CA2562411A1 - Compounds for enzyme inhibition - Google Patents
Compounds for enzyme inhibition Download PDFInfo
- Publication number
- CA2562411A1 CA2562411A1 CA002562411A CA2562411A CA2562411A1 CA 2562411 A1 CA2562411 A1 CA 2562411A1 CA 002562411 A CA002562411 A CA 002562411A CA 2562411 A CA2562411 A CA 2562411A CA 2562411 A1 CA2562411 A1 CA 2562411A1
- Authority
- CA
- Canada
- Prior art keywords
- 6alkyl
- compound
- 8alkyl
- hydrogen
- zaz
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
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Landscapes
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Cited By (1)
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| US9340820B2 (en) | 2009-08-26 | 2016-05-17 | Queen's University Of Belfast | Compounds and methods for protease detection |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7232818B2 (en) * | 2004-04-15 | 2007-06-19 | Proteolix, Inc. | Compounds for enzyme inhibition |
| US8198270B2 (en) | 2004-04-15 | 2012-06-12 | Onyx Therapeutics, Inc. | Compounds for proteasome enzyme inhibition |
| DK1745064T3 (da) | 2004-04-15 | 2011-04-11 | Proteolix Inc | Forbindelser til proteasomenzyminhibering |
| AU2012203602B2 (en) * | 2004-04-15 | 2015-08-27 | Onyx Therapeutics, Inc. | Compounds for proteasome enzyme inhibition |
| RU2384585C2 (ru) | 2004-05-10 | 2010-03-20 | Протеоликс, Инк. | Соединения для ингибирования ферментов |
| DK1819353T3 (da) * | 2004-12-07 | 2011-05-16 | Proteolix Inc | Sammensætning til proteasomhæmning |
| MX2008006090A (es) | 2005-11-09 | 2008-10-23 | Proteolix Inc | Compuestos para inhibicion de la enzima. |
| NZ573759A (en) * | 2006-06-19 | 2012-03-30 | Proteolix Inc | Peptide epoxyketones for proteasome inhibition |
| MY173938A (en) | 2007-10-04 | 2020-02-27 | Onyx Therapeutics Inc | Crystalline peptide epoxy ketone protease inhibitors and the synthesis of amino acid keto-epoxides |
| EP2796134B1 (en) * | 2008-10-21 | 2016-12-07 | Onyx Therapeutics, Inc. | Combination of the peptide epoxyketone proteasome inhibitor carfilzomib with melphalan for use in the treatment of multiple myeloma |
| ES2634431T3 (es) * | 2009-03-16 | 2017-09-27 | The Governing Council Of The University Of Toronto | Moléculas de aminoácidos cíclicos y procedimientos de preparación de las mismas |
| TWI504598B (zh) | 2009-03-20 | 2015-10-21 | Onyx Therapeutics Inc | 結晶性三肽環氧酮蛋白酶抑制劑 |
| EP2498793B1 (en) | 2009-11-13 | 2019-07-10 | Onyx Therapeutics, Inc. | Oprozomib for use in metastasis suppression |
| CN102892417A (zh) | 2010-03-01 | 2013-01-23 | 欧尼斯治疗公司 | 用于免疫蛋白酶体抑制的化合物 |
| RU2012147246A (ru) | 2010-04-07 | 2014-05-20 | Оникс Терапьютикс, Инк. | Кристаллический пептидный эпоксикетонный ингебитор иммунопротеасомы |
| US10159746B2 (en) * | 2012-05-08 | 2018-12-25 | Onyx Therapeutics, Inc. | Cyclodextrin complexation methods for formulating peptide proteasome inhibitors |
| US20140105921A1 (en) | 2012-07-09 | 2014-04-17 | Onyx Therapeutics, Inc. | Prodrugs of Peptide Epoxy Ketone Protease Inhibitors |
| US10076384B2 (en) | 2013-03-08 | 2018-09-18 | Symple Surgical, Inc. | Balloon catheter apparatus with microwave emitter |
| EP2968555B1 (en) | 2013-03-13 | 2020-06-17 | Sanofi | Compositions comprising anti-cd38 antibodies and carfilzomib |
| US20160166632A1 (en) | 2013-07-19 | 2016-06-16 | Onyx Therapeutics, Inc. | Peptide epoxyketone proteasome inhibitors in combination with pim kinase inhibitors for treatment of cancers |
| CN103360348B (zh) * | 2013-07-25 | 2015-06-24 | 苏州鹏旭医药科技有限公司 | 一种Carfilzomib中间体及其制备方法和制备Carfilzomib的方法 |
