CA2674837C - Anti-ige vaccines - Google Patents

Anti-ige vaccines Download PDF

Info

Publication number
CA2674837C
CA2674837C CA2674837A CA2674837A CA2674837C CA 2674837 C CA2674837 C CA 2674837C CA 2674837 A CA2674837 A CA 2674837A CA 2674837 A CA2674837 A CA 2674837A CA 2674837 C CA2674837 C CA 2674837C
Authority
CA
Canada
Prior art keywords
ige
seq
amino acid
antigenic
peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2674837A
Other languages
English (en)
French (fr)
Other versions
CA2674837A1 (en
Inventor
Mohamad Ali Morsey
Michael George Sheppard
David Walter Wheeler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zoetis P LLC
Original Assignee
PAH USA 15 LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PAH USA 15 LLC filed Critical PAH USA 15 LLC
Publication of CA2674837A1 publication Critical patent/CA2674837A1/en
Application granted granted Critical
Publication of CA2674837C publication Critical patent/CA2674837C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0008Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/14Decongestants or antiallergics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00Drug, bio-affecting and body treating compositions
    • Y10S424/805Drug, bio-affecting and body treating compositions involving IgE or IgD
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/81Packaged device or kit
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/868Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, or immunotolerance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Otolaryngology (AREA)
  • Urology & Nephrology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
CA2674837A 2000-08-30 2001-08-28 Anti-ige vaccines Expired - Fee Related CA2674837C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22898900P 2000-08-30 2000-08-30
US60/228,989 2000-08-30
CA002356124A CA2356124A1 (en) 2000-08-30 2001-08-28 Anti-ige vaccines

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA002356124A Division CA2356124A1 (en) 2000-08-30 2001-08-28 Anti-ige vaccines

Publications (2)

Publication Number Publication Date
CA2674837A1 CA2674837A1 (en) 2002-02-28
CA2674837C true CA2674837C (en) 2013-02-26

Family

ID=22859366

Family Applications (5)

Application Number Title Priority Date Filing Date
CA2674837A Expired - Fee Related CA2674837C (en) 2000-08-30 2001-08-28 Anti-ige vaccines
CA002356124A Abandoned CA2356124A1 (en) 2000-08-30 2001-08-28 Anti-ige vaccines
CA2674838A Expired - Fee Related CA2674838C (en) 2000-08-30 2001-08-28 Anti-ige vaccines
CA2674885A Expired - Fee Related CA2674885C (en) 2000-08-30 2001-08-28 Anti-ige vaccines
CA002674888A Abandoned CA2674888A1 (en) 2000-08-30 2001-08-28 Anti-ige vaccines

Family Applications After (4)

Application Number Title Priority Date Filing Date
CA002356124A Abandoned CA2356124A1 (en) 2000-08-30 2001-08-28 Anti-ige vaccines
CA2674838A Expired - Fee Related CA2674838C (en) 2000-08-30 2001-08-28 Anti-ige vaccines
CA2674885A Expired - Fee Related CA2674885C (en) 2000-08-30 2001-08-28 Anti-ige vaccines
CA002674888A Abandoned CA2674888A1 (en) 2000-08-30 2001-08-28 Anti-ige vaccines

Country Status (4)

