CA2466122A1 - Systems and methods for freezing, storing and thawing biopharmaceutical material - Google Patents
Systems and methods for freezing, storing and thawing biopharmaceutical material Download PDFInfo
- Publication number
- CA2466122A1 CA2466122A1 CA002466122A CA2466122A CA2466122A1 CA 2466122 A1 CA2466122 A1 CA 2466122A1 CA 002466122 A CA002466122 A CA 002466122A CA 2466122 A CA2466122 A CA 2466122A CA 2466122 A1 CA2466122 A1 CA 2466122A1
- Authority
- CA
- Canada
- Prior art keywords
- container
- frame
- control unit
- temperature control
- flexible container
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000000463 material Substances 0.000 title claims abstract description 258
- 229960000074 biopharmaceutical Drugs 0.000 title claims abstract description 232
- 238000007710 freezing Methods 0.000 title claims abstract description 107
- 230000008014 freezing Effects 0.000 title claims abstract description 107
- 238000010257 thawing Methods 0.000 title claims abstract description 54
- 238000000034 method Methods 0.000 title claims description 42
- 238000003860 storage Methods 0.000 claims abstract description 50
- 230000001681 protective effect Effects 0.000 claims description 21
- 238000012546 transfer Methods 0.000 claims description 19
- 230000001105 regulatory effect Effects 0.000 claims description 17
- 239000012530 fluid Substances 0.000 claims description 6
- 238000004891 communication Methods 0.000 claims description 5
- 230000002401 inhibitory effect Effects 0.000 claims description 5
- 230000001276 controlling effect Effects 0.000 claims description 4
- 230000005484 gravity Effects 0.000 claims description 4
- 239000007788 liquid Substances 0.000 description 25
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 24
- 239000013078 crystal Substances 0.000 description 21
- 238000001816 cooling Methods 0.000 description 16
- 210000001787 dendrite Anatomy 0.000 description 14
- 239000007787 solid Substances 0.000 description 13
- 210000004027 cell Anatomy 0.000 description 9
- -1 polypropylene Polymers 0.000 description 9
- 238000011049 filling Methods 0.000 description 8
- 238000010438 heat treatment Methods 0.000 description 8
- 239000007791 liquid phase Substances 0.000 description 7
- 229920003023 plastic Polymers 0.000 description 7
- 239000004033 plastic Substances 0.000 description 7
- 230000006378 damage Effects 0.000 description 6
- 239000011159 matrix material Substances 0.000 description 6
- 239000004698 Polyethylene Substances 0.000 description 5
- 229920000573 polyethylene Polymers 0.000 description 5
- 238000012545 processing Methods 0.000 description 5
- 238000003466 welding Methods 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 239000007789 gas Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 238000004321 preservation Methods 0.000 description 4
- 239000004952 Polyamide Substances 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 230000001413 cellular effect Effects 0.000 description 3
- 239000002131 composite material Substances 0.000 description 3
- 238000005138 cryopreservation Methods 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 230000001627 detrimental effect Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000005496 eutectics Effects 0.000 description 3
- 238000001746 injection moulding Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 229920002492 poly(sulfone) Polymers 0.000 description 3
- 229920002647 polyamide Polymers 0.000 description 3
- 229920000515 polycarbonate Polymers 0.000 description 3
- 239000004417 polycarbonate Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 230000002829 reductive effect Effects 0.000 description 3
- 238000007665 sagging Methods 0.000 description 3
- 239000000523 sample Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 229910001220 stainless steel Inorganic materials 0.000 description 3
- 239000010935 stainless steel Substances 0.000 description 3
- KFSLWBXXFJQRDL-UHFFFAOYSA-N Peracetic acid Chemical compound CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 description 2
- 239000004743 Polypropylene Substances 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
- 229910052782 aluminium Inorganic materials 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 238000012512 characterization method Methods 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000005038 ethylene vinyl acetate Substances 0.000 description 2
- 230000004907 flux Effects 0.000 description 2
- 230000036512 infertility Effects 0.000 description 2
