CA2471974C - Quinazolinone derivatives and their use as cb agonists - Google Patents
Quinazolinone derivatives and their use as cb agonists Download PDFInfo
- Publication number
- CA2471974C CA2471974C CA2471974A CA2471974A CA2471974C CA 2471974 C CA2471974 C CA 2471974C CA 2471974 A CA2471974 A CA 2471974A CA 2471974 A CA2471974 A CA 2471974A CA 2471974 C CA2471974 C CA 2471974C
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- c4alkyl
- dimethyl
- hydrogen
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 48
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
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- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Neurology (AREA)
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- Pulmonology (AREA)
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- Psychology (AREA)
- Anesthesiology (AREA)
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- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0202755.5 | 2002-02-06 | ||
| GB0202755A GB0202755D0 (en) | 2002-02-06 | 2002-02-06 | Organic compounds |
| GB0213285.0 | 2002-06-10 | ||
| GB0213285A GB0213285D0 (en) | 2002-06-10 | 2002-06-10 | Organic compound |
| GB0221460.9 | 2002-09-16 | ||
| GB0221460A GB0221460D0 (en) | 2002-09-16 | 2002-09-16 | Organic compound |
| GB0221459.1 | 2002-09-16 | ||
| GB0221459A GB0221459D0 (en) | 2002-09-16 | 2002-09-16 | Organic compound |
| PCT/EP2003/001140 WO2003066603A1 (en) | 2002-02-06 | 2003-02-05 | Quinazolinone derivatives and their use as cb agonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2471974A1 CA2471974A1 (en) | 2003-08-14 |
| CA2471974C true CA2471974C (en) | 2011-11-22 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2471974A Expired - Fee Related CA2471974C (en) | 2002-02-06 | 2003-02-05 | Quinazolinone derivatives and their use as cb agonists |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US20050085493A1 (enExample) |
| EP (2) | EP1472234B1 (enExample) |
| JP (2) | JP4428479B2 (enExample) |
| KR (1) | KR100954626B1 (enExample) |
| CN (1) | CN100579968C (enExample) |
| AR (1) | AR038483A1 (enExample) |
| AT (1) | ATE551329T1 (enExample) |
| AU (1) | AU2003210212A1 (enExample) |
| BR (1) | BR0307461A (enExample) |
| CA (1) | CA2471974C (enExample) |
| CO (1) | CO5601021A2 (enExample) |
| EC (1) | ECSP045219A (enExample) |
| ES (1) | ES2384967T3 (enExample) |
| MX (1) | MXPA04007641A (enExample) |
| MY (1) | MY143958A (enExample) |
| NO (1) | NO328305B1 (enExample) |
| NZ (1) | NZ571615A (enExample) |
| PE (1) | PE20030867A1 (enExample) |
| PL (1) | PL370657A1 (enExample) |
| TW (1) | TW200306839A (enExample) |
| WO (1) | WO2003066603A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000055153A1 (en) | 1999-03-17 | 2000-09-21 | Astrazeneca Ab | Amide derivatives |
| TW200306839A (en) | 2002-02-06 | 2003-12-01 | Novartis Ag | Quinazolinone derivatives and their use as CB agonists |
| GB0324790D0 (en) * | 2003-10-24 | 2003-11-26 | Astrazeneca Ab | Amide derivatives |
| JP2007510649A (ja) | 2003-11-04 | 2007-04-26 | メルク エンド カムパニー インコーポレーテッド | 置換ナフチリジノン誘導体 |
| SE0303491D0 (sv) * | 2003-12-19 | 2003-12-19 | Astrazeneca Ab | New use VI |
| CN100506802C (zh) * | 2004-06-04 | 2009-07-01 | 中国科学院上海药物研究所 | 一类甲酰肽样受体-1调节剂、其制备方法和用途 |
| GB0413618D0 (en) * | 2004-06-17 | 2004-07-21 | Novartis Ag | Organic compounds |
| EP1904068A1 (en) * | 2005-07-11 | 2008-04-02 | N.V. Organon | Synergistic combination for the treatment of pain (cannabioid receptor agonist and opiod receptor agonist) |
| GB0525068D0 (en) | 2005-12-08 | 2006-01-18 | Novartis Ag | Organic compounds |
| US20090209536A1 (en) * | 2007-06-17 | 2009-08-20 | Kalypsys, Inc. | Aminoquinazoline cannabinoid receptor modulators for treatment of disease |
| US8349852B2 (en) | 2009-01-13 | 2013-01-08 | Novartis Ag | Quinazolinone derivatives useful as vanilloid antagonists |
| FR2944013B1 (fr) * | 2009-04-07 | 2011-07-15 | Sanofi Aventis | Derives de 1-alkyl-cinnolin-4(1h)-one substitues,leur preparation et leur application en therapeutique. |
| EP2531510B1 (en) | 2010-02-01 | 2014-07-23 | Novartis AG | Pyrazolo[5,1b]oxazole derivatives as crf-1 receptor antagonists |
| AR080056A1 (es) | 2010-02-01 | 2012-03-07 | Novartis Ag | Derivados de ciclohexil-amida como antagonistas de los receptores de crf |
| ES2527849T3 (es) | 2010-02-02 | 2015-01-30 | Novartis Ag | Derivados de ciclohexilamida como antagonistas del receptor de CRF |
| US8546416B2 (en) | 2011-05-27 | 2013-10-01 | Novartis Ag | 3-spirocyclic piperidine derivatives as ghrelin receptor agonists |
