CA2466863A1 - Oral pharmaceutical compositions comprising cromolyn sodium and an acylated amino acid - Google Patents
Oral pharmaceutical compositions comprising cromolyn sodium and an acylated amino acid Download PDFInfo
- Publication number
- CA2466863A1 CA2466863A1 CA002466863A CA2466863A CA2466863A1 CA 2466863 A1 CA2466863 A1 CA 2466863A1 CA 002466863 A CA002466863 A CA 002466863A CA 2466863 A CA2466863 A CA 2466863A CA 2466863 A1 CA2466863 A1 CA 2466863A1
- Authority
- CA
- Canada
- Prior art keywords
- cromolyn
- cromolyn sodium
- dosage form
- delivery agent
- sodium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pain & Pain Management (AREA)
- Otolaryngology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33439501P | 2001-11-29 | 2001-11-29 | |
| US60/334,395 | 2001-11-29 | ||
| US38491602P | 2002-05-24 | 2002-05-24 | |
| US60/384,916 | 2002-05-24 | ||
| PCT/US2002/038247 WO2003045331A2 (en) | 2001-11-29 | 2002-11-29 | Formulations for oral administration of cromolyn sodium |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2466863A1 true CA2466863A1 (en) | 2003-06-05 |
Family
ID=26989179
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002466863A Abandoned CA2466863A1 (en) | 2001-11-29 | 2002-11-29 | Oral pharmaceutical compositions comprising cromolyn sodium and an acylated amino acid |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20040259952A1 (enExample) |
| EP (1) | EP1461031B1 (enExample) |
| JP (1) | JP5196701B2 (enExample) |
| AU (1) | AU2002352974A1 (enExample) |
| CA (1) | CA2466863A1 (enExample) |
| WO (1) | WO2003045331A2 (enExample) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050209141A1 (en) * | 2003-10-17 | 2005-09-22 | Silver Randi B | Mast cell-derived renin |
| US7217703B2 (en) | 2004-04-16 | 2007-05-15 | Emisphere Technologies, Inc. | 8-(2-hydroxyphenoxy)octyldiethanolamine and salts thereof for delivery of active agents |
| EP1756039B1 (en) | 2004-05-14 | 2012-10-17 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| NZ588373A (en) | 2004-05-19 | 2012-01-12 | Emisphere Tech Inc | Topical cromolyn formulations |
| AU2005244985B2 (en) | 2004-05-19 | 2011-09-01 | Emisphere Technologies, Inc. | Acyclovir formulations |
| NZ556373A (en) | 2004-12-29 | 2010-01-29 | Emisphere Tech Inc | Pharmaceutical formulations of gallium salts |
| US8110547B2 (en) | 2005-01-12 | 2012-02-07 | Emisphere Technologies, Inc. | Compositions for buccal delivery of parathyroid hormone |
| WO2007052398A1 (ja) * | 2005-11-01 | 2007-05-10 | Reverse Proteomics Research Institute Co., Ltd. | アレルギー疾患の治療に有用な化合物をスクリーニングする方法 |
| GB0522566D0 (en) * | 2005-11-04 | 2005-12-14 | Novartis Ag | Organic compounds |
| US20070249727A1 (en) | 2006-04-21 | 2007-10-25 | The Proctor & Gamble Company | Compositions and kits useful for treatment of respiratory illness |
| US10022339B2 (en) | 2006-04-21 | 2018-07-17 | The Procter & Gamble Company | Compositions and methods useful for treatment of respiratory illness |
| CA2656019C (en) | 2006-06-28 | 2016-09-13 | Emisphere Technologies, Inc. | Gallium nitrate formulations |
| US8445437B2 (en) * | 2006-07-27 | 2013-05-21 | The Brigham And Women's Hospital, Inc. | Treatment and prevention of cardiovascular disease using mast cell stabilizers |
