CA2624524C - Carbamate compounds which inhibit leukocyte adhesion mediated by vla-4 - Google Patents

Carbamate compounds which inhibit leukocyte adhesion mediated by vla-4 Download PDF

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Publication number
CA2624524C
CA2624524C CA2624524A CA2624524A CA2624524C CA 2624524 C CA2624524 C CA 2624524C CA 2624524 A CA2624524 A CA 2624524A CA 2624524 A CA2624524 A CA 2624524A CA 2624524 C CA2624524 C CA 2624524C
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CA
Canada
Prior art keywords
diethylamino
pyrimidin
phenylalanine
pyrrolidin
carbonyloxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2624524A
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English (en)
French (fr)
Other versions
CA2624524A1 (en
Inventor
Christopher Michael Semko
Ying-Zi Xu
Frank Stappenbeck
Jenifer Lea Smith
Kassandra Inez Rossiter
Juri Y. Fukuda
Andrei W. Konradi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Elan Pharmaceuticals LLC
Original Assignee
Wyeth LLC
Elan Pharmaceuticals LLC
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Filing date
Publication date
Application filed by Wyeth LLC, Elan Pharmaceuticals LLC filed Critical Wyeth LLC
Priority to CA2851103A priority Critical patent/CA2851103A1/en
Publication of CA2624524A1 publication Critical patent/CA2624524A1/en
Application granted granted Critical
Publication of CA2624524C publication Critical patent/CA2624524C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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    • A61P7/06—Antianaemics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/50—Three nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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CA2624524A 2005-09-29 2006-09-28 Carbamate compounds which inhibit leukocyte adhesion mediated by vla-4 Expired - Fee Related CA2624524C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2851103A CA2851103A1 (en) 2005-09-29 2006-09-28 Carbamate compounds which inhibit leukocyte adhesion mediated by vla-4

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US72235505P 2005-09-29 2005-09-29
US60/722,355 2005-09-29
PCT/US2006/038113 WO2007041324A1 (en) 2005-09-29 2006-09-28 Carbamate compounds which inhibit leukocyte adhesion mediated by vla-4

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2851103A Division CA2851103A1 (en) 2005-09-29 2006-09-28 Carbamate compounds which inhibit leukocyte adhesion mediated by vla-4

Publications (2)

Publication Number Publication Date
CA2624524A1 CA2624524A1 (en) 2007-04-12
CA2624524C true CA2624524C (en) 2014-07-08

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ID=37591849

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2624524A Expired - Fee Related CA2624524C (en) 2005-09-29 2006-09-28 Carbamate compounds which inhibit leukocyte adhesion mediated by vla-4
CA2851103A Abandoned CA2851103A1 (en) 2005-09-29 2006-09-28 Carbamate compounds which inhibit leukocyte adhesion mediated by vla-4

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2851103A Abandoned CA2851103A1 (en) 2005-09-29 2006-09-28 Carbamate compounds which inhibit leukocyte adhesion mediated by vla-4

Country Status (11)

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US (3) US7727996B2 (enExample)
EP (1) EP1940827B1 (enExample)
JP (2) JP5081828B2 (enExample)
CN (1) CN101273035A (enExample)
AT (1) ATE502031T1 (enExample)
AU (1) AU2006297180A1 (enExample)
BR (1) BRPI0616643A2 (enExample)
CA (2) CA2624524C (enExample)
DE (1) DE602006020754D1 (enExample)
WO (1) WO2007041324A1 (enExample)
ZA (1) ZA200803016B (enExample)

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NZ567270A (en) * 2005-09-29 2011-06-30 Elan Pharm Inc Pyrimidinyl amide compounds which inhibit leukocyte adhesion mediated by VLA-4
CA2624524C (en) 2005-09-29 2014-07-08 Elan Pharmaceuticals, Inc. Carbamate compounds which inhibit leukocyte adhesion mediated by vla-4
MY151045A (en) 2006-02-27 2014-03-31 Elan Pharm Inc Pyrimidinyl sulfonamide compounds which inhibit leukocyte adhesion mediated by vla-4
US8367836B2 (en) * 2009-04-27 2013-02-05 Elan Pharmaceuticals, Inc. Pyridinone antagonists of alpha-4 integrins
WO2011020874A1 (en) 2009-08-20 2011-02-24 Inserm (Institut National De La Sante Et De La Recherche Medicale) Vla-4 as a biomarker for prognosis and target for therapy in duchenne muscular dystrophy
JP2019512493A (ja) * 2016-03-14 2019-05-16 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 移植片対宿主病の処置または予防の方法
KR20200061363A (ko) * 2017-10-04 2020-06-02 셀진 코포레이션 시스-4-[2-｛[(3ｓ,4ｒ)-3-플루오로옥산-4-일]아미노｝-8-(2,4,6-트리클로로아닐리노)-9ｈ-퓨린-9-일]-1-메틸사이클로헥산-1-카르복스아미드의 제조 공정
CN114302881B (zh) * 2019-08-16 2025-03-25 沃尔克·亚当斯 适用于治疗和预防肌肉萎缩和其他状况的化合物
EP4284947A1 (en) 2021-01-29 2023-12-06 Institut National de la Santé et de la Recherche Médicale (INSERM) Methods of assessing the risk of developing progressive multifocal leukoencephalopathy in patients treated with vla-4 antagonists

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US20100261715A1 (en) 2010-10-14
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US7727996B2 (en) 2010-06-01
EP1940827B1 (en) 2011-03-16
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BRPI0616643A2 (pt) 2011-06-28
CN101273035A (zh) 2008-09-24
US8367688B2 (en) 2013-02-05
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