CN101652346B - 吲哚衍生物、其制备方法以及其用途，尤其是作为抗菌剂的用途 - Google Patents

吲哚衍生物、其制备方法以及其用途，尤其是作为抗菌剂的用途 Download PDF

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Publication number
CN101652346B
CN101652346B CN2008800097669A CN200880009766A CN101652346B CN 101652346 B CN101652346 B CN 101652346B CN 2008800097669 A CN2008800097669 A CN 2008800097669A CN 200880009766 A CN200880009766 A CN 200880009766A CN 101652346 B CN101652346 B CN 101652346B
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China
Prior art keywords
compound
formula
hydrogen atom
group
indole
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Expired - Fee Related
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CN2008800097669A
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English (en)
Chinese (zh)
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CN101652346A (zh
Inventor
J-N·M·L·丹尼斯
X·J·G·M·古因查德
N·J·莫雷亚氏拉丰
L·尼维勒
Y·沃里
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Joseph fourier university
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Joseph fourier university
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Publication of CN101652346A publication Critical patent/CN101652346A/zh
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Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
CN2008800097669A 2007-02-01 2008-01-31 吲哚衍生物、其制备方法以及其用途，尤其是作为抗菌剂的用途 Expired - Fee Related CN101652346B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0700717A FR2912133B1 (fr) 2007-02-01 2007-02-01 Nouveaux derives indoliques,leurs procedes de preparation et leurs utilisations notamment en tant qu'antibacteriens
FR0700717 2007-02-01
PCT/FR2008/000118 WO2008110690A2 (fr) 2007-02-01 2008-01-31 Nouveaux derives indoliques, leurs procedes de preparation et leurs utilisations notamment en tant qu'antibacteriens

Publications (2)

Publication Number Publication Date
CN101652346A CN101652346A (zh) 2010-02-17
CN101652346B true CN101652346B (zh) 2013-10-30

Family

ID=38476052

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2008800097669A Expired - Fee Related CN101652346B (zh) 2007-02-01 2008-01-31 吲哚衍生物、其制备方法以及其用途，尤其是作为抗菌剂的用途

Country Status (9)

Country Link
US (1) US8343964B2 (cg-RX-API-DMAC10.html)
EP (1) EP2121601B8 (cg-RX-API-DMAC10.html)
JP (1) JP5368317B2 (cg-RX-API-DMAC10.html)
CN (1) CN101652346B (cg-RX-API-DMAC10.html)
AU (1) AU2008224776B2 (cg-RX-API-DMAC10.html)
CA (1) CA2677146C (cg-RX-API-DMAC10.html)
FR (1) FR2912133B1 (cg-RX-API-DMAC10.html)
RU (1) RU2464261C2 (cg-RX-API-DMAC10.html)
WO (1) WO2008110690A2 (cg-RX-API-DMAC10.html)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011060976A1 (en) 2009-11-20 2011-05-26 Universite De Liege Tryptamine-derived compounds as antibacterial agents
FR2969150B1 (fr) * 2010-12-20 2013-07-26 Centre Nat Rech Scient Nouvelles molecules indoliques demontrant des activites antibacteriennes dans une variete de bacteries a gram-negatif et positif dont des bacteries multidrogues-resistantes
ES2464598T3 (es) 2011-07-22 2014-06-03 Université Joseph Fourier Nuevos derivados bis-indólicos, procedimiento para su preparación, y sus utilizaciones como fármaco
EP2548865B1 (en) 2011-07-22 2014-03-05 Université Joseph Fourier Novel bis-indolic derivatives, their uses in particular as antibacterials
EP2639220A1 (en) * 2012-03-15 2013-09-18 Omnia Molecular, S. L. Indole derivatives and their use as antibiotics
CN103664733B (zh) * 2013-12-10 2016-04-20 邯郸惠达化工有限公司 一种吲哚啉的制备方法
CN105669519B (zh) * 2016-01-04 2018-01-05 北方民族大学 吲哚类化合物、制备方法及其作为抗耐药菌药物的应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4492694A (en) * 1983-04-12 1985-01-08 Eli Lilly And Company Indolylglycyl cephalosporin derivatives
CN1784380A (zh) * 2003-05-08 2006-06-07 诺瓦蒂什股份公司 新的放线酰胺素生物电子等排体

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5328902A (en) * 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
JP4387804B2 (ja) * 2001-04-06 2009-12-24 アフィニアム・ファーマシューティカルズ・インコーポレイテッド ＦａｂＩ阻害剤
EP1608377B1 (en) 2003-03-17 2008-10-01 Affinium Pharmaceuticals, Inc. Pharmaceutical compositions comprising inhibitors of fab i and further antibiotics

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4492694A (en) * 1983-04-12 1985-01-08 Eli Lilly And Company Indolylglycyl cephalosporin derivatives
CN1784380A (zh) * 2003-05-08 2006-06-07 诺瓦蒂什股份公司 新的放线酰胺素生物电子等排体

Also Published As

Publication number Publication date
JP5368317B2 (ja) 2013-12-18
US20100144726A1 (en) 2010-06-10
FR2912133B1 (fr) 2009-04-24
CA2677146A1 (fr) 2008-09-18
WO2008110690A3 (fr) 2009-03-19
RU2464261C2 (ru) 2012-10-20
CA2677146C (fr) 2016-11-15
CN101652346A (zh) 2010-02-17
EP2121601B1 (fr) 2016-06-15
FR2912133A1 (fr) 2008-08-08
RU2009132657A (ru) 2011-03-10
WO2008110690A2 (fr) 2008-09-18
JP2010517983A (ja) 2010-05-27
EP2121601B8 (fr) 2016-12-07
AU2008224776A1 (en) 2008-09-18
AU2008224776B2 (en) 2012-09-06
US8343964B2 (en) 2013-01-01
EP2121601A2 (fr) 2009-11-25

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Granted publication date: 20131030

Termination date: 20190131

CF01 Termination of patent right due to non-payment of annual fee