| JP5460600B2 (ja) * | 2007-09-28 | 2014-04-02 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド | 肥満症治療における肥満細胞安定化薬 |
| US10517839B2 (en) * | 2008-06-09 | 2019-12-31 | Cornell University | Mast cell inhibition in diseases of the retina and vitreous |
| EP2391618B1 (en) * | 2009-01-29 | 2019-04-03 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
| US9925282B2 (en) | 2009-01-29 | 2018-03-27 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
| JP5985985B2 (ja) * | 2009-08-03 | 2016-09-06 | エミスフィアー テクノロジーズ インコーポレイテッドEmisphere Technologies,Inc. | 胃腸への影響が減少した即効型ナプロキセン組成物 |
| US20110142889A1 (en) * | 2009-12-16 | 2011-06-16 | Nod Pharmaceuticals, Inc. | Compositions and methods for oral drug delivery |
| RS56998B1 (sr) | 2010-12-16 | 2018-05-31 | Novo Nordisk As | Čvrste kompozicije koje sadrže agonist glp-1 i so n-(8-(2-hidroksibenzoil)amino)kaprilne kiseline |
| EP2696687B1 (en) | 2011-04-12 | 2016-10-26 | Novo Nordisk A/S | Double-acylated glp-1 derivatives |
| US8843456B2 (en) | 2011-12-06 | 2014-09-23 | International Business Machines Corporation | Database table compression |
| CN104203266B (zh) | 2012-03-22 | 2017-12-26 | 诺和诺德股份有限公司 | Glp‑1肽组合物及其制备 |
| DK2827845T3 (en) | 2012-03-22 | 2019-04-01 | Novo Nordisk As | COMPOSITIONS INCLUDING A PROCEDURE AND PREPARING THEREOF |
| ES2965469T3 (es) | 2012-03-22 | 2024-04-15 | Novo Nordisk As | Composiciones que comprenden un agente de suministro y preparación de estas |
| CN104487056A (zh) | 2012-06-20 | 2015-04-01 | 诺和诺德A/S(股份有限公司) | 包含肽和递送剂的片剂制剂 |
| US10058530B2 (en) | 2012-10-25 | 2018-08-28 | The General Hospital Corporation | Combination therapies for the treatment of Alzheimer's disease and related disorders |
| JP6499077B2 (ja) | 2012-10-25 | 2019-04-10 | ザ ジェネラル ホスピタル コーポレイション | アルツハイマー病と関連疾患の治療のための併用療法 |
| EP2978441A4 (en) * | 2013-03-27 | 2017-02-08 | ScPharmaceuticals Inc. | Combination therapy for subcutaneous administration of glycopeptide antibiotics |
| BR112015026325A2 (pt) | 2013-05-02 | 2017-07-25 | Novo Nordisk As | dosagem oral de compostos glp-1 |
| US10525005B2 (en) | 2013-05-23 | 2020-01-07 | The General Hospital Corporation | Cromolyn compositions and methods thereof |
| CA2928028A1 (en) | 2013-10-22 | 2015-04-30 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
| EP3068375B1 (en) * | 2013-11-11 | 2020-04-22 | Harish, Ziv | Formulations and methods for prevention and treatment of oral allergy syndrome |
| US9962363B2 (en) | 2014-02-10 | 2018-05-08 | Patara Pharma, LLC | Mast cell stabilizers treatment for systemic disorders |
| CA2938996A1 (en) | 2014-02-10 | 2015-08-13 | Patara Pharma, LLC | Methods for the treatment of lung diseases with mast cell stabilizers |
| US10583177B2 (en) | 2015-02-09 | 2020-03-10 | Entera Bio Ltd. | Formulations for oral administration of active agents |
| WO2017027402A1 (en) | 2015-08-07 | 2017-02-16 | Patara Pharma, LLC | Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders |
| US10238625B2 (en) | 2015-08-07 | 2019-03-26 | Respivant Sciences Gmbh | Methods for the treatment of mast cell related disorders with mast cell stabilizers |
| MX382853B (es) | 2016-04-22 | 2025-03-13 | Spoke Sciences Inc | Compuestos medicinales y suplementos nutricionales de base vegetal de rápida acción. |