Country Link
US (5) US6887472B2 (enExample)
EP (5) EP1195161A3 (enExample)
JP (5) JP2002281984A (enExample)
CA (5) CA2674837C (enExample)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1195161A3 (en) * 2000-08-30 2002-07-24 Pfizer Products Inc. Anti-IgE vaccines
EP2687593A1 (en) * 2001-05-15 2014-01-22 Ortho-McNeil Pharmaceutical, Inc. Ex-vivo priming for generating cytotoxic T lymphocytes specific for non-tumor antigens to treat autoimmune and allergic disease
JP2003047482A (ja) * 2001-05-22 2003-02-18 Pfizer Prod Inc 非アナフィラキシー誘発性IgEワクチン
ATE414540T1 (de) * 2002-09-05 2008-12-15 Resistentia Pharmaceuticals Ab Impfstoffe gegen allergien
US20070178082A1 (en) * 2002-11-08 2007-08-02 Ablynx N.V. Stabilized single domain antibodies
US9320792B2 (en) 2002-11-08 2016-04-26 Ablynx N.V. Pulmonary administration of immunoglobulin single variable domains and constructs thereof
US20100003253A1 (en) * 2002-11-08 2010-01-07 Ablynx N.V. Single domain antibodies directed against epidermal growth factor receptor and uses therefor
WO2004041862A2 (en) * 2002-11-08 2004-05-21 Ablynx N.V. Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor
US20060034845A1 (en) * 2002-11-08 2006-02-16 Karen Silence Single domain antibodies directed against tumor necrosis factor alpha and uses therefor
KR20070008578A (ko) 2004-02-02 2007-01-17 타녹스 인코퍼레이티드 신규한 IgE 에피토프의 확인
JP4520923B2 (ja) * 2005-09-28 2010-08-11 本田技研工業株式会社 エンジン始動装置
JP2007172129A (ja) * 2005-12-20 2007-07-05 Sony Corp 不揮発性メモリアクセス制御装置および不揮発性メモリ制御システム
AU2013204233B2 (en) * 2008-12-09 2015-06-25 Pfizer Vaccines Llc IgE CH3 peptide vaccine
PE20110891A1 (es) * 2008-12-09 2011-12-23 Pfizer Vaccines Llc Vacuna de peptido ch3 de ige
RU2015109110A (ru) * 2009-02-25 2015-07-20 Академиа Синика Применение семх пептидов для индукции иммунного ответа на мембрансвязанный ige (mige) на человеческих в лимфоцитах
EP2575868A1 (en) 2010-06-07 2013-04-10 Pfizer Vaccines LLC Ige ch3 peptide vaccine
KR101163472B1 (ko) * 2010-06-08 2012-07-18 기아자동차주식회사 자동차의 오프닝 웨더스트립 고정구조
US9187553B2 (en) * 2012-01-25 2015-11-17 Swey-Shen Chen Displaying native human IgE neutralizing FcepsilonRIa-contacting IgE B-cell epitopes by constraining super beta(b)-strands and cystine knots on thermostable protein scaffold
CN104603150A (zh) 2012-04-20 2015-05-06 中央研究院 与CH4和CεmX结构域之间的连接处结合的抗mIgE抗体
CN102660569B (zh) * 2012-04-21 2013-11-06 大连理工大学 一种重组人IgE受体蛋白的制备方法及应用
EP2862873B1 (en) * 2012-06-18 2020-04-29 Nippon Zenyaku Kogyo Co., Ltd. IgE PEPTIDE VACCINE
US10428112B2 (en) 2014-06-11 2019-10-01 Riken Multiplexed same type-antigenic peptide
CA2982213C (en) * 2015-04-09 2022-10-18 Cornell University Gene therapy to prevent reactions to allergens
IL277911B2 (en) 2017-10-31 2025-07-01 Oneness Biotech Co Ltd Treating ige-mediated allergic diseases
US11857623B2 (en) * 2020-08-07 2024-01-02 King Abdulaziz University Pan-antiallergy vaccine
US20260035484A1 (en) * 2021-10-29 2026-02-05 Longbio Pharma (Suzhou) Co., Ltd. Isolated antigen binding protein and use thereof
CN115873867B (zh) * 2022-09-28 2023-06-23 云南省农业科学院农业环境资源研究所 一种抗稻瘟病基因Pi69及其编码蛋白与应用
CN120271714A (zh) * 2022-12-07 2025-07-08 南开大学 一种针对IgE的抗体或其抗原结合片段以及Fc变体
CN118878689B (zh) * 2024-08-28 2025-03-28 上海索莱宝生化科技有限公司 抗猪IgG抗体及其应用

