CA2464478C - A system and method for uniaxial compression of an article, such as a three-dimensionally printed dosage form - Google Patents

A system and method for uniaxial compression of an article, such as a three-dimensionally printed dosage form Download PDF

Info

Publication number
CA2464478C
CA2464478C CA2464478A CA2464478A CA2464478C CA 2464478 C CA2464478 C CA 2464478C CA 2464478 A CA2464478 A CA 2464478A CA 2464478 A CA2464478 A CA 2464478A CA 2464478 C CA2464478 C CA 2464478C
Authority
CA
Canada
Prior art keywords
dosage form
active pharmaceutical
pharmaceutical ingredient
compressed
printed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2464478A
Other languages
English (en)
French (fr)
Other versions
CA2464478A1 (en
Inventor
Wendy E. Pryce Lewis
Charles William Rowe
Michael J. Cima
Peter A. Materna
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
Original Assignee
Massachusetts Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Institute of Technology filed Critical Massachusetts Institute of Technology
Priority to CA2763676A priority Critical patent/CA2763676C/en
Publication of CA2464478A1 publication Critical patent/CA2464478A1/en
Application granted granted Critical
Publication of CA2464478C publication Critical patent/CA2464478C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
    • B29C64/10—Processes of additive manufacturing
    • B29C64/165—Processes of additive manufacturing using a combination of solid and fluid materials, e.g. a powder selectively bound by a liquid binder, catalyst, inhibitor or energy absorber
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y70/00—Materials specially adapted for additive manufacturing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y80/00—Products made by additive manufacturing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/753—Medical equipment; Accessories therefor

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Materials Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Manufacturing & Machinery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Mechanical Engineering (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Application Of Or Painting With Fluid Materials (AREA)
  • Treatment Of Fiber Materials (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Ink Jet (AREA)
CA2464478A 2001-10-29 2002-10-29 A system and method for uniaxial compression of an article, such as a three-dimensionally printed dosage form Expired - Lifetime CA2464478C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2763676A CA2763676C (en) 2001-10-29 2002-10-29 A system and method for uniaxial compression of an article, such as a three-dimensionally printed dosage form

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33992001P 2001-10-29 2001-10-29
US60/339,920 2001-10-29
PCT/US2002/034836 WO2003037607A1 (en) 2001-10-29 2002-10-29 A system and method for uniaxial compression of an article, such as a three-dimensionally printed dosage form

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2763676A Division CA2763676C (en) 2001-10-29 2002-10-29 A system and method for uniaxial compression of an article, such as a three-dimensionally printed dosage form

Publications (2)

Publication Number Publication Date
CA2464478A1 CA2464478A1 (en) 2003-05-08
CA2464478C true CA2464478C (en) 2012-03-20

Family

ID=23331181

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2464478A Expired - Lifetime CA2464478C (en) 2001-10-29 2002-10-29 A system and method for uniaxial compression of an article, such as a three-dimensionally printed dosage form

Country Status (8)