| CN116850132A (zh) | 2016-08-17 | 2023-10-10 | 安提拉生物有限公司 | 用于口服的活性剂的制剂 |
| CN116889562A (zh) | 2016-08-31 | 2023-10-17 | 通用医疗公司 | 与神经退行性疾病相关的神经炎症中的巨噬细胞/小胶质细胞 |
| EP3506893A4 (en) * | 2016-08-31 | 2020-01-22 | Respivant Sciences GmbH | CROMOLYN COMPOSITIONS FOR THE TREATMENT OF CHRONIC COUGH DUE TO IDIOPATHIC PULMONAL FIBROSIS |
| AU2017339366A1 (en) | 2016-10-07 | 2019-04-11 | Respivant Sciences Gmbh | Cromolyn compositions for treatment of pulmonary fibrosis |
| EA201892396A1 (ru) | 2016-12-02 | 2019-04-30 | Ресептор Лайф Сайенсиз, Инк. | Быстродействующие растительные лекарственные соединения и биологически активные добавки |
| MX2019007968A (es) * | 2017-01-03 | 2019-12-05 | Receptor Holdings Inc | Compuestos medicinales y suplementos nutricionales. |
| AU2017423862A1 (en) | 2017-07-20 | 2020-02-06 | Aztherapies, Inc. | Powdered formulations of cromolyn sodium and ibuprofen |
| CA3084593A1 (en) * | 2017-12-04 | 2019-06-13 | The General Hospital Corporation | Cromolyn compositions and methods thereof |
| WO2019149880A1 (en) | 2018-02-02 | 2019-08-08 | Novo Nordisk A/S | Solid compositions comprising a glp-1 agonist, a salt of n-(8-(2-hydroxybenzoyl)amino)caprylic acid and a lubricant |
| EP3817739A4 (en) | 2018-07-02 | 2022-04-13 | The General Hospital Corporation | POWDERED FORMULATIONS OF CROMOLYN SODIUM AND ALPHA-LACTOSE |
| UA122811C2 (uk) * | 2018-08-10 | 2021-01-06 | Наталія Миколаївна Тихонівська | Фармацевтична композиція |
| WO2020097686A1 (en) * | 2018-11-14 | 2020-05-22 | Holman Pharmaceuticals Pty Ltd | Compositions and uses thereof |
| AU2019385420A1 (en) | 2018-11-19 | 2021-07-08 | Spoke Sciences, Inc. | N-acylated fatty amino acids to reduce absorption variability in cannabinoid based compositions |
| KR20210113610A (ko) | 2018-12-10 | 2021-09-16 | 더 제너럴 하스피탈 코포레이션 | 크로몰린 에스테르 및 이의 용도 |
| US12458622B2 (en) | 2020-04-06 | 2025-11-04 | The General Hospital Corporation | Methods of treatment of coronavirus-induced inflammation conditions |
| US11986492B2 (en) * | 2022-09-21 | 2024-05-21 | Ashley Wolchina Allison | Oral supplement for preventing colic in horses |
| CN116509836A (zh) * | 2023-03-23 | 2023-08-01 | 中山万汉制药有限公司 | 色甘酸钠-季铵盐复合物及其制备方法与用途 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6281380A (ja) * | 1985-10-04 | 1987-04-14 | Kyoto Yakuhin Kogyo Kk | クロモグリク酸誘導体、その製造法および抗アレルギ−剤 |
| US5629020A (en) | 1994-04-22 | 1997-05-13 | Emisphere Technologies, Inc. | Modified amino acids for drug delivery |
| US5447728A (en) | 1992-06-15 | 1995-09-05 | Emisphere Technologies, Inc. | Desferrioxamine oral delivery system |
| JPH06281380A (ja) | 1993-03-26 | 1994-10-07 | Hisaka Works Ltd | プレート式熱交換器用ガスケット |
| US5643957A (en) * | 1993-04-22 | 1997-07-01 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| JP4361601B2 (ja) | 1993-04-22 | 2009-11-11 | エミスフェアー・テクノロジーズ・インク | 経口薬剤移送組成物およびその方法 |
| US5650386A (en) | 1995-03-31 | 1997-07-22 | Emisphere Technologies, Inc. | Compositions for oral delivery of active agents |
| JP3124041B2 (ja) * | 1996-08-30 | 2001-01-15 | 京都薬品工業株式会社 | アレルギー性皮膚炎治療剤 |
| EP0993831B1 (en) | 1997-02-07 | 2008-01-09 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US5888529A (en) * | 1997-03-28 | 1999-03-30 | The Regents Of The University Of California | Ileus treatment method |