- 238000003754 machining Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 239000012071 phase Substances 0.000 description 2
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 2
- 229920000728 polyester Polymers 0.000 description 2
- 229920001155 polypropylene Polymers 0.000 description 2
- 229920002635 polyurethane Polymers 0.000 description 2
- 239000004814 polyurethane Substances 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 230000035939 shock Effects 0.000 description 2
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 2
- 238000004781 supercooling Methods 0.000 description 2
- 229920000049 Carbon (fiber) Polymers 0.000 description 1
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- 239000002033 PVDF binder Substances 0.000 description 1
- 229920006328 Styrofoam Polymers 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- 239000004708 Very-low-density polyethylene Substances 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 229960004424 carbon dioxide Drugs 0.000 description 1
- 235000011089 carbon dioxide Nutrition 0.000 description 1
- 239000004917 carbon fiber Substances 0.000 description 1
- 230000005779 cell damage Effects 0.000 description 1
- 208000037887 cell injury Diseases 0.000 description 1
- 210000003850 cellular structure Anatomy 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 239000012809 cooling fluid Substances 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000000875 corresponding effect Effects 0.000 description 1
- 238000012864 cross contamination Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 229920006351 engineering plastic Polymers 0.000 description 1
- 239000004794 expanded polystyrene Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000010101 extrusion blow moulding Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000011152 fibreglass Substances 0.000 description 1
- 229920002313 fluoropolymer Polymers 0.000 description 1
- 239000004811 fluoropolymer Substances 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000009477 glass transition Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000010102 injection blow moulding Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 229920001684 low density polyethylene Polymers 0.000 description 1
- 239000004702 low-density polyethylene Substances 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 238000009828 non-uniform distribution Methods 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 229920002981 polyvinylidene fluoride Polymers 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000008261 styrofoam Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- BFKJFAAPBSQJPD-UHFFFAOYSA-N tetrafluoroethene Chemical compound FC(F)=C(F)F BFKJFAAPBSQJPD-UHFFFAOYSA-N 0.000 description 1
- 230000007723 transport mechanism Effects 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 229920001866 very low density polyethylene Polymers 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Classifications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D31/00—Other cooling or freezing apparatus
- F25D31/001—Plate freezers
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/14—Mechanical aspects of preservation; Apparatus or containers therefor
- A01N1/142—Apparatus
- A01N1/144—Apparatus for temperature control, e.g. refrigerators or freeze-drying apparatus
- A01N1/145—Stationary or portable vessels generating cryogenic temperatures, e.g. liquid nitrogen baths
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/14—Mechanical aspects of preservation; Apparatus or containers therefor
- A01N1/146—Non-refrigerated containers specially adapted for transporting or storing living parts whilst preserving
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23B—PRESERVATION OF FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; CHEMICAL RIPENING OF FRUIT OR VEGETABLES
- A23B2/00—Preservation of foods or foodstuffs, in general
- A23B2/80—Freezing; Subsequent thawing; Cooling
- A23B2/805—Materials not being transported through or in the apparatus with or without shaping, e.g. in the form of powders, granules or flakes
- A23B2/8055—Materials not being transported through or in the apparatus with or without shaping, e.g. in the form of powders, granules or flakes with packages or with shaping in the form of blocks or portions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23B—PRESERVATION OF FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; CHEMICAL RIPENING OF FRUIT OR VEGETABLES
- A23B2/00—Preservation of foods or foodstuffs, in general
