ZA200803016B - Carbamate compounds which inhibit leukocyte adhesion mediated by VLA-4 - Google Patents

Carbamate compounds which inhibit leukocyte adhesion mediated by VLA-4

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Publication number
ZA200803016B
ZA200803016B ZA200803016A ZA200803016A ZA200803016B ZA 200803016 B ZA200803016 B ZA 200803016B ZA 200803016 A ZA200803016 A ZA 200803016A ZA 200803016 A ZA200803016 A ZA 200803016A ZA 200803016 B ZA200803016 B ZA 200803016B
Authority
ZA
South Africa
Prior art keywords
compounds
vla
leukocyte adhesion
adhesion mediated
inhibit leukocyte
Prior art date
Application number
ZA200803016A
Other languages
English (en)
Inventor
Semko Christopher Michael
Xu Ying-Zi
Stappenbeck Frank
Smith Jenifer Lea
Rossiter Kassandra Inez
Juri Y Fukuda
Andrei W Konradi
Original Assignee
Elan Pharmaceuticals Inc Wyeth
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharmaceuticals Inc Wyeth filed Critical Elan Pharmaceuticals Inc Wyeth
Publication of ZA200803016B publication Critical patent/ZA200803016B/xx

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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
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ZA200803016A 2005-09-29 2006-09-28 Carbamate compounds which inhibit leukocyte adhesion mediated by VLA-4 ZA200803016B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US72235505P 2005-09-29 2005-09-29

Publications (1)

Publication Number Publication Date
ZA200803016B true ZA200803016B (en) 2009-10-28

Family

ID=37591849

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Application Number Title Priority Date Filing Date
ZA200803016A ZA200803016B (en) 2005-09-29 2006-09-28 Carbamate compounds which inhibit leukocyte adhesion mediated by VLA-4

Country Status (11)

Country Link
US (3) US7727996B2 (xx)
EP (1) EP1940827B1 (xx)
JP (2) JP5081828B2 (xx)
CN (1) CN101273035A (xx)
AT (1) ATE502031T1 (xx)
AU (1) AU2006297180A1 (xx)
BR (1) BRPI0616643A2 (xx)
CA (2) CA2851103A1 (xx)
DE (1) DE602006020754D1 (xx)
WO (1) WO2007041324A1 (xx)
ZA (1) ZA200803016B (xx)

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CN101273035A (zh) * 2005-09-29 2008-09-24 伊兰制药公司 抑制由vla-4介导的白细胞粘附的氨基甲酸酯化合物
NZ567270A (en) * 2005-09-29 2011-06-30 Elan Pharm Inc Pyrimidinyl amide compounds which inhibit leukocyte adhesion mediated by VLA-4
EA017110B1 (ru) * 2006-02-27 2012-09-28 Элан Фамэсьютикэлс, Инк. ПИРИМИДИНИЛСУЛЬФОНАМИДНЫЕ СОЕДИНЕНИЯ (ВАРИАНТЫ), СПОСОБ ПОЛУЧЕНИЯ ПИРИМИДИНИЛСУЛЬФОНАМИДНЫХ СОЕДИНЕНИЙ (ВАРИАНТЫ), ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СПОСОБ ЛЕЧЕНИЯ ЗАБОЛЕВАНИЯ, ОПОСРЕДОВАННОГО ИНТЕГРИНОМ α4, СПОСОБ СНИЖЕНИЯ И/ИЛИ ПРЕДУПРЕЖДЕНИЯ ВОСПАЛИТЕЛЬНОГО КОМПОНЕНТА ЗАБОЛЕВАНИЯ ИЛИ АУТОИММУННОГО ОТВЕТА
MX2011011326A (es) * 2009-04-27 2012-02-13 Elan Pharm Inc Antagonistas de piridinona de las integrinas alfa-4.
WO2011020874A1 (en) 2009-08-20 2011-02-24 Inserm (Institut National De La Sante Et De La Recherche Medicale) Vla-4 as a biomarker for prognosis and target for therapy in duchenne muscular dystrophy
US20190077868A1 (en) * 2016-03-14 2019-03-14 Millennium Pharmaceuticals, Inc. Methods of treating or preventing graft versus host disease
CN111417634A (zh) * 2017-10-04 2020-07-14 细胞基因公司 用于制备顺式-4-[2-{[(3s,4r)-3-氟噁烷-4-基]氨基}-8-(2,4,6-三氯苯胺基)-9h-嘌呤-9-基]-1-甲基环己烷-1-甲酰胺的方法
AU2020334194A1 (en) * 2019-08-16 2022-02-24 Volker Adams Compounds suitable for the treatment and prophylaxis of muscle wasting and other conditions
EP4284947A1 (en) 2021-01-29 2023-12-06 Institut National de la Santé et de la Recherche Médicale (INSERM) Methods of assessing the risk of developing progressive multifocal leukoencephalopathy in patients treated with vla-4 antagonists

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