| US20160215016A1 (en) * | 2013-09-06 | 2016-07-28 | Sandoz Ag | Synthesis of peptide epoxy ketones |
| CN105517998A (zh) * | 2013-09-06 | 2016-04-20 | 桑多斯股份公司 | 通过曼尼希反应立体选择性合成二醇和三醇以及它们在卡非佐米合成中的用途 |
| CN104710507B (zh) * | 2013-12-11 | 2018-08-14 | 深圳翰宇药业股份有限公司 | 一种卡非佐米的制备方法 |
| WO2015121769A1 (en) | 2014-02-13 | 2015-08-20 | Ranbaxy Laboratories Limited | Process for the preparation of methyl n-[(benzyloxy)-carbonyl]-l-leucyl-l-phenylalaninate |
| JP6608442B2 (ja) | 2014-07-14 | 2019-11-20 | セントラックス インターナショナル，インコーポレイテッド | 酵素阻害に用いられるエポキシケトン化合物 |
| WO2016046843A1 (en) | 2014-09-24 | 2016-03-31 | Biophore India Pharmaceuticals Pvt. Ltd. | Process for the preparation of (s)-4-methyl-n-((s)-1-(((s)-4-methyl-1-((r)-2-methyloxiran-2-yl)-1-oxo pentan-2-yl) amino)-1-oxo-3-phenylpropan-2-yl)-2-((s)-2-(2-morpholinoacetamido)-4-phenylbutanamido) pentanamide |
| WO2016069479A1 (en) | 2014-10-27 | 2016-05-06 | Apicore Us Llc | Methods of making carfilzomib and intermediates thereof |
| EP3227312B1 (en) | 2014-12-02 | 2019-05-29 | Fresenius Kabi Oncology Limited | A process for purification of carfilzomib |
| WO2016108204A1 (en) | 2014-12-31 | 2016-07-07 | Dr. Reddy's Laboratories Limited | Co-crystal of carfilzomib with maleic acid and process for the preparation of pure carfilzomib |
| WO2016116882A2 (en) * | 2015-01-23 | 2016-07-28 | Leiutis Pharmaceuticals Pvt Ltd | Novel compositions of carfilzomib |
| WO2016170544A1 (en) * | 2015-04-22 | 2016-10-27 | Msn Laboratories Private Limited | Process for the preparation of (2s)-n-((s)-1-((s)-4-methyl-1-((r)-2-methyl oxiran-2-yl)-1-oxopentan-2-ylcarbamoyl)-2-phenylethyl)-2-((s)-2-(2-morpholino acetamido)-4-phenylbutanamido)-4-methylpentanamide |
| WO2016170489A1 (en) | 2015-04-24 | 2016-10-27 | Fresenius Kabi Oncology Ltd. | Pharmaceutical compositions of proteasome inhibitor |
| WO2016185450A1 (en) | 2015-05-21 | 2016-11-24 | Laurus Labs Private Limited | An improved processes for the preparation of carfilzomib or pharmaceutically acceptable salts thereof |
| EP3377471A4 (en) | 2015-11-11 | 2019-11-20 | Encycle Therapeutics, Inc. | FRAGMENT SYNTHESIS OF CYCLIC PEPTIDES |
| EP3494126A1 (en) | 2016-08-02 | 2019-06-12 | Synthon BV | Process for making carfilzomib |
| ES2874683T3 (es) | 2016-09-14 | 2021-11-05 | Fresenius Kabi Oncology Ltd | Un proceso para la purificación de un intermedio de carfilzomib |
| CA3042576A1 (en) | 2016-11-11 | 2018-05-17 | Encycle Therapeutics, Inc. | Cyclic peptides multimers targeting .alpha.4.beta.7 integrin |
| EP3330260A1 (en) | 2016-12-01 | 2018-06-06 | Enantia, S.L. | Process for the preparation of an intermediate for the synthesis of i.a. carfilzomib |
| CN106946981B (zh) * | 2017-03-08 | 2020-08-21 | 南京陵瑞医药科技有限公司 | 一种四肽环氧丙烷衍生物及其制备方法和用途 |
| MX2019013362A (es) | 2017-05-10 | 2020-08-17 | Zealand Pharma As | PÉPTIDOS CÍCLICOS HOMODÉTICOS CON LA INTEGRINA A4ß7 COMO DIANA. |
| WO2019053611A1 (en) | 2017-09-14 | 2019-03-21 | Glaxosmithkline Intellectual Property Development Limited | POLY THERAPY FOR THE TREATMENT OF CANCER |
| CN113185575B (zh) * | 2021-05-11 | 2022-07-12 | 四川大学 | 一种花生抗氧化多肽及其制备方法 |
| EP4522183A2 (en) | 2022-05-11 | 2025-03-19 | Celgene Corporation | Methods and uses related to t cell therapy and production of same |
| WO2023220655A1 (en) | 2022-05-11 | 2023-11-16 | Celgene Corporation | Methods to overcome drug resistance by re-sensitizing cancer cells to treatment with a prior therapy via treatment with a t cell therapy |
