CA2632286C - Use of (r)-3-[1-(2,6-dichloro-3-fluror-phenyl)-ethoxyl]-5-(1-piperidin-4-yl-1h-pyrazol-4-yl)-pyridin-2-ylamine for treatment of cancer - Google Patents
Use of (r)-3-[1-(2,6-dichloro-3-fluror-phenyl)-ethoxyl]-5-(1-piperidin-4-yl-1h-pyrazol-4-yl)-pyridin-2-ylamine for treatment of cancer Download PDFInfo
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- 210000001835 viscera Anatomy 0.000 description 1
- 208000013013 vulvar carcinoma Diseases 0.000 description 1
- 239000011534 wash buffer Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000003871 white petrolatum Substances 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74276605P | 2005-12-05 | 2005-12-05 | |
| US60/742,766 | 2005-12-05 | ||
| US86463706P | 2006-11-07 | 2006-11-07 | |
| US60/864,637 | 2006-11-07 | ||
| PCT/IB2006/003397 WO2007066187A2 (en) | 2005-12-05 | 2006-11-23 | Method of treating abnormal cell growth |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2632286A1 CA2632286A1 (en) | 2007-06-14 |
| CA2632286C true CA2632286C (en) | 2011-11-15 |
Family
ID=38123250
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2632286A Active CA2632286C (en) | 2005-12-05 | 2006-11-23 | Use of (r)-3-[1-(2,6-dichloro-3-fluror-phenyl)-ethoxyl]-5-(1-piperidin-4-yl-1h-pyrazol-4-yl)-pyridin-2-ylamine for treatment of cancer |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7825137B2 (OSRAM) |
| EP (1) | EP1959955B1 (OSRAM) |
| JP (1) | JP4619346B2 (OSRAM) |
| KR (1) | KR101026676B1 (OSRAM) |
| AR (1) | AR056832A1 (OSRAM) |
| AT (1) | ATE488237T1 (OSRAM) |
| AU (1) | AU2006323027B2 (OSRAM) |
| BR (1) | BRPI0619424B1 (OSRAM) |
| CA (1) | CA2632286C (OSRAM) |
| CY (1) | CY1110931T1 (OSRAM) |
| DE (1) | DE602006018354D1 (OSRAM) |
| DK (1) | DK1959955T3 (OSRAM) |
| IL (1) | IL191471A (OSRAM) |
| NZ (1) | NZ568654A (OSRAM) |
| PL (1) | PL1959955T3 (OSRAM) |
| PT (1) | PT1959955E (OSRAM) |
| RU (1) | RU2384331C2 (OSRAM) |
| SI (1) | SI1959955T1 (OSRAM) |
| TW (1) | TWI321050B (OSRAM) |
| WO (1) | WO2007066187A2 (OSRAM) |
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| KR100859891B1 (ko) | 2004-08-26 | 2008-09-23 | 화이자 인코포레이티드 | 단백질 키나제 억제제로서 거울상이성질체적으로 순수한아미노헤테로아릴 화합물 |
| TWI377198B (en) * | 2005-08-24 | 2012-11-21 | Eisai R&D Man Co Ltd | Novel pyridine derivatives and pyrimidine derivatives (3) |
| US8217057B2 (en) * | 2005-12-05 | 2012-07-10 | Pfizer Inc. | Polymorphs of a c-MET/HGFR inhibitor |
| US20120208824A1 (en) | 2006-01-20 | 2012-08-16 | Cell Signaling Technology, Inc. | ROS Kinase in Lung Cancer |
| EP2447360A1 (en) | 2006-04-14 | 2012-05-02 | Cell Signaling Technology, Inc. | Gene defects and mutant ALK kinase in human solid tumors |
| US8168383B2 (en) | 2006-04-14 | 2012-05-01 | Cell Signaling Technology, Inc. | Gene defects and mutant ALK kinase in human solid tumors |
| ATE535520T1 (de) * | 2006-08-23 | 2011-12-15 | Eisai R&D Man Co Ltd | Salz eines phenoxypyridinderivats oder kristall davon und verfahren zu dessen herstellung |
| US7790885B2 (en) | 2006-08-31 | 2010-09-07 | Eisai R&D Management Co., Ltd. | Process for preparing phenoxypyridine derivatives |
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| US20110206691A1 (en) | 2008-02-15 | 2011-08-25 | Mosse Yael P | Methods and Compositions for Treating Neuroblastoma |
| WO2009103061A2 (en) * | 2008-02-15 | 2009-08-20 | The Children's Hospital Of Philadelphia | Methods and compositions for identifying, diagnosing, and treating neuroblastoma |
| EP2248810A4 (en) * | 2008-02-18 | 2011-05-25 | Eisai R&D Man Co Ltd | METHOD FOR PRODUCING A PHENOXYPYRIDINE DERIVATIVE |
| EP2143441A1 (en) * | 2008-07-08 | 2010-01-13 | Pierre Fabre Medicament | Combination of a c-Met antagonist and an aminoheteroaryl compound for the treatment of cancer |
| CN101653607B (zh) * | 2008-08-19 | 2013-02-13 | 鼎泓国际投资（香港）有限公司 | 含有肝细胞生长因子受体抑制剂和丝裂原细胞外激酶抑制剂的药物组合物及其用途 |
