PT1490066E - Utilização de ranolazina para a preparação de um medicamento para o tratamento de arritmias - Google Patents

Utilização de ranolazina para a preparação de um medicamento para o tratamento de arritmias Download PDF

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Publication number
PT1490066E
PT1490066E PT03723907T PT03723907T PT1490066E PT 1490066 E PT1490066 E PT 1490066E PT 03723907 T PT03723907 T PT 03723907T PT 03723907 T PT03723907 T PT 03723907T PT 1490066 E PT1490066 E PT 1490066E
Authority
PT
Portugal
Prior art keywords
ranolazine
arrhythmias
medicament
preparation
treatment
Prior art date
Application number
PT03723907T
Other languages
English (en)
Inventor
Luiz Belardinelli
Antzelevitch Charles
Brent Blackburn
Original Assignee
Cv Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cv Therapeutics Inc filed Critical Cv Therapeutics Inc
Publication of PT1490066E publication Critical patent/PT1490066E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
PT03723907T 2002-04-04 2003-04-04 Utilização de ranolazina para a preparação de um medicamento para o tratamento de arritmias PT1490066E (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37015002P 2002-04-04 2002-04-04
US40829202P 2002-09-05 2002-09-05
US42258902P 2002-10-30 2002-10-30

Publications (1)

Publication Number Publication Date
PT1490066E true PT1490066E (pt) 2008-07-22

Family

ID=29255318

Family Applications (2)

Application Number Title Priority Date Filing Date
PT03723907T PT1490066E (pt) 2002-04-04 2003-04-04 Utilização de ranolazina para a preparação de um medicamento para o tratamento de arritmias
PT08004276T PT1930007E (pt) 2002-04-04 2003-04-04 Utilização de ranolazina para a preparação de um medicamento para o tratamento de pós-despolarizações precoces (ead)

Family Applications After (1)

Application Number Title Priority Date Filing Date
PT08004276T PT1930007E (pt) 2002-04-04 2003-04-04 Utilização de ranolazina para a preparação de um medicamento para o tratamento de pós-despolarizações precoces (ead)

Country Status (20)

Country Link
US (2) US20030220344A1 (pt)
EP (3) EP2198866A1 (pt)
JP (1) JP4608217B2 (pt)
KR (2) KR20100119804A (pt)
CN (2) CN101843619A (pt)
AT (2) ATE397932T1 (pt)
AU (3) AU2003230810B2 (pt)
CA (1) CA2481192C (pt)
CY (1) CY1110400T1 (pt)
DE (2) DE60332975D1 (pt)
DK (2) DK1490066T3 (pt)
ES (2) ES2304507T3 (pt)
HK (1) HK1120390A1 (pt)
IL (1) IL197406A0 (pt)
MX (1) MXPA04009637A (pt)
NO (1) NO330953B1 (pt)
NZ (1) NZ535610A (pt)
PT (2) PT1490066E (pt)
SI (2) SI1490066T1 (pt)
WO (1) WO2003086401A1 (pt)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030220344A1 (en) * 2002-04-04 2003-11-27 Luiz Belardinelli Method of treating arrhythmias
CA2486712C (en) * 2002-05-21 2012-01-03 Cv Therapeutics, Inc. Method of treating diabetes
US8822473B2 (en) * 2002-05-21 2014-09-02 Gilead Sciences, Inc. Method of treating diabetes
EP1723129A1 (en) * 2003-12-18 2006-11-22 Cv Therapeutics, Inc. 1-akan-2-ol substituted piperazine and piperidine compounds
SG156681A1 (en) * 2004-11-09 2009-11-26 Cv Therapeutics Inc Use of ranolazine in combination with at least one remodeling agent for reversing left ventricular remodeling in the treatment of heart failure
KR20070093988A (ko) * 2005-01-06 2007-09-19 씨브이 쎄러퓨틱스, 인코포레이티드 라놀라진 함유 서방성 약제학적 제형물
WO2006119389A2 (en) * 2005-05-03 2006-11-09 Mutual Pharmaceutical Company, Inc. Quinine-containing controlled-release formulations
WO2008080012A1 (en) * 2006-12-21 2008-07-03 Cv Therapeutics, Inc. Reduction of cardiovascular symptoms
CA2677931A1 (en) * 2007-02-13 2008-08-21 Cv Therapeutics, Inc. Use of ranolazine for the treatment of cardiovascular diseases
JP2010518171A (ja) * 2007-02-13 2010-05-27 ギリアード・パロ・アルト・インコーポレイテッド 非冠微小血管疾患の処置のためのラノラジンの使用
CA2678319A1 (en) * 2007-02-13 2008-08-21 Cv Therapeutics, Inc. Use of ranolazine for the treatment of coronary microvascular diseases
US20090111826A1 (en) * 2007-02-13 2009-04-30 Louis Lange Use of ranolazine for the treatment of cardiovascular diseases
US20080233191A1 (en) * 2007-03-22 2008-09-25 Brent Blackburn Use of ranolazine for elevated brain-type natriuretic peptide
EA200971073A1 (ru) * 2007-05-31 2010-08-30 Джилид Пало Альто, Инк. Применение ранолазина при повышенном уровне натрийуретического пептида мозгового типа
AU2009212254A1 (en) * 2008-02-06 2009-08-13 Cv Therapeutics, Inc. Use of Ranolazine for treating pain
JP2012502047A (ja) * 2008-09-04 2012-01-26 ギリアード サイエンシーズ， インコーポレイテッド 心房細動を治療する方法
US20100113514A1 (en) 2008-10-30 2010-05-06 Gilead Palo Alto, Inc. Fused heterocyclic compounds as ion channel modulators
MX2011012140A (es) * 2009-05-14 2012-02-28 Gilead Sciences Inc Ranolazina para el tratamiento de problemas del snc.
WO2014037832A2 (en) 2012-09-06 2014-03-13 Mahesh Kandula Compositions and methods for the treatment of epilepsy and neurological diseases
AU2013257742A1 (en) 2012-05-07 2014-11-27 Cellixbio Private Limited Compositions and methods for treatment of neuromuscular disorders and neurodegenerative disorders
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JP2015518855A (ja) 2012-05-23 2015-07-06 セリックスビオ プライヴェート リミテッド 粘膜炎の治療のための組成物および方法
US9492409B2 (en) 2012-05-23 2016-11-15 Cellix Bio Private Limited Compositions and methods for the treatment of local pain
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US9187427B2 (en) 2012-08-03 2015-11-17 Cellix Bio Private Limited N-substituted nicotinamide compounds and compositions for the treatment migraine and neurologic diseases
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TW201717919A (zh) 2015-07-02 2017-06-01 國際藥品股份公司 雷諾多重壓縮錠劑
WO2018001582A1 (en) 2016-06-30 2018-01-04 Interquim, S.A. Ranolazine multiple compressed tablets