Country Link
US (2) US7931914B2 (https=)
EP (1) EP1439945B1 (https=)
JP (2) JP4845340B2 (https=)
AT (1) ATE322972T1 (https=)
CA (1) CA2464478C (https=)
DE (1) DE60210650T2 (https=)
ES (1) ES2262851T3 (https=)
WO (1) WO2003037607A1 (https=)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001034371A2 (en) 1999-11-05 2001-05-17 Z Corporation Material systems and methods of three-dimensional printing
US6544555B2 (en) 2000-02-24 2003-04-08 Advancis Pharmaceutical Corp. Antibiotic product, use and formulation thereof
US6565882B2 (en) 2000-02-24 2003-05-20 Advancis Pharmaceutical Corp Antibiotic composition with inhibitor
US20010050031A1 (en) 2000-04-14 2001-12-13 Z Corporation Compositions for three-dimensional printing of solid objects
US6541014B2 (en) 2000-10-13 2003-04-01 Advancis Pharmaceutical Corp. Antiviral product, use and formulation thereof
US20020068078A1 (en) 2000-10-13 2002-06-06 Rudnic Edward M. Antifungal product, use and formulation thereof
CA2526100A1 (en) 2003-05-21 2004-12-29 Z Corporation Thermoplastic powder material system for appearance models from 3d printing systems
AU2004258953B2 (en) 2003-07-21 2011-02-10 Shionogi, Inc. Antibiotic product, use and formulation thereof
AU2004258949B2 (en) 2003-07-21 2011-02-10 Shionogi, Inc. Antibiotic product, use and formulation thereof
JP2006528185A (ja) 2003-07-21 2006-12-14 アドバンシス ファーマスーティカル コーポレイション 抗生物質製剤、その使用法及び作成方法
CA2535177A1 (en) 2003-08-11 2005-02-24 Advancis Pharmaceutical Corporation Robust pellet
US8062672B2 (en) 2003-08-12 2011-11-22 Shionogi Inc. Antibiotic product, use and formulation thereof
AU2004270170B2 (en) 2003-08-29 2011-01-27 Shionogi, Inc. Antibiotic product, use and formulation thereof
CA2538064C (en) 2003-09-15 2013-12-17 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
US8080097B2 (en) * 2003-11-06 2011-12-20 Hewlett-Packard Development Company, L.P. System and a method for the creation of edible, optically invisible images
CA2572292A1 (en) 2004-07-02 2006-02-09 Advancis Pharmaceutical Corporation Tablet for pulsed delivery
US8609198B2 (en) * 2004-07-21 2013-12-17 Hewlett-Packard Development Company, L.P. Pharmaceutical dose form with a patterned coating and method of making the same
EP1827391B1 (en) * 2004-11-26 2015-09-23 Aprecia Pharmaceuticals Co. Three dimensionally printed dosage forms
US8357394B2 (en) 2005-12-08 2013-01-22 Shionogi Inc. Compositions and methods for improved efficacy of penicillin-type antibiotics
US8778924B2 (en) 2006-12-04 2014-07-15 Shionogi Inc. Modified release amoxicillin products
US8299052B2 (en) 2006-05-05 2012-10-30 Shionogi Inc. Pharmaceutical compositions and methods for improved bacterial eradication
CN101568422B (zh) 2006-12-08 2013-02-13 3D系统公司 使用过氧化物固化的三维印刷材料体系和方法
WO2008086033A1 (en) 2007-01-10 2008-07-17 Z Corporation Three-dimensional printing material system with improved color, article performance, and ease of use
US7968626B2 (en) 2007-02-22 2011-06-28 Z Corporation Three dimensional printing material system and method using plasticizer-assisted sintering
CN102470237A (zh) 2009-06-26 2012-05-23 塔里斯生物医药公司 用于可植入药物递送装置的固体药物片剂
JP2011074015A (ja) * 2009-09-30 2011-04-14 Tomita Pharmaceutical Co Ltd 固形製剤及びその製造方法
US9381154B2 (en) * 2011-06-09 2016-07-05 Xerox Corporation Direct inkjet fabrication of drug delivery devices
US8414654B1 (en) * 2011-11-23 2013-04-09 Amendia, Inc. Bone implants and method of manufacture
US9974446B2 (en) 2012-08-31 2018-05-22 Volcano Corporation Mounting structures for components of intravascular devices
DK2892708T3 (en) 2012-09-05 2019-01-28 Aprecia Pharmaceuticals LLC THREE-DIMENSIONAL PRESSURE SYSTEM AND EQUIPMENT
US8888480B2 (en) 2012-09-05 2014-11-18 Aprecia Pharmaceuticals Company Three-dimensional printing system and equipment assembly
CA2906029C (en) * 2013-03-15 2017-09-05 Aprecia Pharmaceuticals Company Rapid disperse dosage form containing levetiracetam
US9339489B2 (en) 2013-03-15 2016-05-17 Aprecia Pharmaceuticals Company Rapid disperse dosage form containing levetiracetam
JP6466399B2 (ja) * 2013-03-15 2019-02-06 アプレシア・ファーマスーティカルズ・カンパニー トピラマートの急速分散性の剤形
EP3033188A4 (en) 2013-08-16 2017-03-22 The Exone Company Three-dimensional printed metal-casting molds and methods for making the same
US9289917B2 (en) * 2013-10-01 2016-03-22 General Electric Company Method for 3-D printing a pattern for the surface of a turbine shroud
US20160243621A1 (en) 2013-10-17 2016-08-25 The Exone Company Three-Dimensional Printed Hot Isostatic Pressing Containers and Processes for Making Same
EP2884259A1 (en) * 2013-12-11 2015-06-17 Rockwool International A/S Method for detecting curing of the binder in a mineral fibre product
US11001048B2 (en) 2013-12-23 2021-05-11 The Exone Company Method of three-dimensional printing using a multi-component build powder
US20160332373A1 (en) 2013-12-23 2016-11-17 The Exone Company Methods and Systems for Three-Dimensional Printing Utilizing Multiple Binder Fluids
US9415546B2 (en) * 2014-01-29 2016-08-16 Xerox Corporation System and method for controlling material drop volume in three dimensional object printing
EP3148730A1 (en) 2014-05-29 2017-04-05 The Exone Company Process for making nickel-based superalloy articles by three-dimensional printing
US9446556B2 (en) 2014-06-06 2016-09-20 Xerox Corporation System for compensating for drop volume variation during three-dimensional printing of an object
US9327537B2 (en) 2014-06-06 2016-05-03 Xerox Corporation System for adjusting operation of a printer during three-dimensional object printing using an optical sensor
US9738032B2 (en) 2014-06-06 2017-08-22 Xerox Corporation System for controlling operation of a printer during three-dimensional object printing with reference to a distance from the surface of object
EP3169499A2 (en) 2014-07-17 2017-05-24 The Exone Company Methods and apparatuses for curing three-dimensional printed articles
US9857784B2 (en) * 2014-11-12 2018-01-02 International Business Machines Corporation Method for repairing with 3D printing
EP3227109B1 (en) 2014-12-03 2020-08-19 The Exone Company Process for making densified carbon articles by three dimensional printing
AU2016272089B2 (en) 2015-06-03 2021-02-18 Triastek, Inc. Dosage forms and use thereof
CN108721242B (zh) * 2015-06-03 2021-03-02 南京三迭纪医药科技有限公司 药品剂型及其使用
JP6903659B2 (ja) * 2015-08-21 2021-07-14 アプレシア・ファーマスーティカルズ・エルエルシー ３次元プリントシステムおよび装置アセンブリ
CN105196550B (zh) * 2015-10-30 2018-01-23 兰红波 一种单喷头多材料多尺度3d打印装置及其工作方法
CN107019676B (zh) * 2016-01-29 2020-08-04 南京三迭纪医药科技有限公司 一种抗凝血药物的制备方法
CA3018011A1 (en) * 2016-03-18 2017-09-21 Grunenthal Gmbh Floating pharmaceutical dosage form
CN105687151A (zh) * 2016-03-22 2016-06-22 西北工业大学 一种基于喷墨3d打印技术制备片剂药物的方法
AU2017261372B2 (en) 2016-05-05 2019-02-14 Triastek, Inc. Controlled release dosage form
US10765658B2 (en) 2016-06-22 2020-09-08 Mastix LLC Oral compositions delivering therapeutically effective amounts of cannabinoids
WO2018028972A1 (en) 2016-08-08 2018-02-15 Ratiopharm Gmbh Method for manufacturing a dosage form by additive manufacturing, a dosage form and a device for manufacturing a dosage form
JP6592800B2 (ja) * 2016-08-17 2019-10-23 株式会社マイクロジェット 成型物を成型するシステム
EP3573602A4 (en) 2017-01-26 2020-09-16 Triastek, Inc. DOSAGE FORMS OF CONTROLLED RELEASE AT SPECIFIC GASTROINTESTINAL SITES
US11229605B2 (en) 2017-02-15 2022-01-25 Hewlett-Packard Development Company, L.P. Printed support structure
US11602502B2 (en) 2017-02-24 2023-03-14 Hewlett-Packard Development Company, L.P. Three-dimensional (3D) printing a pharmaceutical tablet
JP7358340B2 (ja) 2017-05-26 2023-10-10 インフィニット・マテリアル・ソリューションズ，エルエルシー 水溶性ポリマー組成物
US20200291347A1 (en) * 2017-10-26 2020-09-17 Merck Patent Gmbh Methods for performing cell culture
MX2020006886A (es) * 2017-12-29 2020-11-11 Laxxon Medical Ag Sistema para suministro de medicamento.
KR102718551B1 (ko) * 2017-12-29 2024-10-17 락손 메디칼 아게 약물 전달 시스템을 제조하기 위한 방법
US10350822B1 (en) 2018-01-09 2019-07-16 Triastek Inc. Dosage forms with desired release profiles and methods of designing and making thereof
US10201503B1 (en) * 2018-01-09 2019-02-12 Triastek, Inc. Precision pharmaceutical 3D printing device
CN116270513A (zh) 2018-01-09 2023-06-23 南京三迭纪医药科技有限公司 一种包含固定剂量adhd非兴奋剂和adhd兴奋剂的复方口服药物剂型
US11241830B2 (en) 2018-01-11 2022-02-08 Hewlett-Packard Development Company, L.P. Build material spreaders
FR3086567B1 (fr) * 2018-10-02 2022-07-22 Norimat Procede de realisation de contreforme et procede de fabrication de piece de forme complexe utilisant une telle contre-forme
JP7614103B2 (ja) * 2018-10-15 2025-01-15 アプレシア・ファーマスーティカルズ・エルエルシー 包装内に剤形を形成する方法およびシステム
AU2020277668A1 (en) * 2019-05-21 2021-11-25 Dfe Pharma Gmbh & Co. Kg Lactose powder bed three dimensional printing
US12179433B2 (en) * 2019-06-18 2024-12-31 Bio Medical 3D Printing Co., Ltd. 3D object containing CBD and printing operating system therefor
US11583501B1 (en) * 2020-01-02 2023-02-21 Robert Edwin Douglas Method and apparatus for 3D printing a precision pharmacologic dosing regimen
WO2021164660A1 (en) 2020-02-17 2021-08-26 Triastek, Inc. Continuous unloading and packaging system for pharmaceutical additive manufacturing
US12544310B2 (en) 2020-03-02 2026-02-10 Craft Health Pte Ltd. Method of manufacturing oral dosage forms for extended drug release
US12371581B2 (en) 2020-03-25 2025-07-29 Infinite Material Solutions, Llc High performance water soluble polymer compositions
EP4238556A4 (en) 2020-10-30 2024-09-25 Triastek, Inc. GASTRORETENTIVE PHARMACEUTICAL DOSAGE FORM
WO2023235372A1 (en) * 2022-06-01 2023-12-07 Cyrus Scientific, Llc Pharmaceutical apparatus and method of manufacturing a patient-tailored pharmaceutical tablet

