CA2662897C - Macrocyclic antagonists of the motilin receptor for treatment of gastrointestinal dysmotility disorders - Google Patents
Macrocyclic antagonists of the motilin receptor for treatment of gastrointestinal dysmotility disorders Download PDFInfo
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- CA2662897C CA2662897C CA2662897A CA2662897A CA2662897C CA 2662897 C CA2662897 C CA 2662897C CA 2662897 A CA2662897 A CA 2662897A CA 2662897 A CA2662897 A CA 2662897A CA 2662897 C CA2662897 C CA 2662897C
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- LBLYYCQCTBFVLH-UHFFFAOYSA-M toluenesulfonate group Chemical group C=1(C(=CC=CC1)S(=O)(=O)[O-])C LBLYYCQCTBFVLH-UHFFFAOYSA-M 0.000 description 1
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- PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
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- Public Health (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Immunology (AREA)
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- Molecular Biology (AREA)
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- Biophysics (AREA)
- Otolaryngology (AREA)
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- Child & Adolescent Psychology (AREA)
- Rheumatology (AREA)
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- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82523706P | 2006-09-11 | 2006-09-11 | |
| US60/825,237 | 2006-09-11 | ||
| PCT/US2007/019705 WO2008033328A2 (en) | 2006-09-11 | 2007-09-11 | Macrocyclic antagonists of the motilin receptor for treatment of gastrointestinal dysmotility disorders |
Publications (2)
| Publication Number | Publication Date |
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| CA2662897A1 CA2662897A1 (en) | 2008-03-20 |
| CA2662897C true CA2662897C (en) | 2017-11-07 |
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| Application Number | Title | Priority Date | Filing Date |
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| CA2662897A Expired - Fee Related CA2662897C (en) | 2006-09-11 | 2007-09-11 | Macrocyclic antagonists of the motilin receptor for treatment of gastrointestinal dysmotility disorders |
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| Country | Link |
|---|---|
| US (1) | US9133235B2 (enExample) |
| EP (2) | EP2431380A3 (enExample) |
| JP (1) | JP5684474B2 (enExample) |
| CN (1) | CN101528765B (enExample) |
| CA (1) | CA2662897C (enExample) |
| WO (1) | WO2008033328A2 (enExample) |
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| US7491695B2 (en) * | 2003-06-18 | 2009-02-17 | Tranzyme Pharma Inc. | Methods of using macrocyclic modulators of the ghrelin receptor |
| DE602004025569D1 (de) | 2003-06-18 | 2010-04-01 | Tranzyme Pharma Inc | Makrozyklische motilin rezeptorantagonisten |
| US20080287371A1 (en) * | 2007-05-17 | 2008-11-20 | Tranzyme Pharma Inc. | Macrocyclic antagonists of the motilin receptor for modulation of the migrating motor complex |
| EP2322515B1 (en) | 2008-08-29 | 2016-04-20 | JSR Corporation | A process for the preparation of an N-carboxy amino acid anhydride or an amino acid carbamate |
| JP2010078398A (ja) * | 2008-09-25 | 2010-04-08 | Saitama Univ | 消化管運動機能物質のスクリーニング方法 |
| JP2013508409A (ja) * | 2009-10-23 | 2013-03-07 | トランザイム・ファーマ，インコーポレイテッド | セリンプロテアーゼ酵素の大環状阻害剤 |