| US5863944A (en) * | 1997-04-30 | 1999-01-26 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US5952353A (en) * | 1997-09-19 | 1999-09-14 | Auburn University | Treating/preventing heart failure via inhibition of mast cell degranulation |
| US6287594B1 (en) * | 1998-01-20 | 2001-09-11 | Edward S. Wilson | Oral liquid compositions |
| ES2242412T3 (es) * | 1998-07-27 | 2005-11-01 | Emisphere Technologies, Inc. | Compuestos que permiten administrar agentes activos y composiciones a base de estos compuestos. |
| CN1313439C (zh) * | 1998-08-07 | 2007-05-02 | 艾米斯菲尔技术有限公司 | 用于送递活性剂的化合物和组合物 |
| GB9824604D0 (en) * | 1998-11-11 | 1999-01-06 | Hewlett Healthcare Limited | Treatment of allergic conditions |
| AU3378100A (en) * | 1999-02-26 | 2000-09-14 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| IL145546A0 (en) | 1999-04-05 | 2002-06-30 | Emisphere Tech Inc | Disodium salts, monohydrates, and ethanol solvates for delivering active agents |
| CA2388240C (en) * | 1999-11-05 | 2010-04-20 | Emisphere Technologies, Inc. | Phenoxy carboxylic acid compounds and compositions for delivering active agents |
| WO2001044199A1 (en) * | 1999-12-16 | 2001-06-21 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| CA2292902C (en) * | 1999-12-24 | 2012-12-18 | Alain Cadieux | Use of calcitonin gene-related peptide in the prevention and alleviation of asthma and related bronchospastic pulmonary diseases |
| JP4879433B2 (ja) * | 2000-01-13 | 2012-02-22 | エミスフェアー・テクノロジーズ・インク | 活性剤を送達するための化合物および組成物 |
| US6225356B1 (en) * | 2000-01-20 | 2001-05-01 | Jones, Iii Tudor | Cromolyn sodium containing composition and method of treatment for vilvar vestibulitis interstitial cystitis vukvar vaginitis and vaginitis dynea |
| AU2001245273A1 (en) * | 2000-02-15 | 2001-08-27 | Board Of Trustees Of The University Of Arkansas | Recombinant vector expressing a beta2-adrenergic receptor and use in treating airway and vascular diseases |
| JP2004521857A (ja) * | 2000-06-29 | 2004-07-22 | エミスフェアー・テクノロジーズ・インク | 活性剤の送達のための化合物及び組成物 |
| ATE429416T1 (de) * | 2000-09-06 | 2009-05-15 | Emisphere Tech Inc | Cyanophenoxy-carbonsäuren und zusammensetzungen für die freisetzung aktiver substanzen |
-
2002
- 2002-11-29 WO PCT/US2002/038247 patent/WO2003045331A2/en not_active Ceased
- 2002-11-29 JP JP2003546836A patent/JP5196701B2/ja not_active Expired - Fee Related
- 2002-11-29 AU AU2002352974A patent/AU2002352974A1/en not_active Abandoned
- 2002-11-29 CA CA002466863A patent/CA2466863A1/en not_active Abandoned
- 2002-11-29 US US10/497,286 patent/US20040259952A1/en not_active Abandoned
- 2002-11-29 EP EP02789934.3A patent/EP1461031B1/en not_active Expired - Lifetime
-
2008
- 2008-04-16 US US12/103,821 patent/US8513300B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20040259952A1 (en) | 2004-12-23 |
| US20080194676A1 (en) | 2008-08-14 |
| EP1461031B1 (en) | 2016-06-29 |
| JP5196701B2 (ja) | 2013-05-15 |
| EP1461031A4 (en) | 2011-06-22 |
| AU2002352974A1 (en) | 2003-06-10 |
| WO2003045331A3 (en) | 2003-08-14 |
| JP2005510535A (ja) | 2005-04-21 |
| EP1461031A2 (en) | 2004-09-29 |
| AU2002352974A8 (en) | 2003-06-10 |
| WO2003045331A2 (en) | 2003-06-05 |
| US8513300B2 (en) | 2013-08-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20180411 |