CA2587505C - Low-profile microneedle array applicator - Google Patents

Low-profile microneedle array applicator Download PDF

Info

Publication number
CA2587505C
CA2587505C CA2587505A CA2587505A CA2587505C CA 2587505 C CA2587505 C CA 2587505C CA 2587505 A CA2587505 A CA 2587505A CA 2587505 A CA2587505 A CA 2587505A CA 2587505 C CA2587505 C CA 2587505C
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CA
Canada
Prior art keywords
microneedle
flexible sheet
skin surface
skin
sheet
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2587505A
Other languages
English (en)
French (fr)
Other versions
CA2587505A1 (en
Inventor
Adam S. Cantor
Franklyn L. Frederickson
Peter R. Johnson
Ted K. Ringsred
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
3M Innovative Properties Co
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3M Innovative Properties Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 3M Innovative Properties Co filed Critical 3M Innovative Properties Co
Publication of CA2587505A1 publication Critical patent/CA2587505A1/en
Application granted granted Critical
Publication of CA2587505C publication Critical patent/CA2587505C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023Drug applicators using microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Micromachines (AREA)
CA2587505A 2004-11-18 2005-11-18 Low-profile microneedle array applicator Expired - Fee Related CA2587505C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62921504P 2004-11-18 2004-11-18
US60/629,215 2004-11-18
PCT/US2005/041854 WO2006055795A1 (en) 2004-11-18 2005-11-18 Low-profile microneedle array applicator

Publications (2)

Publication Number Publication Date
CA2587505A1 CA2587505A1 (en) 2006-05-26
CA2587505C true CA2587505C (en) 2013-01-08

Family

ID=35809616

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2587505A Expired - Fee Related CA2587505C (en) 2004-11-18 2005-11-18 Low-profile microneedle array applicator

Country Status (12)

Country Link
US (2) US8267889B2 (https=)
EP (1) EP1833547A1 (https=)
JP (2) JP2008520369A (https=)
KR (2) KR20130026511A (https=)
CN (1) CN101060883B (https=)
AU (1) AU2005306422A1 (https=)
BR (1) BRPI0517749A (https=)
CA (1) CA2587505C (https=)
IL (1) IL183204A (https=)
MX (1) MX2007005813A (https=)
WO (1) WO2006055795A1 (https=)
ZA (1) ZA200705102B (https=)

Families Citing this family (115)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7828827B2 (en) 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
GB0402131D0 (en) 2004-01-30 2004-03-03 Isis Innovation Delivery method
WO2005094526A2 (en) * 2004-03-24 2005-10-13 Corium International, Inc. Transdermal delivery device
CN101060883B (zh) 2004-11-18 2010-06-23 3M创新有限公司 低轮廓微针阵列施放器
US10035008B2 (en) 2005-04-07 2018-07-31 3M Innovative Properties Company System and method for tool feedback sensing
EP1904158B1 (en) 2005-06-24 2013-07-24 3M Innovative Properties Company Collapsible patch with microneedle array
EP2258441A3 (en) * 2005-09-02 2011-09-21 Intercell USA, Inc. Devices for transcutaneous delivery of vaccines and transdermal delivery of drugs
US9119945B2 (en) * 2006-04-20 2015-09-01 3M Innovative Properties Company Device for applying a microneedle array
