02-28 | 2018-06-20 | 대구가톨릭대학교산학협력단 | Srebp-1 디코이 올리고디옥시뉴클레오티드 및 이를 유효성분으로 함유하는 지방간 질환의 예방 또는 치료용 약학 조성물 |
| US12090129B2 (en) | 2017-11-22 | 2024-09-17 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use |
| CA3089134A1 (en) | 2018-01-29 | 2019-08-01 | Capulus Therapeutics, Llc | Srebp inhibitors comprising a 6-membered central ring |
| WO2020132700A1 (en) | 2018-12-21 | 2020-06-25 | Fgh Biotech Inc. | Methods of using inhibitors of srebp in combination with niclosamide and analogs thereof |
| CN113631163A (zh) * | 2019-01-28 | 2021-11-09 | 卡普勒斯疗法有限责任公司 | 包括噻吩中心环的srebp抑制剂 |
| US12472200B2 (en) | 2019-05-15 | 2025-11-18 | Axcess Global Sciences, Llc | Autobiotic compositions and method for promoting healthy gut microbiome |
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2008
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- 2008-02-01 CA CA2677264A patent/CA2677264C/en active Active
- 2008-02-01 JP JP2009548468A patent/JP5461197B2/ja not_active Expired - Fee Related
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Also Published As
| Publication number | Publication date |
|---|---|
| CA2677264A1 (en) | 2008-08-14 |
| WO2008097835A2 (en) | 2008-08-14 |
| US8927578B2 (en) | 2015-01-06 |
| US8207196B2 (en) | 2012-06-26 |
| AU2008214095B2 (en) | 2014-07-10 |
| EP2120580A2 (en) | 2009-11-25 |
| US8778976B2 (en) | 2014-07-15 |
| EP2120580B1 (en) | 2017-12-27 |
| JP2014088431A (ja) | 2014-05-15 |
| US20130005768A1 (en) | 2013-01-03 |
| JP5878937B2 (ja) | 2016-03-08 |
| JP5461197B2 (ja) | 2014-04-02 |
| AU2008214095A1 (en) | 2008-08-14 |
| CN101674730A (zh) | 2010-03-17 |
| CN101674730B (zh) | 2014-09-10 |
| EP2120580A4 (en) | 2011-09-28 |
| WO2008097835A3 (en) | 2008-10-30 |
| JP2010519181A (ja) | 2010-06-03 |
| US20090131475A1 (en) | 2009-05-21 |
| US20130012538A1 (en) | 2013-01-10 |
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