| WO2010064300A1 (ja) * | 2008-12-02 | 2010-06-10 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 食道癌治療用組成物 |
| DE102009003954A1 (de) | 2009-01-07 | 2010-07-08 | Merck Patent Gmbh | Pyridazinonderivate |
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| JP5675850B2 (ja) | 2010-02-05 | 2015-02-25 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | ヘタリール−［１，８］ナフチリジン誘導体 |
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| JP6291179B2 (ja) * | 2013-07-26 | 2018-03-14 | 関東化學株式会社 | 光学活性２級アルコールの製造方法 |
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| RU2550346C2 (ru) | 2013-09-26 | 2015-05-10 | Общество с ограниченной ответственностью "Отечественные Фармацевтические Технологии" ООО"ФармТех" | Новые химические соединения (варианты) и их применение для лечения онкологических заболеваний |
| WO2015069922A2 (en) | 2013-11-06 | 2015-05-14 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Alk antibodies, conjugates, and chimeric antigen receptors, and their use |
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| SMT202200367T1 (it) | 2014-08-28 | 2022-11-18 | Eisai R&D Man Co Ltd | Derivato di chinolina a elevata purezza e metodo per la produzione dello stesso |
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| KR102662228B1 (ko) | 2015-03-04 | 2024-05-02 | 머크 샤프 앤드 돔 코포레이션 | 암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합 |
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| CA3061888A1 (en) | 2017-05-16 | 2018-11-22 | Eisai R&D Management Co., Ltd. | Treatment of hepatocellular carcinoma |
| CN108047231B (zh) * | 2018-01-02 | 2020-02-11 | 江苏医药职业学院 | [1,2,4]三嗪并[6,1-a]异吲哚化合物的盐酸盐及其应用 |
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| JP2008510792A (ja) * | 2004-08-26 | 2008-04-10 | ファイザー・インク | タンパク質チロシンキナーゼ阻害剤としてのアミノヘテロアリール化合物 |
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2006
- 2006-11-23 NZ NZ568654A patent/NZ568654A/en unknown
- 2006-11-23 BR BRPI0619424-9A patent/BRPI0619424B1/pt active IP Right Grant
- 2006-11-23 CA CA2632286A patent/CA2632286C/en active Active
- 2006-11-23 RU RU2008122471/14A patent/RU2384331C2/ru active
- 2006-11-23 US US12/095,114 patent/US7825137B2/en active Active
- 2006-11-23 DK DK06820997.2T patent/DK1959955T3/da active
- 2006-11-23 AU AU2006323027A patent/AU2006323027B2/en active Active
- 2006-11-23 DE DE602006018354T patent/DE602006018354D1/de active Active
- 2006-11-23 AT AT06820997T patent/ATE488237T1/de active
- 2006-11-23 SI SI200630864T patent/SI1959955T1/sl unknown
- 2006-11-23 EP EP06820997A patent/EP1959955B1/en active Active
- 2006-11-23 PT PT06820997T patent/PT1959955E/pt unknown
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Also Published As
| Publication number | Publication date |
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| AR056832A1 (es) | 2007-10-24 |
| US7825137B2 (en) | 2010-11-02 |
| IL191471A (en) | 2013-03-24 |
| WO2007066187A2 (en) | 2007-06-14 |
| BRPI0619424A2 (pt) | 2011-10-04 |
| PT1959955E (pt) | 2011-01-04 |
| JP4619346B2 (ja) | 2011-01-26 |
| JP2007153894A (ja) | 2007-06-21 |
| CA2632286A1 (en) | 2007-06-14 |
| DE602006018354D1 (de) | 2010-12-30 |
| AU2006323027B2 (en) | 2012-08-02 |
| US20080300273A1 (en) | 2008-12-04 |
| EP1959955B1 (en) | 2010-11-17 |
| SI1959955T1 (sl) | 2011-02-28 |
| NZ568654A (en) | 2012-02-24 |
| RU2384331C2 (ru) | 2010-03-20 |
| KR20080072965A (ko) | 2008-08-07 |
| ATE488237T1 (de) | 2010-12-15 |
| PL1959955T3 (pl) | 2011-04-29 |
| AU2006323027A1 (en) | 2007-06-14 |
| HK1126121A1 (en) | 2009-08-28 |
| BRPI0619424B1 (pt) | 2022-02-08 |
| TWI321050B (en) | 2010-03-01 |
| WO2007066187A3 (en) | 2008-01-17 |
| KR101026676B1 (ko) | 2011-04-04 |
| TW200727899A (en) | 2007-08-01 |
| DK1959955T3 (da) | 2011-02-07 |
| IL191471A0 (en) | 2009-08-03 |
| CY1110931T1 (el) | 2015-06-10 |
| EP1959955A2 (en) | 2008-08-27 |
| RU2008122471A (ru) | 2009-12-10 |
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