KR100886633B1 (ko) * 2006-07-14 2009-03-04 호남석유화학 주식회사 전면부에 피부를 통해 체내로 전달하고자 하는 물질의 수용공간을 갖는 피부 침투용 미세 돌기 장치
EP1884223A1 (en) 2006-08-04 2008-02-06 IP Randwyck B.V. Wound-stimulating unit
US8821446B2 (en) * 2007-01-22 2014-09-02 Corium International, Inc. Applicators for microneedles
KR100893250B1 (ko) * 2007-02-28 2009-04-17 광주과학기술원 능동형 미세바늘 장치
JP4978245B2 (ja) * 2007-03-08 2012-07-18 凸版印刷株式会社 針状体、針状体製造方法および薬物輸送デバイス
ES2817249T3 (es) 2007-04-16 2021-04-06 Corium Inc Matrices de microagujas obtenidas mediante disolución y colada que contienen un principio activo
GB2448493B (en) 2007-04-16 2009-10-14 Dewan Fazlul Hoque Chowdhury Microneedle transdermal delivery device
JP5222512B2 (ja) * 2007-09-19 2013-06-26 凸版印刷株式会社 マイクロニードルチップ
WO2009048607A1 (en) 2007-10-10 2009-04-16 Corium International, Inc. Vaccine delivery via microneedle arrays
JP5178132B2 (ja) * 2007-10-11 2013-04-10 キヤノン株式会社 画像処理システム並びに画像処理方法
KR101013581B1 (ko) * 2008-08-06 2011-02-14 라종주 전기 피부 미용기
WO2010022326A2 (en) * 2008-08-22 2010-02-25 Us Worldmeds Llc Transdermal delivery of apomorphine using microneedles
US8579862B2 (en) 2009-02-23 2013-11-12 Medrx Co., Ltd. Applicator for microneedle array
EP2429627B1 (en) * 2009-04-24 2017-06-14 Corium International, Inc. Methods for manufacturing microprojection arrays
JP5663792B2 (ja) * 2009-08-07 2015-02-04 株式会社 メドレックス 剣山型マイクロニードルのアプリケータデバイス
US8834423B2 (en) 2009-10-23 2014-09-16 University of Pittsburgh—of the Commonwealth System of Higher Education Dissolvable microneedle arrays for transdermal delivery to human skin
US20110172645A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Wearable drug delivery device including integrated pumping and activation elements
USD638534S1 (en) 2010-01-08 2011-05-24 Ratio, Inc. Drug delivery device
US20110172638A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Drug delivery device including multi-functional cover
US20110172639A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Device and method for delivery of microneedle to desired depth within the skin
US20110172637A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Drug delivery device including tissue support structure
USD619245S1 (en) 2010-01-08 2010-07-06 Ratio, Inc. Drug delivery device
US20110172609A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Microneedle component assembly for drug delivery device
EP2526995A4 (en) 2010-01-22 2013-07-03 Medrx Co Ltd ADHESIVE AID FOR HEALING FOR A MICRO NEEDLE ADHESIVE TRANSDERMAL STAMP
US8911422B2 (en) 2010-02-24 2014-12-16 Hisamitsu Pharmaceutical Co., Inc. Micro-needle device
BR112012028263B1 (pt) 2010-05-04 2020-06-02 Corium, Inc. Aplicador e dispositivo para matriz de microprojeção
EP2566501B1 (en) 2010-05-04 2019-03-13 Corium International, Inc. Method and device for transdermal delivery of parathyroid hormone using a microprojection array
WO2011141426A1 (en) 2010-05-10 2011-11-17 Tt Seed S.R.L. Needle device for detecting biosignals through the skin
US8668675B2 (en) 2010-11-03 2014-03-11 Flugen, Inc. Wearable drug delivery device having spring drive and sliding actuation mechanism
CN101972499B (zh) * 2010-11-10 2016-07-06 吉林大学 轻松无痛输药装置
IT1403293B1 (it) 2010-12-27 2013-10-17 Fond Don Carlo Gnocchi Onlus Apparecchiatura ad aghi per la somministrazione transdermica di farmaci.
