CA2635717A1 - Crystalline forms of 1-benzoyl-4-[2[4-methoxy-7-(3-methyl-1h-1,2,4-triazol-1-yl)-1-[(phosphonooxy)methyl]-1h-pyrrolo[2,3-c]pyridin-3-yl]-1,2-dioxoethyl]-piperazine - Google Patents
Crystalline forms of 1-benzoyl-4-[2[4-methoxy-7-(3-methyl-1h-1,2,4-triazol-1-yl)-1-[(phosphonooxy)methyl]-1h-pyrrolo[2,3-c]pyridin-3-yl]-1,2-dioxoethyl]-piperazine Download PDFInfo
- Publication number
- CA2635717A1 CA2635717A1 CA002635717A CA2635717A CA2635717A1 CA 2635717 A1 CA2635717 A1 CA 2635717A1 CA 002635717 A CA002635717 A CA 002635717A CA 2635717 A CA2635717 A CA 2635717A CA 2635717 A1 CA2635717 A1 CA 2635717A1
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- Prior art keywords
- crystalline form
- form according
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- temperature
- compound
- Prior art date
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- Abandoned
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- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
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- VUNXBQRNMNVUMV-UHFFFAOYSA-N phenyl(piperazin-1-yl)methanone Chemical compound C=1C=CC=CC=1C(=O)N1CCNCC1 VUNXBQRNMNVUMV-UHFFFAOYSA-N 0.000 description 1
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 description 1
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- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75024705P | 2005-12-14 | 2005-12-14 | |
| US60/750,247 | 2005-12-14 | ||
| PCT/US2006/047571 WO2007070589A2 (en) | 2005-12-14 | 2006-12-13 | Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1h-1,2,4-triazol-1-yl)-1-[(phosphonooxy)methyl]-1h-pyrrolo[2,3-c]pyridin-3-yl]-1,2-dioxoethyl]-piperazine |
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| CA2635717A1 true CA2635717A1 (en) | 2007-06-21 |
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| CA002635717A Abandoned CA2635717A1 (en) | 2005-12-14 | 2006-12-13 | Crystalline forms of 1-benzoyl-4-[2[4-methoxy-7-(3-methyl-1h-1,2,4-triazol-1-yl)-1-[(phosphonooxy)methyl]-1h-pyrrolo[2,3-c]pyridin-3-yl]-1,2-dioxoethyl]-piperazine |
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| BR (1) | BRPI0619851A2 (enExample) |
| CA (1) | CA2635717A1 (enExample) |
| EA (1) | EA014706B1 (enExample) |
| GE (1) | GEP20125413B (enExample) |
| IL (1) | IL191769A (enExample) |
| MY (1) | MY144293A (enExample) |
| NO (1) | NO20082477L (enExample) |
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| WO (1) | WO2007070589A2 (enExample) |
| ZA (1) | ZA200805063B (enExample) |
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| US20040110785A1 (en) * | 2001-02-02 | 2004-06-10 | Tao Wang | Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives |
| US7745625B2 (en) * | 2004-03-15 | 2010-06-29 | Bristol-Myers Squibb Company | Prodrugs of piperazine and substituted piperidine antiviral agents |
| ES2389478T3 (es) * | 2008-06-25 | 2012-10-26 | Bristol-Myers Squibb Company | Derivados de dicetopiperidina como inhibidores de la fijación del VIH |
| CN102131810B (zh) * | 2008-06-25 | 2014-02-26 | 百时美施贵宝公司 | 作为抗hiv剂的二酮稠合的吡咯并哌啶类和吡咯并哌嗪类 |
| JP5638527B2 (ja) * | 2008-09-04 | 2014-12-10 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | Ｈｉｖ結合阻害剤の最適な送達のための安定な医薬組成物 |
| US8912195B2 (en) | 2010-12-02 | 2014-12-16 | Bristol-Myers Squibb Company | Alkyl amides as HIV attachment inhibitors |
| PT2670751E (pt) * | 2011-01-31 | 2015-07-29 | Bristol Myers Squibb Co | Métodos de fabrico de um composto profármaco inibidor da fixação do vih e intermediários |
| EP2696937B1 (en) | 2011-04-12 | 2017-05-17 | VIIV Healthcare UK (No.5) Limited | Thioamide, amidoxime and amidrazone derivatives as hiv attachment inhibitors |
| EP2751118B1 (en) | 2011-08-29 | 2016-10-12 | Bristol-Myers Squibb Company | Spiro bicyclic diamine derivatives as hiv attachment inhibitors |
| WO2013033061A1 (en) | 2011-08-29 | 2013-03-07 | Bristol-Myers Squibb Company | Fused bicyclic diamine derivatives as hiv attachment inhibitors |
| WO2013138436A1 (en) | 2012-03-14 | 2013-09-19 | Bristol-Myers Squibb Company | Cyclolic hydrazine derivatives as hiv attachment inhibitors |
| EP2895471B1 (en) | 2012-08-09 | 2016-11-23 | VIIV Healthcare UK (No.5) Limited | Piperidine amide derivatives as hiv attachment inhibitors |
