CA2519432C - Pharmaceutical compositions comprising cetp inhibitors and a water-insoluble concentration-enhancing additive for the treatment of cardiovascular disease - Google Patents
Pharmaceutical compositions comprising cetp inhibitors and a water-insoluble concentration-enhancing additive for the treatment of cardiovascular disease Download PDFInfo
- Publication number
- CA2519432C CA2519432C CA002519432A CA2519432A CA2519432C CA 2519432 C CA2519432 C CA 2519432C CA 002519432 A CA002519432 A CA 002519432A CA 2519432 A CA2519432 A CA 2519432A CA 2519432 C CA2519432 C CA 2519432C
- Authority
- CA
- Canada
- Prior art keywords
- phenyl
- group
- isopentylcyclohexanecarbonylamino
- substituted
- unsubstituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/82—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/265—Esters, e.g. nitroglycerine, selenocyanates of carbonic, thiocarbonic, or thiocarboxylic acids, e.g. thioacetic acid, xanthogenic acid, trithiocarbonic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US45529303P | 2003-03-17 | 2003-03-17 | |
US60/455,293 | 2003-03-17 | ||
US46052103P | 2003-04-04 | 2003-04-04 | |
US60/460,521 | 2003-04-04 | ||
US47720203P | 2003-06-10 | 2003-06-10 | |
US60/477,202 | 2003-06-10 | ||
US49364903P | 2003-08-08 | 2003-08-08 | |
US60/493,649 | 2003-08-08 | ||
PCT/JP2004/003585 WO2004082593A2 (en) | 2003-03-17 | 2004-03-17 | Pharmaceutical compositions of cetp inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2519432A1 CA2519432A1 (en) | 2004-09-30 |
CA2519432C true CA2519432C (en) | 2009-06-09 |
Family
ID=33033290
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002519432A Expired - Fee Related CA2519432C (en) | 2003-03-17 | 2004-03-17 | Pharmaceutical compositions comprising cetp inhibitors and a water-insoluble concentration-enhancing additive for the treatment of cardiovascular disease |
Country Status (21)
Country | Link |
---|---|
US (2) | US20040225018A1 (es) |
EP (2) | EP2289507A1 (es) |
JP (2) | JP5546715B2 (es) |
KR (2) | KR20080008440A (es) |
AT (1) | ATE534381T1 (es) |
AU (1) | AU2004222434B2 (es) |
BR (1) | BRPI0408466B8 (es) |
CA (1) | CA2519432C (es) |
CO (1) | CO5640101A2 (es) |
CY (1) | CY1112324T1 (es) |
DK (1) | DK1603553T3 (es) |
ES (1) | ES2377121T3 (es) |
HK (1) | HK1084882A1 (es) |
IL (1) | IL170749A (es) |
MX (1) | MXPA05009848A (es) |
NO (1) | NO336891B1 (es) |
NZ (1) | NZ542852A (es) |
PL (1) | PL1603553T3 (es) |
PT (1) | PT1603553E (es) |
SI (1) | SI1603553T1 (es) |
WO (1) | WO2004082593A2 (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7879840B2 (en) | 2005-08-25 | 2011-02-01 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
US8022058B2 (en) | 2000-05-10 | 2011-09-20 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
US7718644B2 (en) | 2004-01-22 | 2010-05-18 | The Trustees Of Columbia University In The City Of New York | Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof |
US7186735B2 (en) * | 2002-08-07 | 2007-03-06 | Sanofi-Aventis Deutschland Gmbh | Acylated arylcycloalkylamines and their use as pharmaceuticals |
DK1603553T3 (da) * | 2003-03-17 | 2012-01-30 | Japan Tobacco Inc | Farmaceutiske præparater af CETP-inhibitorer |
MXPA05009976A (es) * | 2003-03-17 | 2005-11-04 | Japan Tobacco Inc | Metodo para incrementar la biodisponibilidad oral del 2-metilpropantioato de s-[2-([[1- 2-etilbutil) ciclohexil] carbonil] amino) fenilo]. |
TWI494102B (zh) * | 2003-05-02 | 2015-08-01 | Japan Tobacco Inc | 包含s-〔2(〔〔1-(2-乙基丁基)環己基〕羰基〕胺基)苯基〕2-甲基丙烷硫酯及hmg輔酶a還原酶抑制劑之組合 |
CN1886124A (zh) * | 2003-09-26 | 2006-12-27 | 日本烟草产业株式会社 | 抑制残余脂蛋白产生的方法 |
US8710045B2 (en) | 2004-01-22 | 2014-04-29 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the ryanodine receptors |
DOP2005000123A (es) | 2004-07-02 | 2011-07-15 | Merck Sharp & Dohme | Inhibidores de cetp |
WO2006098394A1 (ja) * | 2005-03-14 | 2006-09-21 | Japan Tobacco Inc. | 脂質吸収抑制方法および脂質吸収抑制剤 |
