AU2008224776B2 - Novel indole derivatives, methods for preparing same, and use thereof particularly as antibacterial agents - Google Patents

Novel indole derivatives, methods for preparing same, and use thereof particularly as antibacterial agents Download PDF

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Publication number
AU2008224776B2
AU2008224776B2 AU2008224776A AU2008224776A AU2008224776B2 AU 2008224776 B2 AU2008224776 B2 AU 2008224776B2 AU 2008224776 A AU2008224776 A AU 2008224776A AU 2008224776 A AU2008224776 A AU 2008224776A AU 2008224776 B2 AU2008224776 B2 AU 2008224776B2
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AU
Australia
Prior art keywords
group
formula
hydrogen atom
nhboc
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2008224776A
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English (en)
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AU2008224776A1 (en
Inventor
Jean-Noel Marie Leon Denis
Xavier Jean Georges Marie Guinchard
Nicole Jeanne Moreau Nee Laffont
Luc Neuville
Yannick Vallee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique
Joseph Fourier University
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Centre National de la Recherche Scientifique
Joseph Fourier University
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Publication of AU2008224776A1 publication Critical patent/AU2008224776A1/en
Application granted granted Critical
Publication of AU2008224776B2 publication Critical patent/AU2008224776B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
AU2008224776A 2007-02-01 2008-01-31 Novel indole derivatives, methods for preparing same, and use thereof particularly as antibacterial agents Ceased AU2008224776B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0700717A FR2912133B1 (fr) 2007-02-01 2007-02-01 Nouveaux derives indoliques,leurs procedes de preparation et leurs utilisations notamment en tant qu'antibacteriens
FR0700717 2007-02-01
PCT/FR2008/000118 WO2008110690A2 (fr) 2007-02-01 2008-01-31 Nouveaux derives indoliques, leurs procedes de preparation et leurs utilisations notamment en tant qu'antibacteriens

Publications (2)

Publication Number Publication Date
AU2008224776A1 AU2008224776A1 (en) 2008-09-18
AU2008224776B2 true AU2008224776B2 (en) 2012-09-06

Family

ID=38476052

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2008224776A Ceased AU2008224776B2 (en) 2007-02-01 2008-01-31 Novel indole derivatives, methods for preparing same, and use thereof particularly as antibacterial agents

Country Status (9)

Country Link
US (1) US8343964B2 (cg-RX-API-DMAC10.html)
EP (1) EP2121601B8 (cg-RX-API-DMAC10.html)
JP (1) JP5368317B2 (cg-RX-API-DMAC10.html)
CN (1) CN101652346B (cg-RX-API-DMAC10.html)
AU (1) AU2008224776B2 (cg-RX-API-DMAC10.html)
CA (1) CA2677146C (cg-RX-API-DMAC10.html)
FR (1) FR2912133B1 (cg-RX-API-DMAC10.html)
RU (1) RU2464261C2 (cg-RX-API-DMAC10.html)
WO (1) WO2008110690A2 (cg-RX-API-DMAC10.html)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011060976A1 (en) 2009-11-20 2011-05-26 Universite De Liege Tryptamine-derived compounds as antibacterial agents
FR2969150B1 (fr) * 2010-12-20 2013-07-26 Centre Nat Rech Scient Nouvelles molecules indoliques demontrant des activites antibacteriennes dans une variete de bacteries a gram-negatif et positif dont des bacteries multidrogues-resistantes
ES2464598T3 (es) 2011-07-22 2014-06-03 Université Joseph Fourier Nuevos derivados bis-indólicos, procedimiento para su preparación, y sus utilizaciones como fármaco
EP2548865B1 (en) 2011-07-22 2014-03-05 Université Joseph Fourier Novel bis-indolic derivatives, their uses in particular as antibacterials
EP2639220A1 (en) * 2012-03-15 2013-09-18 Omnia Molecular, S. L. Indole derivatives and their use as antibiotics
CN103664733B (zh) * 2013-12-10 2016-04-20 邯郸惠达化工有限公司 一种吲哚啉的制备方法
CN105669519B (zh) * 2016-01-04 2018-01-05 北方民族大学 吲哚类化合物、制备方法及其作为抗耐药菌药物的应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0122157A2 (en) * 1983-04-12 1984-10-17 Eli Lilly And Company Improvements in or relating to indolylglycyl cephalosporin derivatives

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5328902A (en) * 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
JP4387804B2 (ja) * 2001-04-06 2009-12-24 アフィニアム・ファーマシューティカルズ・インコーポレイテッド ＦａｂＩ阻害剤
EP1608377B1 (en) 2003-03-17 2008-10-01 Affinium Pharmaceuticals, Inc. Pharmaceutical compositions comprising inhibitors of fab i and further antibiotics
DE10320453A1 (de) * 2003-05-08 2004-11-25 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Neue Bioisostere von Actinonin

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0122157A2 (en) * 1983-04-12 1984-10-17 Eli Lilly And Company Improvements in or relating to indolylglycyl cephalosporin derivatives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SIAVOSH M et al: "Indole derivatives with antimycobacterial activity", Archiv der Pharmazie (Weinheim, Germany) (1994), 327(2), 105-14 *

Also Published As

Publication number Publication date
JP5368317B2 (ja) 2013-12-18
US20100144726A1 (en) 2010-06-10
FR2912133B1 (fr) 2009-04-24
CA2677146A1 (fr) 2008-09-18
WO2008110690A3 (fr) 2009-03-19
RU2464261C2 (ru) 2012-10-20
CA2677146C (fr) 2016-11-15
CN101652346A (zh) 2010-02-17
EP2121601B1 (fr) 2016-06-15
FR2912133A1 (fr) 2008-08-08
RU2009132657A (ru) 2011-03-10
WO2008110690A2 (fr) 2008-09-18
CN101652346B (zh) 2013-10-30
JP2010517983A (ja) 2010-05-27
EP2121601B8 (fr) 2016-12-07
AU2008224776A1 (en) 2008-09-18
US8343964B2 (en) 2013-01-01
EP2121601A2 (fr) 2009-11-25

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired