CA2629638A1 - Scutellaria barbata extract for the treatment of cancer - Google Patents
Scutellaria barbata extract for the treatment of cancer Download PDFInfo
- Publication number
- CA2629638A1 CA2629638A1 CA002629638A CA2629638A CA2629638A1 CA 2629638 A1 CA2629638 A1 CA 2629638A1 CA 002629638 A CA002629638 A CA 002629638A CA 2629638 A CA2629638 A CA 2629638A CA 2629638 A1 CA2629638 A1 CA 2629638A1
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- cancer
- cells
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- extract
- mammal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
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- Medical Informatics (AREA)
- Neurosurgery (AREA)
- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73662005P | 2005-11-14 | 2005-11-14 | |
| US60/736,620 | 2005-11-14 | ||
| US11/559,324 US7700136B2 (en) | 2005-11-14 | 2006-11-13 | Scutellaria barbata extract for the treatment of cancer |
| US11/559,324 | 2006-11-13 | ||
| PCT/US2006/044224 WO2007059149A2 (en) | 2005-11-14 | 2006-11-14 | Scutellaria barbata extract for the treatment of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2629638A1 true CA2629638A1 (en) | 2007-05-24 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002629638A Abandoned CA2629638A1 (en) | 2005-11-14 | 2006-11-14 | Scutellaria barbata extract for the treatment of cancer |
Country Status (7)
| Country | Link |
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| US (2) | US7700136B2 (enExample) |
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Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1824340A4 (en) * | 2004-12-17 | 2009-08-05 | Bionovo Inc | PROCESS FOR USING EXTRACTS OF SPECIES OF THE GENUS EPIMEDIUM |
| US7482029B2 (en) | 2005-04-01 | 2009-01-27 | Bionovo, Inc. | Composition for treatment of menopause |
| US7700136B2 (en) | 2005-11-14 | 2010-04-20 | Bionovo, Inc. | Scutellaria barbata extract for the treatment of cancer |
| US20080319051A1 (en) * | 2007-06-22 | 2008-12-25 | Bionovo, Inc. | Liquiritigenin and derivatives as selective estrogen receptor beta agonists |
| US20090042818A1 (en) * | 2007-06-22 | 2009-02-12 | Bionovo, Inc. | Liquiritigenin and Derivatives as Selective Estrogen Receptor Beta Agonists |
| JP2010535815A (ja) * | 2007-08-08 | 2010-11-25 | バイオノボ・インコーポレーテッド | モクセイ科トウネズミモチのエストロゲン性抽出物およびその使用 |
| AU2008296072A1 (en) * | 2007-09-07 | 2009-03-12 | Bionovo, Inc. | Estrogenic extracts of Astragalus membranaceus Fisch.Bge.Var.mongolicus Bge. of the Leguminosae Family and uses thereof |
| JP2010538090A (ja) * | 2007-09-07 | 2010-12-09 | バイオノボ・インコーポレーテッド | ユリ科ファミリーのクサスギカズラのエストロゲン性抽出物およびその使用 |
| JP2010539086A (ja) * | 2007-09-07 | 2010-12-16 | バイオノボ・インコーポレーテッド | マメ科ファミリーのクズのエストロゲン性抽出物およびその使用 |
| JP2010538093A (ja) * | 2007-09-07 | 2010-12-09 | バイオノボ・インコーポレーテッド | シソ科ファミリーのセイタカナミキソウのエストロゲン性抽出物およびその使用 |
| AU2008329902A1 (en) * | 2007-11-19 | 2009-06-04 | Bionovo, Inc. | A process of making purified extract of scutellaria barbata D. Don |