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4208479A (en) * 1977-07-14 1980-06-17 Syva Company Label modified immunoassays
JPS5668615A (en) * 1979-11-09 1981-06-09 Eisai Co Ltd Ricin-containing agent for immunological enhancement
US4980286A (en) 1985-07-05 1990-12-25 Whitehead Institute For Biomedical Research In vivo introduction and expression of foreign genetic material in epithelial cells
GB8616166D0 (en) * 1986-07-02 1986-08-06 Research Corp Ltd Polypeptide competitor
JPS63225397A (ja) 1986-10-03 1988-09-20 Dainippon Pharmaceut Co Ltd 抗アレルギー作用を有する新規ペプチド
GB8913737D0 (en) 1989-06-15 1989-08-02 Univ Birmingham A novel anti-allergy treatment
US5436146A (en) 1989-09-07 1995-07-25 The Trustees Of Princeton University Helper-free stocks of recombinant adeno-associated virus vectors
WO1992006180A1 (en) 1990-10-01 1992-04-16 University Of Connecticut Targeting viruses and cells for selective internalization by cells
CA2103064A1 (en) 1991-05-14 1992-11-15 George Y. Wu Targeted delivery of genes encoding immunogenic proteins
AU657345B2 (en) 1991-05-24 1995-03-09 Northwestern University Method of using substance P to treat allergy
WO1992022635A1 (en) 1991-06-05 1992-12-23 University Of Connecticut Targeted delivery of genes encoding secretory proteins
US5965709A (en) * 1991-08-14 1999-10-12 Genentech, Inc. IgE antagonists
SE9102808L (sv) 1991-09-26 1993-03-27 Lars T Hellman Inst F Immunolo Vaccin, foer humant bruk, vars avsedda effekt aer att lindra symptomen eller foerhindra uppkomsten av ige-medierade allergiska reaktioner
WO1993014188A1 (en) 1992-01-17 1993-07-22 The Regents Of The University Of Michigan Targeted virus
WO1993020221A1 (en) 1992-04-03 1993-10-14 Young Alexander T Gene therapy using targeted viral vectors
WO1994008598A1 (en) 1992-10-09 1994-04-28 Advanced Tissue Sciences, Inc. Liver reserve cells
JPH08503855A (ja) 1992-12-03 1996-04-30 ジェンザイム・コーポレイション 嚢胞性線維症に対する遺伝子治療
GB9324013D0 (en) * 1993-11-22 1994-01-12 3I Res Expl Ltd Polypeptides
FR2715304B1 (fr) * 1994-01-26 1996-04-26 Merieux Serums Vaccins Pasteur Vaccin anti-allergique.
US5629415A (en) * 1994-11-09 1997-05-13 Merck & Co., Inc. DNA encoding canine immunoglobulin E
JPH09169795A (ja) * 1995-12-22 1997-06-30 Hitachi Chem Co Ltd イヌ免疫グロブリンeペプチド断片、それをコードするdna、そのdnaを含む組換えベクター、その組換えベクターを含む形質転換体及び抗イヌ免疫グロブリンe抗体の製造法
WO1997030156A2 (en) 1996-02-14 1997-08-21 Idexx Laboratories, Inc. NUCLEOTIDES AND PEPTIDES CORRESPONDING TO THE CANINE IgE HEAVY CHAIN CONSTANT REGION AND RELATED METHODS
CN1174998C (zh) 1996-03-01 2004-11-10 诺瓦提斯公司 用于预防和治疗过敏的肽免疫原
ES2165626T3 (es) 1996-08-30 2002-03-16 Exxonmobil Chem Patents Inc Reactor y procedimiento en lecho fluidizado.
WO1998024808A2 (en) * 1996-12-06 1998-06-11 THE UNITED STATES OF AMERICA represented by THE SECRETARY DEPARTMENT OF HEALTH & HUMAN SERVICES, THE NATIONAL INSTITUTES OF HEALTH INHIBITION OF IgE-MEDIATED ALLERGIES BY A HUMAN IgE-DERIVED OLIGOPEPTIDE
ES2234180T3 (es) * 1998-04-09 2005-06-16 Idexx Laboratories, Inc. Proteinas de fijacion especifica para el tratamiento de la alergia canina.
US6734287B1 (en) * 1998-04-09 2004-05-11 Idexx Laboratories, Inc. Specific binding proteins for treating canine allergy
TWI229679B (en) * 1998-06-20 2005-03-21 United Biomedical Inc Artificial T helper cell epitopes as immune stimulators for synthetic peptide immunogens
TWI227241B (en) * 1998-06-20 2005-02-01 United Biomedical Inc IgE-CH3 domain antigen peptide, peptide conjugate containing the same, and pharmaceutical composition for treating allergies containing the peptide conjugate
PL198236B1 (pl) * 1998-06-24 2008-06-30 Alk Abello As Sposób określania działania swoistego szczepienia przeciw alergii oraz sposób określania stanu immunologicznego osobnika alergicznego
GB9822763D0 (en) * 1998-10-20 1998-12-16 Univ Sheffield Immunoglobin variant
US6913749B2 (en) * 1998-11-02 2005-07-05 Resistentia Pharmaceuticals Ab Immunogenic polypeptides for inducing anti-self IgE responses
CN1202125C (zh) * 1998-11-12 2005-05-18 卫生部上海生物制品研究所 肽免疫原、用其制成的治疗变态反应的疫苗及其制备方法
EP1195161A3 (en) * 2000-08-30 2002-07-24 Pfizer Products Inc. Anti-IgE vaccines
JP2003047482A (ja) 2001-05-22 2003-02-18 Pfizer Prod Inc 非アナフィラキシー誘発性IgEワクチン

