AU2006326432B2 - Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-c]pyridin-3-yl]-1,2-dioxoethyl]-piperazine - Google Patents
Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-c]pyridin-3-yl]-1,2-dioxoethyl]-piperazine Download PDFInfo
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- AU2006326432B2 AU2006326432B2 AU2006326432A AU2006326432A AU2006326432B2 AU 2006326432 B2 AU2006326432 B2 AU 2006326432B2 AU 2006326432 A AU2006326432 A AU 2006326432A AU 2006326432 A AU2006326432 A AU 2006326432A AU 2006326432 B2 AU2006326432 B2 AU 2006326432B2
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- VUNXBQRNMNVUMV-UHFFFAOYSA-N phenyl(piperazin-1-yl)methanone Chemical compound C=1C=CC=CC=1C(=O)N1CCNCC1 VUNXBQRNMNVUMV-UHFFFAOYSA-N 0.000 description 1
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- WROMPOXWARCANT-UHFFFAOYSA-N tfa trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F WROMPOXWARCANT-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
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| US75024705P | 2005-12-14 | 2005-12-14 | |
| US60/750,247 | 2005-12-14 | ||
| PCT/US2006/047571 WO2007070589A2 (en) | 2005-12-14 | 2006-12-13 | Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1h-1,2,4-triazol-1-yl)-1-[(phosphonooxy)methyl]-1h-pyrrolo[2,3-c]pyridin-3-yl]-1,2-dioxoethyl]-piperazine |
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| AU2006326432A1 AU2006326432A1 (en) | 2007-06-21 |
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| BR (1) | BRPI0619851A2 (enExample) |
| CA (1) | CA2635717A1 (enExample) |
| EA (1) | EA014706B1 (enExample) |
| GE (1) | GEP20125413B (enExample) |
| IL (1) | IL191769A (enExample) |
| MY (1) | MY144293A (enExample) |
| NO (1) | NO20082477L (enExample) |
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| WO (1) | WO2007070589A2 (enExample) |
| ZA (1) | ZA200805063B (enExample) |
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| US20040110785A1 (en) * | 2001-02-02 | 2004-06-10 | Tao Wang | Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives |
| US7745625B2 (en) * | 2004-03-15 | 2010-06-29 | Bristol-Myers Squibb Company | Prodrugs of piperazine and substituted piperidine antiviral agents |
| CN102076686B (zh) * | 2008-06-25 | 2013-03-06 | 百时美施贵宝公司 | 作为hiv附着抑制剂的二酮哌啶衍生物 |
| WO2009158394A1 (en) * | 2008-06-25 | 2009-12-30 | Bristol-Myers Squibb Company | Diketo azolopiperidines and azolopiperazines as anti-hiv agents |
| ES2383149T3 (es) * | 2008-09-04 | 2012-06-18 | Bristol-Myers Squibb Company | Composicion farmacéutica estable para la administración optimizada de un inhibidor de la unión del VIH |
| ES2585396T3 (es) | 2010-12-02 | 2016-10-05 | VIIV Healthcare UK (No.5) Limited | Alquilamidas como inhibidores de la unión del VIH |
| ES2539908T3 (es) * | 2011-01-31 | 2015-07-07 | Bristol-Myers Squibb Company | Métodos de preparación de un compuesto profármaco inhibidor de la fijación del VIH e intermedios |
| EP2696937B1 (en) | 2011-04-12 | 2017-05-17 | VIIV Healthcare UK (No.5) Limited | Thioamide, amidoxime and amidrazone derivatives as hiv attachment inhibitors |
| ES2616268T3 (es) | 2011-08-29 | 2017-06-12 | VIIV Healthcare UK (No.5) Limited | Derivados condensados de diamina bicíclica como inhibidores de la unión de VIH |
| ES2609579T3 (es) | 2011-08-29 | 2017-04-21 | VIIV Healthcare UK (No.5) Limited | Derivados espiro de diamina bicíclica como inhibidores de la unión del VIH |
| US9193725B2 (en) | 2012-03-14 | 2015-11-24 | Bristol-Meyers Squibb Company | Cyclic hydrazine derivatives as HIV attachment inhibitors |
| ES2616492T3 (es) | 2012-08-09 | 2017-06-13 | VIIV Healthcare UK (No.5) Limited | Derivados de piperidina amida como inhibidores de la fijación del VIH |
| ES2616432T3 (es) | 2012-08-09 | 2017-06-13 | VIIV Healthcare UK (No.5) Limited | Derivados de alquenos tricíclicos como inhibidores de la unión del VIH |
| TW201946625A (zh) | 2013-11-15 | 2019-12-16 | 美商阿克比治療有限公司 | {[5-(3-氯苯基)-3-羥基吡啶-2-羰基]胺基}乙酸之固體型式，其組合物及用途 |
| RU2663466C1 (ru) * | 2017-03-20 | 2018-08-06 | Общество с ограниченной ответственностью "МБА-групп" | Композиция для профилактики и/или лечения вич-инфекции |