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4865789A (en) * 1983-11-14 1989-09-12 Akzo Nv Method for making porous structures
US5204055A (en) 1989-12-08 1993-04-20 Massachusetts Institute Of Technology Three-dimensional printing techniques
US5490962A (en) * 1993-10-18 1996-02-13 Massachusetts Institute Of Technology Preparation of medical devices by solid free-form fabrication methods
US6280771B1 (en) * 1997-02-20 2001-08-28 Therics, Inc. Dosage forms exhibiting multi-phasic release kinetics and methods of manufacture thereof
DE4439782B4 (de) * 1993-11-05 2005-07-28 Sanyo Electric Co., Ltd., Moriguchi Behälter, der mit einer Anzahl von Pulvern von wasserstoffabsorbierenden Legierungen gepackt ist, und Formkörper
US5587203A (en) * 1993-11-29 1996-12-24 Nippon Oil Co. Method for preparing a carbon/carbon composite material
CA2281474C (en) * 1997-02-20 2006-10-31 Therics, Inc. Dosage forms exhibiting multiphasic release kinetics and methods of manufacture thereof
WO1998036738A1 (en) * 1997-02-20 1998-08-27 Therics, Inc. Dosage form exhibiting rapid disperse properties, methods of use and process for the manufacture of same
AU768641B2 (en) * 1998-10-12 2003-12-18 Massachusetts Institute Of Technology Composites for tissue regeneration and methods of manufacture thereof
JP3756017B2 (ja) * 1999-08-12 2006-03-15 株式会社リコー 定着装置
JP5178982B2 (ja) * 2000-05-18 2013-04-10 セリックス， インコーポレイテッド 経口投薬形態における、毒性コアの非毒性領域中へのカプセル化

