CA2491131A1 - Nouveaux composes utilises comme inhibiteurs de l'histone-deacetylase - Google Patents
Nouveaux composes utilises comme inhibiteurs de l'histone-deacetylase Download PDFInfo
- Publication number
- CA2491131A1 CA2491131A1 CA002491131A CA2491131A CA2491131A1 CA 2491131 A1 CA2491131 A1 CA 2491131A1 CA 002491131 A CA002491131 A CA 002491131A CA 2491131 A CA2491131 A CA 2491131A CA 2491131 A1 CA2491131 A1 CA 2491131A1
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- Prior art keywords
- compound according
- cancer
- medicament
- compounds
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La présente invention concerne des composés correspondant à la formule générale (I), ou bien des sel pharmaceutiquement acceptables ou des dérivés physiologiquement fonctionnels de ces composés. Dans ladite formule (I): n représente un cycle non aromatique contenant deux à sept atomes de carbone, le système cyclique pouvant contenir au moins deux doubles liaisons; X représente C, CH ou CH¿2?; Y est sélectionné parmi C, CH, CH¿2?, S, NR, CH¿2?-CH¿2?, H¿2?C- -CH, HC- -CH¿2?, C- -CH¿2?, H¿2?C- -C, ou bien C- -C, au moins un des atomes hydrogènes pouvant être éventuellement substitué par au moins un substituant R'; chacune des lignes pointillées représente une liaison simple, double ou triple, une combinaison d'une triple liaison et d'une triple liaison, ainsi que d'une double liaison et d'une triple liaison étant exclue; les symboles R' représentent, indépendamment l'un de l'autre, H, -CN, alkyle, cycloalkyle, aminoalkyle, alkylamino, alcoxy, -OH, -SH, alkylthio, hydroxyalkyle, hydroxyalkylamino, halogène, haloalkyle, haloalkyloxy; R représente H, un groupe alkyle ou cycloalkyle; Z représente CH, C, ou P; p vaut 0 ou 1.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10233412A DE10233412A1 (de) | 2002-07-23 | 2002-07-23 | Neue Verbindungen als Histondeacetylase-Inhibitoren |
DE10233412.9 | 2002-07-23 | ||
PCT/EP2003/007794 WO2004009536A1 (fr) | 2002-07-23 | 2003-07-17 | Nouveaux composes utilises comme inhibiteurs de l'histone-deacetylase |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2491131A1 true CA2491131A1 (fr) | 2004-01-29 |
CA2491131C CA2491131C (fr) | 2013-05-07 |
Family
ID=30128280
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2491131A Expired - Fee Related CA2491131C (fr) | 2002-07-23 | 2003-07-17 | Nouveaux composes utilises comme inhibiteurs de l'histone-deacetylase |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1523470A1 (fr) |
JP (1) | JP4644829B2 (fr) |
AU (1) | AU2003254371A1 (fr) |
CA (1) | CA2491131C (fr) |
DE (1) | DE10233412A1 (fr) |
WO (1) | WO2004009536A1 (fr) |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7884105B2 (en) | 2005-10-27 | 2011-02-08 | Janssen Pharmaceutica, N.V. | Squaric acid derivatives as inhibitors of histone deacetylase |
US8071615B2 (en) | 2002-03-13 | 2011-12-06 | Janssen Pharmaceutica N.V. | Carbonylamino-derivatives as novel inhibitors of histone deacetylase |
US8101616B2 (en) | 2006-01-19 | 2012-01-24 | Janssen Pharmaceutica N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
US8114876B2 (en) | 2006-01-19 | 2012-02-14 | Janssen Pharmaceutica N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
US8114999B2 (en) | 2002-03-13 | 2012-02-14 | Janssen Pharmaceutica N.V. | Aminocarbonyl-derivatives as novel inhibitors of histone deacetylase |
US8119650B2 (en) | 2006-01-19 | 2012-02-21 | Janssen Pharmaceutica N.V. | Aminophenyl derivatives as novel inhibitors of histone deacetylase |
US8138198B2 (en) | 2005-05-18 | 2012-03-20 | Angibaud Patrick Rene | Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase |
US8163765B2 (en) | 2006-01-19 | 2012-04-24 | Janssen Pharmaceutica N.V. | Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase |
US8163733B2 (en) | 2002-03-13 | 2012-04-24 | Janssen Pharmaceutica N.V. | Sulfonylamino-derivatives as novel inhibitors of histone deacetylase |
US8193205B2 (en) | 2004-07-28 | 2012-06-05 | Janssen Pharmaceutica N.V. | Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase |
US8501737B2 (en) | 2002-03-13 | 2013-08-06 | Janssen Pharmaceutica N.V. | Piperazinyl-, piperidinyl- and morpholinyl-derivatives as novel inhibitors of histone deacetylase |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ME01058B (fr) | 2004-07-28 | 2012-10-20 | Janssen Pharmaceutica Nv | Derives de piperazine de propenyle substituee comme nouveaux inhibiteurs de l'histone deacetylase |
NZ589276A (en) | 2005-02-03 | 2012-06-29 | Topotarget Uk Ltd | Combination therapies using hdac inhibitors and erlotinib (tarceva) |
KR101340824B1 (ko) | 2005-05-13 | 2013-12-11 | 토포타겟 유케이 리미티드 | Hdac 억제제의 약학 제형 |
JP2009501236A (ja) | 2005-07-14 | 2009-01-15 | タケダ サン ディエゴ インコーポレイテッド | ヒストンデアセチラーゼ阻害剤 |
CA2627923C (fr) | 2005-11-10 | 2016-01-12 | Topotarget Uk Limited | Inhibiteurs d'histone desacetylase (hdac) pour le traitement du cancer |
ATE539073T1 (de) | 2006-01-19 | 2012-01-15 | Janssen Pharmaceutica Nv | Heterocyclylalkylderivate als neue inhibitoren von histondeacetylase |
CA2633100C (fr) | 2006-01-19 | 2014-12-09 | Janssen Pharmaceutica N.V. | Derives de pyridine et de pyrimidine en tant qu'inibiteurs d'histone desacetylase |
MX2010003230A (es) | 2007-09-25 | 2010-04-07 | Topotarget Uk Ltd | Metodos para la sintesis de ciertos compuestos de acido hidroxamico. |
JP5564033B2 (ja) | 2008-03-27 | 2014-07-30 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ヒストンデアセチラーゼの新規インヒビターとしてのアザ−ビシクロヘキシル置換インドリルアルキルアミノ誘導体 |
CN102659630B (zh) * | 2011-05-04 | 2016-01-06 | 成都地奥九泓制药厂 | 一种异羟肟酸类化合物及其制备方法和用途 |
TWI650139B (zh) * | 2017-10-11 | 2019-02-11 | 行政院原子能委員會核能硏究所 | 含有放射性同位素氟的異羥肟酸類造影劑、其製備方法及其用途 |
KR102236356B1 (ko) * | 2017-11-24 | 2021-04-05 | 주식회사 종근당 | 루푸스의 예방 또는 치료를 위한 조성물 |
KR20190118251A (ko) * | 2018-04-10 | 2019-10-18 | 주식회사 종근당 | 건성안의 예방 또는 치료를 위한 조성물 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS50121218A (fr) * | 1974-03-01 | 1975-09-23 | ||
US3994997A (en) * | 1975-05-09 | 1976-11-30 | Gulf Oil Corporation | O,O-diethyl-O-carboxamidophosphate esters |
US4604407A (en) * | 1985-04-04 | 1986-08-05 | E. R. Squibb & Sons, Inc. | Hydroxamates |
JPH01221371A (ja) * | 1988-02-29 | 1989-09-04 | Hokko Chem Ind Co Ltd | 環状オキシアミン誘導体の製造方法 |
US6043389A (en) * | 1997-03-11 | 2000-03-28 | Mor Research Applications, Ltd. | Hydroxy and ether-containing oxyalkylene esters and uses thereof |
JP4269041B2 (ja) * | 1999-03-02 | 2009-05-27 | 国立大学法人九州工業大学 | 新規な環状テトラペプチド誘導体とその医薬用途 |
JP2001081031A (ja) * | 1999-08-30 | 2001-03-27 | Schering Ag | 溶解性および経口吸収性を改善したベンズアミド誘導体含有製剤 |
WO2001070675A2 (fr) * | 2000-03-24 | 2001-09-27 | Methylgene, Inc. | Inhibiteurs d'histone desacetylase |
-
2002
- 2002-07-23 DE DE10233412A patent/DE10233412A1/de not_active Ceased
-
2003
- 2003-07-17 JP JP2004522493A patent/JP4644829B2/ja not_active Expired - Fee Related
- 2003-07-17 WO PCT/EP2003/007794 patent/WO2004009536A1/fr active Application Filing
- 2003-07-17 EP EP03765029A patent/EP1523470A1/fr not_active Withdrawn
- 2003-07-17 CA CA2491131A patent/CA2491131C/fr not_active Expired - Fee Related
- 2003-07-17 AU AU2003254371A patent/AU2003254371A1/en not_active Abandoned
Cited By (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8697717B2 (en) | 2002-03-13 | 2014-04-15 | Janssen Pharmaceutica N.V. | Inhibitors of histone deacetylase |
US8114999B2 (en) | 2002-03-13 | 2012-02-14 | Janssen Pharmaceutica N.V. | Aminocarbonyl-derivatives as novel inhibitors of histone deacetylase |
US8455498B2 (en) | 2002-03-13 | 2013-06-04 | Janssen Pharmaceutica N.V. | Inhibitors of histone deacetylase |
US9556161B2 (en) | 2002-03-13 | 2017-01-31 | Janssen Pharmaceutica Nv | Inhibitors of histone deacetylase |