| EP2222321A4 (en) * | 2007-11-19 | 2013-02-13 | Bionovo Inc | THERAPY AGAINST CANCER WITH AN EXTRACT OF SCUTELLARIA BARBATA |
| CA2706313A1 (en) * | 2007-11-19 | 2009-05-28 | Bionovo, Inc. | Methods of detecting and treatment of cancers using scuttelaria barbata extract |
| EP2222322A4 (en) * | 2007-11-19 | 2012-07-25 | Bionovo Inc | EXTRACT OF SCUTELLARIA BARBATA AND COMBINATIONS CONTAINING IT FOR THE TREATMENT OF CANCER |
| CA2721191A1 (en) * | 2008-04-14 | 2009-10-22 | Bionovo, Inc. | Calycosin and analogs thereof for the treatment of estrogen receptor beta-mediated diseases |
| EP2310024A4 (en) * | 2008-05-06 | 2012-07-25 | Bionovo Inc | ESTROGENIC EXTRACTS FOR THE TREATMENT OF VAGINA AND VULVAATROPHY |
| US20090311349A1 (en) * | 2008-06-05 | 2009-12-17 | Bionovo, Inc., A Delaware Corporation | Method of quantification of multiple bioactives from botanical compositions |
| WO2009148620A2 (en) * | 2008-06-06 | 2009-12-10 | Bionovo, Inc. | Anthraquinones and analogs from rhuem palmatum for treatment of estrogen receptor beta-mediated conditions |
| EP2323641A4 (en) * | 2008-06-13 | 2012-06-20 | Bionovo Inc | NYASOL AND ANALOGUE THEREOF FOR THE TREATMENT OF ESTROGEN RECEPTOR-BETA-MEDIATED ILLNESSES |
| US20100069481A1 (en) * | 2008-09-03 | 2010-03-18 | Bionovo, Inc. | Methods and compositions for the treatment of cancer |
| AU2010229167A1 (en) * | 2009-03-24 | 2011-10-20 | Bionovo, Inc. | Methods and compositions for the treatment of cancer |
| US20100303936A1 (en) * | 2009-04-28 | 2010-12-02 | Bionovo, Inc. A Delaware Corporation | Method of reducing fat accumulation and inducing weight loss |
| US8858953B2 (en) | 2011-05-09 | 2014-10-14 | Yu-Hwa Peter Sheng | Herbal composition for treating cancer |
| CN103599237B (zh) * | 2013-11-28 | 2015-06-03 | 姜永华 | 一种治疗瘀阻胃络型胃癌的中药及其制备方法 |
| US9789153B2 (en) | 2014-07-02 | 2017-10-17 | Hsiu-Hsien Tsai | Composition for preventing cancer and treating cancer and intensifying the effects of other anticancer drugs |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1175485A1 (ru) * | 1983-12-21 | 1985-08-30 | Киевский Ордена Трудового Красного Знамени Медицинский Институт Им.Акад.А.А.Богомольца | Способ лечени гипертонической болезни (его варианты) |
| FR2616328B1 (fr) | 1987-06-12 | 1990-03-02 | Moet Hennessy Rech | Composition a base de phases lamellaires lipidiques hydratees ou de liposomes contenant un extrait de murier, ou au moins une flavone, en particulier une kuwanone et composition pharmaceutique, notamment dermatologique, a activite depigmentante, ou anti-inflammatoire, ou cosmetique, l'incorporant |
| JPH01175942A (ja) | 1987-12-28 | 1989-07-12 | Sanyo Kokusaku Pulp Co Ltd | 抗ウイルス性医薬用組成物 |
| AU655160B2 (en) * | 1989-11-03 | 1994-12-08 | Alexander S. Sun | Herbal treatment of malignancy |
| JPH0725761A (ja) | 1993-07-09 | 1995-01-27 | Kureha Chem Ind Co Ltd | 軟骨保護剤 |
| US5874084A (en) | 1996-07-19 | 1999-02-23 | Yng-Wong; Quing Non | Using complex herbal formulations to treat hot flashes |
| US20040101576A1 (en) | 1997-03-21 | 2004-05-27 | Eiichiro Yagi | Immunopotentiators |
| MC2441A1 (fr) | 1997-07-31 | 1998-03-11 | Exsymol Sa | Composition cosmétique utile notamment pour le blanchiment de la peau et agent inhibiteur de la mélanogénèse comprenant une telle composition cosmétique |
| EP1027045A4 (en) * | 1997-10-31 | 2004-12-08 | Arch Dev Corp | METHODS AND COMPILATIONS FOR REGULATING S-ALPHA REDUCTASE ACTIVITY |
| US6294526B1 (en) * | 1998-02-06 | 2001-09-25 | Alps Pharmaceutical Ind. Co., Ltd. | Use of flavone derivatives for induction of β-lactam-sensitivity of MRSA |
| FR2784294B1 (fr) | 1998-10-12 | 2000-11-17 | Oreal | Composition cosmetique et/ou dermatologique renfermant au moins un extrait de murier, au moins un extrait de scutellaire et au moins un derive d'acide salicylique |
| US6304825B1 (en) | 1999-01-19 | 2001-10-16 | Xerox Corporation | Rotary encoder error compensation system and method for photoreceptor surface motion sensing and control |
| FR2791573B1 (fr) | 1999-03-30 | 2003-04-11 | Pf Medicament | Utilisation d'un extrait de serenoa repens pour la fabrication d'un medicament destine au traitement du cancer de la prostate |
| JP2001122871A (ja) | 1999-10-26 | 2001-05-08 | Nippon Kayaku Co Ltd | エストロゲン様作用薬剤 |
| CN1294009A (zh) * | 1999-10-28 | 2001-05-09 | 马金发 | 抗癌中药制剂及其置备方法 |
| DE10031650A1 (de) | 2000-06-29 | 2002-01-17 | Schwabe Willmar Gmbh & Co | Verwendung von Extrakten aus Sophora flavescens oder Sophora subprostrata zur Prophylaxe und Therapie von Krankheitszuständen, die durch einen Mangel an Östrogenen oder durch andere hormonelle Dysregulationen verursacht werden |
| JP4693963B2 (ja) | 2000-07-12 | 2011-06-01 | 丸善製薬株式会社 | エストロゲン様作用剤、コラーゲン産生促進剤、及び線維芽細胞増殖剤 |
| US6238707B1 (en) | 2000-10-11 | 2001-05-29 | Zhang Chun | Herbal hormone balance composition |
| JP2005501816A (ja) * | 2000-12-12 | 2005-01-20 | ワックヴォム リミテッド | Ｓｃｕｔｅｌｌａｒｉａｅｂａｒｂａｔａｅから単離された活性な画分を含む組成物および使用方法 |
| US6551627B1 (en) | 2001-05-03 | 2003-04-22 | Holomed Pharmaceuticals, Ltd. | Medicinal herbal compounds for the prevention and treatment of diabetes |
| US6855344B2 (en) | 2001-07-17 | 2005-02-15 | Integrated Chinese Medicine Holdings, Ltd. | Compositions and methods for prostate and kidney health and disorders, an herbal preparation |
| US6750248B2 (en) | 2001-11-09 | 2004-06-15 | National University Of Singapore | Methods for preparing an estrogenic preparation and isolated estrogenic compounds from a plant and uses thereof |
| US20030165588A1 (en) * | 2002-03-01 | 2003-09-04 | Unigen Pharmaceuticals, Inc. | Identification of free-B-ring flavonoids as potent COX-2 inhibitors |
| US20050032882A1 (en) | 2002-03-06 | 2005-02-10 | Sophie Chen | Botanical extract compositions and methods of use |
| JP2004155779A (ja) | 2002-10-16 | 2004-06-03 | Taisho Pharmaceut Co Ltd | 更年期症の予防・治療用経口組成物 |
| AU2002952453A0 (en) | 2002-11-01 | 2002-11-21 | Novogen Research Pty Ltd | Aminated isoflavonoid derivatives and uses thereof |
| WO2004087909A1 (ja) | 2003-03-28 | 2004-10-14 | Nihon University | ２－ヒドロキシイソフラバノンデヒドラターゼをコードするポリヌクレオチドおよびその応用 |
| US20070122501A1 (en) | 2003-06-27 | 2007-05-31 | Hong Kong University Of Science And Technology | Formulations containing astragalus extracts and uses thereof |
| EP1663103B1 (en) | 2003-09-08 | 2011-11-09 | Genyous Biomed International Inc. | Compositions of botanical extracts for cancer therapy |
| US20050196409A1 (en) * | 2003-09-24 | 2005-09-08 | James Dao | Compositions of botanical extracts for treating malignancy-associated changes |
| US20050208159A1 (en) | 2004-03-16 | 2005-09-22 | Kang Kyung S | Phytoestrogenic composition comprising an extract of chinese licorice root, liquiritin or isoliquiritin |
| US8080577B2 (en) | 2004-05-06 | 2011-12-20 | Bioresponse, L.L.C. | Diindolylmethane formulations for the treatment of leiomyomas |
| US20050260285A1 (en) * | 2004-05-21 | 2005-11-24 | Dimateeo-Leggio Giovina | Healthy prostate formula |
| AU2005304878B2 (en) | 2004-11-05 | 2010-07-08 | Genomic Health, Inc. | Molecular indicators of breast cancer prognosis and prediction of treatment response |
| CA2629529A1 (en) | 2004-11-18 | 2006-05-26 | Biopharmacopae Design International Inc. | Plant extracts and dermatological uses thereof |
| US7511152B2 (en) | 2004-12-09 | 2009-03-31 | Merck & Co., Inc. | Estrogen receptor modulators |
| EP1824340A4 (en) | 2004-12-17 | 2009-08-05 | Bionovo Inc | PROCESS FOR USING EXTRACTS OF SPECIES OF THE GENUS EPIMEDIUM |
| JP2008524222A (ja) | 2004-12-17 | 2008-07-10 | バイオノボ・インコーポレーテッド | Ｍｏｒｕｓａｌｂａのエストロゲン様抽出物およびその使用 |
| US7482029B2 (en) | 2005-04-01 | 2009-01-27 | Bionovo, Inc. | Composition for treatment of menopause |
| CN100488524C (zh) | 2005-06-06 | 2009-05-20 | 广东医学院 | 一种由黄芪和司坦唑醇组成的治疗骨质疏松症的药物制剂 |
| EP1907858A4 (en) | 2005-06-13 | 2009-04-08 | Univ Michigan | COMPOSITIONS AND METHODS OF TREATMENT AND DIAGNOSIS OF CANCER |
| CN1723989A (zh) | 2005-07-08 | 2006-01-25 | 山东省中医药研究院 | 葛藤提取物、制备方法及用途 |
| US7700136B2 (en) | 2005-11-14 | 2010-04-20 | Bionovo, Inc. | Scutellaria barbata extract for the treatment of cancer |
| EP1966214B9 (en) | 2005-12-21 | 2017-09-13 | Janssen Pharmaceutica N.V. | Triazolopyridazines as tyrosine kinase modulators |
| CN1840134A (zh) | 2006-01-21 | 2006-10-04 | 端智 | 舒更颗粒 |
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2006
- 2006-11-13 US US11/559,324 patent/US7700136B2/en not_active Expired - Fee Related
- 2006-11-14 GB GB0810224A patent/GB2448249A/en not_active Withdrawn
- 2006-11-14 JP JP2008541285A patent/JP2009515977A/ja active Pending
- 2006-11-14 WO PCT/US2006/044224 patent/WO2007059149A2/en not_active Ceased
- 2006-11-14 EP EP06837591A patent/EP1965819A4/en not_active Withdrawn
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| GB0810224D0 (en) | 2008-07-09 |
| WO2007059149A2 (en) | 2007-05-24 |
| WO2007059149A3 (en) | 2008-01-24 |
| JP2009515977A (ja) | 2009-04-16 |
| US20100143511A1 (en) | 2010-06-10 |
| AU2006315459A1 (en) | 2007-05-24 |
| GB0808665D0 (en) | 2008-06-18 |
| EP1965819A2 (en) | 2008-09-10 |
| EP1965819A4 (en) | 2011-03-23 |
| US7700136B2 (en) | 2010-04-20 |
| GB2448249A (en) | 2008-10-08 |
| US20070110832A1 (en) | 2007-05-17 |
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