JPS5657768A - Novel 4-quinazolone derivative substituted by aromatic residue at 3-position - Google Patents

Novel 4-quinazolone derivative substituted by aromatic residue at 3-position

Info

Publication number
JPS5657768A
JPS5657768A JP13358279A JP13358279A JPS5657768A JP S5657768 A JPS5657768 A JP S5657768A JP 13358279 A JP13358279 A JP 13358279A JP 13358279 A JP13358279 A JP 13358279A JP S5657768 A JPS5657768 A JP S5657768A
Authority
JP
Japan
Prior art keywords
formula
novel
alkyl
quinazolone
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP13358279A
Other languages
Japanese (ja)
Inventor
Masayuki Ishikawa
Masao Eguchi
Hiromichi Tanaka
Shigeru Ito
Yoshimi Takashima
Masahiko Kobayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to JP13358279A priority Critical patent/JPS5657768A/en
Priority to NZ192392A priority patent/NZ192392A/en
Priority to YU03063/79A priority patent/YU306379A/en
Priority to US06/103,841 priority patent/US4276295A/en
Priority to DE19792950376 priority patent/DE2950376A1/en
Priority to IT28062/79A priority patent/IT1126577B/en
Priority to AR279316A priority patent/AR225028A1/en
Priority to SE7910376A priority patent/SE7910376L/en
Priority to AU53932/79A priority patent/AU526309B2/en
Priority to GB7943565A priority patent/GB2040927B/en
Priority to DK539979A priority patent/DK539979A/en
Priority to ES487014A priority patent/ES8102102A1/en
Priority to NO794135A priority patent/NO794135L/en
Priority to NL7909118A priority patent/NL7909118A/en
Priority to FR7931059A priority patent/FR2444671A1/en
Priority to CA342,295A priority patent/CA1111849A/en
Priority to CH1125779A priority patent/CH644112A5/en
Priority to DD79217854A priority patent/DD150462A5/en
Priority to HU79II311A priority patent/HU182733B/en
Publication of JPS5657768A publication Critical patent/JPS5657768A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:A quinazolone derivative expressed by formula I (R1 and R3 are alkyls; R2 is alkoxycarbonyl; R1, R2 and R3 are at the 5-, 6- and 7- positions or 6-, 7- and 8-positions in the order; R4 is alkyl, monohalogenomethyl, etc.; R5 is residue of formula II or III; R6 is H, halogen, alkyl, etc.; R7 is R6, CF3, etc.; R8 is R6, cyano, hydroxyl group, etc.; R9 is H or alkyl).
EXAMPLE: 6-Ethoxycarbonyl-2,5,7-trimethyl-3-(o-tolyl)-4-quinazolone.
USE: A vasodilator, an ameliorant for blood circulation, a hypotensive agent, and an antiarteriosclerotic agent.
PROCESS: A compound of formula IV is reacted with a compound of formula V [X is halogen or -O-C(=O)-R4], and then a compound of the formula R5-NH2, and if necessary hydrolyzed.
COPYRIGHT: (C)1981,JPO&Japio
JP13358279A 1978-12-19 1979-10-18 Novel 4-quinazolone derivative substituted by aromatic residue at 3-position Pending JPS5657768A (en)

Priority Applications (19)

