CA2677146C - Nouveaux derives indoliques, leurs procedes de preparation et leurs utilisations notamment en tant qu'antibacteriens - Google Patents

Nouveaux derives indoliques, leurs procedes de preparation et leurs utilisations notamment en tant qu'antibacteriens Download PDF

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Publication number
CA2677146C
CA2677146C CA2677146A CA2677146A CA2677146C CA 2677146 C CA2677146 C CA 2677146C CA 2677146 A CA2677146 A CA 2677146A CA 2677146 A CA2677146 A CA 2677146A CA 2677146 C CA2677146 C CA 2677146C
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CA
Canada
Prior art keywords
group
hydrogen atom
representing
carbon atoms
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2677146A
Other languages
English (en)
French (fr)
Other versions
CA2677146A1 (fr
Inventor
Jean-Noel Marie Leon Denis
Xavier Jean Georges Marie Guinchard
Nicole Jeanne Moreau Nee Laffont
Luc Neuville
Yannick Vallee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique
Joseph Fourier University
Original Assignee
Centre National de la Recherche Scientifique
Joseph Fourier University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique, Joseph Fourier University filed Critical Centre National de la Recherche Scientifique
Publication of CA2677146A1 publication Critical patent/CA2677146A1/fr
Application granted granted Critical
Publication of CA2677146C publication Critical patent/CA2677146C/fr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
CA2677146A 2007-02-01 2008-01-31 Nouveaux derives indoliques, leurs procedes de preparation et leurs utilisations notamment en tant qu'antibacteriens Expired - Fee Related CA2677146C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0700717A FR2912133B1 (fr) 2007-02-01 2007-02-01 Nouveaux derives indoliques,leurs procedes de preparation et leurs utilisations notamment en tant qu'antibacteriens
FR0700717 2007-02-01
PCT/FR2008/000118 WO2008110690A2 (fr) 2007-02-01 2008-01-31 Nouveaux derives indoliques, leurs procedes de preparation et leurs utilisations notamment en tant qu'antibacteriens

Publications (2)

Publication Number Publication Date
CA2677146A1 CA2677146A1 (fr) 2008-09-18
CA2677146C true CA2677146C (fr) 2016-11-15

Family

ID=38476052

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2677146A Expired - Fee Related CA2677146C (fr) 2007-02-01 2008-01-31 Nouveaux derives indoliques, leurs procedes de preparation et leurs utilisations notamment en tant qu'antibacteriens

Country Status (9)

Country Link
US (1) US8343964B2 (cg-RX-API-DMAC10.html)
EP (1) EP2121601B8 (cg-RX-API-DMAC10.html)
JP (1) JP5368317B2 (cg-RX-API-DMAC10.html)
CN (1) CN101652346B (cg-RX-API-DMAC10.html)
AU (1) AU2008224776B2 (cg-RX-API-DMAC10.html)
CA (1) CA2677146C (cg-RX-API-DMAC10.html)
FR (1) FR2912133B1 (cg-RX-API-DMAC10.html)
RU (1) RU2464261C2 (cg-RX-API-DMAC10.html)
WO (1) WO2008110690A2 (cg-RX-API-DMAC10.html)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011060976A1 (en) 2009-11-20 2011-05-26 Universite De Liege Tryptamine-derived compounds as antibacterial agents
FR2969150B1 (fr) * 2010-12-20 2013-07-26 Centre Nat Rech Scient Nouvelles molecules indoliques demontrant des activites antibacteriennes dans une variete de bacteries a gram-negatif et positif dont des bacteries multidrogues-resistantes
ES2464598T3 (es) 2011-07-22 2014-06-03 Université Joseph Fourier Nuevos derivados bis-indólicos, procedimiento para su preparación, y sus utilizaciones como fármaco
EP2548865B1 (en) 2011-07-22 2014-03-05 Université Joseph Fourier Novel bis-indolic derivatives, their uses in particular as antibacterials
EP2639220A1 (en) * 2012-03-15 2013-09-18 Omnia Molecular, S. L. Indole derivatives and their use as antibiotics
CN103664733B (zh) * 2013-12-10 2016-04-20 邯郸惠达化工有限公司 一种吲哚啉的制备方法
CN105669519B (zh) * 2016-01-04 2018-01-05 北方民族大学 吲哚类化合物、制备方法及其作为抗耐药菌药物的应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4492694A (en) * 1983-04-12 1985-01-08 Eli Lilly And Company Indolylglycyl cephalosporin derivatives
US5328902A (en) * 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
JP4387804B2 (ja) * 2001-04-06 2009-12-24 アフィニアム・ファーマシューティカルズ・インコーポレイテッド ＦａｂＩ阻害剤
EP1608377B1 (en) 2003-03-17 2008-10-01 Affinium Pharmaceuticals, Inc. Pharmaceutical compositions comprising inhibitors of fab i and further antibiotics
DE10320453A1 (de) * 2003-05-08 2004-11-25 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Neue Bioisostere von Actinonin

Also Published As

Publication number Publication date
JP5368317B2 (ja) 2013-12-18
US20100144726A1 (en) 2010-06-10
FR2912133B1 (fr) 2009-04-24
CA2677146A1 (fr) 2008-09-18
WO2008110690A3 (fr) 2009-03-19
RU2464261C2 (ru) 2012-10-20
CN101652346A (zh) 2010-02-17
EP2121601B1 (fr) 2016-06-15
FR2912133A1 (fr) 2008-08-08
RU2009132657A (ru) 2011-03-10
WO2008110690A2 (fr) 2008-09-18
CN101652346B (zh) 2013-10-30
JP2010517983A (ja) 2010-05-27
EP2121601B8 (fr) 2016-12-07
AU2008224776A1 (en) 2008-09-18
AU2008224776B2 (en) 2012-09-06
US8343964B2 (en) 2013-01-01
EP2121601A2 (fr) 2009-11-25

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Effective date: 20210201