EP2722072A4 (en) 2011-06-14 2015-02-25 Jong Ju Na DEVICE AND METHOD FOR IMPROVING THE SKIN WITH A RA EFFECT OR AN RA-PLUS EFFECT
WO2013051568A1 (ja) 2011-10-06 2013-04-11 久光製薬株式会社 アプリケータ
US20140236090A1 (en) * 2011-10-12 2014-08-21 3M Innovative Properties Company Integrated microneedle array delivery system
AU2012323782B2 (en) 2011-10-12 2017-04-06 Vaxxas Pty Limited Delivery device
CN103874518A (zh) * 2011-10-12 2014-06-18 3M创新有限公司 一体化微针阵列递送系统
US8469900B2 (en) * 2011-11-30 2013-06-25 Lincoln Diagnostics, Inc. Allergy testing device and method of testing for allergies
US9011350B2 (en) 2011-11-30 2015-04-21 Lincoln Diagnostics, Inc. Allergy testing device and method of testing for allergies
DE102011089723A1 (de) * 2011-12-23 2013-06-27 Robert Bosch Gmbh Mikronadelarray-Applikator und Verfahren zur Applikation eines Mikronadelarrays
WO2013166162A1 (en) 2012-05-01 2013-11-07 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Tip-loaded microneedle arrays for transdermal insertion
EP2852352B1 (en) 2012-05-04 2021-09-01 Roger Khouri Surgical tools
JP5593355B2 (ja) * 2012-07-23 2014-09-24 凸版印刷株式会社 針状体および針状体製造方法
WO2014058746A1 (en) 2012-10-10 2014-04-17 3M Innovative Properties Company Force-controlled applicator for applying a microneedle device to skin
CN104736192B (zh) 2012-10-10 2018-02-13 3M创新有限公司 用于将微针装置施用至皮肤的施用装置和方法
EP2919849B1 (en) * 2012-11-16 2021-01-06 Kindeva Drug Delivery L.P. Force-controlled applicator for applying a microneedle device to skin
CN105142529A (zh) 2012-11-21 2015-12-09 电路治疗公司 用于光遗传疗法的系统和方法
EP2934660B1 (en) 2012-12-21 2019-07-17 Corium, Inc. Microarray for delivery of therapeutic agent and method of making same
EP4094799A1 (en) 2013-03-12 2022-11-30 Corium, Inc. Microprojection applicators
US10384046B2 (en) 2013-03-15 2019-08-20 Corium, Inc. Microarray for delivery of therapeutic agent and methods of use
WO2014150285A2 (en) 2013-03-15 2014-09-25 Corium International, Inc. Multiple impact microprojection applicators and methods of use
US10384045B2 (en) 2013-03-15 2019-08-20 Corium, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
EP2968119B1 (en) 2013-03-15 2019-09-18 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
EP3027263A1 (en) 2013-07-30 2016-06-08 ZP Opco, Inc. Low-profile microneedle patch applicator
CA2925333C (en) * 2013-09-30 2021-09-07 Georgia Tech Research Corporation Microneedle patches, systems, and methods
JP6489025B2 (ja) * 2014-01-24 2019-03-27 凸版印刷株式会社 マイクロニードルユニット
CN105916543B (zh) * 2014-01-24 2020-06-30 凸版印刷株式会社 微针单元以及微针组件
US10994112B2 (en) 2014-02-05 2021-05-04 Amgen Inc. Drug delivery system with electromagnetic field generator
USD763504S1 (en) 2014-04-02 2016-08-09 Hisamitsu Pharmaceutical Co., Inc. Cosmetic pack sheet
CA2981974C (en) 2014-04-24 2023-06-20 Georgia Tech Research Corporation Microneedles and methods of manufacture thereof
US10624843B2 (en) 2014-09-04 2020-04-21 Corium, Inc. Microstructure array, methods of making, and methods of use
EP3251721B1 (en) * 2015-01-27 2019-12-18 Toppan Printing Co., Ltd. Transdermal administration device
WO2016123665A1 (en) * 2015-02-02 2016-08-11 Vaxxas Pty Limited Microprojection array applicator and method
CN106456954A (zh) * 2015-02-13 2017-02-22 美德阿利克斯株式会社 微针的穿刺装置及微针贴片的敷贴装置
WO2016149673A1 (en) 2015-03-18 2016-09-22 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Bioactive components conjugated to substrates of microneedle arrays
US10857093B2 (en) 2015-06-29 2020-12-08 Corium, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
CN108136165B (zh) 2015-09-02 2020-11-06 久光制药株式会社 施放器
WO2017045031A1 (en) 2015-09-18 2017-03-23 Vaxxas Pty Limited Microprojection arrays with microprojections having large surface area profiles
CA2999538A1 (en) * 2015-09-28 2017-04-06 Vaxxas Pty Limited Microprojection arrays with enhanced skin penetrating properties and methods thereof
