CA2481192C - Use of ranolazine for the preparation of a medicament for the treatment of arrhythmias - Google Patents

Use of ranolazine for the preparation of a medicament for the treatment of arrhythmias Download PDF

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Publication number
CA2481192C
CA2481192C CA2481192A CA2481192A CA2481192C CA 2481192 C CA2481192 C CA 2481192C CA 2481192 A CA2481192 A CA 2481192A CA 2481192 A CA2481192 A CA 2481192A CA 2481192 C CA2481192 C CA 2481192C
Authority
CA
Canada
Prior art keywords
ranolazine
composition
isomer
arrhythmias
ion channels
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2481192A
Other languages
English (en)
French (fr)
Other versions
CA2481192A1 (en
Inventor
Luiz Belardinelli
Charles Antzelevitch
Brent Blackburn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gilead Sciences Inc
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of CA2481192A1 publication Critical patent/CA2481192A1/en
Application granted granted Critical
Publication of CA2481192C publication Critical patent/CA2481192C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CA2481192A 2002-04-04 2003-04-04 Use of ranolazine for the preparation of a medicament for the treatment of arrhythmias Expired - Fee Related CA2481192C (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US37015002P 2002-04-04 2002-04-04
US60/370,150 2002-04-04
US40829202P 2002-09-05 2002-09-05
US60/408,292 2002-09-05
US42258902P 2002-10-30 2002-10-30
US60/422,589 2002-10-30
PCT/US2003/010434 WO2003086401A1 (en) 2002-04-04 2003-04-04 Use of ranolazine for the preparation of a medicament for the treatment of arrhythmias

Publications (2)

Publication Number Publication Date
CA2481192A1 CA2481192A1 (en) 2003-10-23
CA2481192C true CA2481192C (en) 2012-07-03

Family

ID=29255318

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2481192A Expired - Fee Related CA2481192C (en) 2002-04-04 2003-04-04 Use of ranolazine for the preparation of a medicament for the treatment of arrhythmias

Country Status (19)

Country Link
US (2) US20030220344A1 (enExample)
EP (3) EP1930007B1 (enExample)
JP (1) JP4608217B2 (enExample)
KR (2) KR20040099395A (enExample)
CN (2) CN101843619A (enExample)
AT (2) ATE470445T1 (enExample)
AU (3) AU2003230810B2 (enExample)
CA (1) CA2481192C (enExample)
CY (1) CY1110400T1 (enExample)
DE (2) DE60332975D1 (enExample)
DK (2) DK1490066T3 (enExample)
ES (2) ES2304507T3 (enExample)
IL (1) IL197406A0 (enExample)
MX (1) MXPA04009637A (enExample)
NO (1) NO330953B1 (enExample)
NZ (1) NZ535610A (enExample)
PT (2) PT1490066E (enExample)
SI (2) SI1490066T1 (enExample)
WO (1) WO2003086401A1 (enExample)

