CA2475595C - Method of reducing and preventing uvb-induced immunosuppression - Google Patents
Method of reducing and preventing uvb-induced immunosuppression Download PDFInfo
- Publication number
- CA2475595C CA2475595C CA2475595A CA2475595A CA2475595C CA 2475595 C CA2475595 C CA 2475595C CA 2475595 A CA2475595 A CA 2475595A CA 2475595 A CA2475595 A CA 2475595A CA 2475595 C CA2475595 C CA 2475595C
- Authority
- CA
- Canada
- Prior art keywords
- amine
- immune response
- response modifier
- modifier compound
- agonist
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 230000001506 immunosuppresive effect Effects 0.000 title claims abstract description 25
- 206010062016 Immunosuppression Diseases 0.000 title claims abstract description 24
- 238000000034 method Methods 0.000 title abstract description 6
- 150000001875 compounds Chemical class 0.000 claims abstract description 56
- 230000028993 immune response Effects 0.000 claims abstract description 47
- 239000003607 modifier Substances 0.000 claims abstract description 45
- 102000002689 Toll-like receptor Human genes 0.000 claims abstract description 26
- 108020000411 Toll-like receptor Proteins 0.000 claims abstract description 26
- 239000000556 agonist Substances 0.000 claims abstract description 20
- -1 imidazoquinoline amine Chemical class 0.000 claims description 55
- 238000011282 treatment Methods 0.000 claims description 17
- 229940124669 imidazoquinoline Drugs 0.000 claims description 14
- 150000001412 amines Chemical class 0.000 claims description 10
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Transplantation (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35898202P | 2002-02-22 | 2002-02-22 | |
| US60/358,982 | 2002-02-22 | ||
| PCT/US2003/004957 WO2003072026A2 (en) | 2002-02-22 | 2003-02-20 | Method of reducing and treating uvb-induced immunosuppression |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2475595A1 CA2475595A1 (en) | 2003-09-04 |
| CA2475595C true CA2475595C (en) | 2012-07-10 |
Family
ID=27766029
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2475595A Expired - Fee Related CA2475595C (en) | 2002-02-22 | 2003-02-20 | Method of reducing and preventing uvb-induced immunosuppression |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US7030129B2 (enExample) |
| EP (1) | EP1478327B1 (enExample) |
| JP (1) | JP2005518433A (enExample) |
| AU (1) | AU2003213125B2 (enExample) |
| BR (1) | BR0307788A (enExample) |
| CA (1) | CA2475595C (enExample) |
| DK (1) | DK1478327T3 (enExample) |
| ES (1) | ES2541132T3 (enExample) |
| HU (1) | HUE025145T2 (enExample) |
| MX (1) | MXPA04008023A (enExample) |
| NZ (1) | NZ534566A (enExample) |
| PT (1) | PT1478327E (enExample) |
| SI (1) | SI1478327T1 (enExample) |
| WO (1) | WO2003072026A2 (enExample) |
| ZA (1) | ZA200407605B (enExample) |
Families Citing this family (101)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA67760C2 (uk) * | 1997-12-11 | 2004-07-15 | Міннесота Майнінг Енд Мануфакчурінг Компані | Імідазонафтиридин та тетрагідроімідазонафтиридин, фармацевтична композиція, спосіб індукування біосинтезу цитокінів та спосіб лікування вірусної інфекції, проміжні сполуки |
| US6573273B1 (en) | 1999-06-10 | 2003-06-03 | 3M Innovative Properties Company | Urea substituted imidazoquinolines |
| US6331539B1 (en) * | 1999-06-10 | 2001-12-18 | 3M Innovative Properties Company | Sulfonamide and sulfamide substituted imidazoquinolines |
| US6756382B2 (en) * | 1999-06-10 | 2004-06-29 | 3M Innovative Properties Company | Amide substituted imidazoquinolines |
| JP3436512B2 (ja) * | 1999-12-28 | 2003-08-11 | 株式会社デンソー | アクセル装置 |
| US20060142202A1 (en) * | 2000-12-08 | 2006-06-29 | 3M Innovative Properties Company | Compositions and methods for targeted delivery of immune response modifiers |
| US6667312B2 (en) * | 2000-12-08 | 2003-12-23 | 3M Innovative Properties Company | Thioether substituted imidazoquinolines |
| US6545017B1 (en) * | 2000-12-08 | 2003-04-08 | 3M Innovative Properties Company | Urea substituted imidazopyridines |
| US6525064B1 (en) | 2000-12-08 | 2003-02-25 | 3M Innovative Properties Company | Sulfonamido substituted imidazopyridines |
| US6664265B2 (en) | 2000-12-08 | 2003-12-16 | 3M Innovative Properties Company | Amido ether substituted imidazoquinolines |
| UA74852C2 (en) * | 2000-12-08 | 2006-02-15 | 3M Innovative Properties Co | Urea-substituted imidazoquinoline ethers |
| US6545016B1 (en) | 2000-12-08 | 2003-04-08 | 3M Innovative Properties Company | Amide substituted imidazopyridines |
| US6660735B2 (en) * | 2000-12-08 | 2003-12-09 | 3M Innovative Properties Company | Urea substituted imidazoquinoline ethers |
| US6664264B2 (en) * | 2000-12-08 | 2003-12-16 | 3M Innovative Properties Company | Thioether substituted imidazoquinolines |