KR101757866B1 (ko) * 2015-10-08 2017-07-14 주식회사 라파스 마이크로니들패치 포장케이스
WO2017066768A1 (en) 2015-10-16 2017-04-20 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Mullti-component biio-active drug delivery and controlled release to the skin by microneedle array devices
CN112089961B (zh) 2015-12-21 2022-08-09 美德阿利克斯株式会社 微针贴片施用器及其壳体
WO2017120322A1 (en) 2016-01-05 2017-07-13 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Skin microenvironment targeted delivery for promoting immune and other responses
US10500351B2 (en) * 2016-02-12 2019-12-10 Shawn Michael Michels Aid for subcutaneous tissue injection and process of effecting the injection with the aid
CN121588347A (zh) 2016-12-16 2026-03-03 索伦托治疗有限公司 用于流体递送装置的施用机构及其使用方法
KR101745445B1 (ko) * 2017-01-25 2017-06-09 송득영 가압형 약물 주입 시스템
ES2960937T3 (es) 2017-03-31 2024-03-07 Vaxxas Pty Ltd Dispositivo y método para recubrir superficies
JP2018191783A (ja) * 2017-05-15 2018-12-06 富士フイルム株式会社 マイクロニードルアレイユニット、および容器
JP2018192177A (ja) * 2017-05-22 2018-12-06 コスメディ製薬株式会社 水溶性化粧用シート保持フィルム
US11175128B2 (en) 2017-06-13 2021-11-16 Vaxxas Pty Limited Quality control of substrate coatings
EP4473998A3 (en) * 2017-08-04 2025-02-26 Vaxxas Pty Limited Compact high mechanical energy storage and low trigger force actuator for the delivery of microprojection array patches (map)
KR20190027233A (ko) * 2017-09-06 2019-03-14 주식회사 라파스 마이크로니들 보호 성능이 개선된 마이크로니들 패치 및 이러한 마이크로니들 패치와 어플리케이터로 구성되는 마이크로니들 패치 어플리케이터 시스템
US10786203B1 (en) * 2018-01-30 2020-09-29 Daniel M. Besser Medical patch applicator device
WO2019166572A1 (en) 2018-02-28 2019-09-06 Pharming Intellectual Property B.V. Pharmaceutical system for transdermal administration of a c1 -esterase inhibitor
ES3034959T3 (en) * 2018-03-13 2025-08-27 Medrx Co Ltd Adhesion member and microneedle patch
CN108671385A (zh) * 2018-06-21 2018-10-19 陈宏� 一种穴位自动贴敷直压微针及使用方法
JP1632957S (https=) 2018-10-30 2019-06-03
EP3875141B1 (en) * 2018-10-31 2022-12-14 FUJIFILM Corporation Micro-needle array device
CA3124933A1 (en) * 2018-12-25 2020-07-02 Hirosaki University Medicine administering device and medicine administering system
DE102019200557A1 (de) * 2019-01-17 2020-07-23 Lts Lohmann Therapie-Systeme Ag Applikator
AU2020275934B2 (en) 2019-05-16 2025-09-25 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Microneedle arrays with undercut features for cutaneous and non-cutaneous drug delivery
JPWO2021251464A1 (https=) * 2020-06-12 2021-12-16
US12611530B2 (en) 2020-12-21 2026-04-28 Mediccene Inc. Intradermal drug delivery device
US11389632B2 (en) 2020-12-21 2022-07-19 Mediccene Inc. Intradermal drug delivery device
US12048543B2 (en) 2021-11-08 2024-07-30 Satio, Inc. Dermal patch for collecting a physiological sample with removable vial
US12178979B2 (en) 2021-10-13 2024-12-31 Satio, Inc. Dermal patch for delivering a pharmaceutical
US11877848B2 (en) 2021-11-08 2024-01-23 Satio, Inc. Dermal patch for collecting a physiological sample
US12053284B2 (en) 2021-11-08 2024-08-06 Satio, Inc. Dermal patch for collecting a physiological sample
US12023156B2 (en) 2021-10-13 2024-07-02 Satio, Inc. Dermal patch for collecting a physiological sample
US11964121B2 (en) 2021-10-13 2024-04-23 Satio, Inc. Mono dose dermal patch for pharmaceutical delivery
US11452474B1 (en) 2021-04-14 2022-09-27 Satio, Inc. Dual lever dermal patch system
US12214346B2 (en) 2021-10-13 2025-02-04 Satio, Inc. Dermal patch with a diagnostic test strip
US11654270B2 (en) 2021-09-28 2023-05-23 Biolinq Incorporated Microneedle enclosure and applicator device for microneedle array based continuous analyte monitoring device
USD1033641S1 (en) 2021-12-17 2024-07-02 Biolinq Incorporated Microneedle array sensor applicator device
KR102764041B1 (ko) * 2022-04-14 2025-02-07 주식회사 에스엔비아 마이크로니들 어플리케이터