| US9655888B2 (en) | 2012-08-09 | 2017-05-23 | VIIV Healthcare UK (No.5) Limited | Tricyclic alkene derivatives as HIV attachment inhibitors |
| AU2014348523B2 (en) | 2013-11-15 | 2019-01-03 | Akebia Therapeutics, Inc. | Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid, compositions, and uses thereof |
| RU2663466C1 (ru) * | 2017-03-20 | 2018-08-06 | Общество с ограниченной ответственностью "МБА-групп" | Композиция для профилактики и/или лечения вич-инфекции |
| WO2019006393A1 (en) | 2017-06-29 | 2019-01-03 | G1 Therapeutics, Inc. | Morphic forms of git38 and methods of manufacture thereof |
| KR102195348B1 (ko) | 2018-11-15 | 2020-12-24 | 에이치케이이노엔 주식회사 | 단백질 키나제 억제제로서의 신규 화합물 및 이를 포함하는 약제학적 조성물 |
| WO2020219524A1 (en) | 2019-04-24 | 2020-10-29 | Elanco Us Inc. | A 7h-pyrrolo[2,3-d]pyrimidine jak-inhibitor |
| KR102847760B1 (ko) | 2019-04-30 | 2025-08-18 | 베이징 타이드 파마슈티컬 코퍼레이션 리미티드 | 디아미노피리미딘 화합물 또는 이의 수화물의 고체 형태, 이의 제조 방법 및 이의 용도 |
| AU2020288270B2 (en) | 2019-06-06 | 2023-07-13 | Genfleet Therapeutics (Shanghai) Inc. | Polymorph of CDK9 inhibitor and preparation method for polymorph and use thereof |
| BR112022000207A2 (pt) | 2019-07-08 | 2022-05-17 | Activesite Pharmaceuticals Inc | Formas cristalinas de inibidores de calicreína plasmática |
| DK4011881T3 (da) | 2019-08-06 | 2025-03-10 | Wuxi Biocity Biopharmaceutics Co Ltd | Krystallinske former af en atr-hæmmer og anvendelse deraf |
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| US5192770A (en) | 1990-12-07 | 1993-03-09 | Syntex (U.S.A.) Inc. | Serotonergic alpha-oxoacetamides |
| DE69217224T2 (de) | 1991-07-03 | 1997-06-05 | Pharmacia & Upjohn Co., Kalamazoo, Mich. | Substituierte indole als anti-aids pharmaceutische zubereitungen |
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| DE69719766T2 (de) | 1996-08-29 | 2004-01-15 | Takeda Chemical Industries Ltd | Zyklische etherverbindungen als natriumkanal-modulatoren |
| DE19636150A1 (de) | 1996-09-06 | 1998-03-12 | Asta Medica Ag | N-substituierte Indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender Wirkung |
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-
2006
- 2006-12-11 US US11/636,755 patent/US7851476B2/en active Active
- 2006-12-13 WO PCT/US2006/047571 patent/WO2007070589A2/en not_active Ceased
- 2006-12-13 EA EA200801529A patent/EA014706B1/ru not_active IP Right Cessation
- 2006-12-13 AU AU2006326432A patent/AU2006326432B2/en active Active
- 2006-12-13 BR BRPI0619851-1A patent/BRPI0619851A2/pt not_active Application Discontinuation
- 2006-12-13 CN CN2006800472167A patent/CN101365708B/zh active Active
- 2006-12-13 GE GEAP200610811A patent/GEP20125413B/en unknown
- 2006-12-13 UA UAA200809079A patent/UA94928C2/ru unknown
- 2006-12-13 JP JP2008545772A patent/JP5400387B2/ja active Active
- 2006-12-13 CA CA002635717A patent/CA2635717A1/en not_active Abandoned
- 2006-12-13 EP EP06848592A patent/EP1963342A2/en not_active Withdrawn
- 2006-12-13 NZ NZ568776A patent/NZ568776A/en unknown
- 2006-12-13 MY MYPI20082090A patent/MY144293A/en unknown
- 2006-12-13 NZ NZ592684A patent/NZ592684A/en unknown
- 2006-12-13 KR KR1020087016884A patent/KR20080077010A/ko not_active Ceased
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2008
- 2008-05-27 IL IL191769A patent/IL191769A/en active IP Right Grant
- 2008-05-29 NO NO20082477A patent/NO20082477L/no not_active Application Discontinuation
- 2008-06-10 ZA ZA200805063A patent/ZA200805063B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1963342A2 (en) | 2008-09-03 |
| IL191769A0 (en) | 2008-12-29 |
| WO2007070589A2 (en) | 2007-06-21 |
| MY144293A (en) | 2011-08-29 |
| GEP20125413B (en) | 2012-03-12 |
| JP2009521414A (ja) | 2009-06-04 |
| EA014706B1 (ru) | 2011-02-28 |
| US20070155702A1 (en) | 2007-07-05 |
| US7851476B2 (en) | 2010-12-14 |
| JP5400387B2 (ja) | 2014-01-29 |
| KR20080077010A (ko) | 2008-08-20 |
| CN101365708B (zh) | 2012-12-12 |
| AU2006326432A1 (en) | 2007-06-21 |
| BRPI0619851A2 (pt) | 2011-10-25 |
| CN101365708A (zh) | 2009-02-11 |
| NO20082477L (no) | 2008-09-05 |
| EA200801529A1 (ru) | 2009-02-27 |
| ZA200805063B (en) | 2009-10-28 |
| NZ568776A (en) | 2011-06-30 |
| WO2007070589A3 (en) | 2007-09-27 |
| IL191769A (en) | 2011-08-31 |
| NZ592684A (en) | 2012-07-27 |
| AU2006326432B2 (en) | 2012-07-12 |
| UA94928C2 (en) | 2011-06-25 |
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