| EP4611798A1 (en) | 2022-11-02 | 2025-09-10 | Celgene Corporation | Methods of treatment with t cell therapy and immunomodulatory agent maintenance therapy |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4733665C2 (en) * | 1985-11-07 | 2002-01-29 | Expandable Grafts Partnership | Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft |
| JPH01136498A (ja) | 1987-11-21 | 1989-05-29 | Nec Corp | 状態監視用情報伝送装置 |
| US5135919A (en) * | 1988-01-19 | 1992-08-04 | Children's Medical Center Corporation | Method and a pharmaceutical composition for the inhibition of angiogenesis |
| US5441944A (en) * | 1989-04-23 | 1995-08-15 | The Trustees Of The University Of Pennsylvania | Substituted cyclodextrin sulfates and their uses as growth modulating agents |
| US5071957A (en) * | 1989-08-04 | 1991-12-10 | Bristol-Myers Company | Antibiotic BU-4061T |
| US4990448A (en) | 1989-08-04 | 1991-02-05 | Bristol-Myers Company | Bu-4061T |
| US5376645A (en) * | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| KR0166088B1 (ko) * | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| WO1991013904A1 (en) | 1990-03-05 | 1991-09-19 | Cephalon, Inc. | Chymotrypsin-like proteases and their inhibitors |
| US5340736A (en) | 1991-05-13 | 1994-08-23 | The President & Fellows Of Harvard College | ATP-dependent protease and use of inhibitors for same in the treatment of cachexia and muscle wasting |
| GB9300048D0 (en) | 1993-01-04 | 1993-03-03 | Wellcome Found | Endothelin converting enzyme inhibitors |
| US5693617A (en) | 1994-03-15 | 1997-12-02 | Proscript, Inc. | Inhibitors of the 26s proteolytic complex and the 20s proteasome contained therein |
| US6083903A (en) | 1994-10-28 | 2000-07-04 | Leukosite, Inc. | Boronic ester and acid compounds, synthesis and uses |
| US6335358B1 (en) | 1995-04-12 | 2002-01-01 | President And Fellows Of Harvard College | Lactacystin analogs |
| AU4499697A (en) | 1996-09-13 | 1998-04-02 | New York University | Method for treating parasitic diseases with proteasome inhibitors |
| SI0932617T1 (en) | 1996-10-18 | 2002-06-30 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease |
| UA66767C2 (uk) * | 1996-10-18 | 2004-06-15 | Вертекс Фармасьютикалс Інкорпорейтед | Інгібітори серин-протеаз, фармацевтична композиція, спосіб інгібування активності та спосіб лікування або профілактики вірусної інфекції гепатиту с |
| US6022887A (en) | 1996-12-13 | 2000-02-08 | Osteoscreen, Inc. | Compositions and methods for stimulating bone growth |
| US6046177A (en) * | 1997-05-05 | 2000-04-04 | Cydex, Inc. | Sulfoalkyl ether cyclodextrin based controlled release solid pharmaceutical formulations |
| US5874418A (en) * | 1997-05-05 | 1999-02-23 | Cydex, Inc. | Sulfoalkyl ether cyclodextrin based solid pharmaceutical formulations and their use |
| DE69819721T2 (de) * | 1997-06-13 | 2004-09-23 | Cydex Inc., Overland Park | Zusammensetzung mit erhöhter lagerstabilität enthaltend cyclodextrin und wirkstoffe oder wirkstoff-vorstufen, die in wasserunlösliche komponenten zersetzt werden |
| US6099851A (en) * | 1998-06-02 | 2000-08-08 | Weisman; Kenneth M. | Therapeutic uses of leuprolide acetate |
| US6462019B1 (en) * | 1998-07-10 | 2002-10-08 | Osteoscreen, Inc. | Inhibitors of proteasomal activity and production for stimulating bone growth |
| US6838436B1 (en) * | 1998-07-10 | 2005-01-04 | Osteoscreen Inc. | Inhibitors of proteasomal activity for stimulating bone growth |
| US6902721B1 (en) * | 1998-07-10 | 2005-06-07 | Osteoscreen, Inc. | Inhibitors of proteasomal activity for stimulating bone growth |