USD1057153S1 (en) 2022-04-29 2025-01-07 Biolinq Incorporated Microneedle array sensor applicator device
CA3267298A1 (en) * 2022-09-13 2024-03-21 Micron Biomedical, Inc. MICRO-NECK STAMP WITH FEEDBACK INDICATOR
USD1085416S1 (en) * 2023-10-27 2025-07-22 Guangzhou Ekai Electronic Technology Co., Ltd. Skincare microneedling device for beauty machine

Family Cites Families (127)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE25637E (en) 1964-09-08 Means for vaccinating
US3123212A (en) 1964-03-03 Multiple disposable intracutaneous injector package
US3072122A (en) 1959-01-15 1963-01-08 Rosenthal Sol Roy Package for transcutaneous injection
US3034507A (en) 1960-05-10 1962-05-15 American Cyanamid Co Intracutaneous injection device
US3136314A (en) 1960-08-01 1964-06-09 Kravitz Harvey Vaccinating devices
US3246647A (en) 1962-07-23 1966-04-19 American Cyanamid Co Disposable intracutaneous injector
US3221740A (en) 1962-08-31 1965-12-07 Rosenthal Sol Roy Injection device
GB1080986A (en) 1964-09-02 1967-08-31 Allen And Hanburys Surgical En Multiple puncture apparatus
US3322121A (en) 1965-11-26 1967-05-30 Oscar H Banker Skin-puncturing unit with a collapsible protective cover
US3510933A (en) 1967-05-26 1970-05-12 American Cyanamid Co Apparatus and method for continuously forming intracutaneous injectors
US3466131A (en) 1967-09-07 1969-09-09 Becton Dickinson Co Dispensing applicator package
US3512520A (en) 1967-11-01 1970-05-19 Michael N Cowan Antigenic test applicator
US3596660A (en) 1969-05-12 1971-08-03 Illinois Tool Works Injection device
US3675766A (en) 1970-02-04 1972-07-11 Sol Roy Rosenthal Multiple puncture injector device
US3688764A (en) 1970-08-20 1972-09-05 Bard Hamilton Co Inc Intracutaneous injection system
US3964482A (en) 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US3678150A (en) 1971-07-27 1972-07-18 American Cyanamid Co Process for improving the stability of ppd, qt and histoplasmin on tine applicators
DE2250293A1 (de) 1972-10-13 1974-04-25 Bayern Freistaat Impfstempel zur cutanen pockenimpfung mittels trockenimpfstoff
OA05448A (fr) 1975-10-16 1981-03-31 Manufrance Manufacture Francai Dispositif vaccinateur multipénétrant.
US4304241A (en) 1978-09-05 1981-12-08 Aller-Screen, Inc. Skin testing device
US4237906A (en) 1978-12-06 1980-12-09 Havstad Harold R Antigen injection assembly
GB2064329B (en) 1979-11-01 1983-06-22 Matburn Holdings Ltd Multiple puncture apparatus
FR2474856A1 (fr) 1980-01-31 1981-08-07 Merieux Inst Dispositif scarificateur
US4360016A (en) 1980-07-01 1982-11-23 Transidyne General Corp. Blood collecting device
US4503856A (en) 1981-06-29 1985-03-12 Sherwood Medical Company Lancet injector
US4517978A (en) 1983-01-13 1985-05-21 Levin Paul D Blood sampling instrument
US4474751A (en) 1983-05-16 1984-10-02 Merck & Co., Inc. Ophthalmic drug delivery system utilizing thermosetting gels
US4627445A (en) 1985-04-08 1986-12-09 Garid, Inc. Glucose medical monitoring system
GB8710470D0 (en) 1987-05-01 1987-06-03 Mumford Ltd Owen Blood sampling devices
US4858607A (en) 1987-10-16 1989-08-22 Pavel Jordan & Associates Plastic device for injection and obtaining blood samples
US5192535A (en) 1988-02-08 1993-03-09 Insite Vision Incorporated Ophthalmic suspensions
GB2221394B (en) 1988-08-05 1992-03-04 Eilert Eilertsen An injection device
US4924879A (en) 1988-10-07 1990-05-15 Brien Walter J O Blood lancet device
US4920977A (en) 1988-10-25 1990-05-01 Becton, Dickinson And Company Blood collection assembly with lancet and microcollection tube
EP0429842B1 (en) 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Device for the transdermal administration of protein or peptide drug
US5402798A (en) * 1991-07-18 1995-04-04 Swierczek; Remi Disposable skin perforator and blood testing device