US7704990B2 (en) | 2005-08-25 | 2010-04-27 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
KR101418267B1 (ko) | 2006-02-09 | 2014-07-11 | 머크 샤프 앤드 돔 코포레이션 | Cetp 억제제의 중합체 제형 |
KR101459181B1 (ko) * | 2008-12-08 | 2014-11-07 | 에프. 호프만-라 로슈 아게 | 병용 약물 투여 |
CN102293734A (zh) * | 2010-06-25 | 2011-12-28 | 江苏恒瑞医药股份有限公司 | 托伐普坦固体分散体及其制备方法 |
EA025649B1 (ru) * | 2010-11-04 | 2017-01-30 | Ф.Хоффманн-Ля Рош Аг | Таблетка, содержащая s-[2-([[1-(2-этилбутил)циклогексил]карбонил]амино)фенил]-2-метилпропантиоат и кроскарамеллозу натрия |
CN103237542A (zh) * | 2010-12-08 | 2013-08-07 | 霍夫曼-拉罗奇有限公司 | 达塞曲匹的脂质体制剂 |
KR20140006879A (ko) * | 2011-02-17 | 2014-01-16 | 에프. 호프만-라 로슈 아게 | 고온 용융 압출에 의해 활성 약학 성분을 과냉된 액체 상태로부터 제어되는 방식으로 결정화시키는 방법 |
JP6539661B2 (ja) | 2013-12-19 | 2019-07-03 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 眼疾患の処置において使用するためのcetpモデュレーター |
MX2021001520A (es) * | 2018-08-09 | 2021-05-27 | Dalcor Pharma Uk Ltd Leatherhead Zug Branch | Metodos para retardar la ocurrencia de diabetes tipo 2 de nuevo inicio y para desacelerar el progreso de y tratamiento de la diabetes tipo 2. |
WO2023064794A1 (en) * | 2021-10-12 | 2023-04-20 | Hdl Therapeutics, Inc. | Methods and systems for prophylactically preventing, slowing the progression of, or treating cerebral amyloid angiopathy, alzheimer's disease and/or acute stroke |
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US7071210B2 (en) * | 2002-07-02 | 2006-07-04 | Pfizer Inc. | CETP inhibitors in combination with antihypertensive agents and uses thereof |
DK1603553T3 (da) * | 2003-03-17 | 2012-01-30 | Japan Tobacco Inc | Farmaceutiske præparater af CETP-inhibitorer |
-
2004
- 2004-03-17 DK DK04721345.9T patent/DK1603553T3/da active
- 2004-03-17 PT PT04721345T patent/PT1603553E/pt unknown
- 2004-03-17 MX MXPA05009848A patent/MXPA05009848A/es active IP Right Grant
- 2004-03-17 AU AU2004222434A patent/AU2004222434B2/en not_active Expired
- 2004-03-17 KR KR1020087000175A patent/KR20080008440A/ko not_active Application Discontinuation
- 2004-03-17 SI SI200431822T patent/SI1603553T1/sl unknown
- 2004-03-17 EP EP10179280A patent/EP2289507A1/en not_active Withdrawn
- 2004-03-17 KR KR1020057017449A patent/KR100857759B1/ko active IP Right Grant
- 2004-03-17 PL PL04721345T patent/PL1603553T3/pl unknown
- 2004-03-17 ES ES04721345T patent/ES2377121T3/es not_active Expired - Lifetime
- 2004-03-17 JP JP2006507668A patent/JP5546715B2/ja not_active Expired - Lifetime
- 2004-03-17 CA CA002519432A patent/CA2519432C/en not_active Expired - Fee Related
- 2004-03-17 EP EP04721345A patent/EP1603553B9/en not_active Expired - Lifetime
- 2004-03-17 BR BRPI0408466A patent/BRPI0408466B8/pt active IP Right Grant
- 2004-03-17 NZ NZ542852A patent/NZ542852A/en not_active IP Right Cessation
- 2004-03-17 WO PCT/JP2004/003585 patent/WO2004082593A2/en active Application Filing
- 2004-03-17 US US10/802,220 patent/US20040225018A1/en not_active Abandoned
- 2004-03-17 AT AT04721345T patent/ATE534381T1/de active
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2005
- 2005-09-08 IL IL170749A patent/IL170749A/en active IP Right Grant
- 2005-10-14 CO CO05105279A patent/CO5640101A2/es not_active Application Discontinuation
- 2005-10-14 NO NO20054740A patent/NO336891B1/no not_active IP Right Cessation
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2006
- 2006-04-28 HK HK06105103.7A patent/HK1084882A1/xx not_active IP Right Cessation
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2010
- 2010-11-10 JP JP2010252215A patent/JP2011052006A/ja active Pending
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2012
- 2012-02-06 CY CY20121100126T patent/CY1112324T1/el unknown
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2013
- 2013-07-26 US US13/951,909 patent/US20140243414A1/en not_active Abandoned
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