- A23B2/80—Freezing; Subsequent thawing; Cooling
- A23B2/82—Thawing subsequent to freezing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0272—Apparatus for treatment of blood or blood constituents prior to or for conservation, e.g. freezing, drying or centrifuging
- A61M1/0277—Frames constraining or supporting bags, e.g. during freezing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0281—Apparatus for treatment of blood or blood constituents prior to transfusion, e.g. washing, filtering or thawing
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D25/00—Charging, supporting, and discharging the articles to be cooled
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25B—REFRIGERATION MACHINES, PLANTS OR SYSTEMS; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS
- F25B2600/00—Control issues
- F25B2600/07—Remote controls
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D2331/00—Details or arrangements of other cooling or freezing apparatus not provided for in other groups of this subclass
- F25D2331/80—Type of cooled receptacles
- F25D2331/801—Bags
- F25D2331/8014—Bags for medical use
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D2400/00—General features of, or devices for refrigerators, cold rooms, ice-boxes, or for cooling or freezing apparatus not covered by any other subclass
- F25D2400/20—Carts specially adapted for transporting objects to be cooled
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D2400/00—General features of, or devices for refrigerators, cold rooms, ice-boxes, or for cooling or freezing apparatus not covered by any other subclass
- F25D2400/30—Quick freezing
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D2500/00—Problems to be solved
- F25D2500/02—Geometry problems
Landscapes
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Anesthesiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Combustion & Propulsion (AREA)
- Biomedical Technology (AREA)
- Mechanical Engineering (AREA)
- Thermal Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Animal Behavior & Ethology (AREA)
- Vascular Medicine (AREA)
- Environmental Sciences (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Packages (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Freezing, Cooling And Drying Of Foods (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33462201P | 2001-11-01 | 2001-11-01 | |
| US60/334,622 | 2001-11-01 | ||
| PCT/US2002/035135 WO2003037082A1 (en) | 2001-11-01 | 2002-11-01 | Systems and methods for freezing, storing and thawing biopharmaceutical material |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2466122A1 true CA2466122A1 (en) | 2003-05-08 |
Family
ID=23308033
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002466122A Abandoned CA2466122A1 (en) | 2001-11-01 | 2002-11-01 | Systems and methods for freezing, storing and thawing biopharmaceutical material |
| CA002466130A Abandoned CA2466130A1 (en) | 2001-11-01 | 2002-11-01 | Systems and methods for freezing and storing biopharmaceutical material |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002466130A Abandoned CA2466130A1 (en) | 2001-11-01 | 2002-11-01 | Systems and methods for freezing and storing biopharmaceutical material |
Country Status (9)
| Country | Link |
|---|---|
| EP (2) | EP1441585B1 (https=) |
| JP (2) | JP2005523843A (https=) |
| CN (3) | CN1242670C (https=) |
| AT (2) | ATE330466T1 (https=) |
| CA (2) | CA2466122A1 (https=) |
| DE (2) | DE60211731T2 (https=) |
| DK (2) | DK1441586T3 (https=) |
| ES (2) | ES2265057T3 (https=) |
| WO (2) | WO2003037082A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12239127B2 (en) | 2021-07-28 | 2025-03-04 | Sartorius Stedim North America Inc. | Thermal capacitors, systems, and methods for rapid freezing or heating of biological materials |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1542894T3 (da) * | 2002-09-23 | 2006-10-09 | Integrated Biosystems Inc | Anlæg og fremgangsmåder til frysning, lagring, transport og optöning af biofarmaceutisk materiale |
| WO2004055456A1 (en) * | 2002-12-13 | 2004-07-01 | Integrated Biosystems, Inc. | Scaled down freezing and thawing system for bioparmaceuticals and biologics |
| DE102004015090A1 (de) | 2004-03-25 | 2005-11-03 | Hüttinger Elektronik Gmbh + Co. Kg | Bogenentladungserkennungseinrichtung |
| JP4939405B2 (ja) | 2005-04-28 | 2012-05-23 | 株式会社大塚製薬工場 | 薬液容器収容体およびその製造方法 |
| WO2007023907A1 (ja) * | 2005-08-24 | 2007-03-01 | Transcu Ltd. | 冷凍型イオントフォレーシス用電極構造体 |
| US20090217677A1 (en) * | 2005-12-02 | 2009-09-03 | Youn-Ok Shin | Freezing and storage container for biopharmaceutical drug products |