Also Published As

Publication number Publication date
EP2065052A2 (en) 2009-06-03
EP2361635A3 (en) 2011-09-14
US20040146504A1 (en) 2004-07-29
EP2065052A3 (en) 2009-08-19
JP2005043374A (ja) 2005-02-17
US20100113361A1 (en) 2010-05-06
US7897151B2 (en) 2011-03-01
CA2674888A1 (en) 2002-02-28
EP1195161A2 (en) 2002-04-10
JP2005102701A (ja) 2005-04-21
JP2013056904A (ja) 2013-03-28
JP2012161322A (ja) 2012-08-30
CA2674838C (en) 2014-02-18
EP1967206A3 (en) 2009-01-07
US8273356B2 (en) 2012-09-25
CA2674885C (en) 2013-02-26
CA2674885A1 (en) 2002-02-28
EP1967205A2 (en) 2008-09-10
US20120321651A1 (en) 2012-12-20
EP1967205A3 (en) 2009-01-07
EP1967206B1 (en) 2012-10-10
CA2356124A1 (en) 2002-02-28
CA2674838A1 (en) 2002-02-28
EP1967206A2 (en) 2008-09-10
US6887472B2 (en) 2005-05-03
EP2361635A2 (en) 2011-08-31
CA2674837A1 (en) 2002-02-28
US20060062782A1 (en) 2006-03-23
EP1195161A3 (en) 2002-07-24
EP1967205B1 (en) 2012-10-10
JP2002281984A (ja) 2002-10-02
US20020064525A1 (en) 2002-05-30

Similar Documents

Publication Publication Date Title
US8273356B2 (en) Anti-IgE vaccines
US20080193439A1 (en) Non-Anaphylactogenic IgE Fusion Proteins
JP3472297B2 (ja) 特定のt細胞集団の病原性応答により生じる疾患に対するワクチン接種および方法
US6464978B1 (en) Vaccination and methods against multiple sclerosis resulting from pathogenic responses by specific T cell populations
CA2851244A1 (en) Anti-human sema4a antibodies useful to treat disease
CA2134083C (en) Prophylactic and therapeutic agents for autoimmune diseases
CN102702359A (zh) 新的IgE表位的鉴别
US6113903A (en) Peptides and methods against diabetes
JP2000502995A (ja) Bリンパ球による抗体放出を刺激する組成物および方法
WO2000029443A1 (en) Contraceptive antibody vaccines

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20150828