| CN104271579A (zh) | 2012-05-03 | 2015-01-07 | 诺华股份有限公司 | 作为生长素释放肽受体激动剂的2,7-二氮杂-螺[4,5]癸烷-7-基衍生物的l-苹果酸盐及其结晶 |
| UY35675A (es) | 2013-07-24 | 2015-02-27 | Novartis Ag | Derivados sustituidos de quinazolin-4-ona |
| CN106146414A (zh) * | 2016-07-07 | 2016-11-23 | 浙江大学 | 喹唑啉二酮类衍生物及其制备方法和用途 |
| CN106831502A (zh) * | 2017-03-13 | 2017-06-13 | 苏州市泽宸贸易有限公司 | 邻硝基苯磺酰氯、其合成方法及应用 |
| CN109796360B (zh) * | 2019-01-30 | 2022-03-18 | 上海阿拉丁生化科技股份有限公司 | 一种3-氨基-2-萘甲酸类化合物的制备工艺 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR6200M (enExample) | 1967-04-18 | 1968-07-22 | ||
| DE1803210A1 (de) | 1968-10-16 | 1970-05-14 | Troponwerke Dinklage & Co | 2-Methyl-3-(3-[4-phenylpiperazinyl-(1)]-2-hydroxypropyl)-chinazolinon-(4) und Verfahren zu seiner Herstellung |
| JPS5657768A (en) * | 1979-10-18 | 1981-05-20 | Masayuki Ishikawa | Novel 4-quinazolone derivative substituted by aromatic residue at 3-position |
| NZ192392A (en) * | 1978-12-19 | 1983-02-15 | M Ishikawa | 3-(substituted (phenyl or pyridyl)) -3,4-dihydroquinazolin-4-ones |
| JPS57118570A (en) * | 1981-01-16 | 1982-07-23 | Masayuki Ishikawa | Novel 3-phenyl-4-quinazolone derivative |
| AU543928B2 (en) * | 1981-01-16 | 1985-05-09 | Masayuki Ishikawa | 4(311)-quinazolinone derivatives |
| EP0639986A1 (en) * | 1992-05-13 | 1995-03-01 | Alcon Laboratories, Inc. | Topical ophthalmic compositions comprising a combination of calcium antagonists with known antiglaucoma agents |
| US6017919A (en) | 1996-02-06 | 2000-01-25 | Japan Tobacco Inc. | Compounds and pharmaceutical use thereof |
| TW200306839A (en) | 2002-02-06 | 2003-12-01 | Novartis Ag | Quinazolinone derivatives and their use as CB agonists |
| SE0303491D0 (sv) | 2003-12-19 | 2003-12-19 | Astrazeneca Ab | New use VI |
| GB0413618D0 (en) * | 2004-06-17 | 2004-07-21 | Novartis Ag | Organic compounds |
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2003
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- 2003-02-04 PE PE2003000129A patent/PE20030867A1/es not_active Application Discontinuation
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- 2003-02-05 PL PL03370657A patent/PL370657A1/xx unknown
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- 2003-02-05 AT AT03737316T patent/ATE551329T1/de active
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- 2003-02-05 EP EP03737316A patent/EP1472234B1/en not_active Expired - Lifetime
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- 2003-02-05 CA CA2471974A patent/CA2471974C/en not_active Expired - Fee Related
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- 2003-02-05 ES ES03737316T patent/ES2384967T3/es not_active Expired - Lifetime
- 2003-02-05 US US10/503,779 patent/US20050085493A1/en not_active Abandoned
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- 2003-02-05 AU AU2003210212A patent/AU2003210212A1/en not_active Abandoned
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- 2004-08-27 NO NO20043580A patent/NO328305B1/no not_active IP Right Cessation
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2007
- 2007-06-26 US US11/823,315 patent/US8552015B2/en not_active Expired - Fee Related
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2009
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Also Published As
| Publication number | Publication date |
|---|---|
| US8552015B2 (en) | 2013-10-08 |
| NO20043580D0 (no) | 2004-08-27 |
| CN1628104A (zh) | 2005-06-15 |
| EP1472234B1 (en) | 2012-03-28 |
| JP2009149658A (ja) | 2009-07-09 |
| BR0307461A (pt) | 2004-11-09 |
| NO328305B1 (no) | 2010-01-25 |
| ATE551329T1 (de) | 2012-04-15 |
| AR038483A1 (es) | 2005-01-19 |
| EP2319839A1 (en) | 2011-05-11 |
| US20050085493A1 (en) | 2005-04-21 |
| JP4428479B2 (ja) | 2010-03-10 |
| US20070265285A1 (en) | 2007-11-15 |
| KR100954626B1 (ko) | 2010-04-27 |
| CO5601021A2 (es) | 2006-01-31 |
| WO2003066603A1 (en) | 2003-08-14 |
| NZ571615A (en) | 2010-01-29 |
| AU2003210212A1 (en) | 2003-09-02 |
| CN100579968C (zh) | 2010-01-13 |
| TW200306839A (en) | 2003-12-01 |
| NO20043580L (no) | 2004-09-21 |
| CA2471974A1 (en) | 2003-08-14 |
| ES2384967T3 (es) | 2012-07-16 |
| ECSP045219A (es) | 2004-09-28 |
| EP1472234A1 (en) | 2004-11-03 |
| PL370657A1 (en) | 2005-05-30 |
| MY143958A (en) | 2011-07-29 |
| KR20040083501A (ko) | 2004-10-02 |
| PE20030867A1 (es) | 2003-12-04 |
| HK1079518A1 (zh) | 2006-04-07 |
| MXPA04007641A (es) | 2004-11-10 |
| JP2005522439A (ja) | 2005-07-28 |
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