DE4212315A1 (de) 1992-04-13 1993-10-14 Boehringer Mannheim Gmbh Blutlanzettenvorrichtung zur Entnahme von Blut für Diagnosezwecke
DE4212723C1 (de) * 1992-04-16 1993-11-04 Arta Plast Ab Tyresoe Lanzettenvorrichtung zum punktieren der haut
US5340572A (en) 1993-02-08 1994-08-23 Insite Vision Incorporated Alkaline ophthalmic suspensions
JP2630197B2 (ja) 1993-04-28 1997-07-16 株式会社ニッショー 血液吸出器具
US5611806A (en) 1994-05-23 1997-03-18 Samsung Electro-Mechanics Co., Ltd. Skin perforating device for transdermal medication
US5487726A (en) 1994-06-16 1996-01-30 Ryder International Corporation Vaccine applicator system
US5636640A (en) * 1995-02-06 1997-06-10 Volunteers For Medical Engineering Liquid sampling and test apparatus
AU5869796A (en) 1995-05-22 1996-12-11 Ned A. Godshall Micromechanical patch for enhancing the delivery of compound s through the skin
WO1996037155A1 (en) 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical device and method for enhancing delivery of compounds through the skin
DE19525607A1 (de) 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneales Arzneimittelfreigabesystem
CA2253549C (en) * 1996-06-18 2005-10-25 Alza Corporation Device for enhancing transdermal agent delivery or sampling
US5983136A (en) 1996-09-17 1999-11-09 Deka Products Limited Partnership System for delivery of drugs by transport
US6797276B1 (en) 1996-11-14 2004-09-28 The United States Of America As Represented By The Secretary Of The Army Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response
US6293925B1 (en) 1997-12-31 2001-09-25 Minimed Inc. Insertion device for an insertion set and method of using the same
US5968633A (en) * 1997-06-06 1999-10-19 The Procter & Gamble Company Selectively-activatible sheet material for dispensing and dispersing a substance onto a target surface
DE69806963T2 (de) 1997-12-11 2002-11-21 Alza Corp., Mountain View Vorrichtung zur erhöhung des transdermalen wirkstoffeflusses
ES2314995T3 (es) 1997-12-11 2009-03-16 Alza Corporation Dispositivo para mejorar el flujo de agentes tansdermicos.
US6091975A (en) 1998-04-01 2000-07-18 Alza Corporation Minimally invasive detecting device
CA2229522A1 (en) * 1998-04-15 1999-10-15 Thomas Randall Inkpen Needle aid
US6503231B1 (en) 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
EP1086214B1 (en) 1998-06-10 2009-11-25 Georgia Tech Research Corporation Microneedle devices and methods of their manufacture
GB9817662D0 (en) 1998-08-13 1998-10-07 Crocker Peter J Substance delivery
US6532386B2 (en) 1998-08-31 2003-03-11 Johnson & Johnson Consumer Companies, Inc. Electrotransort device comprising blades
US6022368A (en) * 1998-11-30 2000-02-08 Gavronsky; Stas Acupuncture method and device
US6713291B2 (en) 1999-01-28 2004-03-30 Alan D. King Electrodes coated with treating agent and uses thereof
EP1163024B1 (en) 1999-01-28 2003-12-17 Cyto Pulse Sciences, Inc. Delivery of macromolecules into cells
US6611707B1 (en) * 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
US6743211B1 (en) * 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
AU2005200910B2 (en) 1999-06-04 2006-08-03 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6379324B1 (en) * 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
US6256533B1 (en) 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6312612B1 (en) * 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
US6623457B1 (en) 1999-09-22 2003-09-23 Becton, Dickinson And Company Method and apparatus for the transdermal administration of a substance
US6835184B1 (en) * 1999-09-24 2004-12-28 Becton, Dickinson And Company Method and device for abrading skin
US20020095134A1 (en) 1999-10-14 2002-07-18 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
ES2253278T3 (es) 1999-12-10 2006-06-01 Alza Corporation Dispositivo y procedimiento para mejorar la perforacion cutanea con microprotuberancias.