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3845770A (en) * 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US4326525A (en) * 1980-10-14 1982-04-27 Alza Corporation Osmotic device that improves delivery properties of agent in situ
US4567264A (en) 1983-05-18 1986-01-28 Syntex (U.S.A.) Inc. Cardioselective aryloxy- and arylthio- hydroxypropylene-piperazinyl acetanilides which affect calcium entry
US5364620A (en) * 1983-12-22 1994-11-15 Elan Corporation, Plc Controlled absorption diltiazem formulation for once daily administration
US5023252A (en) * 1985-12-04 1991-06-11 Conrex Pharmaceutical Corporation Transdermal and trans-membrane delivery of drugs
US5001139A (en) 1987-06-12 1991-03-19 American Cyanamid Company Enchancers for the transdermal flux of nivadipine
US4992445A (en) * 1987-06-12 1991-02-12 American Cyanamid Co. Transdermal delivery of pharmaceuticals
US4902514A (en) * 1988-07-21 1990-02-20 Alza Corporation Dosage form for administering nilvadipine for treating cardiovascular symptoms
EP0714660B1 (en) * 1989-06-23 2002-09-04 Syntex (U.S.A.) LLC Ranolazine and related piperazines for protecting skeletal muscles
JPH03141258A (ja) * 1989-10-25 1991-06-17 Kowa Co 新規なピペラジン誘導体
DE69429524T2 (de) * 1993-09-24 2002-08-08 Univ British Columbia Aminocyclohexylester und ihre anwendung
US6303607B1 (en) 1998-09-10 2001-10-16 Cv Therapeutics, Inc. Method for administering a sustained release ranolanolazine formulation
US6528511B2 (en) * 2000-02-18 2003-03-04 Cv Therapeutics, Inc. Partial fatty acid oxidation inhibitors in the treatment of congestive heart failure
US6677336B2 (en) * 2000-02-22 2004-01-13 Cv Therapeutics, Inc. Substituted piperazine compounds
KR100518046B1 (ko) * 2000-05-19 2005-10-04 아밀린 파마슈티칼스, 인크. Ｇｌｐ-1을 사용한 급성 관상동맥 증후군의 치료
US20020052377A1 (en) * 2000-07-21 2002-05-02 Wolff Andrew A. Method for treating angina
US6573264B1 (en) * 2000-10-23 2003-06-03 Cv Therapeutics, Inc. Heteroaryl alkyl piperazine derivatives
US20080109040A1 (en) * 2002-04-04 2008-05-08 Luiz Belardinelli Method of treating arrhythmias
US20030220344A1 (en) * 2002-04-04 2003-11-27 Luiz Belardinelli Method of treating arrhythmias

Also Published As

Publication number Publication date
CN100548300C (zh) 2009-10-14
EP1490066A1 (en) 2004-12-29
DK1490066T3 (da) 2008-10-13
EP2198866A1 (en) 2010-06-23
DK1930007T3 (da) 2010-08-30
CA2481192A1 (en) 2003-10-23
PT1930007E (pt) 2010-08-17
CN1646127A (zh) 2005-07-27
ATE397932T1 (de) 2008-07-15
EP1490066B1 (en) 2008-06-11
CA2481192C (en) 2012-07-03
JP4608217B2 (ja) 2011-01-12
US20030220344A1 (en) 2003-11-27
AU2009201065B2 (en) 2011-07-21
NO330953B1 (no) 2011-08-22
ES2304507T3 (es) 2008-10-16
AU2011202135A1 (en) 2011-05-26
AU2009201065A1 (en) 2009-04-09
CY1110400T1 (el) 2015-04-29
AU2003230810B2 (en) 2009-02-26
MXPA04009637A (es) 2005-07-14
WO2003086401A1 (en) 2003-10-23
ATE470445T1 (de) 2010-06-15
IL197406A0 (en) 2011-07-31
NO20044783L (no) 2004-11-03
HK1120390A1 (en) 2009-04-03
JP2005528393A (ja) 2005-09-22
SI1490066T1 (sl) 2008-10-31
AU2003230810A1 (en) 2003-10-27
SI1930007T1 (sl) 2010-08-31
EP1930007B1 (en) 2010-06-09
US20100004255A1 (en) 2010-01-07
DE60321550D1 (de) 2008-07-24
EP1930007A1 (en) 2008-06-11
KR20100119804A (ko) 2010-11-10
KR20040099395A (ko) 2004-11-26
CN101843619A (zh) 2010-09-29
NZ535610A (en) 2006-05-26
ES2345573T3 (es) 2010-09-27
DE60332975D1 (de) 2010-07-22

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