CA2602755A1 - Antibacterial amide-macrocycles v - Google Patents

Antibacterial amide-macrocycles v Download PDF

Info

Publication number
CA2602755A1
CA2602755A1 CA002602755A CA2602755A CA2602755A1 CA 2602755 A1 CA2602755 A1 CA 2602755A1 CA 002602755 A CA002602755 A CA 002602755A CA 2602755 A CA2602755 A CA 2602755A CA 2602755 A1 CA2602755 A1 CA 2602755A1
Authority
CA
Canada
Prior art keywords
boc
amino
represents hydrogen
independently
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002602755A
Other languages
English (en)
French (fr)
Inventor
Rainer Endermann
Kerstin Ehlert
Siegfried Raddatz
Martin Michels
Yolanda Cancho-Grande
Stefan Weigand
Karin Fischer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aicuris GmbH and Co KG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2602755A1 publication Critical patent/CA2602755A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CA002602755A 2005-03-30 2006-03-22 Antibacterial amide-macrocycles v Abandoned CA2602755A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102005014245A DE102005014245A1 (de) 2005-03-30 2005-03-30 Antibakterielle Amid-Makrozyklen V
DE102005014245.1 2005-03-30
PCT/EP2006/002617 WO2006103015A1 (de) 2005-03-30 2006-03-22 Antibakterielle amid-makrozyklen v

Publications (1)

Publication Number Publication Date
CA2602755A1 true CA2602755A1 (en) 2006-10-05

Family

ID=36572224

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002602755A Abandoned CA2602755A1 (en) 2005-03-30 2006-03-22 Antibacterial amide-macrocycles v

Country Status (17)

Country Link
US (1) US20080275018A1 (cg-RX-API-DMAC7.html)
EP (1) EP1869068A1 (cg-RX-API-DMAC7.html)
JP (1) JP2008534540A (cg-RX-API-DMAC7.html)
KR (1) KR20070116169A (cg-RX-API-DMAC7.html)
CN (1) CN101228182A (cg-RX-API-DMAC7.html)
AU (1) AU2006228751A1 (cg-RX-API-DMAC7.html)
BR (1) BRPI0612219A2 (cg-RX-API-DMAC7.html)
CA (1) CA2602755A1 (cg-RX-API-DMAC7.html)
DE (1) DE102005014245A1 (cg-RX-API-DMAC7.html)
IL (1) IL185899A0 (cg-RX-API-DMAC7.html)
MX (1) MX2007012146A (cg-RX-API-DMAC7.html)
NO (1) NO20075270L (cg-RX-API-DMAC7.html)
NZ (1) NZ562003A (cg-RX-API-DMAC7.html)
RU (1) RU2409588C2 (cg-RX-API-DMAC7.html)
UA (1) UA91541C2 (cg-RX-API-DMAC7.html)
WO (1) WO2006103015A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA200709336B (cg-RX-API-DMAC7.html)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10358824A1 (de) 2003-12-16 2005-07-21 Bayer Healthcare Ag Antibakterielle Makrozyklen mit substituiertem Biphenyl
DE102005032781A1 (de) * 2005-07-14 2007-01-18 Aicuris Gmbh & Co. Kg Antibakterielle Amid-Markozyklen VII
WO2012036907A2 (en) 2010-09-15 2012-03-22 Romesberg Floyd E Broad spectrum antibiotic arylomycin analogs
US10501493B2 (en) 2011-05-27 2019-12-10 Rqx Pharmaceuticals, Inc. Broad spectrum antibiotics
TWI642684B (zh) * 2011-05-27 2018-12-01 Ｒｑｘ製藥股份有限公司 廣效性抗生素
BR112015011697A2 (pt) 2012-11-21 2017-07-11 Rqx Pharmaceuticals Inc antibióticos macrocíclicos de amplo espectro
EP3145944B1 (en) 2014-05-20 2021-05-05 RQX Pharmaceuticals, Inc. Macrocyclic broad spectrum antibiotics
PL3368544T3 (pl) 2015-10-27 2020-11-16 F. Hoffmann-La Roche Ag Peptydowe związki makrocykliczne przeciwko Acinetobacter baumannii
RU2761476C2 (ru) 2015-11-20 2021-12-08 АрКьюИкс ФАРМАСЬЮТИКЭЛС, ИНК. Макроциклические антибиотики широкого спектра действия
EP3388444A1 (en) * 2017-04-10 2018-10-17 F. Hoffmann-La Roche AG Anti-bacterial peptide macrocycles and use thereof
MX2020002010A (es) 2017-08-21 2020-07-13 Celgene Corp Procesos para la preparacion de 4,5-diamino-5-oxopentanoato de (s)-terc-butilo.
US11505573B2 (en) 2018-03-28 2022-11-22 Hoffmann-La Roche Inc. Peptide macrocycles against Acinetobacter baumannii
US11819532B2 (en) 2018-04-23 2023-11-21 Hoffmann-La Roche Inc. Peptide macrocycles against Acinetobacter baumannii
HRP20231497T8 (hr) 2019-05-28 2024-08-02 F. Hoffmann-La Roche Ag Makrociklični antibiotici širokog spektra
WO2024262518A1 (ja) * 2023-06-20 2024-12-26 国立大学法人北海道大学 スキャニング用アミノ酸化合物、スキャニング用改変ペプチド、スキャニング用キット及びペプチドの活性部位のスキャニング方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3452136A (en) * 1968-04-17 1969-06-24 American Cyanamid Co Antibiotic af283 and production thereof
FR2720066B1 (fr) * 1994-05-20 1996-06-28 Rhone Poulenc Rorer Sa Peptides antagonistes de la neurotensine.
DE10226921A1 (de) * 2002-06-17 2003-12-24 Bayer Ag Antibakterielle Amid-Makrozyklen
DE10234422A1 (de) * 2002-07-29 2004-02-12 Bayer Ag Antibakterielle Ester-Makrozyklen
CA2540646A1 (en) * 2003-10-01 2005-04-14 Bayer Healthcare Ag Antibacterial amide macrocycles
DE10358824A1 (de) * 2003-12-16 2005-07-21 Bayer Healthcare Ag Antibakterielle Makrozyklen mit substituiertem Biphenyl
DE102005014240A1 (de) * 2004-09-24 2006-03-30 Bayer Healthcare Ag Antibakterielle Amid-Makrozyklen IV

Also Published As

Publication number Publication date
DE102005014245A1 (de) 2006-10-05
RU2007139760A (ru) 2009-05-10
CN101228182A (zh) 2008-07-23
MX2007012146A (es) 2007-12-10
EP1869068A1 (de) 2007-12-26
UA91541C2 (ru) 2010-08-10
JP2008534540A (ja) 2008-08-28
NO20075270L (no) 2007-12-18
NZ562003A (en) 2010-11-26
BRPI0612219A2 (pt) 2009-01-13
KR20070116169A (ko) 2007-12-06
RU2409588C2 (ru) 2011-01-20
IL185899A0 (en) 2008-12-29
US20080275018A1 (en) 2008-11-06
WO2006103015A1 (de) 2006-10-05
ZA200709336B (en) 2009-09-30
AU2006228751A1 (en) 2006-10-05

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued

Effective date: 20130322