| CN110913861B (zh) | 2017-06-29 | 2024-01-09 | G1治疗公司 | G1t38的形态学形式及其制造方法 |
| KR102195348B1 (ko) | 2018-11-15 | 2020-12-24 | 에이치케이이노엔 주식회사 | 단백질 키나제 억제제로서의 신규 화합물 및 이를 포함하는 약제학적 조성물 |
| AU2020262100B2 (en) | 2019-04-24 | 2023-03-16 | Elanco Us Inc. | A 7H-pyrrolo[2,3-d]pyrimidine JAK-inhibitor |
| SG11202111907UA (en) | 2019-04-30 | 2021-11-29 | Beijing Tide Pharmaceutical Co Ltd | Solid form of diaminopyrimidine compound or hydrate thereof, preparation method therefor, and application thereof |
| KR102886764B1 (ko) | 2019-06-06 | 2025-11-14 | 젠플리트 테라퓨틱스 (상하이) 아이엔씨. | Cdk9 억제제의 결정다형 및 이의 제조방법과 용도 |
| EP3996707A4 (en) | 2019-07-08 | 2023-02-22 | Rezolute, Inc. | CRYSTALLINE FORMS OF PLASMACALLICREIN INHIBITORS |
| PL4011881T3 (pl) | 2019-08-06 | 2025-04-07 | Wuxi Biocity Biopharmaceutics Co., Ltd. | Postacie krystaliczne inhibitora atr i ich zastosowanie |
Citations (1)
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| US20050209246A1 (en) * | 2004-03-15 | 2005-09-22 | Yasutsugu Ueda | Prodrugs of piperazine and substituted piperidine antiviral agents |
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| WO1990007926A1 (en) | 1989-01-20 | 1990-07-26 | Pfizer Inc. | 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridines |
| US5023265A (en) * | 1990-06-01 | 1991-06-11 | Schering Corporation | Substituted 1-H-pyrrolopyridine-3-carboxamides |
| IL99843A0 (en) | 1990-11-01 | 1992-08-18 | Merck & Co Inc | Synergistic combination of hiv reverse transcriptase inhibitors |
| US5811432A (en) * | 1990-11-09 | 1998-09-22 | Pfizer Inc | Azaoxindole derivatives |
| US5192770A (en) * | 1990-12-07 | 1993-03-09 | Syntex (U.S.A.) Inc. | Serotonergic alpha-oxoacetamides |
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2006
- 2006-12-11 US US11/636,755 patent/US7851476B2/en active Active
- 2006-12-13 CN CN2006800472167A patent/CN101365708B/zh active Active
- 2006-12-13 KR KR1020087016884A patent/KR20080077010A/ko not_active Ceased
- 2006-12-13 CA CA002635717A patent/CA2635717A1/en not_active Abandoned
- 2006-12-13 JP JP2008545772A patent/JP5400387B2/ja active Active
- 2006-12-13 AU AU2006326432A patent/AU2006326432B2/en active Active
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- 2006-12-13 WO PCT/US2006/047571 patent/WO2007070589A2/en not_active Ceased
- 2006-12-13 MY MYPI20082090A patent/MY144293A/en unknown
- 2006-12-13 NZ NZ592684A patent/NZ592684A/en unknown
- 2006-12-13 NZ NZ568776A patent/NZ568776A/en unknown
- 2006-12-13 GE GEAP200610811A patent/GEP20125413B/en unknown
- 2006-12-13 BR BRPI0619851-1A patent/BRPI0619851A2/pt not_active Application Discontinuation
- 2006-12-13 EP EP06848592A patent/EP1963342A2/en not_active Withdrawn
- 2006-12-13 UA UAA200809079A patent/UA94928C2/ru unknown
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- 2008-05-29 NO NO20082477A patent/NO20082477L/no not_active Application Discontinuation
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| US20050209246A1 (en) * | 2004-03-15 | 2005-09-22 | Yasutsugu Ueda | Prodrugs of piperazine and substituted piperidine antiviral agents |
Also Published As
| Publication number | Publication date |
|---|---|
| US7851476B2 (en) | 2010-12-14 |
| NZ592684A (en) | 2012-07-27 |
| ZA200805063B (en) | 2009-10-28 |
| NO20082477L (no) | 2008-09-05 |
| US20070155702A1 (en) | 2007-07-05 |
| GEP20125413B (en) | 2012-03-12 |
| IL191769A0 (en) | 2008-12-29 |
| UA94928C2 (en) | 2011-06-25 |
| WO2007070589A3 (en) | 2007-09-27 |
| NZ568776A (en) | 2011-06-30 |
| CN101365708A (zh) | 2009-02-11 |
| EA200801529A1 (ru) | 2009-02-27 |
| CA2635717A1 (en) | 2007-06-21 |
| CN101365708B (zh) | 2012-12-12 |
| KR20080077010A (ko) | 2008-08-20 |
| AU2006326432A1 (en) | 2007-06-21 |
| WO2007070589A2 (en) | 2007-06-21 |
| EA014706B1 (ru) | 2011-02-28 |
| MY144293A (en) | 2011-08-29 |
| EP1963342A2 (en) | 2008-09-03 |
| JP2009521414A (ja) | 2009-06-04 |
| JP5400387B2 (ja) | 2014-01-29 |
| BRPI0619851A2 (pt) | 2011-10-25 |
| IL191769A (en) | 2011-08-31 |
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