MXPA02005765A (es) 1999-12-10 2003-01-28 Alza Corp Aparato de tratamiento de piel para el suministro de farmaco transdermico sostenido.
US6881538B1 (en) 2000-03-05 2005-04-19 3M Innovative Properties Company Array comprising diamond-like glass film
US6595947B1 (en) 2000-05-22 2003-07-22 Becton, Dickinson And Company Topical delivery of vaccines
US7473244B2 (en) 2000-06-02 2009-01-06 The University Of Utah Research Foundation Active needle devices with integrated functionality
US6537242B1 (en) * 2000-06-06 2003-03-25 Becton, Dickinson And Company Method and apparatus for enhancing penetration of a member for the intradermal sampling or administration of a substance
US6589202B1 (en) 2000-06-29 2003-07-08 Becton Dickinson And Company Method and apparatus for transdermally sampling or administering a substance to a patient
US6440096B1 (en) 2000-07-14 2002-08-27 Becton, Dickinson And Co. Microdevice and method of manufacturing a microdevice
US6656147B1 (en) * 2000-07-17 2003-12-02 Becton, Dickinson And Company Method and delivery device for the transdermal administration of a substance
GB0017999D0 (en) 2000-07-21 2000-09-13 Smithkline Beecham Biolog Novel device
PL360978A1 (en) 2000-10-13 2004-09-20 Alza Corporation Microblade array impact applicator
DE60138411D1 (de) * 2000-10-13 2009-05-28 Alza Corp Vorrichtung und verfahren zum durchstechen der haut mit micronadeln
ATE416692T1 (de) 2000-10-13 2008-12-15 Alza Corp Mikronadelelementhalter für schlagapplikator
US7419481B2 (en) * 2000-10-13 2008-09-02 Alza Corporation Apparatus and method for piercing skin with microprotrusions
US7131987B2 (en) 2000-10-16 2006-11-07 Corium International, Inc. Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation
NZ525551A (en) * 2000-10-26 2005-09-30 Alza Corp Transdermal drug delivery devices having coated microprotrusions
WO2002045771A2 (en) 2000-11-09 2002-06-13 Biovalve Technologies, Inc. Microneedle adapter
EP2578252B1 (en) 2000-11-30 2019-01-09 Valeritas, Inc. Device with substantially freely movable micro-probe over the housing
EP1345646A2 (en) 2000-12-14 2003-09-24 Georgia Tech Research Corporation Microneedle devices and production thereof
ATE444773T1 (de) * 2001-04-20 2009-10-15 Alza Corp Mikroprojektionsanordnung mit einem überzug, der ein vorteilhaftes mittel enthält
US20020193729A1 (en) * 2001-04-20 2002-12-19 Cormier Michel J.N. Microprojection array immunization patch and method
US6591124B2 (en) 2001-05-11 2003-07-08 The Procter & Gamble Company Portable interstitial fluid monitoring system
JP2004532698A (ja) * 2001-06-08 2004-10-28 ベクトン・ディキンソン・アンド・カンパニー ニードルまたはアブレーダーアレイの操作のための装置
CN1253220C (zh) 2001-06-29 2006-04-26 贝克顿迪肯森公司 通过微管在真皮内输入疫苗和基因治疗剂
US6881203B2 (en) 2001-09-05 2005-04-19 3M Innovative Properties Company Microneedle arrays and methods of manufacturing the same
WO2003022330A2 (en) 2001-09-12 2003-03-20 Becton, Dickinson And Company Microneedle-based pen device for drug delivery and method for using same
US8920375B2 (en) 2001-09-21 2014-12-30 Valeritas, Inc. Gas pressure actuated microneedle arrays, and systems and methods relating to same
US6830562B2 (en) * 2001-09-27 2004-12-14 Unomedical A/S Injector device for placing a subcutaneous infusion set
US7429258B2 (en) * 2001-10-26 2008-09-30 Massachusetts Institute Of Technology Microneedle transport device
US6908453B2 (en) 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