Also Published As

Publication number Publication date
JP2010227590A (ja) 2010-10-14
ES2262851T3 (es) 2006-12-01
US20030143268A1 (en) 2003-07-31
US8758658B2 (en) 2014-06-24
DE60210650D1 (de) 2006-05-24
CA2464478A1 (en) 2003-05-08
ATE322972T1 (de) 2006-04-15
WO2003037607A1 (en) 2003-05-08
JP4845340B2 (ja) 2011-12-28
DE60210650T2 (de) 2007-01-25
US20110187015A1 (en) 2011-08-04
US7931914B2 (en) 2011-04-26
JP2005507723A (ja) 2005-03-24
EP1439945B1 (en) 2006-04-12
EP1439945A1 (en) 2004-07-28

Similar Documents

Publication Publication Date Title
CA2464478C (en) A system and method for uniaxial compression of an article, such as a three-dimensionally printed dosage form
CA2464653C (en) System for manufacturing controlled release dosage forms, such as a zero-order release profile dosage form manufactured by three-dimensional printing
US5089270A (en) Capsule-shaped tablet
DE69315578T2 (de) Verfahren zur herstellung von arzneiformulierungen
US5213738A (en) Method for making a capsule-shaped tablet
JP2005507723A5 (https=)
JP7625309B2 (ja) 固形製剤の製造方法
US20020106412A1 (en) Method and materials for controlling migration of binder liquid in a powder
EP1946737A1 (en) Apparatus for compacting powder
JP2010120938A (ja) 迅速分散性を示す投与剤形医薬組成物
Ochoa et al. Co-processed materials testing as excipients to produce Orally Disintegrating Tablets (ODT) using binder jet 3D-printing technology
CA2763676C (en) A system and method for uniaxial compression of an article, such as a three-dimensionally printed dosage form
AU2002342221A1 (en) A system and method for uniaxial compression of an article, such as a three-dimensionally printed dosage form
CN110200118A (zh) 基于3d打印模具制备的含药糖果
Maiti OSDrC®: a revolution in drug formulation technology
AU2002350064A1 (en) System for manufacturing controlled release dosage forms, such as a zero-order release profile dosage form manufactured by three-dimensional printing
Patel et al. Binder Jetting-Based 3D Printing in Pharmaceutics
HK40114752A (zh) 多色固态化妆品的制造方法
CA3238688A1 (en) Customizable dosage forms containing simethicone

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20221031