US8501737B2 (en) | 2002-03-13 | 2013-08-06 | Janssen Pharmaceutica N.V. | Piperazinyl-, piperidinyl- and morpholinyl-derivatives as novel inhibitors of histone deacetylase |
US9533979B2 (en) | 2002-03-13 | 2017-01-03 | Janssen Pharmaceutica Nv | Amino-derivatives as novel inhibitors of histone deacetylase |
US9150560B2 (en) | 2002-03-13 | 2015-10-06 | Janssen Pharmaceutica Nv | Inhibitors of histone deacetylase |
US8916554B2 (en) | 2002-03-13 | 2014-12-23 | Janssen Pharmaceutica, N.V. | Amino-derivatives as novel inhibitors of histone deacetylase |
US8163733B2 (en) | 2002-03-13 | 2012-04-24 | Janssen Pharmaceutica N.V. | Sulfonylamino-derivatives as novel inhibitors of histone deacetylase |
US8524711B2 (en) | 2002-03-13 | 2013-09-03 | Janssen Pharmaceutica N.V. | Amino-derivatives as novel inhibitors of histone deacetylase |
US8268833B2 (en) | 2002-03-13 | 2012-09-18 | Janssen Pharmaceutica, N.V. | Inhibitors of histone deacetylase |
US8513237B2 (en) | 2002-03-13 | 2013-08-20 | Janssen Pharmaceutica N.V. | Sulfonylamino-derivatives as novel inhibitors of histone deacetylase |
US8343988B2 (en) | 2002-03-13 | 2013-01-01 | Janssen Pharmaceutica, N.V | Inhibitors of histone deacetylase |
US8394831B2 (en) | 2002-03-13 | 2013-03-12 | Janssen Pharmaceutica, N.V. | Carbonylamino-derivatives as novel inhibitors of histone deacetylase |
US8071615B2 (en) | 2002-03-13 | 2011-12-06 | Janssen Pharmaceutica N.V. | Carbonylamino-derivatives as novel inhibitors of histone deacetylase |
US9150543B2 (en) | 2004-07-28 | 2015-10-06 | Janssen Pharmaceutica N. V. | Substituted indolyl alkyl amino derivatives as inhibitors of histone deacetylase |
US9636341B2 (en) | 2004-07-28 | 2017-05-02 | Janssen Pharmaceutica N.V. | Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase |
US8524728B2 (en) | 2004-07-28 | 2013-09-03 | Janssen Pharmaceutica N.V. | Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase |
US8193205B2 (en) | 2004-07-28 | 2012-06-05 | Janssen Pharmaceutica N.V. | Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase |
US8592441B2 (en) | 2004-07-28 | 2013-11-26 | Janssen Pharmaceutica N.V. | Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase |
US8138198B2 (en) | 2005-05-18 | 2012-03-20 | Angibaud Patrick Rene | Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase |
US8377935B2 (en) | 2005-05-18 | 2013-02-19 | Janssen Pharmaceutica N.V. | Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase |
US7884105B2 (en) | 2005-10-27 | 2011-02-08 | Janssen Pharmaceutica, N.V. | Squaric acid derivatives as inhibitors of histone deacetylase |
US8163765B2 (en) | 2006-01-19 | 2012-04-24 | Janssen Pharmaceutica N.V. | Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase |
US8664223B2 (en) | 2006-01-19 | 2014-03-04 | Janssen Pharmaceutica N.V | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
US9078896B2 (en) | 2006-01-19 | 2015-07-14 | Janssen Pharmaceutica, N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
US8101616B2 (en) | 2006-01-19 | 2012-01-24 | Janssen Pharmaceutica N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
US8119650B2 (en) | 2006-01-19 | 2012-02-21 | Janssen Pharmaceutica N.V. | Aminophenyl derivatives as novel inhibitors of histone deacetylase |
US8114876B2 (en) | 2006-01-19 | 2012-02-14 | Janssen Pharmaceutica N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
Also Published As
Publication number | Publication date |
---|---|
JP2005533840A (ja) | 2005-11-10 |
CA2491131C (fr) | 2013-05-07 |
JP4644829B2 (ja) | 2011-03-09 |
EP1523470A1 (fr) | 2005-04-20 |
AU2003254371A1 (en) | 2004-02-09 |
WO2004009536A1 (fr) | 2004-01-29 |
DE10233412A1 (de) | 2004-02-12 |
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EEER | Examination request | ||
MKLA | Lapsed |
Effective date: 20150717 |