US7004928B2 (en) * 2002-02-08 2006-02-28 Rosedale Medical, Inc. Autonomous, ambulatory analyte monitor or drug delivery device
US7858112B2 (en) * 2002-02-28 2010-12-28 Lintec Corporation Percutaneous absorption system and percutaneous absorption method
JP4608187B2 (ja) * 2002-02-28 2011-01-05 リンテック株式会社 経皮吸収型製剤
US6780171B2 (en) 2002-04-02 2004-08-24 Becton, Dickinson And Company Intradermal delivery device
AU2003243750A1 (en) * 2002-06-25 2004-01-06 Sung-Yun Kwon Rapidly dissolving micro-perforator for drug delivery and other applications
CN102872526A (zh) 2002-07-19 2013-01-16 3M创新有限公司 微针装置和微针施用设备
JP4691445B2 (ja) * 2002-07-22 2011-06-01 ベクトン・ディキンソン・アンド・カンパニー パッチ状注入装置
US7422567B2 (en) 2002-08-29 2008-09-09 Becton, Dickinson And Company Microabrader with controlled abrasion features
AU2004251699A1 (en) 2003-06-04 2005-01-06 Georgia Tech Research Corporation Drilling microneedle device
CN1845708A (zh) 2003-07-02 2006-10-11 阿尔扎公司 微突出物阵列免疫贴剂和方法
MXPA06001373A (es) 2003-08-12 2006-05-15 Becton Dickinson Co Dispositivo de infusion similar a un parche.
US8353861B2 (en) 2003-09-18 2013-01-15 Texmac, Inc. Applicator for applying functional substances into human skin
BRPI0415466A (pt) 2003-10-24 2006-12-19 Alza Corp método e sistema de pré-tratamento para intensificar a distribuição transdérmica de fármacos
AU2004287412A1 (en) * 2003-10-28 2005-05-19 Alza Corporation Method and apparatus for reducing the incidence of tobacco use
ES2377647T3 (es) 2003-10-31 2012-03-29 Alza Corporation Aplicador auto-actuado para ordenamiento de microproyecciones
US20050228313A1 (en) * 2003-12-04 2005-10-13 University Technologies International Inc. Fluid sampling, analysis and delivery system
RU2006119485A (ru) * 2003-12-18 2008-01-27 Ново Нордиск А/С (DK) Струйное устройство для инъекций и способ ввода лекарств через кожу
US20070073220A1 (en) * 2004-10-06 2007-03-29 Philip Bunce Inoculation device
CN101060883B (zh) 2004-11-18 2010-06-23 3M创新有限公司 低轮廓微针阵列施放器
US8057842B2 (en) * 2004-11-18 2011-11-15 3M Innovative Properties Company Method of contact coating a microneedle array
WO2006062974A2 (en) * 2004-12-07 2006-06-15 3M Innovative Properties Company Method of molding a microneedle
EP1904158B1 (en) * 2005-06-24 2013-07-24 3M Innovative Properties Company Collapsible patch with microneedle array
EP2474338B1 (en) * 2005-06-27 2013-07-24 3M Innovative Properties Company Microneedle array applicator device
US7658728B2 (en) * 2006-01-10 2010-02-09 Yuzhakov Vadim V Microneedle array, patch, and applicator for transdermal drug delivery
US9119945B2 (en) * 2006-04-20 2015-09-01 3M Innovative Properties Company Device for applying a microneedle array
US8668675B2 (en) 2010-11-03 2014-03-11 Flugen, Inc. Wearable drug delivery device having spring drive and sliding actuation mechanism

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CA2587505A1 (en) 2006-05-26
KR20070102669A (ko) 2007-10-19
MX2007005813A (es) 2007-07-18
US20130006219A1 (en) 2013-01-03
US8267889B2 (en) 2012-09-18
JP2008520369A (ja) 2008-06-19
IL183204A0 (en) 2007-08-19
AU2005306422A1 (en) 2006-05-26
EP1833547A1 (en) 2007-09-19
ZA200705102B (en) 2008-10-29
JP2012183358A (ja) 2012-09-27
US8758298B2 (en) 2014-06-24
CN101060883A (zh) 2007-10-24
IL183204A (en) 2013-07-31
CN101060883B (zh) 2010-06-23
WO2006055795A1 (en) 2006-05-26
US20080114298A1 (en) 2008-05-15
KR20130026511A (ko) 2013-03-13
BRPI0517749A (pt) 2008-10-21

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