Application Number Priority Date Filing Date Title
JP13358279A JPS5657768A (en) 1979-10-18 1979-10-18 Novel 4-quinazolone derivative substituted by aromatic residue at 3-position
NZ192392A NZ192392A (en) 1978-12-19 1979-12-13 3-(substituted (phenyl or pyridyl)) -3,4-dihydroquinazolin-4-ones
YU03063/79A YU306379A (en) 1978-12-19 1979-12-14 Process for producing 3-aromatically substituted 4(3h)-quinazolines
US06/103,841 US4276295A (en) 1978-12-19 1979-12-14 3-Aromatic moiety substituted-4(3H)-quinazolinones, process for production thereof, and use thereof
DE19792950376 DE2950376A1 (en) 1978-12-19 1979-12-14 4 (3H) -QUINAZOLINONES SUBSTITUTED IN A 3-POSITION WITH AROMATIC GROUP AND METHOD FOR THE PRODUCTION AND USE THEREOF
IT28062/79A IT1126577B (en) 1978-12-19 1979-12-17 4 (3H) -CHINAZOLINONES REPLACED IN THE 3-AROMATIC HALF, PROCEDURE FOR THEIR PRODUCTION AND USE
AR279316A AR225028A1 (en) 1978-12-19 1979-12-17 A PROCEDURE FOR PRODUCING A 4 (3H) -QUINAZOLINONE 3-PHENYL OR PIRIDIL-SUBSTITUTED
SE7910376A SE7910376L (en) 1978-12-19 1979-12-17 quinazolinone derivatives
AU53932/79A AU526309B2 (en) 1978-12-19 1979-12-17 Substituted quinazolinones
GB7943565A GB2040927B (en) 1978-12-19 1979-12-18 Pharmaceutically active 3 - aromatic moiety substituted - 4 (3h) - quinazolinone derivatives
DK539979A DK539979A (en) 1978-12-19 1979-12-18 QUINAZOLINO DERIVATIVES AND THEIR PREPARATION AND USE
ES487014A ES8102102A1 (en) 1978-12-19 1979-12-18 A procedure to obtain 4 (3h) -quinazolinones replaced with an aromatic rest in position 3. (Machine-translation by Google Translate, not legally binding)
NO794135A NO794135L (en) 1978-12-19 1979-12-18 SUBSTITUTED 4 (3H) CHINAZOLINONES, PROCEDURE FOR THE PREPARATION AND USE OF THESE
NL7909118A NL7909118A (en) 1978-12-19 1979-12-18 SUBSTITUTED CHINAZOLIN DERIVATIVES AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE DERIVATIVES AS AN ACTIVE COMPONENT.
FR7931059A FR2444671A1 (en) 1978-12-19 1979-12-19 NEW QUINAZOLINONES, THEIR PREPARATION AND THE MEDICINE CONTAINING THESE SUBSTANCES
CA342,295A CA1111849A (en) 1978-12-19 1979-12-19 3-aromatic moiety substituted-4(3h)-quinazolinones, process for production thereof, and use thereof
CH1125779A CH644112A5 (en) 1978-12-19 1979-12-19 3-AROMATIC-SUBSTITUTED-4 (3H) CHINAZOLINONES AND METHOD FOR THE PRODUCTION THEREOF.
DD79217854A DD150462A5 (en) 1978-12-19 1979-12-19 PROCESS FOR PREPARING 4 (3H) -CHINAZOLINONES SUBSTITUTED IN 3-POSITION WITH AROMATIC GROUP
HU79II311A HU182733B (en) 1978-12-19 1979-12-19 Process for producing substituted quinazoline-derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13358279A JPS5657768A (en) 1979-10-18 1979-10-18 Novel 4-quinazolone derivative substituted by aromatic residue at 3-position

Publications (1)

Publication Number Publication Date
JPS5657768A true JPS5657768A (en) 1981-05-20

Family

ID=15108171

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13358279A Pending JPS5657768A (en) 1978-12-19 1979-10-18 Novel 4-quinazolone derivative substituted by aromatic residue at 3-position

Country Status (1)

Country Link
JP (1) JPS5657768A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008156358A (en) * 2004-02-13 2008-07-10 Banyu Pharmaceut Co Ltd Fused ring 4-oxopyrimidine derivative
JP2009149658A (en) * 2002-02-06 2009-07-09 Novartis Ag Quinazolinone derivatives and their use as cb agonists

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009149658A (en) * 2002-02-06 2009-07-09 Novartis Ag Quinazolinone derivatives and their use as cb agonists
JP2008156358A (en) * 2004-02-13 2008-07-10 Banyu Pharmaceut Co Ltd Fused ring 4-oxopyrimidine derivative

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