| US7226928B2 (en) * | 2001-06-15 | 2007-06-05 | 3M Innovative Properties Company | Methods for the treatment of periodontal disease |
| US6677349B1 (en) | 2001-12-21 | 2004-01-13 | 3M Innovative Properties Company | Sulfonamide and sulfamide substituted imidazoquinolines |
| US7030129B2 (en) * | 2002-02-22 | 2006-04-18 | 3M Innovative Properties Company | Method of reducing and treating UVB-induced immunosuppression |
| WO2003103584A2 (en) | 2002-06-07 | 2003-12-18 | 3M Innovative Properties Company | Ether substituted imidazopyridines |
| WO2004032829A2 (en) | 2002-08-15 | 2004-04-22 | 3M Innovative Properties Company | Immunostimulatory compositions and methods of stimulating an immune response |
| JP2006513212A (ja) | 2002-12-20 | 2006-04-20 | スリーエム イノベイティブ プロパティズ カンパニー | アリール／ヘタリール置換されたイミダゾキノリン |
| WO2004078138A2 (en) * | 2003-03-04 | 2004-09-16 | 3M Innovative Properties Company | Prophylactic treatment of uv-induced epidermal neoplasia |
| WO2004080398A2 (en) * | 2003-03-07 | 2004-09-23 | 3M Innovative Properties Company | 1-amino 1h-imidazoquinolines |
| US7163947B2 (en) * | 2003-03-07 | 2007-01-16 | 3M Innovative Properties Company | 1-Amino 1H-imidazoquinolines |
| KR20050109562A (ko) * | 2003-03-13 | 2005-11-21 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | 피부의 질을 개선시키는 방법 |
| WO2004080293A2 (en) * | 2003-03-13 | 2004-09-23 | 3M Innovative Properties Company | Methods for diagnosing skin lesions |
| EP1613956A2 (en) * | 2003-03-25 | 2006-01-11 | 3M Innovative Properties Company | Selective activation of cellular activities mediated through a common toll-like receptor |
| AU2004229478B2 (en) * | 2003-04-10 | 2009-12-24 | 3M Innovative Properties Company | Delivery of immune response modifier compounds |
| US20040265351A1 (en) * | 2003-04-10 | 2004-12-30 | Miller Richard L. | Methods and compositions for enhancing immune response |
| WO2004110991A2 (en) * | 2003-06-06 | 2004-12-23 | 3M Innovative Properties Company | PROCESS FOR IMIDAZO[4,5-c]PYRIDIN-4-AMINES |
| US20050032829A1 (en) * | 2003-06-06 | 2005-02-10 | 3M Innovative Properties Company | Process for imidazo[4,5-c]pyridin-4-amines |
| JP2007501252A (ja) * | 2003-08-05 | 2007-01-25 | スリーエム イノベイティブ プロパティズ カンパニー | 免疫応答調整剤を含有する製剤 |
| WO2005018556A2 (en) | 2003-08-12 | 2005-03-03 | 3M Innovative Properties Company | Hydroxylamine substituted imidazo-containing compounds |
| CA2535338C (en) * | 2003-08-14 | 2013-05-28 | 3M Innovative Properties Company | Substituted 1h-imidazo[4,5-c]pyridin-4-amines,1h-imidazo[4,5-c]quinolin -4-amines and 1h-imidazo[4,5-c]naphthyridin-4-amines as immune response modifiers |
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-
2003
- 2003-02-20 US US10/371,146 patent/US7030129B2/en not_active Expired - Lifetime
- 2003-02-20 SI SI200332434T patent/SI1478327T1/sl unknown
- 2003-02-20 EP EP03709171.7A patent/EP1478327B1/en not_active Expired - Lifetime
- 2003-02-20 JP JP2003570773A patent/JP2005518433A/ja active Pending
- 2003-02-20 NZ NZ534566A patent/NZ534566A/en not_active IP Right Cessation
- 2003-02-20 HU HUE03709171A patent/HUE025145T2/en unknown
- 2003-02-20 CA CA2475595A patent/CA2475595C/en not_active Expired - Fee Related
- 2003-02-20 WO PCT/US2003/004957 patent/WO2003072026A2/en not_active Ceased
- 2003-02-20 ES ES03709171.7T patent/ES2541132T3/es not_active Expired - Lifetime
- 2003-02-20 PT PT37091717T patent/PT1478327E/pt unknown
- 2003-02-20 BR BRPI0307788-8A patent/BR0307788A/pt not_active Application Discontinuation
- 2003-02-20 AU AU2003213125A patent/AU2003213125B2/en not_active Ceased
- 2003-02-20 DK DK03709171.7T patent/DK1478327T3/en active
- 2003-02-20 MX MXPA04008023A patent/MXPA04008023A/es active IP Right Grant
-
2004
- 2004-09-21 ZA ZA200407605A patent/ZA200407605B/en unknown
-
2006
- 2006-02-21 US US11/358,017 patent/US20060142235A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US7030129B2 (en) | 2006-04-18 |
| AU2003213125A1 (en) | 2003-09-09 |
| NZ534566A (en) | 2007-02-23 |
| EP1478327A4 (en) | 2007-07-04 |
| BR0307788A (pt) | 2006-04-04 |
| DK1478327T3 (en) | 2015-07-27 |
| WO2003072026A2 (en) | 2003-09-04 |
| ZA200407605B (en) | 2006-06-28 |
| AU2003213125B2 (en) | 2008-02-21 |
| PT1478327E (pt) | 2015-08-04 |
| ES2541132T3 (es) | 2015-07-16 |
| EP1478327B1 (en) | 2015-04-29 |
| EP1478327A2 (en) | 2004-11-24 |
| WO2003072026A3 (en) | 2003-12-24 |
| US20060142235A1 (en) | 2006-06-29 |
| CA2475595A1 (en) | 2003-09-04 |
| US20030161797A1 (en) | 2003-08-28 |
| JP2005518433A (ja) | 2005-06-23 |
| SI1478327T1 (sl) | 2015-08-31 |
| HUE025145T2 (en) | 2016-01-28 |
| MXPA04008023A (es) | 2004-11-26 |
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