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WO2013168025A1 (en) 2012-05-08 2013-11-14 Mahesh Kandula Compositions and methods for treatment of blood clotting disorders
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WO2013168016A1 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of metabolic syndrome
US9339484B2 (en) 2012-05-10 2016-05-17 Cellix Bio Private Limited Compositions and methods for the treatment of restless leg syndrome and fibromyalgia
US9321775B2 (en) 2012-05-10 2016-04-26 Cellix Bio Private Limited Compositions and methods for the treatment of moderate to severe pain
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US9573927B2 (en) 2012-05-10 2017-02-21 Cellix Bio Private Limited Compositions and methods for the treatment of severe pain
US9499527B2 (en) 2012-05-10 2016-11-22 Cellix Bio Private Limited Compositions and methods for the treatment of familial amyloid polyneuropathy
WO2013168002A1 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of neurological conditions
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US9273061B2 (en) 2012-05-10 2016-03-01 Cellix Bio Private Limited Compositions and methods for the treatment of chronic pain
WO2013167997A2 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of metabolic syndrome
WO2013175357A2 (en) 2012-05-23 2013-11-28 Mahesh Kandula Compositions and methods for the treatment of inflammatory bowel disease
WO2013175376A2 (en) 2012-05-23 2013-11-28 Mahesh Kandula Compositions and methods for the treatment of local pain
US9434729B2 (en) 2012-05-23 2016-09-06 Cellix Bio Private Limited Compositions and methods for the treatment of periodontitis and rheumatoid arthritis
US9765020B2 (en) 2012-05-23 2017-09-19 Cellix Bio Private Limited Dichlorophenyl-imino compounds and compositions, and methods for the treatment of mucositis
CA2873098A1 (en) 2012-05-23 2013-11-28 Cellixbio Private Limited Compositions and methods for the treatment of multiple sclerosis
US9227974B2 (en) 2012-05-23 2016-01-05 Cellex Bio Private Limited Compositions and methods for the treatment of respiratory disorders
US9108942B1 (en) 2014-11-05 2015-08-18 Mahesh Kandula Compositions and methods for the treatment of moderate to severe pain
US9187427B2 (en) 2012-08-03 2015-11-17 Cellix Bio Private Limited N-substituted nicotinamide compounds and compositions for the treatment migraine and neurologic diseases
WO2014027262A2 (en) * 2012-08-14 2014-02-20 Mahesh Kandula Compositions and methods for the treatment angina and cardiovascular conditions
WO2014037833A2 (en) 2012-09-06 2014-03-13 Mahesh Kandula Compositions and methods for the treatment inflammation and lipid disorders
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US9321716B1 (en) 2014-11-05 2016-04-26 Cellix Bio Private Limited Compositions and methods for the treatment of metabolic syndrome
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US9175008B1 (en) 2014-11-05 2015-11-03 Cellix Bio Private Limited Prodrugs of anti-platelet agents
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US10208014B2 (en) 2014-11-05 2019-02-19 Cellix Bio Private Limited Compositions and methods for the treatment of neurological disorders
US9150557B1 (en) 2014-11-05 2015-10-06 Cellix Bio Private Limited Compositions and methods for the treatment of hyperglycemia
US9284287B1 (en) 2014-11-05 2016-03-15 Cellix Bio Private Limited Compositions and methods for the suppression of carbonic anhydrase activity
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CN110845355A (zh) 2015-01-06 2020-02-28 塞尔利克斯生物私人有限公司 用于治疗炎症和疼痛的组合物和方法
KR101617683B1 (ko) 2015-01-09 2016-05-03 연세대학교 산학협력단 부정맥 치료제 효과 평가 시스템 및 방법
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Also Published As

Publication number Publication date
PT1930007E (pt) 2010-08-17
US20030220344A1 (en) 2003-11-27
CA2481192A1 (en) 2003-10-23
AU2003230810A1 (en) 2003-10-27
NO330953B1 (no) 2011-08-22
NZ535610A (en) 2006-05-26
EP2198866A1 (en) 2010-06-23
ATE470445T1 (de) 2010-06-15
JP2005528393A (ja) 2005-09-22
DE60321550D1 (de) 2008-07-24
SI1930007T1 (sl) 2010-08-31
DK1930007T3 (da) 2010-08-30
EP1930007A1 (en) 2008-06-11
ES2304507T3 (es) 2008-10-16
WO2003086401A1 (en) 2003-10-23
EP1490066B1 (en) 2008-06-11
KR20040099395A (ko) 2004-11-26
EP1930007B1 (en) 2010-06-09
CN101843619A (zh) 2010-09-29
CN100548300C (zh) 2009-10-14
AU2009201065A1 (en) 2009-04-09
AU2003230810B2 (en) 2009-02-26
AU2009201065B2 (en) 2011-07-21
HK1120390A1 (en) 2009-04-03
IL197406A0 (en) 2011-07-31
JP4608217B2 (ja) 2011-01-12
US20100004255A1 (en) 2010-01-07
MXPA04009637A (es) 2005-07-14
NO20044783L (no) 2004-11-03
ATE397932T1 (de) 2008-07-15
KR20100119804A (ko) 2010-11-10
PT1490066E (pt) 2008-07-22
SI1490066T1 (sl) 2008-10-31
ES2345573T3 (es) 2010-09-27
AU2011202135A1 (en) 2011-05-26
EP1490066A1 (en) 2004-12-29
CN1646127A (zh) 2005-07-27
DE60332975D1 (de) 2010-07-22
DK1490066T3 (da) 2008-10-13
CY1110400T1 (el) 2015-04-29

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