| US20110105389A1 (en) | 2009-10-30 | 2011-05-05 | Hoveyda Hamid R | Macrocyclic Ghrelin Receptor Antagonists and Inverse Agonists and Methods of Using the Same |
| AU2012207381B2 (en) * | 2011-01-18 | 2016-05-19 | General Atomics | Hydrolase enzyme substrates and uses thereof |
| JP5688647B2 (ja) * | 2011-03-10 | 2015-03-25 | 国立大学法人名古屋大学 | ヨードアレーン誘導体、それを用いた光学活性スピロラクトン化合物の製法及び光学活性な環化付加体の製法 |
| CN102557989B (zh) * | 2011-12-19 | 2013-12-25 | 深圳翰宇药业股份有限公司 | 优利莫瑞林中间体以及优利莫瑞林制备方法 |
| MX2017009011A (es) * | 2015-01-09 | 2017-10-02 | Jaguar Animal Health | Metodos para tratar la diarrea en animales de compañia. |
| CN111747979B (zh) * | 2020-07-07 | 2021-10-08 | 新乡海滨药业有限公司 | 一种美罗培南关键中间体n-三甲基硅咪唑的制备方法 |
Family Cites Families (68)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JPS6187625A (ja) | 1984-10-05 | 1986-05-06 | Satoshi Omura | 消化管収縮運動促進剤 |
| US5008249A (en) | 1985-08-31 | 1991-04-16 | Kitasato Kenkyusho | Therapeutic method of stimulating digestive tract contractile motion in mammals |
| US5175150A (en) | 1985-08-31 | 1992-12-29 | Kitasato, Kenkyusho | Erythromycin derivative |
| US5695952A (en) | 1986-09-12 | 1997-12-09 | Kyowa Hakko Kogyo Co., Ltd. | Method for producing Leu13 !motilin |
| US5420113A (en) | 1986-09-12 | 1995-05-30 | Kyowa Hakko Kogyo Co., Ltd. | [Leu13]motilin, DNAs coding for same and methods for producing same |
| US4920102A (en) | 1988-04-18 | 1990-04-24 | Eli Lilly And Company | Method for treating gastrointestinal disorders |
| EP0378078A1 (en) | 1989-01-06 | 1990-07-18 | Sanwa Kagaku Kenkyusho Co., Ltd. | Motilin-like polypeptide and use thereof |
| US5459049A (en) | 1989-01-06 | 1995-10-17 | Sanwa Kagaku Kenkyushko Co., Ltd. | Motilin-like polypeptide and use thereof |
| US5554605A (en) | 1991-04-09 | 1996-09-10 | Abbott Laboratories | Macrocyclic lactam prokinetic agents |
| JPH06509326A (ja) | 1991-04-09 | 1994-10-20 | アボツト・ラボラトリーズ | 大環式ラクタムプロキネティック剤 |
| DE4200145A1 (de) | 1992-01-07 | 1993-07-08 | Kali Chemie Pharma Gmbh | 7,10-epoxy-oxacyclododecan-derivate, verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| JP2662094B2 (ja) | 1992-01-21 | 1997-10-08 | アボツト・ラボラトリーズ | ４″−デオキシエリスロマイシン誘導体 |
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-
2007
- 2007-09-11 CA CA2662897A patent/CA2662897C/en not_active Expired - Fee Related
- 2007-09-11 EP EP20110075225 patent/EP2431380A3/en not_active Withdrawn
- 2007-09-11 JP JP2009527455A patent/JP5684474B2/ja not_active Expired - Fee Related
- 2007-09-11 US US12/440,802 patent/US9133235B2/en active Active
- 2007-09-11 EP EP20070838009 patent/EP2054429B1/en not_active Ceased
- 2007-09-11 CN CN200780033494.1A patent/CN101528765B/zh not_active Expired - Fee Related
- 2007-09-11 WO PCT/US2007/019705 patent/WO2008033328A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| US9133235B2 (en) | 2015-09-15 |
| CA2662897A1 (en) | 2008-03-20 |
| EP2431380A2 (en) | 2012-03-21 |
| CN101528765A (zh) | 2009-09-09 |
| EP2431380A3 (en) | 2013-07-03 |
| EP2054429B1 (en) | 2013-11-06 |
| US20100093720A1 (en) | 2010-04-15 |
| JP5684474B2 (ja) | 2015-03-11 |
| WO2008033328A3 (en) | 2008-07-24 |
| JP2010503620A (ja) | 2010-02-04 |
| CN101528765B (zh) | 2015-04-22 |
| EP2054429A2 (en) | 2009-05-06 |
| WO2008033328A2 (en) | 2008-03-20 |
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