| US6204257B1 (en) * | 1998-08-07 | 2001-03-20 | Universtiy Of Kansas | Water soluble prodrugs of hindered alcohols |
| ATE278803T1 (de) * | 1998-10-20 | 2004-10-15 | Millennium Pharm Inc | Verfahren zur überwachung der proteasomeinhibitorarzneimitteleffekte |
| US6492333B1 (en) * | 1999-04-09 | 2002-12-10 | Osteoscreen, Inc. | Treatment of myeloma bone disease with proteasomal and NF-κB activity inhibitors |
| US6831099B1 (en) * | 1999-05-12 | 2004-12-14 | Yale University | Enzyme inhibition |
| CA2385958A1 (en) * | 1999-10-20 | 2001-04-26 | Osteoscreen, Inc. | Inhibitors of proteasomal activity for stimulating bone and hair growth |
| EP2305291A1 (de) * | 2000-10-12 | 2011-04-06 | ViroLogik GmbH | Verwendung von Proteasome Hemmern zur Behandlung von HIV Infektionen |
| WO2003059898A2 (en) | 2002-01-08 | 2003-07-24 | Eisai Co. Ltd. | Eponemycin and epoxomicin analogs and uses thereof |
| EP1496916A2 (en) * | 2002-04-09 | 2005-01-19 | Greenville Hospital System | Metastasis modulating activity of highly sulfated oligosaccharides |
| US20030224469A1 (en) * | 2002-06-03 | 2003-12-04 | Buchholz Tonia J. | Methods and kits for assays utilizing fluorescence polarization |
| US7232818B2 (en) | 2004-04-15 | 2007-06-19 | Proteolix, Inc. | Compounds for enzyme inhibition |
| US8198270B2 (en) * | 2004-04-15 | 2012-06-12 | Onyx Therapeutics, Inc. | Compounds for proteasome enzyme inhibition |
| DK1745064T3 (da) * | 2004-04-15 | 2011-04-11 | Proteolix Inc | Forbindelser til proteasomenzyminhibering |
| RU2384585C2 (ru) * | 2004-05-10 | 2010-03-20 | Протеоликс, Инк. | Соединения для ингибирования ферментов |
| AU2005243140A1 (en) * | 2004-05-10 | 2005-11-24 | Proteolix, Inc. | Synthesis of amino acid keto-epoxides |
| WO2006045066A2 (en) | 2004-10-20 | 2006-04-27 | Proteolix, Inc. | Labeled compounds for proteasome inhibition |
| DK1819353T3 (da) * | 2004-12-07 | 2011-05-16 | Proteolix Inc | Sammensætning til proteasomhæmning |
| EP1863513A2 (en) | 2005-03-11 | 2007-12-12 | The University of North Carolina at Chapel Hill | Potent and specific immunoproteasome inhibitors |
| MX2008006090A (es) * | 2005-11-09 | 2008-10-23 | Proteolix Inc | Compuestos para inhibicion de la enzima. |
| AR057227A1 (es) | 2005-12-09 | 2007-11-21 | Centocor Inc | Metodo para usar antagonistas de il6 con inhibidores del proteasoma |
| DE102006026464A1 (de) * | 2006-06-01 | 2007-12-06 | Virologik Gmbh Innovationszentrum Medizintechnik Und Pharma | Pharmazeutische Zusammensetzung zur Behandlung von Virusinfektionen und / oder Tumorerkrankungen durch Inhibition der Proteinfaltung und des Proteinabbaus |
| NZ573759A (en) * | 2006-06-19 | 2012-03-30 | Proteolix Inc | Peptide epoxyketones for proteasome inhibition |
| JP4325683B2 (ja) * | 2007-02-14 | 2009-09-02 | セイコーエプソン株式会社 | 画像表示装置、及び画像表示装置の制御方法 |
| WO2008140782A2 (en) | 2007-05-10 | 2008-11-20 | Proteolix, Inc. | Compounds for enzyme inhibition |
| MY173938A (en) | 2007-10-04 | 2020-02-27 | Onyx Therapeutics Inc | Crystalline peptide epoxy ketone protease inhibitors and the synthesis of amino acid keto-epoxides |
| EP2796134B1 (en) | 2008-10-21 | 2016-12-07 | Onyx Therapeutics, Inc. | Combination of the peptide epoxyketone proteasome inhibitor carfilzomib with melphalan for use in the treatment of multiple myeloma |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9340820B2 (en) | 2009-08-26 | 2016-05-17 | Queen's University Of Belfast | Compounds and methods for protease detection |
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