CA2467731A1 - Conjugues de l'hormone de croissance humaine chimiquement modifiee - Google Patents
Conjugues de l'hormone de croissance humaine chimiquement modifiee Download PDFInfo
- Publication number
- CA2467731A1 CA2467731A1 CA002467731A CA2467731A CA2467731A1 CA 2467731 A1 CA2467731 A1 CA 2467731A1 CA 002467731 A CA002467731 A CA 002467731A CA 2467731 A CA2467731 A CA 2467731A CA 2467731 A1 CA2467731 A1 CA 2467731A1
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- Prior art keywords
- conjugate
- hgh
- group
- peg
- growth hormone
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
La présente invention concerne une hormone de croissance humaine (hGH) chimiquement modifiée obtenue par la liaison d'un polymère soluble dans l'eau à une protéine. La protéine chimiquement modifiée selon la présente invention peut avoir une activité hGH de durée plus longue que celle de la hGH modifiée, ce qui permet d'obtenir une dose réduite et des opportunités de calendrier.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33190701P | 2001-11-20 | 2001-11-20 | |
US60/331,907 | 2001-11-20 | ||
PCT/US2002/037270 WO2003044056A2 (fr) | 2001-11-20 | 2002-11-20 | Conjugues de l'hormone de croissance humaine chimiquement modifiee |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2467731A1 true CA2467731A1 (fr) | 2003-05-30 |
Family
ID=23295870
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002467731A Abandoned CA2467731A1 (fr) | 2001-11-20 | 2002-11-20 | Conjugues de l'hormone de croissance humaine chimiquement modifiee |
Country Status (25)
Country | Link |
---|---|
EP (1) | EP1453859A2 (fr) |
JP (2) | JP2005525302A (fr) |
KR (2) | KR20070072924A (fr) |
CN (1) | CN1608079A (fr) |
AP (1) | AP2004003050A0 (fr) |
AU (1) | AU2002356990A1 (fr) |
BR (1) | BR0214451A (fr) |
CA (1) | CA2467731A1 (fr) |
CO (1) | CO5580794A2 (fr) |
EA (2) | EA200700431A1 (fr) |
EC (1) | ECSP045114A (fr) |
GE (1) | GEP20063860B (fr) |
HR (1) | HRP20040448A2 (fr) |
HU (1) | HUP0500997A2 (fr) |
IL (1) | IL162031A0 (fr) |
IS (1) | IS7268A (fr) |
MA (1) | MA27544A1 (fr) |
MX (1) | MXPA04004809A (fr) |
NO (1) | NO20042182L (fr) |
OA (1) | OA13063A (fr) |
PL (1) | PL374354A1 (fr) |
RS (1) | RS53104A (fr) |
TN (1) | TNSN04090A1 (fr) |
WO (1) | WO2003044056A2 (fr) |
ZA (1) | ZA200403907B (fr) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030171285A1 (en) * | 2001-11-20 | 2003-09-11 | Finn Rory F. | Chemically-modified human growth hormone conjugates |
US6916962B2 (en) | 2001-12-11 | 2005-07-12 | Sun Bio, Inc. | Monofunctional polyethylene glycol aldehydes |
AU2002357806A1 (en) * | 2001-12-11 | 2003-06-23 | Sun Bio, Inc. | Novel monofunctional polyethylene glycol aldehydes |
US7041855B2 (en) | 2001-12-11 | 2006-05-09 | Sun Bio, Inc. | Monofunctional polyethylene glycol aldehydes |
US6956135B2 (en) | 2001-12-11 | 2005-10-18 | Sun Bio, Inc. | Monofunctional polyethylene glycol aldehydes |
WO2003061577A2 (fr) * | 2002-01-18 | 2003-07-31 | Biogen Idec Ma Inc. | Composes polymeres de polyalkylene et utilisations de ceux-ci |
JP4764630B2 (ja) | 2002-09-09 | 2011-09-07 | ネクター セラピューティックス | 水溶性ポリマーアルカナール |
EP1591467A1 (fr) * | 2002-09-09 | 2005-11-02 | Nektar Therapeutics Al, Corporation | Conjugue d un polyethylene glycol comprenant un group terminal alcanal et un hormone de croissance humaine |
US20040142870A1 (en) * | 2002-11-20 | 2004-07-22 | Finn Rory F. | N-terminally monopegylated human growth hormone conjugates, process for their preparation, and methods of use thereof |
US20050281778A1 (en) * | 2003-03-28 | 2005-12-22 | Myung-Ok Park | Human growth hormone conjugated with biocompatible polymer |
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-
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- 2002-11-20 EA EA200700431A patent/EA200700431A1/ru unknown
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- 2002-11-20 AP APAP/P/2004/003050A patent/AP2004003050A0/en unknown
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- 2002-11-20 EP EP02803695A patent/EP1453859A2/fr not_active Withdrawn
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- 2002-11-20 CA CA002467731A patent/CA2467731A1/fr not_active Abandoned
- 2002-11-20 KR KR1020047007708A patent/KR20050044858A/ko active IP Right Grant
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- 2002-11-20 WO PCT/US2002/037270 patent/WO2003044056A2/fr not_active Application Discontinuation
- 2002-11-20 GE GE5599A patent/GEP20063860B/en unknown
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2004
- 2004-05-17 IS IS7268A patent/IS7268A/is unknown
- 2004-05-19 MA MA27686A patent/MA27544A1/fr unknown
- 2004-05-20 EC EC2004005114A patent/ECSP045114A/es unknown
- 2004-05-20 ZA ZA200403907A patent/ZA200403907B/en unknown
- 2004-05-20 HR HR20040448A patent/HRP20040448A2/hr not_active Application Discontinuation
- 2004-05-20 CO CO04046633A patent/CO5580794A2/es not_active Application Discontinuation
- 2004-05-20 TN TNP2004000090A patent/TNSN04090A1/fr unknown
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Also Published As
Publication number | Publication date |
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PL374354A1 (en) | 2005-10-17 |
HUP0500997A2 (en) | 2007-11-28 |
MA27544A1 (fr) | 2005-10-03 |
KR20050044858A (ko) | 2005-05-13 |
AU2002356990A1 (en) | 2003-06-10 |
WO2003044056A3 (fr) | 2003-08-21 |
CN1608079A (zh) | 2005-04-20 |
AP2004003050A0 (en) | 2004-06-30 |
OA13063A (en) | 2006-11-10 |
EA200700431A1 (ru) | 2008-02-28 |
MXPA04004809A (es) | 2004-08-11 |
NO20042182L (no) | 2004-08-11 |
JP2006321808A (ja) | 2006-11-30 |
HRP20040448A2 (en) | 2006-02-28 |
WO2003044056A2 (fr) | 2003-05-30 |
EA200400565A1 (ru) | 2005-06-30 |
JP2005525302A (ja) | 2005-08-25 |
EA008505B1 (ru) | 2007-06-29 |
TNSN04090A1 (fr) | 2006-06-01 |
ZA200403907B (en) | 2007-12-27 |
IL162031A0 (en) | 2005-11-20 |
RS53104A (en) | 2006-10-27 |
IS7268A (is) | 2004-05-17 |
BR0214451A (pt) | 2006-05-30 |
GEP20063860B (en) | 2006-06-26 |
CO5580794A2 (es) | 2005-11-30 |
EP1453859A2 (fr) | 2004-09-08 |
KR20070072924A (ko) | 2007-07-06 |
ECSP045114A (es) | 2004-07-23 |
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