| WO2007103917A2 (en) * | 2006-03-06 | 2007-09-13 | Integrated Biosystems, Inc. | Systems and methods for freezing, storing and thawing biopharmaceutical materials |
| DK2080501T3 (en) | 2006-10-27 | 2015-08-03 | Otsuka Pharma Co Ltd | Package containing drug solution with reduced dissolved oxygen content |
| CN101932235B (zh) * | 2007-12-21 | 2014-06-18 | 赛多利斯斯泰迪北美有限公司 | 用于冷冻、贮存和解冻生物制药材料的系统和方法 |
| US9301520B2 (en) | 2007-12-21 | 2016-04-05 | Sartorius Stedim North America Inc. | Systems and methods for freezing, storing and thawing biopharmaceutical materials |
| US8177123B2 (en) * | 2008-09-24 | 2012-05-15 | Sartorius Stedim North America Inc. | Systems and methods for freezing, storing and thawing biopharmaceutical materials |
| CA2749978A1 (en) | 2009-01-20 | 2010-07-29 | F. Hoffmann-La Roche Ag | Cryogenic container |
| US20110017743A1 (en) * | 2009-07-22 | 2011-01-27 | Honeywell International Inc. | Sealable container linings and sealable containers |
| US8371132B2 (en) * | 2009-11-23 | 2013-02-12 | Sartorius Stedim North America Inc. | Systems and methods for use in freezing, thawing, and storing biopharmaceutical materials |
| IT1397926B1 (it) * | 2010-02-12 | 2013-02-04 | Angelantoni Ind Spa | Congelatore rapido per sacche con rilevazione della temperatura delle sacche. |
| PT105405B (pt) * | 2010-11-26 | 2014-08-21 | Univ Lisboa | Processo e aparelho de congelação em pratos para obtenção de matrizes de gelo com distribuição de solutos uniforme |
| CN104081142B (zh) * | 2011-03-28 | 2017-03-01 | 普莱克斯技术有限公司 | 生物制药的散装冻结 |
| CN102322725B (zh) * | 2011-09-13 | 2013-06-12 | 东莞市品翔饮水设备有限公司 | 制冰、制冷、制热直饮机 |
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-
2002
- 2002-11-01 WO PCT/US2002/035135 patent/WO2003037082A1/en not_active Ceased
- 2002-11-01 JP JP2003539439A patent/JP2005523843A/ja active Pending
- 2002-11-01 DE DE60211731T patent/DE60211731T2/de not_active Expired - Lifetime
- 2002-11-01 WO PCT/US2002/035137 patent/WO2003037083A1/en not_active Ceased
- 2002-11-01 CA CA002466122A patent/CA2466122A1/en not_active Abandoned
- 2002-11-01 JP JP2003539440A patent/JP2005507692A/ja active Pending
- 2002-11-01 DK DK02778703T patent/DK1441586T3/da active
- 2002-11-01 AT AT02778703T patent/ATE330466T1/de not_active IP Right Cessation
- 2002-11-01 ES ES02778702T patent/ES2265057T3/es not_active Expired - Lifetime
- 2002-11-01 CN CNB028218582A patent/CN1242670C/zh not_active Expired - Fee Related
- 2002-11-01 EP EP02778702A patent/EP1441585B1/en not_active Expired - Lifetime
- 2002-11-01 CN CNB2005100978176A patent/CN1315374C/zh not_active Expired - Fee Related
- 2002-11-01 EP EP02778703A patent/EP1441586B1/en not_active Expired - Lifetime
- 2002-11-01 DE DE60212680T patent/DE60212680T2/de not_active Expired - Lifetime
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- 2002-11-01 CN CNB028218566A patent/CN1229018C/zh not_active Expired - Lifetime
- 2002-11-01 AT AT02778702T patent/ATE326841T1/de not_active IP Right Cessation
- 2002-11-01 DK DK02778702T patent/DK1441585T3/da active
- 2002-11-01 CA CA002466130A patent/CA2466130A1/en not_active Abandoned
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12239127B2 (en) | 2021-07-28 | 2025-03-04 | Sartorius Stedim North America Inc. | Thermal capacitors, systems, and methods for rapid freezing or heating of biological materials |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1229018C (zh) | 2005-11-30 |
| ATE330466T1 (de) | 2006-07-15 |
| CA2466130A1 (en) | 2003-05-08 |
| WO2003037082A1 (en) | 2003-05-08 |
| CN1315374C (zh) | 2007-05-16 |
| CN1582112A (zh) | 2005-02-16 |
| DE60211731T2 (de) | 2007-05-16 |
| WO2003037082A9 (en) | 2004-01-15 |
| ATE326841T1 (de) | 2006-06-15 |
| EP1441586A1 (en) | 2004-08-04 |
| JP2005507692A (ja) | 2005-03-24 |
| CN1732776A (zh) | 2006-02-15 |
| CN1582111A (zh) | 2005-02-16 |
| HK1087889A1 (en) | 2006-10-27 |
| JP2005523843A (ja) | 2005-08-11 |
| EP1441585B1 (en) | 2006-05-24 |
| EP1441585A1 (en) | 2004-08-04 |
| CN1242670C (zh) | 2006-02-22 |
| DE60212680T2 (de) | 2007-06-28 |
| WO2003037083A9 (en) | 2004-01-15 |
| DE60212680D1 (de) | 2006-08-03 |
| HK1074749A1 (en) | 2005-11-25 |
| DK1441585T3 (da) | 2006-10-02 |
| ES2265057T3 (es) | 2007-02-01 |
| DE60211731D1 (de) | 2006-06-29 |
| WO2003037083A1 (en) | 2003-05-08 |
| DK1441586T3 (da) | 2006-10-23 |
| EP1441586B1 (en) | 2006-06-21 |
| HK1074748A1 (en) | 2005-11-25 |
| ES2266588T3 (es) | 2007-03-01 |
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